{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:37:46Z","timestamp":1792003066351,"version":"4.4.0"},"reference-count":102,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"am","delay-in-days":498,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007672","name":"Mechanobiology Institute, Singapore","doi-asserted-by":"publisher","award":["NRF-MSG-2023-0001"],"award-info":[{"award-number":["NRF-MSG-2023-0001"]}],"id":[{"id":"10.13039\/501100007672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CIRG21nov-0032, CIRG22jul-0018"],"award-info":[{"award-number":["CIRG21nov-0032, CIRG22jul-0018"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SRG\/2023\/001183"],"award-info":[{"award-number":["SRG\/2023\/001183"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council","doi-asserted-by":"publisher","award":["H18\/01\/a0\/017"],"award-info":[{"award-number":["H18\/01\/a0\/017"]}],"id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>\n                    The key elements in the development of the LEADS chip are highlighted; the crucial features of the chip for mimicking NASH\n                    <jats:italic>in vitro<\/jats:italic>\n                    and its applicability as a pre-clinical drug testing model.\n                  <\/jats:p>","DOI":"10.1039\/d5lc00221d","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:40:48Z","timestamp":1747197648000},"page":"3444-3466","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["LEADS \u2013 a comprehensive human liver-on-a-chip for non-alcoholic steatohepatitis (NASH) drug testing"],"prefix":"10.1039","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2462-9001","authenticated-orcid":false,"given":"Gowri Manohari","family":"Balachander","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering, Indian Institute of Technology (BHU) Varanasi, Varanasi-221005, India"},{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inn Chuan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0311-4399","authenticated-orcid":false,"given":"Roopesh R.","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"},{"name":"Bioprinting Lab, Department of Dermatology, Dr. D.Y. Patil Medical College, Hospital & Research Centre, Sant Tukaram Nagar, Pimpri, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Tasnim","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Industry Partnership Office (BMSIPO), A*STAR, 31 Biopolis Way, 138669, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee Siang","family":"Lim","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Royston","family":"Kwok","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoohyun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-1881","authenticated-orcid":false,"given":"Lai Ping","family":"Yaw","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa Bernice","family":"Quah","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Zhao","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahyunia L.","family":"Septiana","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine, Gunadarma University, Depok, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu Goutham","family":"Kota","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Nano-Bio-Chem Centre and Organoid Innovation Center, Suzhou Institute of Nano-tech and Nano-bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei Hien","family":"Lim","sequence":"additional","affiliation":[{"name":"AIM Biotech Pte. Ltd., 21 Biopolis Road, #01-24 Nucleos, 138567, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huck Hui","family":"Ng","sequence":"additional","affiliation":[{"name":"Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore"},{"name":"Department of Biological Sciences, National University of Singapore, Singapore"},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"School of Biological Sciences, Nanyang Technological University, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-3685","authenticated-orcid":false,"given":"Hanry","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Physiology, The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore"},{"name":"Mechanobiology Institute, National University of Singapore, T-Lab, #05-01, 5A Engineering Drive 1, Singapore 117411, Singapore"},{"name":"CAMP, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, Level 4 Enterprise Wing, Singapore 138602, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"D5LC00221D\/cit1\/1","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","volume":"73","author":"Eslam","year":"2020","journal-title":"J. Hepatol."