{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:17:56Z","timestamp":1782973076028,"version":"3.54.5"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"am","delay-in-days":640,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    An efficient and eco-friendly method was developed for the synthesis of hexahydroquinoline derivatives using biochar\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    @APTMS, and demonstrate the ability of these derivatives to inhibit the polyol pathway through aldose reductase inhibition.\n                  <\/jats:p>","DOI":"10.1039\/d5md00594a","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:43:46Z","timestamp":1759491826000},"page":"5702-5716","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactive assessment of hexahydroquinoline derivatives prepared\n                    <i>via<\/i>\n                    a biochar\/Fe\n                    <sub>3<\/sub>\n                    O\n                    <sub>4<\/sub>\n                    @APTMS magnetic catalyst: focus on antidiabetic and antibacterial properties"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7237-0356","authenticated-orcid":false,"given":"A.","family":"Thoume","sequence":"first","affiliation":[{"name":"Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Maarif, B.P. 2693, Casablanca 20000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Nait Irahal","sequence":"additional","affiliation":[{"name":"Laboratoire sant\u00e9, environnement et biotechnologie, Facult\u00e9 des Sciences Ain Chock, Universit\u00e9 Hassan II de Casablanca, B.P. 5366, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Dahib","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Maarif, B.P. 2693, Casablanca 20000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Chbel","sequence":"additional","affiliation":[{"name":"Laboratoire sant\u00e9, environnement et biotechnologie, Facult\u00e9 des Sciences Ain Chock, Universit\u00e9 Hassan II de Casablanca, B.P. 5366, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Loukhmi","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Maarif, B.P. 2693, Casablanca 20000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Abdou-Allah","sequence":"additional","affiliation":[{"name":"Laboratoire sant\u00e9, environnement et biotechnologie, Facult\u00e9 des Sciences Ain Chock, Universit\u00e9 Hassan II de Casablanca, B.P. 5366, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Achagar","sequence":"additional","affiliation":[{"name":"Team of Biotechnology Materials, and Environment, Faculty of Sciences, Ibn Zohr University, BP 8106, Agadir, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zertoubi","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Maarif, B.P. 2693, Casablanca 20000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8921-7016","authenticated-orcid":false,"given":"D.","family":"Benmessaoud Left","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Maarif, B.P. 2693, Casablanca 20000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bourhim","sequence":"additional","affiliation":[{"name":"Laboratoire sant\u00e9, environnement et biotechnologie, Facult\u00e9 des Sciences Ain Chock, Universit\u00e9 Hassan II de Casablanca, B.P. 5366, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Elmakssoudi","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry, Materials, Electrochemistry, and Environment, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Maarif, B.P. 2693, Casablanca 20000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5MD00594A\/cit1\/1","doi-asserted-by":"crossref","first-page":"126137","DOI":"10.1016\/j.jclepro.2021.126137","volume":"294","author":"Silvestri","year":"2021","journal-title":"J. Cleaner Prod."},{"key":"D5MD00594A\/cit2\/1","doi-asserted-by":"crossref","first-page":"13833","DOI":"10.1021\/acs.joc.1c00805","volume":"86","author":"Mart\u00ednez","year":"2021","journal-title":"J. Org. Chem."},{"key":"D5MD00594A\/cit3\/1","doi-asserted-by":"publisher","DOI":"10.3390\/catal10020246","author":"Palma","year":"2020","journal-title":"Catalysts"},{"key":"D5MD00594A\/cit4\/1","first-page":"114087","volume":"559","author":"Ali","year":"2024","journal-title":"Mol. Catal."},{"key":"D5MD00594A\/cit5\/1","doi-asserted-by":"crossref","first-page":"133964","DOI":"10.1016\/j.tet.2024.133964","volume":"157","author":"Martinho","year":"2024","journal-title":"Tetrahedron"},{"key":"D5MD00594A\/cit6\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41570-021-00340-y","volume":"6","author":"Vogt","year":"2022","journal-title":"Nat. Rev. Chem."