{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:57:47Z","timestamp":1790715467590,"version":"4.1.0"},"reference-count":60,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2026,12,30]],"date-time":"2026-12-30T00:00:00Z","timestamp":1798588800000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD2100604"],"award-info":[{"award-number":["2023YFD2100604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017669","name":"Basic Scientific Fund for National Public Research Institutes of China","doi-asserted-by":"publisher","award":["2025S01"],"award-info":[{"award-number":["2025S01"]}],"id":[{"id":"10.13039\/501100017669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2023CXPT087"],"award-info":[{"award-number":["2023CXPT087"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2023TZXD047"],"award-info":[{"award-number":["2023TZXD047"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2024TSGC0219"],"award-info":[{"award-number":["2024TSGC0219"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42576123"],"award-info":[{"award-number":["42576123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470132"],"award-info":[{"award-number":["32470132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (\n                    <jats:italic>H. pylori<\/jats:italic>\n                    ) infection is a serious public health concern worldwide.\n                  <\/jats:p>","DOI":"10.1039\/d5fo04897d","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T01:02:31Z","timestamp":1767056551000},"page":"1482-1499","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preventive effects of sea cucumber-derived fucoidan on\n                    <i>Helicobacter pylori<\/i>\n                    -induced gastritis: a mechanistic investigation based on regulation of the gut microbiota and metabolic products"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-6307","authenticated-orcid":false,"given":"Junhan","family":"Cao","sequence":"first","affiliation":[{"name":"R&D Center, Tsingtao Brewery Co., Ltd, Qingdao, 266207, China"},{"name":"School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266113, China"},{"name":"College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China"},{"name":"Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao, 266061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao, 266061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Homey Group International Inc., Rongcheng, 264305, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfeng","family":"Qu","sequence":"additional","affiliation":[{"name":"Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao, 266061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wancui","family":"Xie","sequence":"additional","affiliation":[{"name":"Homey Group International Inc., Rongcheng, 264305, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yin","sequence":"additional","affiliation":[{"name":"R&D Center, Tsingtao Brewery Co., Ltd, Qingdao, 266207, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-314X","authenticated-orcid":false,"given":"Xinpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao, 266113, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlai","family":"Miao","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China"},{"name":"Qingdao Key Laboratory of Marine Natural Products Research and Development Laboratory, First Institute of Oceanography, Ministry of Natural Resources, Qingdao, 266061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhu","family":"Xue","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO04897D\/cit1\/1","first-page":"83","volume":"444","author":"Fuchs","year":"2023","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"D5FO04897D\/cit2\/1","first-page":"549","volume":"21","author":"Moghadam","year":"2021","journal-title":"Curr. Mol. Med."},{"key":"D5FO04897D\/cit3\/1","first-page":"207","volume":"444","author":"Naumann","year":"2023","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"D5FO04897D\/cit4\/1","volume-title":"Helicobacter pylori","volume":"2283","year":"2021","unstructured":"Helicobacter pylori , ed.  S. M. Smith ,  Springer US ,  New York, NY ,  2021 , vol.  2283"},{"key":"D5FO04897D\/cit5\/1","doi-asserted-by":"crossref","first-page":"23510","DOI":"10.1039\/D0RA03311A","volume":"10","author":"Yi","year":"2020","journal-title":"RSC Adv."},{"key":"D5FO04897D\/cit6\/1","doi-asserted-by":"crossref","first-page":"2300682","DOI":"10.1002\/adfm.202300682","volume":"33","author":"Liu","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D5FO04897D\/cit7\/1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00284-017-1256-4","volume":"74","author":"Gu","year":"2017","journal-title":"Curr. Microbiol."