{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:00:55Z","timestamp":1788282055383,"version":"build-2803163510"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":225,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["CUHK 14219922"],"award-info":[{"award-number":["CUHK 14219922"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["14207424"],"award-info":[{"award-number":["14207424"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["C5005-23WF"],"award-info":[{"award-number":["C5005-23WF"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010428","name":"Innovation and Technology Fund","doi-asserted-by":"publisher","award":["ITS\/217\/21"],"award-info":[{"award-number":["ITS\/217\/21"]}],"id":[{"id":"10.13039\/501100010428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["8601014"],"award-info":[{"award-number":["8601014"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>This work presents an inverse micelle-based method to load calcium, enabling its passive diffusion into water-in-oil (W\/O) droplets and promoting internal alginate gelation.<\/jats:p>","DOI":"10.1039\/d5lc00175g","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T07:00:53Z","timestamp":1755154853000},"page":"4588-4597","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inverse micelle mediated calcium chloride transportation for facile alginate gelation in microdroplets"],"prefix":"10.1039","volume":"25","author":[{"given":"Fuyang","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinru","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2052-9724","authenticated-orcid":false,"given":"Yi-Ping","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China"},{"name":"State Key Laboratory of Marine Pollution, City University of Hong Kong, Hong Kong SAR, China"},{"name":"Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics, The Chinese University of Hong Kong, Hong Kong SAR, China"},{"name":"The Ministry of Education Key Laboratory of Regeneration Medicine, Shatin, New Territories, Hong Kong SAR, China"},{"name":"Centre for Novel Biomaterials, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5LC00175G\/cit1\/1","doi-asserted-by":"crossref","first-page":"8604","DOI":"10.1021\/ac202028g","volume":"83","author":"Hindson","year":"2011","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit2\/1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/22221751.2020.1772678","volume":"9","author":"Suo","year":"2020","journal-title":"Emerging Microbes Infect."},{"key":"D5LC00175G\/cit3\/1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ces.2018.06.066","volume":"19","author":"Ferreira","year":"2018","journal-title":"Chem. Eng. Sci."},{"key":"D5LC00175G\/cit4\/1","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1021\/acs.analchem.6b03492","volume":"89","author":"Pham","year":"2017","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit5\/1","doi-asserted-by":"crossref","first-page":"11170","DOI":"10.1021\/ja037166v","volume":"125","author":"Zheng","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"D5LC00175G\/cit6\/1","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"D5LC00175G\/cit7\/1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2015.04.044","volume":"161","author":"Klein","year":"2015","journal-title":"Cell"},{"key":"D5LC00175G\/cit8\/1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nbt.3880","volume":"35","author":"Lan","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"D5LC00175G\/cit9\/1","doi-asserted-by":"crossref","first-page":"eabm1483","DOI":"10.1126\/science.abm1483","volume":"376","author":"Zheng","year":"2022","journal-title":"Science"},{"key":"D5LC00175G\/cit10\/1","doi-asserted-by":"crossref","first-page":"e1900188","DOI":"10.1002\/adbi.201900188","volume":"4","author":"Matu\u0142a","year":"2020","journal-title":"Adv. Biosyst."},{"key":"D5LC00175G\/cit11\/1","doi-asserted-by":"crossref","first-page":"24368","DOI":"10.1002\/anie.202016154","volume":"60","author":"Stucki","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5LC00175G\/cit12\/1","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/s41467-018-03492-6","volume":"9","author":"Ma","year":"2018","journal-title":"Nat. Commun."},{"key":"D5LC00175G\/cit13\/1","doi-asserted-by":"crossref","first-page":"E7383","DOI":"10.1073\/pnas.1606927113","volume":"113","author":"Gielen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5LC00175G\/cit14\/1","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1039\/C5LC00923E","volume":"15","author":"Sarkar","year":"2015","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit15\/1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/acs.analchem.6b04039","volume":"89","author":"Courtney","year":"2017","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit16\/1","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1039\/b806706f","volume":"8","author":"Holtze","year":"2008","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit17\/1","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1002\/adma.201602804","volume":"28","author":"Lee","year":"2016","journal-title":"Adv. Mater."