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Soc., Perkin Trans. 1"},{"key":"D5MD00789E\/cit86\/1","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/0040-4020(75)80235-3","volume":"31","author":"Stoodley","year":"1975","journal-title":"Tetrahedron"},{"key":"D5MD00789E\/cit87\/1","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1016\/S0040-4039(01)80900-X","volume":"26","author":"Micetich","year":"1985","journal-title":"Tetrahedron Lett."},{"key":"D5MD00789E\/cit88\/1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/S0960-894X(01)80940-9","volume":"3","author":"Thompson","year":"1993","journal-title":"Bioorg. Med. Chem. 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