{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:05:09Z","timestamp":1783011909344,"version":"3.54.6"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"am","delay-in-days":511,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>The two designed compounds 11 and 12 showed significat antifungal activity supported by molecular studies.<\/jats:p>","DOI":"10.1039\/d5md00122f","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T10:43:54Z","timestamp":1748342634000},"page":"3291-3311","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel benzimidazole hybrids: design, synthesis, mechanistic studies, antifungal potential and molecular dynamics"],"prefix":"10.1039","volume":"16","author":[{"given":"Ahmed A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University in Beni-Suef (NUB), Beni-Suef 62513, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4691-3860","authenticated-orcid":false,"given":"Eman G.","family":"Said","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4243-9401","authenticated-orcid":false,"given":"Asmaa M.","family":"AboulMagd","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Nahda University in Beni-Suef (NUB), Beni-Suef 62513, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha H.","family":"Amin","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-8380","authenticated-orcid":false,"given":"Hamdy M.","family":"Abdel-Rahman","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt"},{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Assiut (BUA), Assiut 2014101, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"8","key":"D5MD00122F\/cit1\/1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41564-022-01172-2","volume":"7","author":"Hoenigl","year":"2022","journal-title":"Nat. Microbiol."},{"issue":"1","key":"D5MD00122F\/cit2\/1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cmi.2024.08.006","volume":"31","author":"Giannella","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"issue":"3","key":"D5MD00122F\/cit3\/1","doi-asserted-by":"crossref","first-page":"100719","DOI":"10.1016\/j.bj.2024.100719","volume":"47","author":"H\u00e9rivaux","year":"2024","journal-title":"Biomed. J."},{"issue":"2","key":"D5MD00122F\/cit4\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/jof5020038","volume":"5","author":"Ocansey","year":"2019","journal-title":"J. Fungi"},{"issue":"5","key":"D5MD00122F\/cit5\/1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/jof10050353","volume":"10","author":"Al Dhaheri","year":"2024","journal-title":"J. Fungi"},{"issue":"9","key":"D5MD00122F\/cit6\/1","first-page":"e2838","volume":"73","author":"Mastrangelo","year":"2021","journal-title":"J. Infect. Dis."},{"issue":"9","key":"D5MD00122F\/cit7\/1","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3390\/jof8090894","volume":"8","author":"Casalini","year":"2022","journal-title":"J. Fungi"},{"key":"D5MD00122F\/cit8\/1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/jof7040279","volume":"7","author":"Morales-L\u00f3pez","year":"2021","journal-title":"J Fungi"},{"key":"D5MD00122F\/cit9\/1","first-page":"27","volume":"20","author":"Feng","year":"2022","journal-title":"Int. J. Parasitol.: Drugs Drug Resist."},{"key":"D5MD00122F\/cit10\/1","doi-asserted-by":"crossref","first-page":"104240","DOI":"10.1016\/j.bioorg.2020.104240","volume":"104","author":"Shafiei","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D5MD00122F\/cit11\/1","doi-asserted-by":"crossref","first-page":"104771","DOI":"10.1016\/j.bioorg.2021.104771","volume":"110","author":"Wang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5MD00122F\/cit12\/1","doi-asserted-by":"crossref","first-page":"104515","DOI":"10.1016\/j.bioorg.2020.104515","volume":"107","author":"Zhang","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5MD00122F\/cit13\/1","doi-asserted-by":"crossref","first-page":"106562","DOI":"10.1016\/j.bioorg.2023.106562","volume":"136","author":"Wani","year":"2023","journal-title":"Bioorg. Chem."},{"key":"D5MD00122F\/cit14\/1","doi-asserted-by":"crossref","first-page":"117543","DOI":"10.1016\/j.bmc.2023.117543","volume":"97","author":"Zhang","year":"2024","journal-title":"Bioorg. Med. Chem."