{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:35:37Z","timestamp":1790789737105,"version":"4.1.0"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2027,1,6]],"date-time":"2027-01-06T00:00:00Z","timestamp":1799193600000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["UMO-2022\/45\/B\/NZ7\/04269"],"award-info":[{"award-number":["UMO-2022\/45\/B\/NZ7\/04269"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["101005077"],"award-info":[{"award-number":["101005077"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-016131"],"award-info":[{"award-number":["INV-016131"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["101003627"],"award-info":[{"award-number":["101003627"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>SARS-CoV-2 non-structural protein 14 (nsp14) is essential for viral mRNA cap guanine-N7 methylation and represents a promising but underexplored antiviral target.<\/jats:p>","DOI":"10.1039\/d5md00896d","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T10:43:34Z","timestamp":1767696214000},"page":"1015-1030","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase"],"prefix":"10.1039","volume":"17","author":[{"given":"Irene","family":"Georgiou","sequence":"first","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Robinson","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean N.","family":"O'Byrne","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"},{"name":"Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Przemys\u0142aw","family":"Grygier","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"},{"name":"Doctoral School of Exact and Natural Sciences, Jagiellonian University, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig D.","family":"Smith","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamshad A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Norval","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Post","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Groenewold","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadya","family":"Urakova","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands"},{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Wanningen","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-8358","authenticated-orcid":false,"given":"Leanid","family":"Kresik","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0307-0907","authenticated-orcid":false,"given":"Jacek","family":"Plewka","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"},{"name":"Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Delpal","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9668-1959","authenticated-orcid":false,"given":"Kexin","family":"See","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-093X","authenticated-orcid":false,"given":"Thomas","family":"Eadsforth","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Wierzbicka","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6046-024X","authenticated-orcid":false,"given":"Etienne","family":"Decroly","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, CNRS, AFMB UMR 7257, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar Singh","family":"Saikatendu","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas Inc, 500 Kendall St, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9534-0291","authenticated-orcid":false,"given":"Edcon","family":"Chang","sequence":"additional","affiliation":[{"name":"Takeda Development Center Americas Inc, 500 Kendall St, Cambridge, MA 02142, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Snijder","sequence":"additional","affiliation":[{"name":"Molecular Virology Laboratory, Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Pyr\u0107","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Czarna","sequence":"additional","affiliation":[{"name":"Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-9576","authenticated-orcid":false,"given":"Duncan E.","family":"Scott","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee DD1 5EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"6","key":"D5MD00896D\/cit1\/1","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/s41573-023-00672-y","volume":"22","author":"Li","year":"2023","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"1","key":"D5MD00896D\/cit2\/1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41580-021-00432-z","volume":"23","author":"Malone","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D5MD00896D\/cit3\/1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-biochem-052521-115653","volume":"91","author":"Lou","year":"2022","journal-title":"Annu. Rev. Biochem."},{"issue":"4","key":"D5MD00896D\/cit4\/1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/s41579-023-01003-z","volume":"22","author":"Steiner","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"D5MD00896D\/cit5\/1","doi-asserted-by":"publisher","first-page":"e0366221","DOI":"10.1128\/mbio.03662-21","volume":"13","author":"Pan","year":"2022","journal-title":"MBio"},{"issue":"16","key":"D5MD00896D\/cit6\/1","doi-asserted-by":"publisher","first-page":"7248","DOI":"10.1128\/JVI.00542-16","volume":"90","author":"Case","year":"2016","journal-title":"J. Virol."