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Chem."],"abstract":"<jats:p>\n                    A new compound, MPOL_B_1, was identified and synthesized. It demonstrated drug-like properties, a favorable safety profile in rodents, and increased the lifespan of\n                    <jats:italic>C. elegans<\/jats:italic>\n                    by up to 30%, suggesting it is a promising pro-longevity candidate.\n                  <\/jats:p>","DOI":"10.1039\/d5md00780a","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:01:06Z","timestamp":1765281666000},"page":"1037-1049","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A new compound that extends the lifespan of worms, with favorable\n                    <i>in vitro<\/i>\n                    properties and a lack of toxicity in rodents"],"prefix":"10.1039","volume":"17","author":[{"given":"Heidi M.","family":"Blank","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Polymenis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Texas A&M University, 300 Olsen Blvd, College Station, TX 77843, USA"},{"name":"Institute for Advancing Health Through Agriculture, 498 Olsen Blvd, College Station, TX 77840, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5MD00780A\/cit1\/1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/acel.12585","volume":"16","author":"Barardo","year":"2017","journal-title":"Aging Cell"},{"key":"D5MD00780A\/cit2\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.18632\/aging.100799","volume":"7","author":"Moskalev","year":"2015","journal-title":"Aging"},{"key":"D5MD00780A\/cit3\/1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1474-9726.2007.00311.x","volume":"6","author":"Miller","year":"2007","journal-title":"Aging Cell"},{"key":"D5MD00780A\/cit4\/1","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1007\/s11357-025-01627-4","volume":"47","author":"Driscoll","year":"2025","journal-title":"GeroScience"},{"key":"D5MD00780A\/cit5\/1","doi-asserted-by":"crossref","first-page":"e53127","DOI":"10.7554\/eLife.53127","volume":"9","author":"Maitra","year":"2020","journal-title":"eLife"},{"key":"D5MD00780A\/cit6\/1","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.celrep.2018.07.089","volume":"24","author":"Barcena","year":"2018","journal-title":"Cell Rep."},{"key":"D5MD00780A\/cit7\/1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2013.02.035","volume":"153","author":"Cabreiro","year":"2013","journal-title":"Cell"},{"key":"D5MD00780A\/cit8\/1","doi-asserted-by":"crossref","first-page":"e97729","DOI":"10.1371\/journal.pone.0097729","volume":"9","author":"Johnson","year":"2014","journal-title":"PLoS One"},{"key":"D5MD00780A\/cit9\/1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/acel.12266","volume":"13","author":"Kozie\u0142","year":"2014","journal-title":"Aging Cell"},{"key":"D5MD00780A\/cit10\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/nyas.12973","volume":"1363","author":"Lee","year":"2016","journal-title":"Ann. 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