{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:14:29Z","timestamp":1788362069287,"version":"build-2803163510"},"reference-count":50,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","license":[{"start":{"date-parts":[[2027,8,4]],"date-time":"2027-08-04T00:00:00Z","timestamp":1817337600000},"content-version":"am","delay-in-days":580,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["KFJN2559"],"award-info":[{"award-number":["KFJN2559"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["KFJN2473"],"award-info":[{"award-number":["KFJN2473"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005054","name":"Nantong University","doi-asserted-by":"publisher","award":["KFJN2446"],"award-info":[{"award-number":["KFJN2446"]}],"id":[{"id":"10.13039\/501100005054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007166","name":"Jiangsu Provincial Department of Education","doi-asserted-by":"publisher","award":["SJCX25_2092"],"award-info":[{"award-number":["SJCX25_2092"]}],"id":[{"id":"10.13039\/501100007166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>W\/O\/W multiple emulsions encapsulate UC-II, protect it from gastrointestinal degradation, enhance uptake by Peyer's patches, modulate the gut-immune axis to promote immune balance and induce tolerance, thereby effectively supporting joint health.<\/jats:p>","DOI":"10.1039\/d5fo04709a","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:47:12Z","timestamp":1785833232000},"page":"7802-7820","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supporting joint health through the gut-immune axis: squalene-based multiple emulsions enhance oral delivery of undenatured collagen type II for immune tolerance"],"prefix":"10.1039","volume":"17","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjie","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoyan","family":"She","sequence":"additional","affiliation":[{"name":"Hangzhou Biosuvit Special Medicine Technology Co., Ltd, Hangzhou 311300, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"Hangzhou Biosuvit Special Medicine Technology Co., Ltd, Hangzhou 311300, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Hong","sequence":"additional","affiliation":[{"name":"Fuzong Clinical Medical College of Fujian Medical University, 900th Hospital of PLA Joint Logistic Support Force, Fuzhou 350001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-6420","authenticated-orcid":false,"given":"Bohui","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Nantong University, Nantong 226019, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO04709A\/cit1\/1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2024.03.031","volume":"32","author":"M\u00f6ller","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"D5FO04709A\/cit2\/1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jphs.2025.06.001","volume":"158","author":"Yasuda","year":"2025","journal-title":"J. Pharmacol. Sci."},{"key":"D5FO04709A\/cit3\/1","doi-asserted-by":"crossref","first-page":"107107","DOI":"10.1016\/j.foodhyd.2021.107107","volume":"122","author":"Xu","year":"2022","journal-title":"Food Hydrocolloids"},{"key":"D5FO04709A\/cit4\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.foodchem.2007.09.022","volume":"108","author":"Cao","year":"2008","journal-title":"Food Chem."},{"key":"D5FO04709A\/cit5\/1","doi-asserted-by":"crossref","first-page":"141023","DOI":"10.1016\/j.foodchem.2024.141023","volume":"462","author":"Ata","year":"2025","journal-title":"Food Chem."},{"key":"D5FO04709A\/cit6\/1","first-page":"481","volume":"10","author":"Costa","year":"2020","journal-title":"Muscles Ligaments Tendons J."},{"key":"D5FO04709A\/cit7\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1550-2783-10-48","volume":"10","author":"Lugo","year":"2013","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"D5FO04709A\/cit8\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s42825-024-00160-y","volume":"6","author":"Zhou","year":"2024","journal-title":"Collagen Leather"},{"key":"D5FO04709A\/cit9\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.13370","volume":"326","author":"Miranda-Waldetario","year":"2024","journal-title":"Immunol. Rev."},{"key":"D5FO04709A\/cit10\/1","doi-asserted-by":"crossref","first-page":"617789","DOI":"10.3389\/fvets.2021.617789","volume":"8","author":"Orhan","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"D5FO04709A\/cit11\/1","doi-asserted-by":"crossref","first-page":"109740","DOI":"10.1016\/j.intimp.2023.109740","volume":"116","author":"Yu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"D5FO04709A\/cit12\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0169-409X(98)00042-8","volume":"34","author":"Simecka","year":"1998","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5FO04709A\/cit13\/1","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.apsb.2022.08.010","volume":"13","author":"Du","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"D5FO04709A\/cit14\/1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.addr.2012.10.013","volume":"65","author":"Wang","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5FO04709A\/cit15\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jim.2015.02.005","volume":"421","author":"Oliveira","year":"2015","journal-title":"J. Immunol. Methods"},{"key":"D5FO04709A\/cit16\/1","doi-asserted-by":"crossref","first-page":"11302","DOI":"10.1080\/10408398.2023.2236699","volume":"64","author":"Cui","year":"2024","journal-title":"Crit. Rev. Food Sci."},{"key":"D5FO04709A\/cit17\/1","doi-asserted-by":"crossref","first-page":"128630","DOI":"10.1016\/j.ijbiomac.2023.128630","volume":"257","author":"Xu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04709A\/cit18\/1","doi-asserted-by":"crossref","first-page":"128555","DOI":"10.1016\/j.foodchem.2020.128555","volume":"343","author":"Xu","year":"2021","journal-title":"Food Chem."