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Chem."],"abstract":"<jats:p>\n                    We report a novel \u03b2-aminosulfone pharmacophore synthesized\n                    <jats:italic>via<\/jats:italic>\n                    a microwave-assisted aza-Michael reaction on water in a single step. The compounds show significant inhibition against CYP51, promising antifungal activity\n                    <jats:italic>in vitro<\/jats:italic>\n                    , and no cytotoxicity.\n                  <\/jats:p>","DOI":"10.1039\/d5md00907c","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:34:51Z","timestamp":1767954891000},"page":"1083-1098","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Microwave-assisted single-step synthesis of cyclic and acyclic \u03b2-aminosulfones and evaluation of their antifungal activity targeting CYP51"],"prefix":"10.1039","volume":"17","author":[{"given":"Abigail Bibiana","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumik","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Madduri","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utpal","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi Sudhir","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-2723","authenticated-orcid":false,"given":"Amrita","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-5531","authenticated-orcid":false,"given":"Mainak","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5MD00907C\/cit1\/1","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1021\/acs.chemrev.0c00199","volume":"121","author":"Lee","year":"2020","journal-title":"Chem. 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