},{"key":"D5LC00175G\/cit18\/1","doi-asserted-by":"crossref","first-page":"e202315552","DOI":"10.1002\/anie.202315552","volume":"63","author":"Li","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5LC00175G\/cit19\/1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1039\/c2lc40121e","volume":"12","author":"Mazutis","year":"2012","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit20\/1","doi-asserted-by":"crossref","first-page":"14195","DOI":"10.1073\/pnas.0903542106","volume":"106","author":"Brouzes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5LC00175G\/cit21\/1","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1039\/b907753g","volume":"9","author":"Mazutis","year":"2009","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit22\/1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1039\/C4LC00078A","volume":"14","author":"Sciambi","year":"2014","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit23\/1","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1021\/ac402057q","volume":"85","author":"Eastburn","year":"2013","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit24\/1","doi-asserted-by":"crossref","first-page":"19163","DOI":"10.1073\/pnas.1006888107","volume":"107","author":"Abate","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5LC00175G\/cit25\/1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1039\/b702472j","volume":"7","author":"Baroud","year":"2007","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit26\/1","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.1021\/acs.analchem.8b05456","volume":"91","author":"Sesen","year":"2019","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit27\/1","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1021\/acs.analchem.9b03521","volume":"91","author":"Bussiere","year":"2019","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit28\/1","doi-asserted-by":"crossref","first-page":"016601","DOI":"10.1088\/0034-4885\/75\/1\/016601","volume":"75","author":"Seemann","year":"2011","journal-title":"Rep. Prog. Phys."},{"key":"D5LC00175G\/cit29\/1","doi-asserted-by":"crossref","first-page":"024501","DOI":"10.1103\/PhysRevLett.100.024501","volume":"100","author":"Bremond","year":"2008","journal-title":"Phys. Rev. Lett."},{"key":"D5LC00175G\/cit30\/1","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1039\/b903608c","volume":"9","author":"Mazutis","year":"2009","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit31\/1","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1039\/c2lc40121e","volume":"12","author":"Mazutis","year":"2012","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit32\/1","doi-asserted-by":"crossref","first-page":"114004","DOI":"10.1088\/0022-3727\/46\/11\/114004","volume":"46","author":"Tran","year":"2013","journal-title":"J. Phys. D: Appl. Phys."},{"key":"D5LC00175G\/cit33\/1","doi-asserted-by":"crossref","first-page":"10618","DOI":"10.1039\/c2sm25934f","volume":"8","author":"Skhiri","year":"2012","journal-title":"Soft Matter"},{"key":"D5LC00175G\/cit34\/1","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1039\/C8LC01000E","volume":"18","author":"Etienne","year":"2018","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit35\/1","doi-asserted-by":"crossref","first-page":"10392","DOI":"10.1038\/ncomms10392","volume":"7","author":"Gruner","year":"2016","journal-title":"Nat. Commun."},{"key":"D5LC00175G\/cit36\/1","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1021\/ac802658n","volume":"81","author":"Courtois","year":"2009","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit37\/1","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1021\/la5004484","volume":"30","author":"Sandoz","year":"2014","journal-title":"Langmuir"},{"key":"D5LC00175G\/cit38\/1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jcis.2006.09.055","volume":"305","author":"Cheng","year":"2007","journal-title":"J. Colloid Interface Sci."},{"key":"D5LC00175G\/cit39\/1","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1021\/jp048838m","volume":"108","author":"Megyes","year":"2004","journal-title":"J. Phys. Chem. A"},{"key":"D5LC00175G\/cit40\/1","doi-asserted-by":"crossref","first-page":"22712","DOI":"10.1021\/jp063421x","volume":"110","author":"Owczarek","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"D5LC00175G\/cit41\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.progpolymsci.2011.06.003","volume":"37","author":"Lee","year":"2012","journal-title":"Prog. Polym. Sci."},{"key":"D5LC00175G\/cit42\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/10837450802712658","volume":"14","author":"Maiti","year":"2009","journal-title":"Pharm. Dev. Technol."},{"key":"D5LC00175G\/cit43\/1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.biomaterials.2009.10.052","volume":"31","author":"Silva","year":"2010","journal-title":"Biomaterials"},{"key":"D5LC00175G\/cit44\/1","doi-asserted-by":"crossref","first-page":"130465","DOI":"10.1016\/j.cej.2021.130465","volume":"420","author":"Ghaderinejad","year":"2021","journal-title":"Chem. Eng. J."