{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:42:09Z","timestamp":1788410529429,"version":"build-2803163510"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T00:00:00Z","timestamp":1758153600000},"content-version":"vor","delay-in-days":260,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100006785","name":"Google","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202008520048"],"award-info":[{"award-number":["202008520048"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["015.013.033"],"award-info":[{"award-number":["015.013.033"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005797","name":"Vereniging Trustfonds Erasmus Universiteit Rotterdam","doi-asserted-by":"publisher","award":["97030.2022.101.718"],"award-info":[{"award-number":["97030.2022.101.718"]}],"id":[{"id":"10.13039\/501100005797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    From 185 fenarimol analogues evaluated against\n                    <jats:italic>M. mycetomatis<\/jats:italic>\n                    , 22 were found to be potent\n                    <jats:italic>in vitro<\/jats:italic>\n                    , with 5 showing promise in an\n                    <jats:italic>in vivo<\/jats:italic>\n                    model; low predicted log\u2009\n                    <jats:italic>D<\/jats:italic>\n                    (&lt;2.5) correlated with better\n                    <jats:italic>in vivo<\/jats:italic>\n                    efficacy, providing insights for future design.\n                  <\/jats:p>","DOI":"10.1039\/d5md00427f","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T06:20:49Z","timestamp":1758176449000},"page":"6094-6108","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structure\u2013activity relationships of fenarimol analogues with potent\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    activity against\n                    <i>Madurella mycetomatis<\/i>\n                    , the main causative agent of mycetoma"],"prefix":"10.1039","volume":"16","author":[{"given":"Hung Phat","family":"Duong","sequence":"first","affiliation":[{"name":"School of Chemistry, Faculty of Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitrij","family":"Melechov","sequence":"additional","affiliation":[{"name":"UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"},{"name":"Structural Genomics Consortium, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7883-3825","authenticated-orcid":false,"given":"Wilson","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-2239","authenticated-orcid":false,"given":"Jingyi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kymberley R.","family":"Scroggie","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxsika","family":"Rajendra","sequence":"additional","affiliation":[{"name":"UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Perry","sequence":"additional","affiliation":[{"name":"The Drugs for Neglected Diseases Initiative, 15 Chemin Camille-Vidart, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza R.","family":"Cruz","sequence":"additional","affiliation":[{"name":"The Drugs for Neglected Diseases Initiative, 15 Chemin Camille-Vidart, 1202 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-4471","authenticated-orcid":false,"given":"Rahman Shah Zaib","family":"Saleem","sequence":"additional","affiliation":[{"name":"UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"},{"name":"Structural Genomics Consortium, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"},{"name":"Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, 54792, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0767-5196","authenticated-orcid":false,"given":"Peter J.","family":"Rutledge","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-7888","authenticated-orcid":false,"given":"Alice","family":"Motion","sequence":"additional","affiliation":[{"name":"School of Chemistry, Faculty of Science, The University of Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8652-8783","authenticated-orcid":false,"given":"Wendy W. J.","family":"van de Sande","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-4751","authenticated-orcid":false,"given":"Matthew H.","family":"Todd","sequence":"additional","affiliation":[{"name":"UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"},{"name":"Structural Genomics Consortium, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"4","key":"D5MD00427F\/cit1\/1","doi-asserted-by":"publisher","first-page":"e0006437","DOI":"10.1371\/journal.pntd.0006437","volume":"12","author":"Lim","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"D5MD00427F\/cit2\/1","doi-asserted-by":"publisher","first-page":"e0003423","DOI":"10.1128\/cmr.00034-23","author":"van de Sande","year":"2024","journal-title":"Clin. Microbiol. Rev."},{"issue":"4","key":"D5MD00427F\/cit3\/1","doi-asserted-by":"publisher","first-page":"e0008190","DOI":"10.1371\/journal.pntd.0008190","volume":"14","author":"Sheehan","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"4","key":"D5MD00427F\/cit4\/1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1093\/trstmh\/traa184","volume":"115","author":"van de Sande","year":"2021","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"3","key":"D5MD00427F\/cit5\/1","doi-asserted-by":"publisher","first-page":"e57774","DOI":"10.1371\/journal.pone.0057774","volume":"8","author":"Ibrahim","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"D5MD00427F\/cit6\/1","doi-asserted-by":"publisher","first-page":"e3218","DOI":"10.1371\/journal.pntd.0003218","volume":"8","author":"Welsh","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"6","key":"D5MD00427F\/cit7\/1","doi-asserted-by":"publisher","first-page":"e0004690","DOI":"10.1371\/journal.pntd.0004690","volume":"10","author":"Suleiman","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"11","key":"D5MD00427F\/cit8\/1","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.trstmh.2012.07.003","volume":"106","author":"Zein","year":"2012","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"10","key":"D5MD00427F\/cit9\/1","doi-asserted-by":"publisher","first-page":"e0005007","DOI":"10.1371\/journal.pntd.0005007","volume":"10","author":"Wadal","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"10","key":"D5MD00427F\/cit10\/1","doi-asserted-by":"publisher","first-page":"e3232","DOI":"10.1371\/journal.pntd.0003232","volume":"8","author":"Crabol","year":"2014","journal-title":"PLoS Neglected Trop. Dis."