{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:59:16Z","timestamp":1782943156051,"version":"3.54.5"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"am","delay-in-days":568,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>Design, synthesis and biological evaluation of bis(indolyl)-tetrazine derivatives.<\/jats:p>","DOI":"10.1039\/d5md00297d","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T10:21:18Z","timestamp":1753266078000},"page":"4878-4891","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Design, synthesis and biological evaluation of novel bis(indolyl)-tetrazine derivatives as anti-breast cancer agents"],"prefix":"10.1039","volume":"16","author":[{"given":"Kamalpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Ghudda, Bathinda, Pb, India-151401"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harkomal","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Zoology, Central University of Punjab, Ghudda, Bathinda, Pb, India-151401"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar","family":"Gangwar","sequence":"additional","affiliation":[{"name":"Department of Zoology, Central University of Punjab, Ghudda, Bathinda, Pb, India-151401"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monisha","family":"Dhiman","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Central University of Punjab, Ghudda, Bathinda, Pb, India-151401"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2811-5251","authenticated-orcid":false,"given":"Vikas","family":"Jaitak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Ghudda, Bathinda, Pb, India-151401"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5MD00297D\/cit1\/1","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1002\/cncr.34391","volume":"128","author":"Moubadder","year":"2022","journal-title":"Cancer"},{"key":"D5MD00297D\/cit2\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s12885-021-08217-5","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Cancer"},{"key":"D5MD00297D\/cit3\/1","doi-asserted-by":"crossref","first-page":"e36905","DOI":"10.1097\/MD.0000000000036905","volume":"103","author":"Obeagu","year":"2024","journal-title":"Medicine"},{"key":"D5MD00297D\/cit4\/1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/molecules22071106","volume":"22","author":"Jab\u0142o\u0144ska-Trypu\u0107","year":"2017","journal-title":"Molecules"},{"key":"D5MD00297D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.cell.2023.01.040","volume":"186","author":"Nolan","year":"2023","journal-title":"Cell"},{"key":"D5MD00297D\/cit6\/1","doi-asserted-by":"crossref","first-page":"47250","DOI":"10.18632\/oncotarget.16872","volume":"8","author":"Fan","year":"2017","journal-title":"Oncotarget"},{"key":"D5MD00297D\/cit7\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/his.14786","volume":"82","author":"Rakha","year":"2023","journal-title":"Histopathology"},{"key":"D5MD00297D\/cit8\/1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12282-016-0732-1","volume":"24","author":"Maruthanila","year":"2017","journal-title":"Breast Cancer"},{"key":"D5MD00297D\/cit9\/1","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1021\/acs.chemrestox.7b00237","volume":"30","author":"Dunlap","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"D5MD00297D\/cit10\/1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ejmech.2017.05.041","volume":"137","author":"Adhikari","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00297D\/cit11\/1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.3390\/molecules22091440","volume":"22","author":"Kelly","year":"2017","journal-title":"Molecules"},{"key":"D5MD00297D\/cit12\/1","doi-asserted-by":"crossref","first-page":"128383","DOI":"10.1016\/j.bmcl.2021.128383","volume":"52","author":"Price","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD00297D\/cit13\/1","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1016\/j.bmc.2016.06.050","volume":"24","author":"Kelly","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"D5MD00297D\/cit14\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejmech.2018.01.051","volume":"146","author":"Singla","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00297D\/cit15\/1","volume-title":"A Phase Ib\/II Study of Palbociclib in Combination with Bazedoxifene in Hormone Receptor Positive Breast Cancer","author":"Jeselsohn","year":"2017","unstructured":"R.Jeselsohn ,  A Phase Ib\/II Study of Palbociclib in Combination with Bazedoxifene in Hormone Receptor Positive Breast Cancer ,  Dana Farber Cancer Institute ,  2017 ,  http:\/\/ClinicalTrials.gov"},{"key":"D5MD00297D\/cit16\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/1574884711308020006","volume":"8","author":"Maximov","year":"2013","journal-title":"Curr. Clin. Pharmacol."},{"key":"D5MD00297D\/cit17\/1","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.3390\/molecules25081909","volume":"25","author":"Kerru","year":"2020","journal-title":"Molecules"},{"key":"D5MD00297D\/cit18\/1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/1573409913666170406144642","volume":"13","author":"Singla","year":"2017","journal-title":"Curr. Comput.