{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:34:11Z","timestamp":1783452851054,"version":"3.55.0"},"reference-count":69,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2027,2,20]],"date-time":"2027-02-20T00:00:00Z","timestamp":1803081600000},"content-version":"am","delay-in-days":415,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374148"],"award-info":[{"award-number":["82374148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Kaempferol protected the structure and function of right ventricle\u00a0 and attenuated RV remodeling in HAPH rats, potentially through the modulation of the AMPK\/ACC\/CPT1B axis and AMPK-mediated LDHA\/PDHA1 pathway.<\/jats:p>","DOI":"10.1039\/d5fo04265h","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:00:58Z","timestamp":1771588858000},"page":"3172-3185","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK\/ACC\/CPT1B axis and the AMPK-mediated LDHA\/PDHA1 pathway"],"prefix":"10.1039","volume":"17","author":[{"given":"Qiongqiong","family":"Zhao","sequence":"first","affiliation":[{"name":"Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University, Xining, 810001, China"},{"name":"Qinghai University Affiliated Hospital, Xining, 810000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7808-8266","authenticated-orcid":false,"given":"Shanshan","family":"Su","sequence":"additional","affiliation":[{"name":"Technical Center of Xining Customs, Key Laboratory of Food Safety Research in Qinghai Province, Xining, 810003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, 610106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiduo","family":"Huayu","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University, Xining, 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingmei","family":"Nan","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University, Xining, 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Li","sequence":"additional","affiliation":[{"name":"Qinghai University Affiliated Hospital, Xining, 810000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-3255","authenticated-orcid":false,"given":"Zhanqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University, Xining, 810001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-2833","authenticated-orcid":false,"given":"Dianxiang","family":"Lu","sequence":"additional","affiliation":[{"name":"Research Center for High Altitude Medicine, Key Laboratory for High Altitude Medicine (Ministry of Education), Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University, Xining, 810001, China"},{"name":"Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, 610106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO04265H\/cit1\/1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41572-024-00526-w","volume":"10","author":"Gatterer","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D5FO04265H\/cit2\/1","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.3390\/ijerph18041692","volume":"18","author":"Sydykov","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"D5FO04265H\/cit3\/1","doi-asserted-by":"publisher","first-page":"H273","DOI":"10.1152\/ajpheart.00758.2013","volume":"307","author":"Liu","year":"2014","journal-title":"Am. J. Physiol.: Heart Circ. Physiol."},{"key":"D5FO04265H\/cit4\/1","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1513\/AnnalsATS.201312-425FR","volume":"11","author":"Gomez-Arroyo","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"D5FO04265H\/cit5\/1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0008-6363(96)00245-3","volume":"33","author":"Stanley","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"D5FO04265H\/cit6\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcb.240550002","volume":"55","author":"Randle","year":"1994","journal-title":"J. Cell. Biochem."},{"key":"D5FO04265H\/cit7\/1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1086\/681227","volume":"5","author":"Talati","year":"2015","journal-title":"Pulm. Circ."},{"key":"D5FO04265H\/cit8\/1","doi-asserted-by":"publisher","first-page":"L355","DOI":"10.1152\/ajplung.00039.2022","volume":"323","author":"Lee","year":"2022","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"D5FO04265H\/cit9\/1","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1111\/bph.13495","volume":"173","author":"Singh","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"D5FO04265H\/cit10\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00109-011-0804-9","volume":"90","author":"Fang","year":"2012","journal-title":"J. Mol. Med."},{"key":"D5FO04265H\/cit11\/1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/bf03164765","volume":"11","author":"Kim","year":"1997","journal-title":"Ann. Nucl. Med."},{"key":"D5FO04265H\/cit12\/1","first-page":"1676","volume":"39","author":"Nagaya","year":"1998","journal-title":"J. Nucl. Med."},{"key":"D5FO04265H\/cit13\/1","doi-asserted-by":"publisher","first-page":"935423","DOI":"10.3389\/fcvm.2022.935423","volume":"9","author":"Banerjee","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"D5FO04265H\/cit14\/1","doi-asserted-by":"publisher","first-page":"14351","DOI":"10.1038\/s41598-020-71264-8","volume":"10","author":"Ho\u0142da","year":"2020","journal-title":"Sci. Rep."