{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:06:47Z","timestamp":1787004407695,"version":"build-2736575974"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["JBYW-AII-2024-09"],"award-info":[{"award-number":["JBYW-AII-2024-09"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Given the potential of polyphenols to mitigate neurodegenerative diseases (NDDs), this meta-analysis investigated whether clinical evidence supports the use of polyphenols for neuroprotection and as nutritional strategies in NDDs.<\/jats:p>","DOI":"10.1039\/d5fo05135e","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:21:28Z","timestamp":1767658888000},"page":"1114-1126","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polyphenol consumption and neurodegeneration risk: a systematic meta-analysis of randomized controlled trials bridging nutrition and cognitive health"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6846-3796","authenticated-orcid":false,"given":"Xiaomei","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Agricultural Information, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Information, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Information, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaihong","family":"Yu","sequence":"additional","affiliation":[{"name":"National Science Library, Chinese Academy of Sciences, Beijing 100020, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Medical Information, Chinese Academy of Medical Sciences, Beijing 100190, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7810-2151","authenticated-orcid":false,"given":"Yingli","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Information, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO05135E\/cit1\/1","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1089\/ars.2012.4581","volume":"18","author":"Del Rio","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"D5FO05135E\/cit2\/1","doi-asserted-by":"publisher","first-page":"215S","DOI":"10.1093\/ajcn\/81.1.215S","volume":"81","author":"Scalbert","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"D5FO05135E\/cit3\/1","doi-asserted-by":"publisher","first-page":"129247","DOI":"10.1016\/j.foodchem.2021.129247","volume":"351","author":"Xiao","year":"2021","journal-title":"Food Chem."},{"key":"D5FO05135E\/cit4\/1","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1136\/jnnp-2012-304792","volume":"84","author":"Mart\u00ednez-Lapiscina","year":"2013","journal-title":"J. Neurol., Neurosurg. Psychiatry"},{"key":"D5FO05135E\/cit5\/1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","volume":"79","author":"Manach","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"D5FO05135E\/cit6\/1","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"Page","year":"2021","journal-title":"Br. Med. J."},{"key":"D5FO05135E\/cit7\/1","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1097\/BRS.0b013e3181b1c99f","volume":"34","author":"Furlan","year":"2009","journal-title":"Spine"},{"key":"D5FO05135E\/cit8\/1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s40120-021-00271-2","volume":"10","author":"Gu","year":"2021","journal-title":"Neurol. Ther."},{"key":"D5FO05135E\/cit9\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","volume":"14","author":"Moussa","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"D5FO05135E\/cit10\/1","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1212\/WNL.0000000000002035","volume":"85","author":"Turner","year":"2015","journal-title":"Neurology"},{"key":"D5FO05135E\/cit11\/1","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jalz.2019.06.1236","volume":"15","author":"Wong","year":"2019","journal-title":"Alzheimers Dement."},{"key":"D5FO05135E\/cit12\/1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.trci.2018.09.009","volume":"4","author":"Zhu","year":"2018","journal-title":"Alzheimers Dement."},{"key":"D5FO05135E\/cit13\/1","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1080\/1028415X.2023.2301163","volume":"27","author":"Navabi","year":"2024","journal-title":"Nutr. Neurosci."