},{"key":"D5FO04897D\/cit8\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature05765","volume":"447","author":"Saadat","year":"2007","journal-title":"Nature"},{"key":"D5FO04897D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1053\/j.gastro.2018.07.007","volume":"155","author":"Savoldi","year":"2018","journal-title":"Gastroenterology"},{"key":"D5FO04897D\/cit10\/1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1473-3099(19)30272-5","volume":"19","author":"Liou","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"D5FO04897D\/cit11\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12935-020-01233-8","volume":"20","author":"Lin","year":"2020","journal-title":"Cancer Cell Int."},{"key":"D5FO04897D\/cit12\/1","doi-asserted-by":"crossref","first-page":"120965","DOI":"10.1016\/j.carbpol.2023.120965","volume":"314","author":"Fernandes","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"D5FO04897D\/cit13\/1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/md17090487","volume":"17","author":"Luthuli","year":"2019","journal-title":"Mar. Drugs"},{"key":"D5FO04897D\/cit14\/1","doi-asserted-by":"crossref","first-page":"0358","DOI":"10.34133\/research.0358","volume":"7","author":"Shu","year":"2024","journal-title":"Research"},{"key":"D5FO04897D\/cit15\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41598-021-04151-5","volume":"12","author":"Chen","year":"2022","journal-title":"Sci. Rep."},{"key":"D5FO04897D\/cit16\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/1751-2980.13215","volume":"24","author":"Wang","year":"2023","journal-title":"J. Dig. Dis."},{"key":"D5FO04897D\/cit17\/1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3177\/jnsv.45.325","volume":"45","author":"Shibata","year":"1999","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"D5FO04897D\/cit18\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/hel.12177","volume":"20","author":"Besednova","year":"2015","journal-title":"Helicobacter"},{"key":"D5FO04897D\/cit19\/1","doi-asserted-by":"crossref","first-page":"141593","DOI":"10.1016\/j.ijbiomac.2025.141593","volume":"306","author":"Cao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04897D\/cit20\/1","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1021\/acs.jafc.5c02190","volume":"73","author":"Cao","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"D5FO04897D\/cit21\/1","doi-asserted-by":"crossref","first-page":"103372","DOI":"10.1016\/j.algal.2023.103372","volume":"77","author":"Oliyaei","year":"2024","journal-title":"Algal Res."},{"key":"D5FO04897D\/cit22\/1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/imm.13722","volume":"171","author":"Xia","year":"2024","journal-title":"Immunology"},{"key":"D5FO04897D\/cit23\/1","doi-asserted-by":"crossref","first-page":"102559","DOI":"10.1016\/j.ceb.2025.102559","volume":"95","author":"Kehrberg","year":"2025","journal-title":"Curr. Opin. Cell Biol."},{"key":"D5FO04897D\/cit24\/1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jcmgh.2017.02.002","volume":"3","author":"Butcher","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"D5FO04897D\/cit25\/1","doi-asserted-by":"crossref","first-page":"113887","DOI":"10.1016\/j.jep.2021.113887","volume":"271","author":"Kim","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"D5FO04897D\/cit26\/1","doi-asserted-by":"crossref","first-page":"141593","DOI":"10.1016\/j.ijbiomac.2025.141593","volume":"306","author":"Cao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04897D\/cit27\/1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/diagnostics12051203","volume":"12","author":"Tsukanov","year":"2022","journal-title":"Diagnostics"},{"key":"D5FO04897D\/cit28\/1","doi-asserted-by":"crossref","first-page":"105933","DOI":"10.1016\/j.micpath.2022.105933","volume":"174","author":"Yuan","year":"2023","journal-title":"Microb. Pathog."},{"key":"D5FO04897D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"key":"D5FO04897D\/cit30\/1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.foodchem.2012.02.028","volume":"133","author":"Wang","year":"2012","journal-title":"Food Chem."},{"key":"D5FO04897D\/cit31\/1","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1039\/C7FO00932A","volume":"8","author":"Shi","year":"2017","journal-title":"Food Funct."},{"key":"D5FO04897D\/cit32\/1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ijbiomac.2018.08.098","volume":"120","author":"Zhu","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04897D\/cit33\/1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/md18110542","volume":"18","author":"Chang","year":"2020","journal-title":"Mar. Drugs"},{"key":"D5FO04897D\/cit34\/1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.carbpol.2013.12.063","volume":"103","author":"Song","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"D5FO04897D\/cit35\/1","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1128\/IAI.69.8.4891-4897.2001","volume":"69","author":"van Vliet","year":"2001","journal-title":"Infect. Immun."},{"key":"D5FO04897D\/cit36\/1","doi-asserted-by":"crossref","first-page":"16061","DOI":"10.1039\/D0RA02363A","volume":"10","author":"Imran","year":"2020","journal-title":"RSC Adv."