-Aided Drug Des."},{"key":"D5MD00297D\/cit19\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mencom.2015.03.001","volume":"25","author":"Ananikov","year":"2015","journal-title":"Mendeleev Commun."},{"key":"D5MD00297D\/cit20\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ejmech.2016.08.039","volume":"124","author":"Mishra","year":"2016","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"D5MD00297D\/cit21\/1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2174\/1871520619666190312125602","volume":"19","author":"Kaur","year":"2019","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"D5MD00297D\/cit22\/1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.2174\/1871520621999210104192644","volume":"21","author":"Devi","year":"2021","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"D5MD00297D\/cit23\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejmech.2018.02.065","volume":"150","author":"Dadashpour","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00297D\/cit24\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s41061-022-00385-7","volume":"380","author":"Mondal","year":"2022","journal-title":"Top. Curr. Chem."},{"key":"D5MD00297D\/cit25\/1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/1087057113502673","volume":"19","author":"Wang","year":"2014","journal-title":"J. Biomol. Screening"},{"key":"D5MD00297D\/cit26\/1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1039\/D3MD00730H","volume":"15","author":"Kaur","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D5MD00297D\/cit27\/1","doi-asserted-by":"crossref","first-page":"107341","DOI":"10.1016\/j.bioorg.2024.107341","volume":"147","author":"Kaur","year":"2024","journal-title":"Bioorg. Chem."},{"key":"D5MD00297D\/cit28\/1","first-page":"S86","author":"Ashok","year":"2002","journal-title":"Eur. J. Cancer Prev."},{"key":"D5MD00297D\/cit29\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jnutbio.2005.10.012","volume":"17","author":"Wang","year":"2006","journal-title":"J. Nutr. Biochem."},{"key":"D5MD00297D\/cit30\/1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cbi.2010.05.015","volume":"186","author":"Nguyen","year":"2010","journal-title":"Chem.-Biol. Interact."},{"key":"D5MD00297D\/cit31\/1","first-page":"3166","volume":"7","author":"Greenberger","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"D5MD00297D\/cit32\/1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2147\/TCRM.S3476","volume":"4","author":"Gennari","year":"2008","journal-title":"Ther. Clin. Risk Manage."},{"key":"D5MD00297D\/cit33\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.canlet.2019.01.026","volume":"448","author":"Fu","year":"2019","journal-title":"Cancer Lett."},{"key":"D5MD00297D\/cit34\/1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/bab.2150","volume":"69","author":"Zafar","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"D5MD00297D\/cit35\/1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0968-0896(00)00337-0","volume":"9","author":"Jiang","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"D5MD00297D\/cit36\/1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0968-0896(99)00290-4","volume":"8","author":"Jiang","year":"2000","journal-title":"Bioorg. Med. Chem."},{"key":"D5MD00297D\/cit37\/1","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.1016\/j.bmcl.2007.09.042","volume":"17","author":"Diana","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD00297D\/cit38\/1","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1016\/j.bmcl.2007.01.065","volume":"17","author":"Diana","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD00297D\/cit39\/1","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1016\/j.bmc.2010.04.061","volume":"18","author":"Diana","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"D5MD00297D\/cit40\/1","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1016\/j.bmcl.2011.07.089","volume":"21","author":"Kumar","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD00297D\/cit41\/1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/cmdc.201200363","volume":"7","author":"Kumar","year":"2012","journal-title":"ChemMedChem"},{"key":"D5MD00297D\/cit42\/1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0968-0896(01)00070-0","volume":"9","author":"Xiong","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"D5MD00297D\/cit43\/1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/cmdc.201200109","volume":"7","author":"Rao","year":"2012","journal-title":"ChemMedChem"},{"key":"D5MD00297D\/cit44\/1","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1016\/j.bmcl.2013.09.036","volume":"23","author":"Rao","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD00297D\/cit45\/1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bmcl.2003.12.056","volume":"14","author":"Hu","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD00297D\/cit46\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1177\/1747519819861865","volume":"43","author":"Shi","year":"2019","journal-title":"J. Chem. Res."