},{"issue":"49","key":"D5MD00896D\/cit7\/1","doi-asserted-by":"publisher","first-page":"e2108709118","DOI":"10.1073\/pnas.2108709118","volume":"118","author":"Ogando","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"D5MD00896D\/cit8\/1","doi-asserted-by":"publisher","first-page":"e2022310118","DOI":"10.1073\/pnas.2022310118","volume":"118","author":"Slanina","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7928","key":"D5MD00896D\/cit9\/1","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/s41586-022-05185-z","volume":"609","author":"Park","year":"2022","journal-title":"Nature"},{"issue":"9","key":"D5MD00896D\/cit10\/1","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/2211-5463.13414","volume":"12","author":"Frazier","year":"2022","journal-title":"FEBS Open Bio"},{"issue":"13","key":"D5MD00896D\/cit11\/1","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1016\/j.cell.2021.05.033","volume":"184","author":"Yan","year":"2021","journal-title":"Cell"},{"issue":"4","key":"D5MD00896D\/cit12\/1","doi-asserted-by":"publisher","first-page":"e1000863","DOI":"10.1371\/journal.ppat.1000863","volume":"6","author":"Bouvet","year":"2010","journal-title":"PLoS Pathog."},{"issue":"5","key":"D5MD00896D\/cit13\/1","doi-asserted-by":"publisher","first-page":"e1002059","DOI":"10.1371\/journal.ppat.1002059","volume":"7","author":"Decroly","year":"2011","journal-title":"PLoS Pathog."},{"issue":"6559","key":"D5MD00896D\/cit14\/1","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1126\/science.abi9310","volume":"373","author":"Liu","year":"2021","journal-title":"Science"},{"issue":"1","key":"D5MD00896D\/cit15\/1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrmicro2675","volume":"10","author":"Decroly","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"D5MD00896D\/cit16\/1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1073\/pnas.1515152113","volume":"113","author":"Devarkar","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"D5MD00896D\/cit17\/1","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1042\/bcj20210219","volume":"478","author":"Basu","year":"2021","journal-title":"Biochem. J."},{"key":"D5MD00896D\/cit18\/1","doi-asserted-by":"publisher","first-page":"105142","DOI":"10.1016\/j.antiviral.2021.105142","volume":"193","author":"Kasprzyk","year":"2021","journal-title":"Antiviral Res."},{"issue":"6","key":"D5MD00896D\/cit19\/1","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1177\/24725552211000652","volume":"26","author":"Pearson","year":"2021","journal-title":"SLAS Discovery"},{"issue":"8","key":"D5MD00896D\/cit20\/1","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1021\/acsinfecdis.1c00131","volume":"7","author":"Otava","year":"2021","journal-title":"ACS Infect. Dis."},{"issue":"12","key":"D5MD00896D\/cit21\/1","doi-asserted-by":"publisher","first-page":"7785","DOI":"10.1021\/acs.jmedchem.2c02120","volume":"66","author":"Singh","year":"2023","journal-title":"J. Med. Chem."},{"issue":"9","key":"D5MD00896D\/cit22\/1","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1177\/24725552211026261","volume":"26","author":"Devkota","year":"2021","journal-title":"SLAS Discovery"},{"issue":"7","key":"D5MD00896D\/cit23\/1","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1021\/acsmedchemlett.1c00140","volume":"12","author":"Bobileva","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"issue":"8","key":"D5MD00896D\/cit24\/1","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1021\/acsinfecdis.1c00131","volume":"7","author":"Otava","year":"2021","journal-title":"ACS Infect. Dis."},{"issue":"8","key":"D5MD00896D\/cit25\/1","doi-asserted-by":"publisher","first-page":"6231","DOI":"10.1021\/acs.jmedchem.2c00120","volume":"65","author":"Ahmed-Belkacem","year":"2022","journal-title":"J. Med. Chem."},{"key":"D5MD00896D\/cit26\/1","doi-asserted-by":"publisher","first-page":"115474","DOI":"10.1016\/j.ejmech.2023.115474","volume":"256","author":"Hausdorff","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"D5MD00896D\/cit27\/1","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1021\/acsmedchemlett.2c00265","volume":"13","author":"Jung","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"issue":"30","key":"D5MD00896D\/cit28\/1","doi-asserted-by":"publisher","first-page":"27410","DOI":"10.1021\/acsomega.3c02815","volume":"8","author":"Stefek","year":"2023","journal-title":"ACS Omega"},{"issue":"30","key":"D5MD00896D\/cit29\/1","doi-asserted-by":"publisher","first-page":"9436","DOI":"10.1073\/pnas.1508686112","volume":"112","author":"Ma","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5MD00896D\/cit30\/1","author":"Birkus","year":"2019","unstructured":"G. P.Birkus ,  O.Pav ,  T.Jandusik ,  I.Rosenberg  and  R.Nencka , 2\u20323\u2032 Cyclic dinucleotides with phosphonate bond activating the sting adaptor protein,  2019"},{"issue":"25","key":"D5MD00896D\/cit31\/1","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1016\/S0040-4039(01)82898-7","volume":"22","author":"Cermak","year":"1981","journal-title":"Tetrahedron Lett."