},{"key":"D5FO04897D\/cit37\/1","doi-asserted-by":"crossref","first-page":"1464484","DOI":"10.3389\/fmicb.2024.1464484","volume":"15","author":"Shaalan","year":"2024","journal-title":"Front. Microbiol."},{"key":"D5FO04897D\/cit38\/1","doi-asserted-by":"crossref","first-page":"121722","DOI":"10.1016\/j.carbpol.2023.121722","volume":"328","author":"Yin","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"D5FO04897D\/cit39\/1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ijbiomac.2019.08.092","volume":"139","author":"Zhou","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04897D\/cit40\/1","doi-asserted-by":"crossref","first-page":"113307","DOI":"10.1016\/j.lwt.2022.113307","volume":"160","author":"Wang","year":"2022","journal-title":"LWT"},{"key":"D5FO04897D\/cit41\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.fbp.2017.08.002","volume":"106","author":"Li","year":"2017","journal-title":"Food Bioprod. Process."},{"key":"D5FO04897D\/cit42\/1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1478-811X-9-29","volume":"9","author":"Wroblewski","year":"2011","journal-title":"Cell Commun. Signaling"},{"key":"D5FO04897D\/cit43\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/md23050180","volume":"23","author":"Feng","year":"2025","journal-title":"Mar. Drugs"},{"key":"D5FO04897D\/cit44\/1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ijbiomac.2022.09.047","volume":"221","author":"Sung","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04897D\/cit45\/1","doi-asserted-by":"crossref","first-page":"e99396","DOI":"10.1371\/journal.pone.0099396","volume":"9","author":"Jin","year":"2014","journal-title":"PLoS One"},{"key":"D5FO04897D\/cit46\/1","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.4014\/jmb.2205.05041","volume":"32","author":"Gao","year":"2022","journal-title":"J. Microbiol. Biotechnol."},{"key":"D5FO04897D\/cit47\/1","doi-asserted-by":"crossref","first-page":"2291164","DOI":"10.1080\/19490976.2023.2291164","volume":"15","author":"Gavzy","year":"2023","journal-title":"Gut Microbes"},{"key":"D5FO04897D\/cit48\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41586-022-04985-7","volume":"608","author":"Bae","year":"2022","journal-title":"Nature"},{"key":"D5FO04897D\/cit49\/1","doi-asserted-by":"crossref","first-page":"141998","DOI":"10.1016\/j.foodchem.2024.141998","volume":"465","author":"Zhou","year":"2025","journal-title":"Food Chem."},{"key":"D5FO04897D\/cit50\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"D5FO04897D\/cit51\/1","doi-asserted-by":"crossref","first-page":"120460","DOI":"10.1016\/j.carbpol.2022.120460","volume":"304","author":"Chen","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"D5FO04897D\/cit52\/1","doi-asserted-by":"crossref","first-page":"16148","DOI":"10.1038\/srep16148","volume":"5","author":"Nastasi","year":"2015","journal-title":"Sci. Rep."},{"key":"D5FO04897D\/cit53\/1","doi-asserted-by":"crossref","first-page":"7141970","DOI":"10.1155\/2020\/7141970","volume":"2020","author":"Bian","year":"2020","journal-title":"Mediators Inflammation"},{"key":"D5FO04897D\/cit54\/1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bjp.2019.03.002","volume":"29","author":"Romero","year":"2019","journal-title":"Rev. Bras. Farmacogn."},{"key":"D5FO04897D\/cit55\/1","first-page":"1","volume":"17","author":"Li","year":"2022","journal-title":"Nat. Prod. Commun."},{"key":"D5FO04897D\/cit56\/1","doi-asserted-by":"crossref","first-page":"18853","DOI":"10.1038\/s41598-024-69028-9","volume":"14","author":"Kang","year":"2024","journal-title":"Sci. Rep."},{"key":"D5FO04897D\/cit57\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4062\/biomolther.2023.204","volume":"32","author":"Lee","year":"2024","journal-title":"Biomol. Ther."},{"key":"D5FO04897D\/cit58\/1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.biopha.2018.04.072","volume":"103","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D5FO04897D\/cit59\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/09168451.2018.1444467","volume":"82","author":"Murota","year":"2018","journal-title":"Biosci., Biotechnol., Biochem."},{"key":"D5FO04897D\/cit60\/1","doi-asserted-by":"crossref","first-page":"158471","DOI":"10.1016\/j.bbalip.2019.05.015","volume":"1865","author":"Blunsom","year":"2020","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO04897D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:28:54Z","timestamp":1782930534000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/3\/1482-1499\/1247864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo04897d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO04897D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04897D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04897D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04897D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04897D\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04897D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO04897D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}