},{"key":"D5MD00297D\/cit47\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jconrel.2021.07.003","volume":"336","author":"Yasaswi","year":"2021","journal-title":"J. Controlled Release"},{"key":"D5MD00297D\/cit48\/1","first-page":"152","volume":"48B","author":"Upadhyay","year":"2009","journal-title":"Indian J. Chem."},{"key":"D5MD00297D\/cit49\/1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0040-4039(00)02195-X","volume":"42","author":"Talukdar","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"D5MD00297D\/cit50\/1","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cclet.2009.06.020","volume":"20","author":"Rostamizadeh","year":"2009","journal-title":"Chin. Chem. Lett."},{"key":"D5MD00297D\/cit51\/1","doi-asserted-by":"crossref","first-page":"7945","DOI":"10.1021\/jo010635w","volume":"66","author":"Demko","year":"2001","journal-title":"J. Org. Chem."},{"key":"D5MD00297D\/cit52\/1","doi-asserted-by":"crossref","first-page":"12210","DOI":"10.1021\/ja0206644","volume":"124","author":"Himo","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5MD00297D\/cit53\/1","doi-asserted-by":"crossref","first-page":"105853","DOI":"10.1016\/j.jaap.2022.105853","volume":"169","author":"Zhang","year":"2023","journal-title":"J. Anal. Appl. Pyrolysis"},{"key":"D5MD00297D\/cit54\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-319-29686-9_5","volume-title":"Cycloadditions in Bioorthogonal Chemistry","author":"Herner","year":"2016","unstructured":"A.Herner  and  Q.Lin ,  Cycloadditions in Bioorthogonal Chemistry ,  2016 ,  pp. 77\u2013107"},{"key":"D5MD00297D\/cit55\/1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s43630-022-00173-8","volume":"21","author":"Pirota","year":"2022","journal-title":"Photochem. Photobiol. Sci."},{"key":"D5MD00297D\/cit56\/1","doi-asserted-by":"crossref","first-page":"113733","DOI":"10.1016\/j.ejmech.2021.113733","volume":"224","author":"Caciolla","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00297D\/cit57\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2017.12.012","volume":"186","author":"Patel","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"D5MD00297D\/cit58\/1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.0308319100","volume":"101","author":"Str\u00f6m","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5MD00297D\/cit59\/1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3892\/etm.2011.226","volume":"2","author":"Al-Bader","year":"2011","journal-title":"Exp. Ther. Med."},{"key":"D5MD00297D\/cit60\/1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s00216-012-5933-7","volume":"403","author":"Li","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"D5MD00297D\/cit61\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bioorg.2017.02.011","volume":"71","author":"Begam","year":"2017","journal-title":"Bioorg. Chem."},{"key":"D5MD00297D\/cit62\/1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1677\/ERC-09-0086","volume":"16","author":"Welboren","year":"2009","journal-title":"Endocr.-Relat. Cancer"},{"key":"D5MD00297D\/cit63\/1","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1021\/jm5006463","volume":"57","author":"Anighoro","year":"2014","journal-title":"J. Med. Chem."},{"key":"D5MD00297D\/cit64\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10555-016-9637-x","volume":"35","author":"Guerrero-Zotano","year":"2016","journal-title":"Cancer Metastasis Rev."},{"key":"D5MD00297D\/cit65\/1","doi-asserted-by":"crossref","first-page":"e28449","DOI":"10.1371\/journal.pone.0028449","volume":"7","author":"Dhiman","year":"2012","journal-title":"PLoS One"},{"key":"D5MD00297D\/cit66\/1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/jnr.23018","volume":"90","author":"Mantha","year":"2012","journal-title":"J. Neurosci. Res."},{"key":"D5MD00297D\/cit67\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-59745-198-7_4","volume-title":"The protein protocols handbook","author":"Kruger","year":"2009","unstructured":"N. J.Kruger ,  The protein protocols handbook ,  2009 ,  pp. 17\u201324"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D5MD00297D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:28:13Z","timestamp":1782941293000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/10\/4878-4891\/896707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":67,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00297d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5MD00297D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00297D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00297D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00297D\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00297D\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}