{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:49:26Z","timestamp":1789321766729,"version":"build-2803163510"},"reference-count":26,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":188,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RU489\/31-2"],"award-info":[{"award-number":["RU489\/31-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TH1358\/3-2"],"award-info":[{"award-number":["TH1358\/3-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>Functionalized hydrogel bead platform for capturing cell-free DNA (cfDNA) as a cancer biomarker.<\/jats:p>","DOI":"10.1039\/d5lc00447k","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:42:05Z","timestamp":1751974925000},"page":"4422-4435","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydrogel beads for enhanced nucleic acid analysis in complex fluid matrices"],"prefix":"10.1039","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3524-9485","authenticated-orcid":false,"given":"Lokman","family":"Alpsoy","sequence":"first","affiliation":[{"name":"Department of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, 79110 Freiburg im Breisgau, Germany"},{"name":"Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT), University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9216-9761","authenticated-orcid":false,"given":"Stephan","family":"Tieu","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0593-6580","authenticated-orcid":false,"given":"Sina","family":"Dehestanizad","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-8295","authenticated-orcid":false,"given":"Thomas","family":"Brandstetter","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-8228","authenticated-orcid":false,"given":"J\u00fcrgen","family":"R\u00fche","sequence":"additional","affiliation":[{"name":"Department of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, 79110 Freiburg im Breisgau, Germany"},{"name":"Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT), University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5LC00447K\/cit1\/1","doi-asserted-by":"crossref","first-page":"101720","DOI":"10.1016\/j.tranon.2023.101720","volume":"34","author":"Wang","year":"2023","journal-title":"Transl. Oncol."},{"key":"D5LC00447K\/cit2\/1","first-page":"e42731","volume":"15","author":"Noor","year":"2023","journal-title":"Cureus"},{"key":"D5LC00447K\/cit3\/1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.21037\/tlcr.2016.08.06","volume":"5","author":"Ili\u00e9","year":"2016","journal-title":"Transl. Lung Cancer Res."},{"key":"D5LC00447K\/cit4\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13045-022-01351-y","volume":"15","author":"Nikanjam","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"D5LC00447K\/cit5\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cancergen.2018.08.005","volume":"228\u2013229","author":"Diefenbach","year":"2018","journal-title":"Cancer Genet."},{"key":"D5LC00447K\/cit6\/1","doi-asserted-by":"crossref","first-page":"8555","DOI":"10.1038\/s41598-022-12118-3","volume":"12","author":"Hu","year":"2022","journal-title":"Sci. Rep."},{"key":"D5LC00447K\/cit7\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-022-01543-7","volume":"21","author":"Lone","year":"2022","journal-title":"Mol. Cancer"},{"key":"D5LC00447K\/cit8\/1","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.3748\/wjg.v30.i15.2175","volume":"30","author":"Liu","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"D5LC00447K\/cit9\/1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrclinonc.2017.14","volume":"14","author":"Siravegna","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D5LC00447K\/cit10\/1","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1021\/acs.analchem.2c00531","volume":"94","author":"Hapsianto","year":"2022","journal-title":"Anal. Chem."},{"key":"D5LC00447K\/cit11\/1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/pd.6212","volume":"42","author":"Zhong","year":"2022","journal-title":"Prenatal Diagn."},{"key":"D5LC00447K\/cit12\/1","doi-asserted-by":"crossref","first-page":"19653","DOI":"10.1038\/s41598-021-98815-x","volume":"11","author":"Janku","year":"2021","journal-title":"Sci. Rep."},{"key":"D5LC00447K\/cit13\/1","doi-asserted-by":"crossref","first-page":"e0231854","DOI":"10.1371\/journal.pone.0231854","volume":"15","author":"Raymond","year":"2020","journal-title":"PLoS One"},{"key":"D5LC00447K\/cit14\/1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12102550","volume":"12","author":"Polatoglou","year":"2022","journal-title":"Diagnostics"},{"key":"D5LC00447K\/cit15\/1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1021\/acs.analchem.0c04152","volume":"93","author":"Kim","year":"2021","journal-title":"Anal. Chem."},{"key":"D5LC00447K\/cit16\/1","first-page":"475","volume-title":"Immobilization Strategies : Biomedical, Bioengineering and Environmental Applications","author":"Roberts","year":"2021","unstructured":"A.Roberts ,  D.Shahdeo  and  S.Gandhi , in  Immobilization Strategies : Biomedical, Bioengineering and Environmental Applications , ed.  A. Tripathi  and  J. S. Melo ,  Springer Singapore ,  Singapore ,  2021 ,  pp. 475\u2013507"},{"key":"D5LC00447K\/cit17\/1","doi-asserted-by":"crossref","first-page":"55346","DOI":"10.1021\/acsami.3c12122","volume":"15","author":"Alpsoy","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5LC00447K\/cit18\/1","doi-asserted-by":"crossref","first-page":"39411","DOI":"10.1021\/acsami.8b11757","volume":"10","author":"Sch\u00f6nberg","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5LC00447K\/cit19\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.mie.2015.10.005","volume":"571","author":"Otieno","year":"2016","journal-title":"Methods Enzymol."},{"key":"D5LC00447K\/cit20\/1","doi-asserted-by":"crossref","first-page":"5646","DOI":"10.1039\/C7CS00263G","volume":"47","author":"Li","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D5LC00447K\/cit21\/1","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1021\/la1050833","volume":"27","author":"Rendl","year":"2011","journal-title":"Langmuir"},{"key":"D5LC00447K\/cit22\/1","doi-asserted-by":"crossref","first-page":"25147","DOI":"10.1021\/acsami.2c04361","volume":"14","author":"Weber","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5LC00447K\/cit23\/1","doi-asserted-by":"crossref","first-page":"10801","DOI":"10.1116\/1.4999786","volume":"13","author":"Prucker","year":"2017","journal-title":"Biointerphases"},{"key":"D5LC00447K\/cit24\/1","doi-asserted-by":"crossref","first-page":"e11862","DOI":"10.1371\/journal.pone.0011862","volume":"5","author":"Scopelliti","year":"2010","journal-title":"PLoS One"},{"key":"D5LC00447K\/cit25\/1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.colsurfb.2014.07.035","volume":"122","author":"Scherag","year":"2014","journal-title":"Colloids Surf., B"},{"key":"D5LC00447K\/cit26\/1","first-page":"528008","volume":"10","author":"Jiang","year":"2020","journal-title":"Front. Oncol."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/LC\/D5LC00447K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:14:06Z","timestamp":1782969246000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/25\/17\/4422-4435\/895326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,8,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d5lc00447k","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}