},{"key":"D5FO04265H\/cit15\/1","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/circulationaha.119.043319","volume":"142","author":"Shao","year":"2020","journal-title":"Circulation"},{"key":"D5FO04265H\/cit16\/1","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1161\/circresaha.112.268128","volume":"111","author":"Kolwicz Jr.","year":"2012","journal-title":"Circ. Res."},{"key":"D5FO04265H\/cit17\/1","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1080\/10408398.2021.1980762","volume":"63","author":"Yang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D5FO04265H\/cit18\/1","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3390\/antiox12081642","volume":"12","author":"Chen","year":"2023","journal-title":"Antioxidants"},{"key":"D5FO04265H\/cit19\/1","first-page":"23","volume-title":"USDA Database for the Flavonoid Content of Selected Foods: Release 3.3","author":"Haytowitz","year":"2018","unstructured":"D. B.Haytowitz ,  X.Wu  and  S.Bhagwat ,  USDA Database for the Flavonoid Content of Selected Foods: Release 3.3 ,  U.S. Department of Agriculture, Agricultural Research Service ,  Beltsville, MD ,  2018 , pp.  23\u201331"},{"key":"D5FO04265H\/cit20\/1","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.fshw.2023.03.028","volume":"12","author":"Moore","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"D5FO04265H\/cit21\/1","doi-asserted-by":"publisher","first-page":"1610613","DOI":"10.3389\/fendo.2025.1610613","volume":"16","author":"Song","year":"2025","journal-title":"Front. Endocrinol."},{"key":"D5FO04265H\/cit22\/1","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1159\/000484304","volume":"43","author":"Liu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"D5FO04265H\/cit23\/1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1097\/fjc.0000000000000713","volume":"74","author":"Du","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"D5FO04265H\/cit24\/1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.21470\/1678-9741-2020-0549","volume":"37","author":"Sun","year":"2022","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"D5FO04265H\/cit25\/1","doi-asserted-by":"publisher","first-page":"116478","DOI":"10.1016\/j.taap.2023.116478","volume":"466","author":"Zhang","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"D5FO04265H\/cit26\/1","doi-asserted-by":"publisher","first-page":"9655","DOI":"10.1080\/21655979.2021.1977552","volume":"12","author":"Li","year":"2021","journal-title":"Bioengineered"},{"key":"D5FO04265H\/cit27\/1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.yjmcc.2021.06.009","volume":"159","author":"Shen","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"D5FO04265H\/cit28\/1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00018-021-04097-x","volume":"79","author":"Ahn","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"D5FO04265H\/cit29\/1","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.3390\/ijms25042433","volume":"25","author":"He","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04265H\/cit30\/1","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1111\/jcmm.17267","volume":"26","author":"Fan","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"D5FO04265H\/cit31\/1","doi-asserted-by":"publisher","first-page":"5362","DOI":"10.18632\/aging.102956","volume":"12","author":"Chen","year":"2020","journal-title":"Aging"},{"key":"D5FO04265H\/cit32\/1","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1002\/tox.24170","volume":"39","author":"Lee","year":"2024","journal-title":"Environ. Toxicol."},{"key":"D5FO04265H\/cit33\/1","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.3390\/ijms24119572","volume":"24","author":"Riou","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04265H\/cit34\/1","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jacc.2016.10.047","volume":"69","author":"Vonk Noordegraaf","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"D5FO04265H\/cit35\/1","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1093\/cvr\/cvx148","volume":"113","author":"Westerhof","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"D5FO04265H\/cit36\/1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/bph.14866","volume":"178","author":"Tello","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"D5FO04265H\/cit37\/1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/s2213-2600(15)00543-3","volume":"4","author":"Hoeper","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"D5FO04265H\/cit38\/1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.2174\/138955711795305335","volume":"11","author":"Calder\u00f3n-Monta\u00f1o","year":"2011","journal-title":"Mini-Rev. Med. Chem."},{"key":"D5FO04265H\/cit39\/1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/oby.2009.509","volume":"18","author":"Lippl","year":"2010","journal-title":"Obesity"},{"key":"D5FO04265H\/cit40\/1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/ppul.20729","volume":"43","author":"Farahani","year":"2008","journal-title":"Pediatr. Pulmonol."},{"key":"D5FO04265H\/cit41\/1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/bf02584226","volume":"12","author":"O'Rourke","year":"1984","journal-title":"Ann. Biomed. Eng."},{"key":"D5FO04265H\/cit42\/1","doi-asserted-by":"publisher","first-page":"e009047","DOI":"10.1161\/circimaging.119.009047","volume":"12","author":"Tello","year":"2019","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"D5FO04265H\/cit43\/1","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1086\/688879","volume":"6","author":"Prins","year":"2016","journal-title":"Pulm. Circ."