{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:07:34Z","timestamp":1787004454284,"version":"build-2736575974"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"am","delay-in-days":212,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ID 2021-13896"],"award-info":[{"award-number":["ID 2021-13896"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","award":["CDRF-II C2\/24\/283"],"award-info":[{"award-number":["CDRF-II C2\/24\/283"]}],"id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","award":["OPERA fellowship (ID -1022)"],"award-info":[{"award-number":["OPERA fellowship (ID -1022)"]}],"id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","award":["SPARKLE\/23\/H30"],"award-info":[{"award-number":["SPARKLE\/23\/H30"]}],"id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["191620023107"],"award-info":[{"award-number":["191620023107"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>Identification and characterization of a novel mitochondrial fusion agonist beneficial against Huntington's disease (HD) pathology.<\/jats:p>","DOI":"10.1039\/d5md00345h","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:40:46Z","timestamp":1754034046000},"page":"705-722","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel small molecule derivatives improve survivability in the cellular model of Huntington's disease\n                    <i>via<\/i>\n                    improving mitochondrial fusion"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4372-9304","authenticated-orcid":false,"given":"Pradeep","family":"Kodam","sequence":"first","affiliation":[{"name":"Department of Biological Science, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-3623","authenticated-orcid":false,"given":"Vaishali","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7939-5241","authenticated-orcid":false,"given":"Paramita","family":"Pattanayak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praharsh","family":"Vitta","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6342-0166","authenticated-orcid":false,"given":"Tanmay","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-4744","authenticated-orcid":false,"given":"Shuvadeep","family":"Maity","sequence":"additional","affiliation":[{"name":"Department of Biological Science, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District, Telangana 500078, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"10","key":"D5MD00345H\/cit1\/1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.embor.7400250","volume":"5","author":"Landles","year":"2004","journal-title":"EMBO Rep."},{"issue":"1","key":"D5MD00345H\/cit2\/1","first-page":"16","volume":"59","author":"Rubinsztein","year":"1996","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"D5MD00345H\/cit3\/1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.parkreldis.2014.03.017","volume":"20","author":"Koutsis","year":"2014","journal-title":"Parkinsonism Relat. Disord."},{"key":"D5MD00345H\/cit4\/1","doi-asserted-by":"crossref","first-page":"11795735221092516","DOI":"10.1177\/11795735221092517","volume":"14","author":"Ferguson","year":"2022","journal-title":"J. Cent. Nerv. Syst. Dis."},{"issue":"15","key":"D5MD00345H\/cit5\/1","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1073\/pnas.85.15.5733","volume":"85","author":"Reiner","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"D5MD00345H\/cit6\/1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.tcb.2007.08.006","volume":"17","author":"Cerveny","year":"2007","journal-title":"Trends Cell Biol."},{"issue":"1","key":"D5MD00345H\/cit7\/1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-genet-110410-132529","volume":"46","author":"Chan","year":"2012","journal-title":"Annu. Rev. Genet."},{"issue":"4","key":"D5MD00345H\/cit8\/1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1083\/jcb.201511036","volume":"212","author":"Mishra","year":"2016","journal-title":"J. Cell Biol."},{"issue":"4","key":"D5MD00345H\/cit9\/1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/hmg\/ddn404","volume":"18","author":"Wang","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"D5MD00345H\/cit10\/1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"issue":"2","key":"D5MD00345H\/cit11\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"D5MD00345H\/cit12\/1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2012.10.050","volume":"151","author":"Ruas","year":"2012","journal-title":"Cell"},{"key":"D5MD00345H\/cit13\/1","doi-asserted-by":"crossref","first-page":"104741","DOI":"10.1016\/j.nbd.2020.104741","volume":"136","author":"Cherubini","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"44","key":"D5MD00345H\/cit14\/1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121273119","volume":"119","author":"Au","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"D5MD00345H\/cit15\/1","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.3390\/ijms23031538","volume":"23","author":"Malla","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"D5MD00345H\/cit16\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110132","volume":"27","author":"Mirzapoiazova","year":"2024","journal-title":"iScience"},{"issue":"4","key":"D5MD00345H\/cit17\/1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41589-022-01224-y","volume":"19","author":"Guo","year":"2023","journal-title":"Nat. Chem. Biol."},{"issue":"9","key":"D5MD00345H\/cit18\/1","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1021\/acs.joc.2c03053","volume":"88","author":"Pattanayak","year":"2023","journal-title":"J. Org. Chem."},{"issue":"1","key":"D5MD00345H\/cit19\/1","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"D5MD00345H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"issue":"7652","key":"D5MD00345H\/cit21\/1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature22078","volume":"545","author":"Ashkenazi","year":"2017","journal-title":"Nature"},{"key":"D5MD00345H\/cit22\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-6606-3-17","volume":"3","author":"Pardo","year":"2010","journal-title":"Mol. Brain"},{"key":"D5MD00345H\/cit23\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1208\/s12248-013-9554-7","volume":"16","author":"Volpe","year":"2014","journal-title":"AAPS J."},{"issue":"3","key":"D5MD00345H\/cit24\/1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.acthis.2017.03.001","volume":"119","author":"Valente","year":"2017","journal-title":"Acta Histochem."