},{"key":"D5FO04709A\/cit19\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2174\/156720106778559056","volume":"3","author":"Khan","year":"2006","journal-title":"Curr. Drug Delivery"},{"key":"D5FO04709A\/cit20\/1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.foodhyd.2005.05.002","volume":"20","author":"Shima","year":"2006","journal-title":"Food Hydrocolloids"},{"key":"D5FO04709A\/cit21\/1","doi-asserted-by":"crossref","first-page":"129856","DOI":"10.1016\/j.foodchem.2021.129856","volume":"358","author":"Huang","year":"2021","journal-title":"Food Chem."},{"key":"D5FO04709A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/polym14071284","volume":"14","author":"Hou","year":"2022","journal-title":"Polymers"},{"key":"D5FO04709A\/cit23\/1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1749-6632.1996.tb21124.x","volume":"778","author":"Elson","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D5FO04709A\/cit24\/1","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.2147\/IJN.S538737","author":"Chen","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"D5FO04709A\/cit25\/1","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0002-9440(10)65077-8","volume":"156","author":"Carlson","year":"2000","journal-title":"Am. J. Pathol."},{"key":"D5FO04709A\/cit26\/1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jff.2015.03.009","volume":"14","author":"C\u00e1rdeno","year":"2015","journal-title":"J. Funct. Foods"},{"key":"D5FO04709A\/cit27\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/bc3005842","volume":"24","author":"Li","year":"2013","journal-title":"Bioconjugate Chem."},{"key":"D5FO04709A\/cit28\/1","doi-asserted-by":"crossref","first-page":"111545","DOI":"10.1016\/j.jbiomech.2023.111545","volume":"151","author":"Pedaprolu","year":"2023","journal-title":"J. Biomech."},{"key":"D5FO04709A\/cit29\/1","doi-asserted-by":"crossref","first-page":"7453","DOI":"10.1039\/D3NR06638J","volume":"16","author":"Karole","year":"2024","journal-title":"Nanoscale"},{"key":"D5FO04709A\/cit30\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acsnano.4c11108","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"D5FO04709A\/cit31\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/mmr.2013.1476","volume":"8","author":"Su","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"D5FO04709A\/cit32\/1","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.2147\/IJN.S522245","author":"Wang","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"D5FO04709A\/cit33\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42358-022-00281-0","volume":"63","author":"Machado","year":"2023","journal-title":"Adv. Rheumatol."},{"key":"D5FO04709A\/cit34\/1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.actbio.2021.04.026","volume":"128","author":"Lee","year":"2021","journal-title":"Acta Biomater."},{"key":"D5FO04709A\/cit35\/1","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3389\/fimmu.2017.01747","volume":"8","author":"Hu","year":"2017","journal-title":"Front. Immunol."},{"key":"D5FO04709A\/cit36\/1","first-page":"5","volume":"27","author":"Jiang","year":"2011","journal-title":"Chin. J. Cell Mol. Immunol."},{"key":"D5FO04709A\/cit37\/1","doi-asserted-by":"crossref","first-page":"2307366","DOI":"10.1002\/smll.202307366","volume":"20","author":"Zhao","year":"2024","journal-title":"Small"},{"key":"D5FO04709A\/cit38\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cellimm.2012.11.017","volume":"280","author":"Thom\u00e9","year":"2012","journal-title":"Cell. Immunol."},{"key":"D5FO04709A\/cit39\/1","doi-asserted-by":"crossref","first-page":"135068","DOI":"10.1016\/j.foodchem.2022.135068","volume":"406","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"D5FO04709A\/cit40\/1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3390\/pharmaceutics12100978","volume":"12","author":"Jang","year":"2020","journal-title":"Pharmaceutics"},{"key":"D5FO04709A\/cit41\/1","first-page":"247","volume":"11","author":"Zhang","year":"2014","journal-title":"Cancer Biol. Med."},{"key":"D5FO04709A\/cit42\/1","first-page":"823710","author":"Jung","year":"2010","journal-title":"Int. J. Inflammation"},{"key":"D5FO04709A\/cit43\/1","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1073\/pnas.061412598","volume":"98","author":"Fujihashi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5FO04709A\/cit44\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autrev.2007.08.001","volume":"7","author":"Cho","year":"2007","journal-title":"Autoimmun. Rev."},{"key":"D5FO04709A\/cit45\/1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00000441-200404000-00006","volume":"327","author":"Kim","year":"2004","journal-title":"Am. J. Med. Sci."},{"key":"D5FO04709A\/cit46\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cellimm.2012.09.001","volume":"279","author":"Huang","year":"2012","journal-title":"Cell. Immunol."},{"key":"D5FO04709A\/cit47\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18053\/jctres.02.201603.005","volume":"2","author":"Farrugia","year":"2016","journal-title":"J. Clin. Transl. Res."},{"key":"D5FO04709A\/cit48\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13075-023-03159-8","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"D5FO04709A\/cit49\/1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4049\/jimmunol.2000455","volume":"207","author":"Carvajal Alegria","year":"2021","journal-title":"J. Immunol."},{"key":"D5FO04709A\/cit50\/1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/s11926-006-0054-y","volume":"8","author":"Kriegel","year":"2006","journal-title":"Curr. Rheumatol. Rep."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/FO\/article-pdf\/doi\/10.1039\/D5FO04709A\/0\/D5FO04709A.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:27:46Z","timestamp":1788359266000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/FO\/article-lookup\/doi\/10.1039\/D5FO04709A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":50,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo04709a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO04709A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04709A\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}