{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:01:16Z","timestamp":1788267676487,"version":"build-2803163510"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2027,2,27]],"date-time":"2027-02-27T00:00:00Z","timestamp":1803686400000},"content-version":"am","delay-in-days":422,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1301004"],"award-info":[{"award-number":["2023YFD1301004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402245"],"award-info":[{"award-number":["32402245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372454"],"award-info":[{"award-number":["32372454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302745"],"award-info":[{"award-number":["32302745"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Dietary \u03b2-sitosterol can effectively alleviate male reproductive toxicity induced by combined exposure to low-dose deoxynivalenol (DON) and high-fat diet, thereby expanding the nutritional intervention strategy for DON toxicity.<\/jats:p>","DOI":"10.1039\/d5fo05222j","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:46:52Z","timestamp":1772189212000},"page":"2759-2772","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary \u03b2-sitosterol alleviates reproductive toxicity induced by combined exposure of low-dose deoxynivalenol and high-fat diet in male C57BL\/6J mice"],"prefix":"10.1039","volume":"17","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"},{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-0946","authenticated-orcid":false,"given":"You","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"},{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"},{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Lin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhang","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering and Technology Research Center of Coarse Cereal Industralization, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Cao","sequence":"additional","affiliation":[{"name":"Technology Innovation Center of Special Food, State Administration for Market Regulation, Wuxi 214142, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Han","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"},{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"},{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"},{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"},{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"},{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhou","family":"Li","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojie","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0736-6641","authenticated-orcid":false,"given":"Shijia","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, International Joint Laboratory on Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4528-3473","authenticated-orcid":false,"given":"Jianhong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Marine Food and Bioengineering, Jiangsu Ocean University, Lianyungang 222005, China"},{"name":"Key Laboratory of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Key Laboratory of Control Technology and Standard for Agro-product Safety and Quality, Ministry of Agriculture and Rural Affairs, Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China"},{"name":"School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5FO05222J\/cit1\/1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s43016-022-00655-z","volume":"3","author":"Johns","year":"2022","journal-title":"Nat. Food"},{"key":"D5FO05222J\/cit2\/1","first-page":"363","volume":"63","author":"FAO","year":"2011","journal-title":"WHO Food Addit. Ser."},{"key":"D5FO05222J\/cit3\/1","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1039\/D3FO04898E","volume":"15","author":"Wang","year":"2024","journal-title":"Food Funct."},{"key":"D5FO05222J\/cit4\/1","doi-asserted-by":"crossref","first-page":"112510","DOI":"10.1016\/j.fct.2021.112510","volume":"156","author":"Zhou","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"D5FO05222J\/cit5\/1","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.1039\/D2FO00185C","volume":"13","author":"Ma","year":"2022","journal-title":"Food Funct."},{"key":"D5FO05222J\/cit6\/1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1080\/10408398.2021.1954598","volume":"63","author":"Hou","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D5FO05222J\/cit7\/1","doi-asserted-by":"crossref","first-page":"151192","DOI":"10.1016\/j.scitotenv.2021.151192","volume":"806","author":"Lu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"D5FO05222J\/cit8\/1","doi-asserted-by":"crossref","first-page":"12829","DOI":"10.1021\/acs.jafc.3c03552","volume":"71","author":"Miao","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"D5FO05222J\/cit9\/1","doi-asserted-by":"crossref","first-page":"114748","DOI":"10.1016\/j.envpol.2020.114748","volume":"264","author":"Cao","year":"2020","journal-title":"Environ. Pollut."},{"key":"D5FO05222J\/cit10\/1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/hep4.1618","volume":"5","author":"Barbosa","year":"2020","journal-title":"Hepatol. Commun."},{"key":"D5FO05222J\/cit11\/1","author":"World Obesith Federation","year":"2023","unstructured":"World Obesith Federation , World Obesity Atlas 2023, URL:  https:\/\/www.worldobesity.org\/resources\/resource-library\/world-obesity-atlas-2023 , 7th November,  2023"},{"key":"D5FO05222J\/cit12\/1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.jacc.2018.02.085","volume":"72","author":"Yu","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"D5FO05222J\/cit13\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-016-0666-8","volume":"13","author":"Guillemot-Legris","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"D5FO05222J\/cit14\/1","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3389\/fphys.2017.00807","volume":"8","author":"Ib\u00e1\u00f1ez","year":"2017","journal-title":"Front. Physiol."},{"key":"D5FO05222J\/cit15\/1","doi-asserted-by":"crossref","first-page":"117075","DOI":"10.1016\/j.biopha.2024.117075","volume":"177","author":"Wu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"D5FO05222J\/cit16\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ygcen.2017.07.013","volume":"252","author":"Zhao","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"D5FO05222J\/cit17\/1","doi-asserted-by":"crossref","first-page":"1274035","DOI":"10.3389\/fendo.2023.1274035","volume":"14","author":"Falvo","year":"2023","journal-title":"Front. Endocrinol."