{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:32:33Z","timestamp":1789223553365,"version":"build-2803163510"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2027,2,25]],"date-time":"2027-02-25T00:00:00Z","timestamp":1803513600000},"content-version":"am","delay-in-days":420,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2025N0054"],"award-info":[{"award-number":["2025N0054"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>As a natural polysaccharide, sulfated fucan from sea cucumber possesses multiple biological activities, but its protective effect on acute liver injury (ALI) is still unclear.<\/jats:p>","DOI":"10.1039\/d5fo04947d","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:51:04Z","timestamp":1772034664000},"page":"2586-2598","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sea cucumber sulfated fucan protects against acute liver injury in mice: insights from inflammatory responses, gut microbiota and hepatic metabolic profile analyses"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5375-8179","authenticated-orcid":false,"given":"Feifei","family":"Shi","sequence":"first","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China"},{"name":"Quanzhou Institute of Marine Bioresources Industry, Quanzhou, 362046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-3093","authenticated-orcid":false,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, 350108, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-2398","authenticated-orcid":false,"given":"Peng","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China"},{"name":"College of Oceanology and Food Science, Quanzhou Normal University, Quanzhou, 362000, China"},{"name":"Quanzhou Institute of Marine Bioresources Industry, Quanzhou, 362046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO04947D\/cit1\/1","doi-asserted-by":"crossref","first-page":"eadp4120","DOI":"10.1126\/science.adp4120","volume":"387","author":"Ding","year":"2025","journal-title":"Science"},{"key":"D5FO04947D\/cit2\/1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/hep.31483","volume":"72","author":"Stratakis","year":"2020","journal-title":"Hepatology"},{"key":"D5FO04947D\/cit3\/1","doi-asserted-by":"crossref","first-page":"046001","DOI":"10.1289\/EHP10092","volume":"130","author":"Costello","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"D5FO04947D\/cit4\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s43094-025-00788-5","volume":"11","author":"Saleh","year":"2025","journal-title":"Future J. Pharm. Sci."},{"key":"D5FO04947D\/cit5\/1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.14309\/ajg.0000000000001259","volume":"116","author":"Chalasani","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"D5FO04947D\/cit6\/1","first-page":"914","volume":"22","author":"Li","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"D5FO04947D\/cit7\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13020-025-01063-8","volume":"20","author":"Zhang","year":"2025","journal-title":"Chin. Med."},{"key":"D5FO04947D\/cit8\/1","doi-asserted-by":"crossref","first-page":"135566","DOI":"10.1016\/j.ijbiomac.2024.135566","volume":"280","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3390\/microorganisms13051053","volume":"13","author":"Laivacuma","year":"2025","journal-title":"Microorganisms"},{"key":"D5FO04947D\/cit10\/1","doi-asserted-by":"crossref","first-page":"8351","DOI":"10.3390\/ijms21218351","volume":"21","author":"Plaza-Diaz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04947D\/cit11\/1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s13679-019-00352-2","volume":"8","author":"Vallianou","year":"2019","journal-title":"Curr. Obes. Rep."},{"key":"D5FO04947D\/cit12\/1","doi-asserted-by":"crossref","first-page":"11689","DOI":"10.3390\/ijms231911689","volume":"23","author":"Kobayashi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04947D\/cit13\/1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ijbiomac.2021.11.142","volume":"194","author":"Arokiarajan","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit14\/1","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3390\/md19110620","volume":"19","author":"Li","year":"2021","journal-title":"Mar. Drugs"},{"key":"D5FO04947D\/cit15\/1","doi-asserted-by":"crossref","first-page":"132882","DOI":"10.1016\/j.ijbiomac.2024.132882","volume":"273","author":"Kraithong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit16\/1","doi-asserted-by":"crossref","first-page":"11771","DOI":"10.3390\/ijms252111771","volume":"25","author":"Jeong","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04947D\/cit17\/1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tifs.2021.03.028","volume":"111","author":"Wen","year":"2021","journal-title":"Trends Food Sci. Tech."},{"key":"D5FO04947D\/cit18\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.carbpol.2018.04.117","volume":"195","author":"Shang","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"D5FO04947D\/cit19\/1","doi-asserted-by":"crossref","first-page":"128092","DOI":"10.1016\/j.ijbiomac.2023.128092","volume":"255","author":"Sun","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit20\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.foodchem.2015.02.034","volume":"180","author":"Yu","year":"2015","journal-title":"Food Chem."