},{"issue":"13","key":"D5MD00122F\/cit15\/1","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1002\/slct.201904832","volume":"5","author":"Faheem","year":"2020","journal-title":"ChemistrySelect"},{"key":"D5MD00122F\/cit16\/1","doi-asserted-by":"crossref","first-page":"213930","DOI":"10.1016\/j.ccr.2021.213930","volume":"439","author":"Hern\u00e1ndez-Romero","year":"2021","journal-title":"Coord. Chem. Rev."},{"issue":"31","key":"D5MD00122F\/cit17\/1","doi-asserted-by":"crossref","first-page":"28733","DOI":"10.1021\/acsomega.3c03530","volume":"8","author":"Phan","year":"2023","journal-title":"ACS Omega"},{"key":"D5MD00122F\/cit18\/1","doi-asserted-by":"crossref","first-page":"129881","DOI":"10.1016\/j.bmcl.2024.129881","volume":"110","author":"Arya","year":"2024","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"48","key":"D5MD00122F\/cit19\/1","doi-asserted-by":"crossref","first-page":"e202301194","DOI":"10.1002\/chem.202301194","volume":"29","author":"Herrmann","year":"2023","journal-title":"Chem. \u2013 Eur. J."},{"key":"D5MD00122F\/cit20\/1","doi-asserted-by":"crossref","first-page":"133822","DOI":"10.1016\/j.molstruc.2022.133822","volume":"1269","author":"Veena","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"3","key":"D5MD00122F\/cit21\/1","first-page":"390","volume":"16","author":"V\u00e1zquez-Jim\u00e9nez","year":"2023","journal-title":"J. Pharm."},{"issue":"1","key":"D5MD00122F\/cit22\/1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41598-022-27351-z","volume":"13","author":"Escala","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"D5MD00122F\/cit23\/1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.2174\/1389557522666220104150051","volume":"22","author":"Hern\u00e1ndez-L\u00f3pez","year":"2022","journal-title":"Mini-Rev. Med. Chem."},{"issue":"2","key":"D5MD00122F\/cit24\/1","first-page":"31","volume":"3","author":"Muhsin","year":"2012","journal-title":"UTJ Sci."},{"key":"D5MD00122F\/cit25\/1","doi-asserted-by":"crossref","first-page":"115146","DOI":"10.1016\/j.ejmech.2023.115146","volume":"249","author":"Ghobadi","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00122F\/cit26\/1","doi-asserted-by":"crossref","first-page":"132095","DOI":"10.1016\/j.molstruc.2021.132095","volume":"1252","author":"\u00c7evik","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D5MD00122F\/cit27\/1","doi-asserted-by":"crossref","first-page":"128234","DOI":"10.1016\/j.molstruc.2020.128234","volume":"1215","author":"Lal","year":"2020","journal-title":"J. Mol. Struct."},{"issue":"1","key":"D5MD00122F\/cit28\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/2211352512666141021002621","volume":"13","author":"Yadav","year":"2015","journal-title":"Anti-Infect. Agents"},{"issue":"8","key":"D5MD00122F\/cit29\/1","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1007\/s00044-012-0369-3","volume":"22","author":"Parikh","year":"2013","journal-title":"Med. Chem. Res."},{"issue":"6","key":"D5MD00122F\/cit30\/1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/antibiotics10060728","volume":"10","author":"Arag\u00f3n-Muriel","year":"2021","journal-title":"J. Antibiot."},{"key":"D5MD00122F\/cit31\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ejmech.2017.05.064","volume":"137","author":"El-Gohary","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"11","key":"D5MD00122F\/cit32\/1","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.3390\/pharmaceutics14112334","volume":"14","author":"Xie","year":"2022","journal-title":"Pharmaceutics"},{"issue":"15","key":"D5MD00122F\/cit33\/1","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1039\/C7OB00036G","volume":"15","author":"Cumine","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"D5MD00122F\/cit34\/1","doi-asserted-by":"crossref","first-page":"104909","DOI":"10.1016\/j.bioorg.2021.104909","volume":"111","author":"Salem","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5MD00122F\/cit35\/1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejmech.2013.08.040","volume":"69","author":"Abdel-Aziz","year":"2013","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"D5MD00122F\/cit36\/1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