},{"key":"D5MD00427F\/cit11\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/17460441.2022.2080195","author":"Lim","year":"2022","journal-title":"Expert Opin. Drug Discovery"},{"issue":"2","key":"D5MD00427F\/cit12\/1","doi-asserted-by":"publisher","first-page":"e0010159","DOI":"10.1371\/journal.pntd.0010159","volume":"16","author":"Lim","year":"2022","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"24","key":"D5MD00427F\/cit13\/1","doi-asserted-by":"publisher","first-page":"10158","DOI":"10.1021\/jm401610c","volume":"56","author":"Keenan","year":"2013","journal-title":"J. Med. Chem."},{"issue":"9","key":"D5MD00427F\/cit14\/1","doi-asserted-by":"publisher","first-page":"4189","DOI":"10.1021\/jm2015809","volume":"55","author":"Keenan","year":"2012","journal-title":"J. Med. Chem."},{"issue":"7","key":"D5MD00427F\/cit15\/1","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/j.bmc.2013.01.050","volume":"21","author":"Keenan","year":"2013","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"D5MD00427F\/cit16\/1","doi-asserted-by":"publisher","first-page":"17273","DOI":"10.3390\/ijms160817273","volume":"16","author":"Oh","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"D5MD00427F\/cit17\/1","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1016\/S0031-9422(00)97862-2","volume":"28","author":"Burden","year":"1989","journal-title":"Phytochemistry"},{"issue":"21","key":"D5MD00427F\/cit18\/1","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1002\/cmdc.201900565","volume":"14","author":"Todd","year":"2019","journal-title":"ChemMedChem"},{"issue":"7","key":"D5MD00427F\/cit19\/1","doi-asserted-by":"publisher","first-page":"e0003926","DOI":"10.1371\/journal.pntd.0003926","volume":"9","author":"Kloezen","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"4","key":"D5MD00427F\/cit20\/1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1093\/mmy\/myx064","volume":"56","author":"Kloezen","year":"2018","journal-title":"Med. Mycol."},{"issue":"6","key":"D5MD00427F\/cit21\/1","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1111\/bjd.14025","volume":"173","author":"van de Sande","year":"2015","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"D5MD00427F\/cit22\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1081\/dmr-120018245","volume":"35","author":"Lewis","year":"2003","journal-title":"Drug Metab. Rev."},{"issue":"5","key":"D5MD00427F\/cit23\/1","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3109\/14756360903514149","volume":"25","author":"Lewis","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5MD00427F\/cit24\/1","author":"MycetOS","year":"2024","unstructured":"MycetOS , What's Open Source Mycetoma (MycetOS)? github,  2024 ,  https:\/\/github.com\/OpenSourceMycetoma\/General-Start-Here , (accessed 2024 04-06-2024)"},{"issue":"10","key":"D5MD00427F\/cit25\/1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/S0022-2275(20)38245-6","volume":"30","author":"Fischer","year":"1989","journal-title":"J. Lipid Res."},{"issue":"21","key":"D5MD00427F\/cit26\/1","doi-asserted-by":"crossref","first-page":"13402","DOI":"10.1016\/S0021-9258(18)90709-X","volume":"259","author":"Trzaskos","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"1","key":"D5MD00427F\/cit27\/1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1056\/NEJM197401032900107","volume":"290","author":"Bennett","year":"1974","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"D5MD00427F\/cit28\/1","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1128\/CMR.12.2.310","volume":"12","author":"Latge","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"issue":"Suppl 1","key":"D5MD00427F\/cit29\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1470-9465.2004.00841.x","volume":"10","author":"Maertens","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"issue":"4","key":"D5MD00427F\/cit30\/1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. Infect. Dis."},{"issue":"18","key":"D5MD00427F\/cit31\/1","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.2165\/11596540-000000000-00000","volume":"71","author":"Lass-Florl","year":"2011","journal-title":"Drugs"},{"issue":"16","key":"D5MD00427F\/cit32\/1","doi-asserted-by":"publisher","first-page":"6728","DOI":"10.1074\/jbc.M117.778308","volume":"292","author":"Hargrove","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"44","key":"D5MD00427F\/cit33\/1","doi-asserted-by":"publisher","first-page":"31602","DOI":"10.1074\/jbc.M113.497990","volume":"288","author":"Hargrove","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"33","key":"D5MD00427F\/cit34\/1","doi-asserted-by":"publisher","first-page":"25582","DOI":"10.1074\/jbc.M110.133215","volume":"285","author":"Lepesheva","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"6","key":"D5MD00427F\/cit35\/1","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1073\/pnas.061562898","volume":"98","author":"Podust","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"D5MD00427F\/cit36\/1","doi-asserted-by":"publisher","first-page":"e31801","DOI":"10.1371\/journal.pone.0031801","volume":"7","author":"Snelders","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"D5MD00427F\/cit37\/1","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/myc.13509","volume":"65","author":"Nyuykonge","year":"2022","journal-title":"Mycoses"},{"key":"D5MD00427F\/cit38\/1","author":"MycetOS","year":"2024","unstructured":"MycetOS , Crystal structures of azole-bound CYP51 enzymes from various organisms (mammals, bacteria, fungi and protozoan) #68. github,  2024 ,  https:\/\/github.com\/OpenSourceMycetoma\/Series-1-Fenarimols\/issues\/68 , (accessed 2024 04-06-2024)"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D5MD00427F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:37:15Z","timestamp":1782927435000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/12\/6094-6108\/896754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00427f","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5MD00427F\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00427F\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00427F\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00427F\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00427F\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD00427F\/v2\/decision1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2025-kj5x1","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}