},{"key":"D5FO05135E\/cit14\/1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.47176\/mjiri.37.123","volume":"37","author":"Rustamzadeh","year":"2023","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"D5FO05135E\/cit15\/1","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.3233\/JAD-190757","volume":"72","author":"Ochiai","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"D5FO05135E\/cit16\/1","doi-asserted-by":"publisher","first-page":"P293","DOI":"10.1016\/j.jalz.2018.06.065","volume":"14","author":"Joo","year":"2018","journal-title":"Alzheimers Dement."},{"key":"D5FO05135E\/cit17\/1","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1007\/s12603-018-1028-2","volume":"22","author":"Carmichael","year":"2018","journal-title":"J. Nutr., Health Aging"},{"key":"D5FO05135E\/cit18\/1","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3233\/JAD-142958","volume":"47","author":"Gleason","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"D5FO05135E\/cit19\/1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13195-022-01097-2","volume":"14","author":"Vi\u00f1a","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"D5FO05135E\/cit20\/1","doi-asserted-by":"publisher","first-page":"4265","DOI":"10.3390\/molecules25184265","volume":"25","author":"Baba","year":"2020","journal-title":"Molecules"},{"key":"D5FO05135E\/cit21\/1","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.3233\/JAD-170969","volume":"62","author":"Ito","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"D5FO05135E\/cit22\/1","doi-asserted-by":"publisher","first-page":"e12155","DOI":"10.1002\/trc2.12155","volume":"7","author":"Forcano","year":"2021","journal-title":"Alzheimers Dement."},{"key":"D5FO05135E\/cit23\/1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jagp.2022.10.002","volume":"31","author":"Aarsland","year":"2023","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"D5FO05135E\/cit24\/1","doi-asserted-by":"publisher","first-page":"e16994","DOI":"10.1016\/j.heliyon.2023.e16994","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"key":"D5FO05135E\/cit25\/1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ajcnut.2023.10.031","volume":"119","author":"Vyas","year":"2024","journal-title":"Am. J. Clin. Nutr."},{"key":"D5FO05135E\/cit26\/1","doi-asserted-by":"publisher","first-page":"e12278","DOI":"10.1002\/trc2.12278","volume":"8","author":"Marianetti","year":"2022","journal-title":"Alzheimers Dement. (N Y)"},{"key":"D5FO05135E\/cit27\/1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/1028415X.2017.1287833","volume":"21","author":"Boespflug","year":"2018","journal-title":"Nutr. Neurosci."},{"key":"D5FO05135E\/cit28\/1","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/nu14081619","volume":"14","author":"Krikorian","year":"2022","journal-title":"Nutrients"},{"key":"D5FO05135E\/cit29\/1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.exger.2016.10.004","volume":"87","author":"Lee","year":"2017","journal-title":"Exp. Gerontol."},{"key":"D5FO05135E\/cit30\/1","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1017\/S0007114516004177","volume":"116","author":"Keane","year":"2016","journal-title":"Br. J. Nutr."},{"key":"D5FO05135E\/cit31\/1","doi-asserted-by":"publisher","first-page":"506","DOI":"10.3945\/ajcn.114.088518","volume":"101","author":"Kean","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"key":"D5FO05135E\/cit32\/1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jns.2010.08.050","volume":"299","author":"Morillas-Ruiz","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"D5FO05135E\/cit33\/1","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1080\/1028415X.2021.1880312","volume":"25","author":"Rosli","year":"2022","journal-title":"Nutr. Neurosci."},{"key":"D5FO05135E\/cit34\/1","year":"2022","unstructured":"Clinicaltrials.Gov, Use muscadine wine nutraceuticals to improve brain health, cognition, and mental health,  2022 ,  https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05541887 , (accessed 14 February, 2025)"},{"key":"D5FO05135E\/cit35\/1","year":"2024","unstructured":"Clinicaltrials.Gov, The effectiveness of MIND diet and forest bathing on stress reduction,  2024 ,  https:\/\/clinicaltrials.gov\/ct2\/show\/NCT06351423 , (accessed 16 February, 2025)"},{"key":"D5FO05135E\/cit36\/1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.2174\/156720505774932287","volume":"2","author":"Schneider","year":"2005","journal-title":"Curr. Alzheimer Res."