},{"key":"D5FO04265H\/cit44\/1","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.vph.2016.09.009","volume":"87","author":"He","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"D5FO04265H\/cit45\/1","doi-asserted-by":"publisher","first-page":"e92903","DOI":"10.1371\/journal.pone.0092903","volume":"9","author":"Cox","year":"2014","journal-title":"PLoS One"},{"key":"D5FO04265H\/cit46\/1","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.3892\/etm.2019.7886","volume":"18","author":"Ren","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"D5FO04265H\/cit47\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ceb.2017.01.005","volume":"45","author":"Carling","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"D5FO04265H\/cit48\/1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1042\/bj20150910","volume":"473","author":"Ross","year":"2016","journal-title":"Biochem. J."},{"key":"D5FO04265H\/cit49\/1","doi-asserted-by":"publisher","first-page":"691585","DOI":"10.3389\/fcell.2021.691585","volume":"9","author":"Zhao","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"D5FO04265H\/cit50\/1","doi-asserted-by":"publisher","first-page":"6205","DOI":"10.3390\/ijms23116205","volume":"23","author":"Flores","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04265H\/cit51\/1","doi-asserted-by":"publisher","first-page":"5784","DOI":"10.1158\/1078-0432.Ccr-05-0149","volume":"11","author":"Bando","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"D5FO04265H\/cit52\/1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/j.1432-1033.1988.tb14201.x","volume":"175","author":"Munday","year":"1988","journal-title":"Eur. J. Biochem."},{"key":"D5FO04265H\/cit53\/1","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.molcel.2013.01.035","volume":"49","author":"Wu","year":"2013","journal-title":"Mol. Cell"},{"key":"D5FO04265H\/cit54\/1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/0-387-31311-7_22","volume":"580","author":"Evans","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"D5FO04265H\/cit55\/1","doi-asserted-by":"publisher","first-page":"112470","DOI":"10.1016\/j.jep.2019.112470","volume":"250","author":"Dang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"D5FO04265H\/cit56\/1","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1042\/cs20171167","volume":"131","author":"Wu","year":"2017","journal-title":"Clin. Sci."},{"key":"D5FO04265H\/cit57\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1749-6632.2009.05041.x","volume":"1177","author":"Evans","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D5FO04265H\/cit58\/1","doi-asserted-by":"publisher","first-page":"702920","DOI":"10.3389\/fcvm.2021.702920","volume":"8","author":"Bae","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"D5FO04265H\/cit59\/1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/2049-3002-1-8","volume":"1","author":"Ros","year":"2013","journal-title":"Cancer Metab."},{"key":"D5FO04265H\/cit60\/1","doi-asserted-by":"publisher","first-page":"80909","DOI":"10.18632\/oncotarget.20757","volume":"8","author":"Yan","year":"2017","journal-title":"Oncotarget"},{"key":"D5FO04265H\/cit61\/1","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/s0960-9822(00)00742-9","volume":"10","author":"Marsin","year":"2000","journal-title":"Curr. Biol."},{"key":"D5FO04265H\/cit62\/1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1743-7075-11-10","volume":"11","author":"Zhang","year":"2014","journal-title":"Nutr. Metab."},{"key":"D5FO04265H\/cit63\/1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/circresaha.113.301129","volume":"115","author":"Ryan","year":"2014","journal-title":"Circ. Res."},{"key":"D5FO04265H\/cit64\/1","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1161\/circulationaha.109.883843","volume":"120","author":"Bogaard","year":"2009","journal-title":"Circulation"},{"key":"D5FO04265H\/cit65\/1","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cardiores.2007.05.012","volume":"75","author":"Redout","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"D5FO04265H\/cit66\/1","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1093\/eurjhf\/hfr173","volume":"14","author":"Ardehali","year":"2012","journal-title":"Eur. J. Heart Failure"},{"key":"D5FO04265H\/cit67\/1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.yjmcc.2024.04.011","volume":"191","author":"Choksey","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"D5FO04265H\/cit68\/1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s00424-019-02285-0","volume":"471","author":"Viglino","year":"2019","journal-title":"Pfluegers Arch."},{"key":"D5FO04265H\/cit69\/1","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.3390\/cells14221811","volume":"14","author":"Alshuweishi","year":"2025","journal-title":"Cells"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO04265H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:25:19Z","timestamp":1783448719000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/7\/3172-3185\/1236890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":69,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo04265h","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}