},{"key":"D5MD00896D\/cit32\/1","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.ejmech.2018.03.008","volume":"150","author":"Wang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"6\u20137","key":"D5MD00896D\/cit33\/1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/15257770701490332","volume":"26","author":"Peng","year":"2007","journal-title":"Nucleosides, Nucleotides Nucleic Acids"},{"issue":"8","key":"D5MD00896D\/cit34\/1","doi-asserted-by":"publisher","first-page":"e00900-20","DOI":"10.1128\/AAC.00900-20","volume":"64","author":"Salgado-Benvindo","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"D5MD00896D\/cit35\/1","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s42003-022-03280-5","volume":"5","author":"Fukumoto","year":"2022","journal-title":"Commun. Biol."},{"issue":"8048","key":"D5MD00896D\/cit36\/1","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41586-024-08320-0","volume":"637","author":"Meyer","year":"2025","journal-title":"Nature"},{"issue":"8","key":"D5MD00896D\/cit37\/1","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.str.2022.04.014","volume":"30","author":"Czarna","year":"2022","journal-title":"Structure"},{"key":"D5MD00896D\/cit38\/1","doi-asserted-by":"publisher","first-page":"107035","DOI":"10.1016\/j.bioorg.2023.107035","volume":"143","author":"Ahmed-Belkacem","year":"2024","journal-title":"Bioorg. Chem."},{"key":"D5MD00896D\/cit39\/1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.antiviral.2017.06.021","volume":"144","author":"Aouadi","year":"2017","journal-title":"Antiviral Res."},{"issue":"3","key":"D5MD00896D\/cit40\/1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.antiviral.2013.06.001","volume":"99","author":"Barral","year":"2013","journal-title":"Antiviral Res."},{"issue":"4","key":"D5MD00896D\/cit41\/1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1042\/BCJ20240608","volume":"482","author":"Pearson","year":"2025","journal-title":"Biochem. J."},{"issue":"Pt 4","key":"D5MD00896D\/cit42\/1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1107\/S0907444911007773","volume":"67","author":"Vonrhein","year":"2011","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"issue":"Pt 2","key":"D5MD00896D\/cit43\/1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1107\/S0907444909047337","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"issue":"Pt 7","key":"D5MD00896D\/cit44\/1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1107\/S0907444913000061","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"issue":"Pt 10","key":"D5MD00896D\/cit45\/1","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1107\/S2059798319011471","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr., Sect. D: Struct. Biol."},{"issue":"Pt 4","key":"D5MD00896D\/cit46\/1","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"issue":"Pt 4","key":"D5MD00896D\/cit47\/1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1107\/S0907444912001308","volume":"68","author":"Afonine","year":"2012","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"issue":"Pt 4","key":"D5MD00896D\/cit48\/1","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"issue":"Pt 1","key":"D5MD00896D\/cit49\/1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1099\/vir.0.015511-0","volume":"91","author":"Selisko","year":"2010","journal-title":"J. Gen. Virol."},{"issue":"15","key":"D5MD00896D\/cit50\/1","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1021\/ac001388j","volume":"73","author":"Camurri","year":"2001","journal-title":"Anal. Chem."},{"key":"D5MD00896D\/cit51\/1","author":"Georgiou","year":"2025","unstructured":"I.Georgiou ,  C.Robinson ,  S. N.O'Byrne ,  A.Matsuda ,  P.Grygier ,  C. D.Smith ,  S.O'Neill ,  S. A.Ahmad ,  S.Norval ,  J. M.Post ,  M.Groenewold ,  N.Urakova ,  P.Wanningen ,  L.Kresik ,  J.Plewka ,  A.Delpal ,  K.See ,  T.Eadsforth ,  K.Wierzbicka ,  E.Decroly ,  K. S.Saikatendu ,  E.Chang ,  E. J.Snijder ,  K.Pyr\u0107 ,  A.Czarna ,  D. E.Scott  and  I. H.Gilbert , Crystallographic characterisation and development of bi-substrate inhibitors of coronavirus nsp14 methyltransferase,  2025"}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D5MD00896D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:47:00Z","timestamp":1782874020000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/17\/2\/1015-1030\/896855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00896d","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.09.30.679521","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}