},{"key":"D5FO05222J\/cit18\/1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3390\/life15060959","volume":"15","author":"Castellanos","year":"2025","journal-title":"Life"},{"key":"D5FO05222J\/cit19\/1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jff.2017.08.036","volume":"37","author":"Kim","year":"2017","journal-title":"J. Funct. Foods"},{"key":"D5FO05222J\/cit20\/1","doi-asserted-by":"crossref","first-page":"18696","DOI":"10.1021\/acs.jafc.3c06647","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"D5FO05222J\/cit21\/1","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1039\/D4FO00783B","volume":"15","author":"Li","year":"2024","journal-title":"Food Funct."},{"key":"D5FO05222J\/cit22\/1","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.1039\/D4FO00024B","volume":"15","author":"Guo","year":"2024","journal-title":"Food Funct."},{"key":"D5FO05222J\/cit23\/1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/09637486.2018.1511689","volume":"70","author":"Alvarez-Sala","year":"2019","journal-title":"Int. J. Food Sci. Nutr."},{"key":"D5FO05222J\/cit24\/1","doi-asserted-by":"crossref","first-page":"8458","DOI":"10.1021\/acs.jafc.2c01847","volume":"70","author":"Hu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"D5FO05222J\/cit25\/1","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.1039\/D5FO01767J","volume":"16","author":"Wang","year":"2025","journal-title":"Food Funct."},{"key":"D5FO05222J\/cit26\/1","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1002\/jcb.27853","volume":"120","author":"Ding","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"D5FO05222J\/cit27\/1","first-page":"1","volume":"32","author":"Singh","year":"2025","journal-title":"Reprod. Sci."},{"key":"D5FO05222J\/cit28\/1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10616-025-00740-8","volume":"77","author":"Chen","year":"2025","journal-title":"Cytotechnology"},{"key":"D5FO05222J\/cit29\/1","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/mnfr.201000640","volume":"55","author":"Kobayashi-Hattori","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"D5FO05222J\/cit30\/1","doi-asserted-by":"crossref","first-page":"108345","DOI":"10.1016\/j.envint.2023.108345","volume":"182","author":"Jin","year":"2023","journal-title":"Environ. Int."},{"key":"D5FO05222J\/cit31\/1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/15376516.2018.1545815","volume":"29","author":"Ponnulakshmi","year":"2019","journal-title":"Toxicol. Mech. Methods"},{"key":"D5FO05222J\/cit32\/1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00204-019-02470-1","volume":"93","author":"Faeste","year":"2019","journal-title":"Arch. Toxicol."},{"key":"D5FO05222J\/cit33\/1","doi-asserted-by":"crossref","first-page":"176432","DOI":"10.1016\/j.scitotenv.2024.176432","volume":"954","author":"Ruan","year":"2024","journal-title":"Sci. Total Environ."},{"key":"D5FO05222J\/cit34\/1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/genes14030557","volume":"14","author":"Zhang","year":"2023","journal-title":"Genes"},{"key":"D5FO05222J\/cit35\/1","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1007\/s43032-025-01825-7","volume":"32","author":"Singh","year":"2025","journal-title":"Reprod. Sci."},{"key":"D5FO05222J\/cit36\/1","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/j.jia.2024.07.037","volume":"24","author":"Pan","year":"2025","journal-title":"J. Integr. Agric."},{"key":"D5FO05222J\/cit37\/1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00394-019-02052-y","volume":"59","author":"Nascimento","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"D5FO05222J\/cit38\/1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s42000-023-00472-4","volume":"22","author":"Liu","year":"2023","journal-title":"Hormones"},{"key":"D5FO05222J\/cit39\/1","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1021\/acs.jafc.7b06146","volume":"66","author":"Feng","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"D5FO05222J\/cit40\/1","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1002\/jcp.26581","volume":"233","author":"Ghosh","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"D5FO05222J\/cit41\/1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3390\/ani14091289","volume":"14","author":"Zhang","year":"2024","journal-title":"Animals"},{"key":"D5FO05222J\/cit42\/1","doi-asserted-by":"crossref","first-page":"111566","DOI":"10.1016\/j.intimp.2024.111566","volume":"129","author":"Arafa","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"D5FO05222J\/cit43\/1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.molmed.2019.05.010","volume":"25","author":"Aryal","year":"2019","journal-title":"Trends Mol. Med."},{"key":"D5FO05222J\/cit44\/1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1210\/er.2018-00064","volume":"39","author":"Bougarne","year":"2018","journal-title":"Endocr. Rev."},{"key":"D5FO05222J\/cit45\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.theriogenology.2020.11.014","volume":"161","author":"Deepa","year":"2021","journal-title":"Theriogenology"},{"key":"D5FO05222J\/cit46\/1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1093\/humrep\/deaa150","volume":"35","author":"Young","year":"2020","journal-title":"Hum. Reprod."},{"key":"D5FO05222J\/cit47\/1","doi-asserted-by":"crossref","first-page":"123170","DOI":"10.1016\/j.envpol.2023.123170","volume":"343","author":"Li","year":"2024","journal-title":"Environ. Pollut."},{"key":"D5FO05222J\/cit48\/1","doi-asserted-by":"crossref","first-page":"109793","DOI":"10.1016\/j.pnpbp.2019.109793","volume":"97","author":"Assaf","year":"2020","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"D5FO05222J\/cit49\/1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/onc.2017.401","volume":"37","author":"Xue","year":"2018","journal-title":"Oncogene"},{"key":"D5FO05222J\/cit50\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.intimp.2019.05.018","volume":"73","author":"Ding","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"D5FO05222J\/cit51\/1","first-page":"101559","volume":"36","author":"Zhao","year":"2023","journal-title":"Biochem. Biophys. Rep."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/FO\/D5FO05222J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:49:06Z","timestamp":1783014546000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/17\/6\/2759-2772\/1241466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,3,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d5fo05222j","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}