},{"key":"D5FO04947D\/cit21\/1","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1021\/acs.jafc.1c01781","volume":"69","author":"Guo","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"D5FO04947D\/cit22\/1","doi-asserted-by":"crossref","first-page":"138400","DOI":"10.1016\/j.ijbiomac.2024.138400","volume":"287","author":"Guo","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit23\/1","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1039\/D4FO02106A","volume":"15","author":"Hao","year":"2024","journal-title":"Food Funct."},{"key":"D5FO04947D\/cit24\/1","doi-asserted-by":"crossref","first-page":"2502001","DOI":"10.1002\/smll.202502001","volume":"21","author":"Chen","year":"2025","journal-title":"Small"},{"key":"D5FO04947D\/cit25\/1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3390\/md13021051","volume":"13","author":"Lim","year":"2015","journal-title":"Mar. Drugs"},{"key":"D5FO04947D\/cit26\/1","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1007\/s10068-025-01865-4","volume":"34","author":"Wu","year":"2025","journal-title":"Food Sci. Biotechnol."},{"key":"D5FO04947D\/cit27\/1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/md21120632","volume":"21","author":"Chen","year":"2023","journal-title":"Mar. Drugs"},{"key":"D5FO04947D\/cit28\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/diseases9030050","volume":"9","author":"McGrowder","year":"2021","journal-title":"Diseases"},{"key":"D5FO04947D\/cit29\/1","doi-asserted-by":"crossref","first-page":"132093","DOI":"10.1016\/j.ijbiomac.2024.132093","volume":"270","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit30\/1","doi-asserted-by":"crossref","first-page":"100220","DOI":"10.1016\/j.crbiot.2024.100220","volume":"7","author":"Raj","year":"2024","journal-title":"Curr. Res. Biotechnol."},{"key":"D5FO04947D\/cit31\/1","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"D5FO04947D\/cit32\/1","doi-asserted-by":"crossref","first-page":"105898","DOI":"10.1016\/j.intimp.2019.105898","volume":"76","author":"Zi","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"D5FO04947D\/cit33\/1","first-page":"579","volume":"12","author":"Cui","year":"2025","journal-title":"Vet. Sci."},{"key":"D5FO04947D\/cit34\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41420-025-02491-z","volume":"11","author":"Yang","year":"2025","journal-title":"Cell Death Discov."},{"key":"D5FO04947D\/cit35\/1","doi-asserted-by":"crossref","first-page":"1538857","DOI":"10.3389\/fphar.2025.1538857","volume":"16","author":"Xiong","year":"2025","journal-title":"Front. Pharmacol."},{"key":"D5FO04947D\/cit36\/1","doi-asserted-by":"crossref","first-page":"e70083","DOI":"10.1111\/1751-7915.70083","volume":"18","author":"Zhang","year":"2025","journal-title":"Microb.\nBiotechnol."},{"key":"D5FO04947D\/cit37\/1","doi-asserted-by":"crossref","first-page":"1331956","DOI":"10.3389\/fphar.2023.1331956","volume":"14","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"D5FO04947D\/cit38\/1","doi-asserted-by":"crossref","first-page":"230014","DOI":"10.1098\/rsob.230014","volume":"13","author":"Ney","year":"2023","journal-title":"Open Biol."},{"key":"D5FO04947D\/cit39\/1","doi-asserted-by":"crossref","first-page":"10879","DOI":"10.3390\/ijms252010879","volume":"25","author":"Ventura","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D5FO04947D\/cit40\/1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41420-025-02364-5","volume":"11","author":"Zhang","year":"2025","journal-title":"Cell Death Discov."},{"key":"D5FO04947D\/cit41\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41538-025-00416-9","volume":"9","author":"Zhou","year":"2025","journal-title":"npj Sci. Food."},{"key":"D5FO04947D\/cit42\/1","doi-asserted-by":"crossref","first-page":"129994","DOI":"10.1016\/j.ijbiomac.2024.129994","volume":"262","author":"Ge","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5FO04947D\/cit43\/1","doi-asserted-by":"crossref","first-page":"111666","DOI":"10.1016\/j.intimp.2024.111666","volume":"130","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"D5FO04947D\/cit44\/1","doi-asserted-by":"crossref","first-page":"111802","DOI":"10.1016\/j.toxlet.2025.111802","volume":"415","author":"Shen","year":"2026","journal-title":"Toxicol. Lett."},{"key":"D5FO04947D\/cit45\/1","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3390\/biom10081133","volume":"10","author":"Sztolsztener","year":"2020","journal-title":"Biomolecules"},{"key":"D5FO04947D\/cit46\/1","doi-asserted-by":"crossref","first-page":"647743","DOI":"10.3389\/fphys.2021.647743","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Physiol."},{"key":"D5FO04947D\/cit47\/1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2147\/CCID.S494806","volume":"18","author":"Hou","year":"2025","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"D5FO04947D\/cit48\/1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/s41598-025-30368-9","volume":"16","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"key":"D5FO04947D\/cit49\/1","doi-asserted-by":"crossref","first-page":"17528","DOI":"10.1038\/srep17528","volume":"5","author":"Rodrigues","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO04947D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:09:16Z","timestamp":1783274956000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/5\/2586-2598\/1243549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":49,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo04947d","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}