},{"issue":"1","key":"D5LC00221D\/cit2\/1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Younossi","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"D5LC00221D\/cit3\/1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","volume":"16","author":"Anstee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"D5LC00221D\/cit4\/1","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/J.CGH.2014.04.014","volume":"13","author":"Singh","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"4","key":"D5LC00221D\/cit5\/1","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.cgh.2018.05.057","volume":"17","author":"Younossi","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"1","key":"D5LC00221D\/cit6\/1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"issue":"4","key":"D5LC00221D\/cit7\/1","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1002\/hep.26226","volume":"58","author":"Begriche","year":"2013","journal-title":"Hepatology"},{"issue":"2","key":"D5LC00221D\/cit8\/1","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3945\/an.116.013151","volume":"8","author":"Mokhtari","year":"2017","journal-title":"Adv. Nutr."},{"issue":"7","key":"D5LC00221D\/cit9\/1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"D5LC00221D\/cit10\/1","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/hep4.1479","volume":"4","author":"Parthasarathy","year":"2020","journal-title":"Hepatol. Commun."},{"key":"D5LC00221D\/cit11\/1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev-pathol-121808-102132","volume":"5","author":"Tiniakos","year":"2010","journal-title":"Annu. Rev. Pathol.: Mech. Dis."},{"key":"D5LC00221D\/cit12\/1","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.2147\/DDDT.S315724","volume":"15","author":"Fraile","year":"2021","journal-title":"Drug Des., Dev. Ther."},{"issue":"S1","key":"D5LC00221D\/cit13\/1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/liv.14844","volume":"41","author":"Albhaisi","year":"2021","journal-title":"Liver Int."},{"issue":"8","key":"D5LC00221D\/cit14\/1","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.cgh.2023.03.041","volume":"21","author":"Harrison","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"9972","key":"D5LC00221D\/cit15\/1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"D5LC00221D\/cit16\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cct.2019.105922","author":"Anstee","year":"2020","journal-title":"Contemp. Clin. Trials"},{"issue":"6","key":"D5LC00221D\/cit17\/1","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","volume":"84","author":"Keam","year":"2024","journal-title":"Drugs"},{"issue":"6444","key":"D5LC00221D\/cit18\/1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1126\/science.aaw7894","volume":"364","author":"Park","year":"2019","journal-title":"Science"},{"issue":"5","key":"D5LC00221D\/cit19\/1","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.molmed.2021.03.001","volume":"27","author":"Kaluthantrige Don","year":"2021","journal-title":"Trends Mol. Med."},{"issue":"32","key":"D5LC00221D\/cit20\/1","doi-asserted-by":"publisher","first-page":"7669","DOI":"10.1039\/d4tb00738g","volume":"12","author":"Karnawat","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"D5LC00221D\/cit21\/1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.biomaterials.2018.11.016","volume":"192","author":"Tasnim","year":"2019","journal-title":"Biomaterials"},{"issue":"1","key":"D5LC00221D\/cit22\/1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.stem.2018.05.027","volume":"23","author":"Coll","year":"2018","journal-title":"Cell Stem Cell"},{"key":"D5LC00221D\/cit23\/1","volume-title":"Derivation of Liver Organoids from Human Pluripotent Stem Cells","author":"Ng","year":"2020","unstructured":"H. H.Ng ,  Y. S.Chan  and  W. J.TNG ,  Derivation of Liver Organoids from Human Pluripotent Stem Cells ,  2020"},{"issue":"2","key":"D5LC00221D\/cit24\/1","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/S0022-3549(15)00192-6","volume":"105","author":"Rose","year":"2016","journal-title":"J. Pharm. Sci."},{"issue":"4","key":"D5LC00221D\/cit25\/1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1440-1746.2006.04758.x","volume":"22","author":"Park","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"1","key":"D5LC00221D\/cit26\/1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jhep.2009.03.008","volume":"51","author":"Baffy","year":"2009","journal-title":"J. Hepatol."},{"issue":"7","key":"D5LC00221D\/cit27\/1","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/01.MP.0000019579.30842.96","volume":"15","author":"Lefkowitch","year":"2002","journal-title":"Mod. Pathol."},{"key":"D5LC00221D\/cit28\/1","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.addr.2014.02.011","volume":"69\u201370","author":"Ebrahimkhani","year":"2014","journal-title":"Adv. Drug Delivery Rev."},{"issue":"1","key":"D5LC00221D\/cit29\/1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/01926230590881826","volume":"33","author":"Malarkey","year":"2005","journal-title":"Toxicol. Pathol."},{"issue":"2","key":"D5LC00221D\/cit30\/1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/hep4.1647","volume":"5","author":"Freag","year":"2021","journal-title":"Hepatol. Commun."