},{"key":"D5FO05135E\/cit37\/1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/psyg.12581","volume":"20","author":"Matsuyama","year":"2020","journal-title":"Psychogeriatrics"},{"key":"D5FO05135E\/cit38\/1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.neuroimage.2018.03.023","volume":"174","author":"Huhn","year":"2018","journal-title":"NeuroImage"},{"key":"D5FO05135E\/cit39\/1","volume-title":"Study on Cognitive Function Improvement & Safety of Plant Pigment for the Elderly with Cognitive Decline","author":"Korean clinical trial registry (KCT)","year":"2018","unstructured":"Korean clinical trial registry (KCT) ,  Study on Cognitive Function Improvement & Safety of Plant Pigment for the Elderly with Cognitive Decline .  Korean clinical trial registry ,  2018 ,  https:\/\/www.who.int\/trialsearch\/Trial2.aspx?TrialID=KCT0002798 , (accessed 17 February, 2025)"},{"key":"D5FO05135E\/cit40\/1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.2147\/NDT.S120790","volume":"13","author":"Demarin","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"D5FO05135E\/cit41\/1","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.3390\/nu13082606","volume":"13","author":"Jung","year":"2021","journal-title":"Nutrients"},{"key":"D5FO05135E\/cit42\/1","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3390\/nu13020434","volume":"13","author":"You","year":"2021","journal-title":"Nutrients"},{"key":"D5FO05135E\/cit43\/1","author":"International Clinical Trials Registry Platform (ICTRP). The effectiveness of curcumin on quality of life, severity of illness, fatigue and sleep quality in Parkinson\u2019s patients","year":"2018","journal-title":"International Clinical Trials Registry Platform"},{"key":"D5FO05135E\/cit44\/1","author":"Clinicaltrials.Gov","year":"2013","unstructured":"Clinicaltrials.Gov ,  Progression rate of MSA under EGCG supplementation as anti-aggregation-approach ,  2013 ,  https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02008721 , (accessed 15 February, 2025)"},{"key":"D5FO05135E\/cit45\/1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00702-016-1507-8","volume":"123","author":"Levin","year":"2016","journal-title":"J. Neural Transm."},{"key":"D5FO05135E\/cit46\/1","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1474-4422(19)30141-3","volume":"18","author":"Levin","year":"2019","journal-title":"Lancet Neurol."},{"key":"D5FO05135E\/cit47\/1","volume-title":"The effect of silymarin on Parkinson's disease","author":"International Clinical Trials Registry Platform (ICTRP)","year":"2017","unstructured":"International Clinical Trials Registry Platform (ICTRP) .  The effect of silymarin on Parkinson's disease ,  International Clinical Trials Registry Platform ,  2017 ,  https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=IRCT2017081435697N1 , (accessed 16 February, 2025)"},{"key":"D5FO05135E\/cit48\/1","volume-title":"Effect of polyphenol rich extract of licorice on improving symptoms of Parkinson disease","author":"International Clinical Trials Registry Platform (ICTRP)","year":"2018","unstructured":"International Clinical Trials Registry Platform (ICTRP) .  Effect of polyphenol rich extract of licorice on improving symptoms of Parkinson disease ,  International Clinical Trials Registry Platform ,  2018 ,  https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=IRCT20120305009204N3 , (accessed 17 February, 2025)"},{"key":"D5FO05135E\/cit49\/1","volume-title":"Effects of grape juice consumption improvements in functionality\nand cognition of individuals with Parkinson's disease who perform aquatic physiotherapy","author":"International Clinical Trials Registry Platform (ICTRP)","year":"2019","unstructured":"International Clinical Trials Registry Platform (ICTRP) .  