},{"key":"D5MD00594A\/cit7\/1","doi-asserted-by":"crossref","first-page":"133408","DOI":"10.1016\/j.tet.2023.133408","volume":"138","author":"Roy","year":"2023","journal-title":"Tetrahedron"},{"key":"D5MD00594A\/cit8\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-50600-8","volume":"14","author":"Peiman","year":"2024","journal-title":"Sci. Rep."},{"key":"D5MD00594A\/cit9\/1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.jcis.2024.09.161","volume":"678","author":"Liang","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"D5MD00594A\/cit10\/1","doi-asserted-by":"publisher","DOI":"10.3390\/app12115487","author":"Achagar","year":"2022","journal-title":"Appl. Sci."},{"key":"D5MD00594A\/cit11\/1","doi-asserted-by":"crossref","first-page":"101276","DOI":"10.1016\/j.eti.2020.101276","volume":"21","author":"Gupta","year":"2021","journal-title":"Environ. Technol. Innovation"},{"key":"D5MD00594A\/cit12\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaap.2021.105405","author":"Xie","year":"2022","journal-title":"J. Anal. Appl. Pyrolysis"},{"key":"D5MD00594A\/cit13\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s43017-022-00306-8","volume":"3","author":"He","year":"2022","journal-title":"Nat. Rev. Earth Environ."},{"key":"D5MD00594A\/cit14\/1","doi-asserted-by":"crossref","first-page":"129027","DOI":"10.1016\/j.cej.2021.129027","volume":"416","author":"Zhou","year":"2021","journal-title":"Chem. Eng. J."},{"key":"D5MD00594A\/cit15\/1","doi-asserted-by":"crossref","first-page":"167681","DOI":"10.1016\/j.scitotenv.2023.167681","volume":"906","author":"Nie","year":"2024","journal-title":"Sci. Total Environ."},{"key":"D5MD00594A\/cit16\/1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.renene.2021.02.027","volume":"170","author":"Al-Mawali","year":"2021","journal-title":"Renewable Energy"},{"key":"D5MD00594A\/cit17\/1","doi-asserted-by":"crossref","first-page":"132537","DOI":"10.1016\/j.jhazmat.2023.132537","volume":"461","author":"Cao","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"D5MD00594A\/cit18\/1","doi-asserted-by":"crossref","first-page":"13061","DOI":"10.1039\/D1RA01588E","volume":"11","author":"Eisavi","year":"2021","journal-title":"RSC Adv."},{"key":"D5MD00594A\/cit19\/1","doi-asserted-by":"crossref","first-page":"121872","DOI":"10.1016\/j.jenvman.2024.121872","volume":"366","author":"Li","year":"2024","journal-title":"J. Environ. Manage."},{"key":"D5MD00594A\/cit20\/1","doi-asserted-by":"crossref","first-page":"134847","DOI":"10.1016\/j.scitotenv.2019.134847","volume":"711","author":"Li","year":"2020","journal-title":"Sci. Total Environ."},{"key":"D5MD00594A\/cit21\/1","doi-asserted-by":"crossref","first-page":"128841","DOI":"10.1016\/j.jhazmat.2022.128841","volume":"434","author":"Qu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"D5MD00594A\/cit22\/1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.biopha.2018.07.157","volume":"107","author":"Giri","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D5MD00594A\/cit23\/1","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.2337\/db06-0138","volume":"55","author":"Sun","year":"2006","journal-title":"Diabetes"},{"key":"D5MD00594A\/cit24\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/metabo11100655","volume":"11","author":"Singh","year":"2021","journal-title":"Metabolites"},{"key":"D5MD00594A\/cit25\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ame2.12001","volume":"1","author":"Yan","year":"2018","journal-title":"Anim. Models Exp. Med."},{"key":"D5MD00594A\/cit26\/1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/00397911.2013.813545","volume":"44","author":"Siddekha","year":"2014","journal-title":"Synth. Commun."},{"key":"D5MD00594A\/cit27\/1","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1007\/s11164-017-2986-4","volume":"43","author":"Moloi","year":"2017","journal-title":"Res. Chem. Intermed."},{"key":"D5MD00594A\/cit28\/1","doi-asserted-by":"crossref","first-page":"S329","DOI":"10.1016\/j.jscs.2014.04.001","volume":"21","author":"Patil","year":"2017","journal-title":"J. Saudi Chem. Soc."},{"key":"D5MD00594A\/cit29\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molliq.2012.10.045","volume":"178","author":"Zare","year":"2013","journal-title":"J. Mol. Liq."