1080\/14756366.2018.1461855","volume":"33","author":"El-Messery","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"6","key":"D5MD00122F\/cit37\/1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/j.ejmech.2011.02.033","volume":"46","author":"Ma","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00122F\/cit38\/1","doi-asserted-by":"crossref","first-page":"104841","DOI":"10.1016\/j.bioorg.2021.104841","volume":"111","author":"Amin","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"5","key":"D5MD00122F\/cit39\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.drudis.2019.03.015","volume":"24","author":"Ferreira","year":"2019","journal-title":"Drug Discovery Today"},{"issue":"1","key":"D5MD00122F\/cit40\/1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.drudis.2019.10.014","volume":"25","author":"Jia","year":"2020","journal-title":"Drug Discovery Today"},{"issue":"1","key":"D5MD00122F\/cit41\/1","first-page":"e202100542","volume":"17","author":"Pantale\u00e3o","year":"2022","journal-title":"ChemistrySelect"},{"issue":"5","key":"D5MD00122F\/cit42\/1","doi-asserted-by":"crossref","first-page":"2300626","DOI":"10.1002\/ardp.202300626","volume":"357","author":"Mansour","year":"2024","journal-title":"Arch. Pharm."},{"issue":"56","key":"D5MD00122F\/cit43\/1","doi-asserted-by":"crossref","first-page":"34033","DOI":"10.1039\/D0RA06424F","volume":"10","author":"Mansour","year":"2020","journal-title":"RSC Adv."},{"issue":"3","key":"D5MD00122F\/cit44\/1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/molecules25030487","volume":"25","author":"Janicka","year":"2020","journal-title":"Molecules"},{"key":"D5MD00122F\/cit45\/1","doi-asserted-by":"crossref","first-page":"105687","DOI":"10.1016\/j.bioorg.2022.105687","volume":"121","author":"Mohamed","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"2","key":"D5MD00122F\/cit46\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3390\/molecules27020515","volume":"27","author":"Zuo","year":"2022","journal-title":"Molecules"},{"issue":"20","key":"D5MD00122F\/cit47\/1","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.3390\/molecules27206899","volume":"27","author":"Nazreen","year":"2022","journal-title":"Molecules"},{"key":"D5MD00122F\/cit48\/1","doi-asserted-by":"crossref","first-page":"103956","DOI":"10.1016\/j.bioorg.2020.103956","volume":"101","author":"Morcoss","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D5MD00122F\/cit49\/1","doi-asserted-by":"crossref","first-page":"103411","DOI":"10.1016\/j.bioorg.2019.103411","volume":"94","author":"Abd El-Aleam","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"17","key":"D5MD00122F\/cit50\/1","doi-asserted-by":"crossref","first-page":"10361","DOI":"10.1039\/C9RA11021F","volume":"10","author":"Hamed","year":"2020","journal-title":"RSC Adv."},{"issue":"1","key":"D5MD00122F\/cit51\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/microorganisms11010143","volume":"11","author":"Mechmechani","year":"2023","journal-title":"Microorganisms"},{"issue":"16","key":"D5MD00122F\/cit52\/1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1002\/jcc.20289","volume":"26","author":"Phillips","year":"2005","journal-title":"J. Comput. Chem."},{"issue":"3","key":"D5MD00122F\/cit53\/1","doi-asserted-by":"crossref","first-page":"673a","DOI":"10.1016\/j.bpj.2017.11.3632","volume":"114","author":"Ribeiro","year":"2018","journal-title":"Biophys. J."},{"issue":"1","key":"D5MD00122F\/cit54\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D5MD00122F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:08:01Z","timestamp":1782968881000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/7\/3291-3311\/896666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00122f","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5MD00122F\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00122F\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00122F\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00122F\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00122F\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00122F\/v2\/review1","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}