Effects of grape juice consumption improvements in functionality\nand cognition of individuals with Parkinson's disease who perform aquatic physiotherapy ,  International Clinical Trials Registry Platform ,  2019 ,  https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=RBR-2c4xxb , (accessed 14 February, 2025)"},{"key":"D5FO05135E\/cit50\/1","author":"Clinicaltrials.Gov","year":"2007","unstructured":"Clinicaltrials.Gov ,  Efficacy and safety of green tea polyphenol in de novo Parkinson\u2019s disease patients ,  2007 ,  https:\/\/clinicaltrials.gov\/show\/NCT00461942 , (accessed 14 February, 2025)"},{"key":"D5FO05135E\/cit51\/1","author":"Clinicaltrials.Gov","year":"2022","unstructured":"Clinicaltrials.Gov ,  Role of saffron and chamomile in the management of Parkinson\u2019s disease ,  2022 ,  https:\/\/clinicaltrials.gov\/show\/NCT05696665 , (accessed 16 February, 2025)"},{"key":"D5FO05135E\/cit52\/1","author":"Clinicaltrials.Gov","year":"2017","unstructured":"Clinicaltrials.Gov ,  Can a flavonoid-rich pure cocoa reduce fatigue in people with Parkinson\u2019s (PD)? ,  2017 ,  https:\/\/clinicaltrials.gov\/show\/NCT03288155  (accessed 16 February, 2025)"},{"key":"D5FO05135E\/cit53\/1","doi-asserted-by":"publisher","first-page":"e22800","DOI":"10.1002\/jbt.22800","volume":"35","author":"Ghiasian","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"D5FO05135E\/cit54\/1","doi-asserted-by":"publisher","first-page":"3792","DOI":"10.3390\/nu12123792","volume":"12","author":"Benlloch","year":"2020","journal-title":"Nutrients"},{"key":"D5FO05135E\/cit55\/1","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1039\/d2fo02207a","volume":"14","author":"Cuerda-Ballester","year":"2023","journal-title":"Food Funct."},{"key":"D5FO05135E\/cit56\/1","year":"2017","unstructured":"Clinicaltrials.Gov, The immunomodulatory effects of oral nanocurcumin in multiple sclerosis patients,  2017 ,  https:\/\/clinicaltrials.gov\/show\/NCT03150966 , (accessed 18 February, 2025)"},{"key":"D5FO05135E\/cit57\/1","year":"2020","unstructured":"Clinicaltrials.Gov, The NO-ALS study: A trial of nicotinamide\/pterostilbene supplement in ALS,  2020 ,  https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04562831 , (accessed 16 February, 2025)"},{"key":"D5FO05135E\/cit58\/1","year":"2021","unstructured":"Clinicaltrials.Gov, A trial of nicotinamide\/pterostilbene supplement in ALS: The NO-ALS extension study,  Clinicaltrials.gov ,  2021 ,  https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05095571 , (accessed 15 February, 2025)"},{"key":"D5FO05135E\/cit59\/1","year":"2020","unstructured":"Clinicaltrials.Gov, Impact of the combined treatment of Liposomed polyphenols with G04CB02 on the ALS patients,  2020 ,  https:\/\/clinicaltrials.gov\/show\/NCT04654689 , (accessed 17 February, 2025)"},{"key":"D5FO05135E\/cit60\/1","year":"2011","unstructured":"Clinicaltrials.Gov, Effects of EGCG (epigallocatechin gallate) in Huntington's disease (ETON-study),  2011 ,  https:\/\/clinicaltrials.gov\/show\/NCT01357681 , (accessed 15 February, 2025)"},{"key":"D5FO05135E\/cit61\/1","year":"2011","unstructured":"European Union Clinical Trials Register (EUCTR). Effects of EGCG (epigallocatechin gallate) in Chorea Huntington,  2011 ,  https:\/\/trialsearch.who.int\/Trial2.aspx?TrialID=EUCTR2010-023941-31-DE , (accessed 14 February, 2025)"},{"key":"D5FO05135E\/cit62\/1","year":"2015","unstructured":"Clinicaltrials.Gov, Evaluation of the therapeutic potential of resveratrol in Huntington disease,  2015 ,  https:\/\/clinicaltrials.gov\/show\/nct02336633 , (accessed 16 February, 2025)"},{"key":"D5FO05135E\/cit63\/1","doi-asserted-by":"publisher","first-page":"fcaf080","DOI":"10.1093\/braincomms\/fcaf080","volume":"7","author":"Assogna","year":"2025","journal-title":"Brain Commun."},{"key":"D5FO05135E\/cit64\/1","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/j.1532-5415.2000.tb02589.x","volume":"48","author":"van Dongen","year":"2000","journal-title":"J. Am. Geriatr. Soc."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO05135E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:48:58Z","timestamp":1782877738000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/3\/1114-1126\/893373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo05135e","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5FO05135E\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO05135E\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO05135E\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO05135E\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO05135E\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5FO05135E\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}