},{"key":"D5MD00594A\/cit30\/1","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.tetlet.2013.04.048","volume":"54","author":"Rostamnia","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"D5MD00594A\/cit31\/1","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1002\/slct.202100769","volume":"6","author":"Bera","year":"2021","journal-title":"ChemistrySelect"},{"key":"D5MD00594A\/cit32\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s42000-021-00347-6","volume":"21","author":"Irahal","year":"2022","journal-title":"Hormones"},{"key":"D5MD00594A\/cit33\/1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/0972060X.2022.2077141","volume":"25","author":"Chbel","year":"2022","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"D5MD00594A\/cit34\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/ffj.3657","volume":"36","author":"Nait Irahal","year":"2021","journal-title":"Flavour Fragrance J."},{"key":"D5MD00594A\/cit35\/1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/0972060X.2022.2091955","volume":"25","author":"Moukhfi","year":"2022","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"D5MD00594A\/cit36\/1","doi-asserted-by":"crossref","first-page":"125063","DOI":"10.1016\/j.cej.2020.125063","volume":"395","author":"Luo","year":"2020","journal-title":"Chem. Eng. J."},{"key":"D5MD00594A\/cit37\/1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cej.2019.03.235","volume":"370","author":"Ouyang","year":"2019","journal-title":"Chem. Eng. J."},{"key":"D5MD00594A\/cit38\/1","doi-asserted-by":"crossref","first-page":"123387","DOI":"10.1016\/j.seppur.2023.123387","volume":"312","author":"Manjuri Bhuyan","year":"2023","journal-title":"Sep. Purif. Technol."},{"key":"D5MD00594A\/cit39\/1","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.fuel.2018.02.149","volume":"224","author":"Miao","year":"2018","journal-title":"Fuel"},{"key":"D5MD00594A\/cit40\/1","doi-asserted-by":"crossref","first-page":"113020","DOI":"10.1016\/j.envres.2022.113020","volume":"211","author":"Foroutan","year":"2022","journal-title":"Environ. Res."},{"key":"D5MD00594A\/cit41\/1","doi-asserted-by":"crossref","first-page":"342837","DOI":"10.1016\/j.aca.2024.342837","volume":"1316","author":"Hosseini","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"D5MD00594A\/cit42\/1","doi-asserted-by":"crossref","first-page":"102005","DOI":"10.1016\/j.rineng.2024.102005","volume":"22","author":"Foroutan","year":"2024","journal-title":"Results Eng."},{"key":"D5MD00594A\/cit43\/1","doi-asserted-by":"crossref","first-page":"133242","DOI":"10.1016\/j.colsurfa.2024.133242","volume":"685","author":"Loukhmi","year":"2024","journal-title":"Colloids Surf., A"},{"key":"D5MD00594A\/cit44\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s12276-023-01153-3","volume":"56","author":"Kang","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"D5MD00594A\/cit45\/1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/jdi.70000","volume":"16","author":"Yamaguchi","year":"2025","journal-title":"J. Diabetes Invest."},{"key":"D5MD00594A\/cit46\/1","doi-asserted-by":"crossref","first-page":"100152","DOI":"10.1016\/j.crbiot.2023.100152","volume":"6","author":"Gonfa","year":"2023","journal-title":"Curr. Res. Biotechnol."},{"key":"D5MD00594A\/cit47\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.biochi.2024.07.004","volume":"227","author":"Chbel","year":"2024","journal-title":"Biochimie"},{"key":"D5MD00594A\/cit48\/1","first-page":"206","volume":"14","author":"Chbel","year":"2022","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"D5MD00594A\/cit49\/1","doi-asserted-by":"crossref","first-page":"e02689","DOI":"10.1016\/j.heliyon.2019.e02689","volume":"5","author":"Rbaa","year":"2019","journal-title":"Heliyon"},{"key":"D5MD00594A\/cit50\/1","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1002\/slct.201904565","volume":"5","author":"Vinoth","year":"2020","journal-title":"ChemistrySelect"},{"key":"D5MD00594A\/cit51\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2147\/DDDT.S49763","volume":"7","author":"Prachayasittikul","year":"2013","journal-title":"Drug Des., Dev. Ther."},{"key":"D5MD00594A\/cit52\/1","first-page":"424","volume":"52","author":"Pourmand","year":"2014","journal-title":"Acta Med. Iran."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D5MD00594A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:55:24Z","timestamp":1782968124000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/11\/5702-5716\/896795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00594a","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}