},{"key":"D5LC00175G\/cit45\/1","doi-asserted-by":"crossref","first-page":"116914","DOI":"10.1016\/j.carbpol.2020.116914","volume":"250","author":"Lee","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"D5LC00175G\/cit46\/1","doi-asserted-by":"crossref","first-page":"117702","DOI":"10.1016\/j.carbpol.2021.117702","volume":"258","author":"Liu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"D5LC00175G\/cit47\/1","doi-asserted-by":"crossref","first-page":"134107","DOI":"10.1016\/j.ijbiomac.2024.134107","volume":"276","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5LC00175G\/cit48\/1","doi-asserted-by":"crossref","first-page":"2101966","DOI":"10.1002\/adma.202101966","volume":"33","author":"Indana","year":"2021","journal-title":"Adv. Mater."},{"key":"D5LC00175G\/cit49\/1","doi-asserted-by":"crossref","first-page":"024103","DOI":"10.1088\/1758-5090\/ac4dd8","volume":"14","author":"Kim","year":"2022","journal-title":"Biofabrication"},{"key":"D5LC00175G\/cit50\/1","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.3390\/molecules26123752","volume":"26","author":"Chen","year":"2021","journal-title":"Molecules"},{"key":"D5LC00175G\/cit51\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/marc.200600776","volume":"28","author":"Zhang","year":"2007","journal-title":"Macromol. Rapid Commun."},{"key":"D5LC00175G\/cit52\/1","doi-asserted-by":"crossref","first-page":"12205","DOI":"10.1021\/ja0635682","volume":"128","author":"Zhang","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"D5LC00175G\/cit53\/1","doi-asserted-by":"crossref","first-page":"066504","DOI":"10.1063\/1.4902943","volume":"8","author":"Kim","year":"2014","journal-title":"Biomicrofluidics"},{"key":"D5LC00175G\/cit54\/1","doi-asserted-by":"crossref","first-page":"044108","DOI":"10.1063\/1.4765337","volume":"6","author":"Lian","year":"2012","journal-title":"Biomicrofluidics"},{"key":"D5LC00175G\/cit55\/1","doi-asserted-by":"crossref","first-page":"034117","DOI":"10.1063\/1.3625604","volume":"5","author":"Lee","year":"2011","journal-title":"Biomicrofluidics"},{"key":"D5LC00175G\/cit56\/1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.snb.2019.04.100","volume":"291","author":"Samandari","year":"2019","journal-title":"Sens. Actuators, B"},{"key":"D5LC00175G\/cit57\/1","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1039\/b819044e","volume":"9","author":"Kim","year":"2009","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit58\/1","doi-asserted-by":"crossref","first-page":"8816","DOI":"10.1021\/ac2022794","volume":"83","author":"Chen","year":"2011","journal-title":"Anal. Chem."},{"key":"D5LC00175G\/cit59\/1","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/adhm.201500021","volume":"4","author":"Utech","year":"2015","journal-title":"Adv. Healthcare Mater."},{"key":"D5LC00175G\/cit60\/1","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1039\/C6LC00769D","volume":"16","author":"H\u00e5ti","year":"2016","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit61\/1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1039\/D1LC00111F","volume":"21","author":"Ahmed","year":"2021","journal-title":"Lab Chip"},{"key":"D5LC00175G\/cit62\/1","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1039\/C9SM00711C","volume":"15","author":"Efremov","year":"2019","journal-title":"Soft Matter"},{"key":"D5LC00175G\/cit63\/1","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1039\/C4SM00788C","volume":"10","author":"Glaubitz","year":"2014","journal-title":"Soft Matter"},{"key":"D5LC00175G\/cit64\/1","doi-asserted-by":"crossref","first-page":"1903463","DOI":"10.1002\/advs.201903463","volume":"7","author":"Wang","year":"2020","journal-title":"Adv. Sci."},{"key":"D5LC00175G\/cit65\/1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/ma00206a031","volume":"23","author":"Hooper","year":"1990","journal-title":"Macromolecules"},{"key":"D5LC00175G\/cit66\/1","first-page":"865","volume-title":"Cellulose-Based Superabsorbent Hydrogels","author":"Lee","year":"2018","unstructured":"D.Lee ,  H.Zhang  and  S.Ryu , in  Cellulose-Based Superabsorbent Hydrogels , ed.  I. H. Mondal ,  Springer Cham , 1st edn,  2018 , ch. 27,  pp. 865\u2013884"},{"key":"D5LC00175G\/cit67\/1","doi-asserted-by":"crossref","first-page":"41695","DOI":"10.1021\/acsami.2c09221","volume":"14","author":"Li","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5LC00175G\/cit68\/1","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1021\/acsbiomaterials.3c01567","volume":"10","author":"Zhang","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D5LC00175G\/cit69\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J. Controlled Release"},{"key":"D5LC00175G\/cit70\/1","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1039\/c2lc40624a","volume":"12","author":"Chen","year":"2012","journal-title":"Lab Chip"}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/LC\/D5LC00175G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:51:25Z","timestamp":1782964285000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/25\/18\/4588-4597\/895236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":70,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9,9]]}},"URL":"https:\/\/doi.org\/10.1039\/d5lc00175g","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}