},{"issue":"20","key":"D5LC00221D\/cit31\/1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1172\/jci.insight.90954","volume":"1","author":"Feaver","year":"2016","journal-title":"JCI Insight"},{"issue":"4","key":"D5LC00221D\/cit32\/1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.14218\/JCTH.2020.00015","volume":"8","author":"Duriez","year":"2020","journal-title":"J. Clin. Transl. Hepatol."},{"issue":"2","key":"D5LC00221D\/cit33\/1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cbi.2006.11.004","volume":"165","author":"G\u00f3mez-Lech\u00f3n","year":"2007","journal-title":"Chem.-Biol. Interact."},{"key":"D5LC00221D\/cit34\/1","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1152\/ajpendo.00283.2010.-As","volume":"299","author":"Dekker","year":"2010","journal-title":"Am. J. Physiol."},{"issue":"4","key":"D5LC00221D\/cit35\/1","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1002\/mnfr.201500635","volume":"60","author":"Zhao","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"7","key":"D5LC00221D\/cit36\/1","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1038\/s41591-018-0061-3","volume":"24","author":"Hoyles","year":"2018","journal-title":"Nat. Med."},{"issue":"3","key":"D5LC00221D\/cit37\/1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.jhep.2010.11.021","volume":"55","author":"Tandra","year":"2011","journal-title":"J. Hepatol."},{"issue":"1","key":"D5LC00221D\/cit38\/1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/modpathol.3800680","volume":"20","author":"Brunt","year":"2007","journal-title":"Mod. Pathol."},{"issue":"2","key":"D5LC00221D\/cit39\/1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1586\/egh.11.8","volume":"5","author":"Lackner","year":"2011","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"D5LC00221D\/cit40\/1","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/path.2888","volume":"224","author":"Rangwala","year":"2011","journal-title":"J. Pathol."},{"issue":"5","key":"D5LC00221D\/cit41\/1","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1016\/j.jhep.2022.01.011","volume":"76","author":"Brunt","year":"2022","journal-title":"J. Hepatol."},{"issue":"8","key":"D5LC00221D\/cit42\/1","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"2","key":"D5LC00221D\/cit43\/1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/qjmed\/hcp158","volume":"103","author":"Dowman","year":"2009","journal-title":"QJM"},{"issue":"27","key":"D5LC00221D\/cit44\/1","doi-asserted-by":"publisher","first-page":"2974","DOI":"10.3748\/wjg.v24.i27.2974","volume":"24","author":"Fang","year":"2018","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"D5LC00221D\/cit45\/1","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1111\/j.1440-1746.2008.05733.x","volume":"24","author":"Ricchi","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"D5LC00221D\/cit46\/1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12986-020-0434-8","volume":"17","author":"Zeng","year":"2020","journal-title":"Nutr. Metab."},{"key":"D5LC00221D\/cit47\/1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.lfs.2018.04.022","volume":"203","author":"Chen","year":"2018","journal-title":"Life Sci."},{"issue":"6","key":"D5LC00221D\/cit48\/1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/j.jhep.2016.02.004","volume":"64","author":"Schmidt-Arras","year":"2016","journal-title":"J. Hepatol."},{"issue":"9","key":"D5LC00221D\/cit49\/1","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1136\/gutjnl-2016-313392","volume":"67","author":"Xiang","year":"2018","journal-title":"Gut"},{"issue":"5","key":"D5LC00221D\/cit50\/1","doi-asserted-by":"publisher","first-page":"e0176173","DOI":"10.1371\/journal.pone.0176173","volume":"12","author":"Kagan","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"D5LC00221D\/cit51\/1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bbrc.2004.10.020","volume":"325","author":"M\u00fchlbauer","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"D5LC00221D\/cit52\/1","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/bjc.2017.414","volume":"118","author":"Khazali","year":"2018","journal-title":"Br. J. Cancer"},{"key":"D5LC00221D\/cit53\/1","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fphys.2012.00213","volume":"3","author":"Saiman","year":"2012","journal-title":"Front. Physiol."},{"issue":"4","key":"D5LC00221D\/cit54\/1","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.jaut.2010.09.003","volume":"35","author":"Hintermann","year":"2010","journal-title":"J. Autoimmun."},{"key":"D5LC00221D\/cit55\/1","doi-asserted-by":"publisher","first-page":"27665","DOI":"10.1038\/srep27665","volume":"6","author":"Xie","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"D5LC00221D\/cit56\/1","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1074\/mcp.M110.000406","volume":"9","author":"Alexopoulos","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"D5LC00221D\/cit57\/1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.cellimm.2003.10.005","volume":"226","author":"Zhang","year":"2003","journal-title":"Cell. Immunol."