},{"issue":"10","key":"D5MD00345H\/cit25\/1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12563","volume":"3","author":"Silvennoinen","year":"2015","journal-title":"Physiol. Rep."},{"issue":"4","key":"D5MD00345H\/cit26\/1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"18","key":"D5MD00345H\/cit27\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38127","volume":"10","author":"Jerom","year":"2024","journal-title":"Heliyon"},{"key":"D5MD00345H\/cit28\/1","doi-asserted-by":"crossref","first-page":"107473","DOI":"10.1016\/j.bpc.2025.107473","volume":"325","author":"Yoo","year":"2025","journal-title":"Biophys. Chem."},{"key":"D5MD00345H\/cit29\/1","first-page":"65","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"issue":"4","key":"D5MD00345H\/cit30\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today: Technol."},{"issue":"6","key":"D5MD00345H\/cit31\/1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/10426507.2013.855763","volume":"189","author":"Ben","year":"2014","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"issue":"12","key":"D5MD00345H\/cit32\/1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/emmm.201000102","volume":"2","author":"Costa","year":"2010","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"D5MD00345H\/cit33\/1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.7150\/thno.40060","volume":"10","author":"Dong","year":"2020","journal-title":"Theranostics"},{"issue":"14","key":"D5MD00345H\/cit34\/1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/hmg\/ddh162","volume":"13","author":"Choo","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"D5MD00345H\/cit35\/1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nn884","volume":"5","author":"Panov","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"1","key":"D5MD00345H\/cit36\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"issue":"1","key":"D5MD00345H\/cit37\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1750-3639.1999.tb00216.x","volume":"9","author":"Browne","year":"1999","journal-title":"Brain Pathol."},{"issue":"1","key":"D5MD00345H\/cit38\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1196\/annals.1427.008","volume":"1147","author":"Stack","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"D5MD00345H\/cit39\/1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.freeradbiomed.2008.05.014","volume":"45","author":"Sorolla","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"D5MD00345H\/cit40\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1385\/NMM:1:3:183","volume":"1","author":"Kiechle","year":"2002","journal-title":"NeuroMol. Med."},{"issue":"25","key":"D5MD00345H\/cit41\/1","doi-asserted-by":"crossref","first-page":"10190","DOI":"10.1073\/pnas.1107402108","volume":"108","author":"Rambold","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"D5MD00345H\/cit42\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4161\/auto.7.3.14502","volume":"7","author":"Wang","year":"2011","journal-title":"Autophagy"},{"issue":"1","key":"D5MD00345H\/cit43\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41420-024-01953-0","volume":"10","author":"You","year":"2024","journal-title":"Cell Death Discovery"},{"key":"D5MD00345H\/cit44\/1","doi-asserted-by":"crossref","first-page":"871357","DOI":"10.3389\/fcell.2022.871357","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"D5MD00345H\/cit45\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"issue":"1","key":"D5MD00345H\/cit46\/1","first-page":"1","volume":"16","author":"Niwata","year":"2025","journal-title":"Discover Oncol."},{"issue":"8","key":"D5MD00345H\/cit47\/1","doi-asserted-by":"crossref","first-page":"e71555","DOI":"10.1371\/journal.pone.0071555","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"D5MD00345H\/cit48\/1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1471-4159.2006.03998.x","volume":"98","author":"Mormone","year":"2006","journal-title":"J. Neurochem."},{"issue":"8","key":"D5MD00345H\/cit49\/1","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1038\/emboj.2012.65","volume":"31","author":"Costa","year":"2012","journal-title":"EMBO J."},{"key":"D5MD00345H\/cit50\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-016-0262-3","volume":"23","author":"Chuang","year":"2016","journal-title":"J. Biomed. Sci."},{"issue":"12","key":"D5MD00345H\/cit51\/1","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"3","key":"D5MD00345H\/cit52\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.chembiol.2017.12.001","volume":"25","author":"Miret-Casals","year":"2018","journal-title":"Cell Chem. Biol."},{"issue":"18","key":"D5MD00345H\/cit53\/1","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1093\/hmg\/ddp281","volume":"18","author":"Malena","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"26","key":"D5MD00345H\/cit54\/1","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1242\/jcs.01565","volume":"117","author":"Ishihara","year":"2004","journal-title":"J. Cell Sci."},{"key":"D5MD00345H\/cit55\/1","first-page":"483","volume":"318","author":"Yap","year":"2020","journal-title":"Am. J. Physiol."},{"key":"D5MD00345H\/cit56\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-6-32","volume":"6","author":"Taherzadeh-Fard","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"D5MD00345H\/cit57\/1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/1873-3468.12989","volume":"592","author":"Kang","year":"2018","journal-title":"FEBS Lett."},{"issue":"4","key":"D5MD00345H\/cit58\/1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"D5MD00345H\/cit59\/1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.18632\/aging.100790","volume":"7","author":"Dabrowska","year":"2015","journal-title":"Aging"}],"updated-by":[{"DOI":"10.1039\/d5md90052b","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000}}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D5MD00345H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:05:58Z","timestamp":1782968758000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/17\/1\/705-722\/1247807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00345h","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5MD00345H\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00345H\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00345H\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00345H\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00345H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00345H\/v2\/review1","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}