{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:30:29Z","timestamp":1782934229949,"version":"3.54.5"},"reference-count":32,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"am","delay-in-days":609,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373737"],"award-info":[{"award-number":["82373737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>We've found a novel class of amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains and evaluated the antifungal mechanism of the preferred compound B3.<\/jats:p>","DOI":"10.1039\/d5md00632e","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:40:54Z","timestamp":1756813254000},"page":"6068-6080","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, synthesis, and antifungal activity of novel amide imidazole CYP51 inhibitors with aromatic fused ring hydrophobic side chains"],"prefix":"10.1039","volume":"16","author":[{"given":"Zixuan","family":"Gao","sequence":"first","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhan","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejian","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zirui","family":"Luo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-2422","authenticated-orcid":false,"given":"Nian","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-6125","authenticated-orcid":false,"given":"Dongmei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9073-4806","authenticated-orcid":false,"given":"Maosheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, 110016 Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5MD00632E\/cit1\/1","doi-asserted-by":"crossref","first-page":"100187","DOI":"10.1016\/j.modpat.2023.100187","volume":"36","author":"Parsons","year":"2023","journal-title":"Mod. Pathol."},{"key":"D5MD00632E\/cit2\/1","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","volume":"4","author":"Brown","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"D5MD00632E\/cit3\/1","doi-asserted-by":"crossref","first-page":"12229","DOI":"10.1021\/acs.jmedchem.5c01068","volume":"68","author":"Sun","year":"2025","journal-title":"J. Med. Chem."},{"key":"D5MD00632E\/cit4\/1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12929-023-00926-2","volume":"30","author":"Fang","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"D5MD00632E\/cit5\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4939-6515-1_2","volume-title":"Human Fungal Pathogen Identification: Methods and Protocols","author":"Enoch","year":"2017","unstructured":"D. A.Enoch ,  H.Yang ,  S. H.Aliyu  and  C.Micallef , in  Human Fungal Pathogen Identification: Methods and Protocols , ed.  T. Lion ,  Springer ,  New York, NY ,  2017 ,  pp. 17\u201365"},{"key":"D5MD00632E\/cit6\/1","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"D5MD00632E\/cit7\/1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/myc.13148","volume":"63","author":"Jenks","year":"2020","journal-title":"Mycoses"},{"key":"D5MD00632E\/cit8\/1","doi-asserted-by":"crossref","first-page":"116949","DOI":"10.1016\/j.ejmech.2024.116949","volume":"280","author":"Sun","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00632E\/cit9\/1","doi-asserted-by":"crossref","first-page":"117337","DOI":"10.1016\/j.ejmech.2025.117337","volume":"287","author":"Yu","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00632E\/cit10\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-024-00503-3","volume":"10","author":"Lass-Fl\u00f6rl","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"D5MD00632E\/cit11\/1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrd3074","volume":"9","author":"Ostrosky-Zeichner","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5MD00632E\/cit12\/1","doi-asserted-by":"crossref","first-page":"e1002870","DOI":"10.1371\/journal.ppat.1002870","volume":"8","author":"Butts","year":"2012","journal-title":"PLoS Pathog."},{"key":"D5MD00632E\/cit13\/1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/antibiotics12050884","volume":"12","author":"Carmo","year":"2023","journal-title":"Antibiotics"},{"key":"D5MD00632E\/cit14\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s40121-020-00382-7","volume":"10","author":"Cavassin","year":"2021","journal-title":"Infect. Dis. Ther."},{"key":"D5MD00632E\/cit15\/1","doi-asserted-by":"crossref","first-page":"151023","DOI":"10.1016\/j.scitotenv.2021.151023","volume":"807","author":"Marena","year":"2022","journal-title":"Sci. Total Environ."},{"key":"D5MD00632E\/cit16\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/cid\/ciz163","volume":"70","author":"Shiri","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"D5MD00632E\/cit17\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jac\/46.2.171","volume":"46","author":"Vermes","year":"2000","journal-title":"J. Antimicrob.\nChemother."},{"key":"D5MD00632E\/cit18\/1","doi-asserted-by":"crossref","first-page":"115658","DOI":"10.1016\/j.ejmech.2023.115658","volume":"259","author":"Zhang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00632E\/cit19\/1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3389\/fmicb.2019.00691","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Microbiol."},{"key":"D5MD00632E\/cit20\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1586\/14787210.2015.1032939","volume":"13","author":"Allen","year":"2015","journal-title":"Expert Rev. Anti-infect. Ther."},{"key":"D5MD00632E\/cit21\/1","doi-asserted-by":"crossref","first-page":"107785","DOI":"10.1016\/j.bioorg.2024.107785","volume":"153","author":"Wu","year":"2024","journal-title":"Bioorg. Chem."},{"key":"D5MD00632E\/cit22\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s44259-023-00007-2","volume":"1","author":"Lee","year":"2023","journal-title":"npj Antimicrob. Resist."},{"key":"D5MD00632E\/cit23\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11908-022-00782-5","volume":"24","author":"Logan","year":"2022","journal-title":"Curr. Infect. Dis. Rep."},{"key":"D5MD00632E\/cit24\/1","doi-asserted-by":"crossref","first-page":"a019752","DOI":"10.1101\/cshperspect.a019752","volume":"5","author":"Cowen","year":"2015","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D5MD00632E\/cit25\/1","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1021\/acs.jmedchem.4c00710","volume":"67","author":"Yu","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5MD00632E\/cit26\/1","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1021\/acs.jmedchem.4c01057","volume":"67","author":"Liu","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5MD00632E\/cit27\/1","doi-asserted-by":"crossref","first-page":"113740","DOI":"10.1016\/j.ejmech.2021.113740","volume":"225","author":"Yin","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00632E\/cit28\/1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1039\/D3MD00589E","volume":"15","author":"Gao","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D5MD00632E\/cit29\/1","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1021\/acs.jmedchem.9b00917","volume":"63","author":"Kalgutkar","year":"2020","journal-title":"J. Med. Chem."},{"key":"D5MD00632E\/cit30\/1","doi-asserted-by":"crossref","first-page":"13247","DOI":"10.1021\/acs.jmedchem.3c01254","volume":"66","author":"Yan","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5MD00632E\/cit31\/1","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.1021\/acs.jmedchem.3c02188","volume":"67","author":"Ni","year":"2024","journal-title":"J. Med. Chem."},{"key":"D5MD00632E\/cit32\/1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/jm9707277","volume":"41","author":"Bartroli","year":"1998","journal-title":"J. Med. Chem."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/MD\/D5MD00632E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:45:31Z","timestamp":1782927931000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/16\/12\/6068-6080\/896809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00632e","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}