},{"issue":"1","key":"D5LC00221D\/cit58\/1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1172\/JCI88881","volume":"127","author":"Koyama","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"11","key":"D5LC00221D\/cit59\/1","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/nm1663","volume":"13","author":"Seki","year":"2007","journal-title":"Nat. Med."},{"issue":"3","key":"D5LC00221D\/cit60\/1","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1210\/me.2011-1233","volume":"26","author":"Miao","year":"2012","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"D5LC00221D\/cit61\/1","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12967-018-1490-y","volume":"16","author":"Chu","year":"2018","journal-title":"J. Transl. Med."},{"key":"D5LC00221D\/cit62\/1","doi-asserted-by":"publisher","first-page":"154789","DOI":"10.1016\/j.cyto.2019.154789","volume":"123","author":"Hanson","year":"2019","journal-title":"Cytokine"},{"key":"D5LC00221D\/cit63\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2147\/MNM.S252991","volume":"7","author":"Okazaki","year":"2020","journal-title":"Metalloproteinases Med."},{"key":"D5LC00221D\/cit64\/1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/mnm.s124363","volume":"4","author":"Zbodakova","year":"2017","journal-title":"Metalloproteinases Med."},{"issue":"9","key":"D5LC00221D\/cit65\/1","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/gutjnl-2011-301857","volume":"61","author":"Syn","year":"2012","journal-title":"Gut"},{"issue":"9","key":"D5LC00221D\/cit66\/1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.7150\/ijbs.16445","volume":"12","author":"Wen","year":"2016","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"D5LC00221D\/cit67\/1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/hep.23998","volume":"53","author":"Syn","year":"2011","journal-title":"Hepatology"},{"issue":"12","key":"D5LC00221D\/cit68\/1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1096\/fba.2020-00056","volume":"2","author":"Olivares","year":"2020","journal-title":"FASEB BioAdv."},{"issue":"1","key":"D5LC00221D\/cit69\/1","doi-asserted-by":"publisher","first-page":"e000683","DOI":"10.1136\/bmjgast-2021-000683","volume":"8","author":"Rivas","year":"2021","journal-title":"BMJ Open Gastroenterol."},{"issue":"3","key":"D5LC00221D\/cit70\/1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1038\/s41419-020-2411-6","volume":"11","author":"Wandrer","year":"2020","journal-title":"Cell Death Discovery"},{"issue":"4","key":"D5LC00221D\/cit71\/1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jgg.2021.09.009","volume":"49","author":"Lu","year":"2022","journal-title":"J. Genet. Genomics"},{"issue":"1","key":"D5LC00221D\/cit72\/1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/hep.20280","volume":"40","author":"Hui","year":"2004","journal-title":"Hepatology"},{"key":"D5LC00221D\/cit73\/1","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1172\/JCI135919","volume":"130","author":"Zheng","year":"2020","journal-title":"J. Clin. Invest."},{"key":"D5LC00221D\/cit74\/1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.thromres.2022.02.023","volume":"213","author":"Eriksen","year":"2022","journal-title":"Thromb. Res."},{"issue":"11","key":"D5LC00221D\/cit75\/1","doi-asserted-by":"publisher","first-page":"2917","DOI":"10.1038\/s41401-022-00907-5","volume":"43","author":"Shen","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"D5LC00221D\/cit76\/1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jceh.2019.11.011","volume":"10","author":"Siddiqui","year":"2020","journal-title":"J. Clin. Exp. Hepatol."},{"issue":"4","key":"D5LC00221D\/cit77\/1","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1002\/hep.31843\/suppinfo","volume":"74","author":"Gawrieh","year":"2021","journal-title":"Trial"},{"issue":"10215","key":"D5LC00221D\/cit78\/1","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1016\/S0140-6736(19)33041-7","volume":"394","author":"Younossi","year":"2019","journal-title":"Lancet"},{"issue":"9972","key":"D5LC00221D\/cit79\/1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"D5LC00221D\/cit80\/1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.cgh.2017.12.001","volume":"16","author":"Bril","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"18","key":"D5LC00221D\/cit81\/1","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1056\/nejmoa0907929","volume":"362","author":"Sanyal","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"D5LC00221D\/cit82\/1","doi-asserted-by":"publisher","first-page":"105922","DOI":"10.1016\/j.cct.2019.105922","volume":"89","author":"Anstee","year":"2020","journal-title":"Contemp. Clin. Trials"},{"issue":"3","key":"D5LC00221D\/cit83\/1","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1002\/hep.31108\/suppinfo","volume":"72","author":"Ratziu","year":"2020","journal-title":"Hepatology"},{"issue":"10213","key":"D5LC00221D\/cit84\/1","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1016\/S0140-6736(19)32517-6","volume":"394","author":"Harrison","year":"2019","journal-title":"Lancet"},{"issue":"8","key":"D5LC00221D\/cit85\/1","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1002\/hep4.1723","volume":"5","author":"Jacques","year":"2021","journal-title":"Hepatol. Commun."},{"issue":"11","key":"D5LC00221D\/cit86\/1","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1038\/s41591-023-02603-1","volume":"29","author":"Harrison","year":"2023","journal-title":"Nat. Med."},{"issue":"2","key":"D5LC00221D\/cit87\/1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.tips.2020.11.009","volume":"42","author":"Ma","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"issue":"8","key":"D5LC00221D\/cit88\/1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41578-018-0034-7","volume":"3","author":"Zhang","year":"2018","journal-title":"Nat. Rev. Mater."},{"issue":"21","key":"D5LC00221D\/cit89\/1","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1056\/NEJMra1503519","volume":"377","author":"Diehl","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"D5LC00221D\/cit90\/1","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.hepres.2005.09.022","volume":"33","author":"Diehl","year":"2005","journal-title":"Hepatol. Res."},{"issue":"8","key":"D5LC00221D\/cit91\/1","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.gastha.2024.08.004","volume":"3","author":"Meyer","year":"2024","journal-title":"Gastro Hep Advances"},{"issue":"8","key":"D5LC00221D\/cit92\/1","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1039\/d1lc00067e","volume":"21","author":"Azizgolshani","year":"2021","journal-title":"Lab Chip"},{"issue":"4","key":"D5LC00221D\/cit93\/1","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.3390\/pharmaceutics15041300","volume":"15","author":"Fu","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"D5LC00221D\/cit94\/1","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1002\/hep4.1450\/suppinfo","volume":"4","author":"Kostrzewski","year":"2019","journal-title":"Hepatol. Commun."},{"key":"D5LC00221D\/cit95\/1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.actbio.2021.07.013","volume":"134","author":"Du","year":"2021","journal-title":"Acta Biomater."},{"issue":"2","key":"D5LC00221D\/cit96\/1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.cmet.2019.05.007","volume":"30","author":"Ouchi","year":"2019","journal-title":"Cell Metab."},{"issue":"1","key":"D5LC00221D\/cit97\/1","doi-asserted-by":"publisher","first-page":"22765","DOI":"10.1038\/s41598-021-01951-7","volume":"11","author":"Str\u00f6bel","year":"2021","journal-title":"Sci. Rep."},{"key":"D5LC00221D\/cit98\/1","doi-asserted-by":"publisher","first-page":"708959","DOI":"10.3389\/fimmu.2021.708959","volume":"12","author":"Fontes-Cal","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"D5LC00221D\/cit99\/1","doi-asserted-by":"publisher","first-page":"4297206","DOI":"10.1155\/2017\/4297206","volume":"2017","author":"Bocsan","year":"2017","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"1","key":"D5LC00221D\/cit100\/1","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s42003-021-02616-x","volume":"4","author":"Kostrzewski","year":"2021","journal-title":"Commun. Biol."},{"issue":"6","key":"D5LC00221D\/cit101\/1","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1056\/NEJMoa2309000","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"D5LC00221D\/cit102\/1","doi-asserted-by":"publisher","first-page":"155835","DOI":"10.1016\/j.metabol.2024.155835","volume":"154","author":"Kokkorakis","year":"2024","journal-title":"Metabolism"}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/LC\/article-pdf\/doi\/10.1039\/D5LC00221D\/0\/D5LC00221D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:42:59Z","timestamp":1789998179000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/LC\/article-lookup\/doi\/10.1039\/D5LC00221D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":102,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2025,7,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5lc00221d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5LC00221D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5LC00221D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5LC00221D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5LC00221D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5LC00221D\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5LC00221D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5LC00221D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}