{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:44:51Z","timestamp":1782891891415,"version":"3.54.5"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA251534"],"award-info":[{"award-number":["R01CA251534"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    Structural requirements for oxindole-based AMPK inhibitors with the 5-(2-cyanoethyl)- and the 3-substituent as the\n                    <jats:italic>Z<\/jats:italic>\n                    -isomer form providing selectivity for AMPK over GSK3\u03b2.\n                  <\/jats:p>","DOI":"10.1039\/d5md00913h","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T07:01:13Z","timestamp":1763794873000},"page":"370-384","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3\u03b2 inhibition"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-388X","authenticated-orcid":false,"given":"Juliet E.","family":"Strang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8504-260X","authenticated-orcid":false,"given":"Daniel D.","family":"Astridge","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9687-2801","authenticated-orcid":false,"given":"Caleb","family":"Chandler","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-9803","authenticated-orcid":false,"given":"Vu T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-1016","authenticated-orcid":false,"given":"Philip","family":"Reigan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5MD00913H\/cit1\/1","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1038\/emm.2016.81","volume":"48","author":"Jeon","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"D5MD00913H\/cit2\/1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.tem.2017.05.004","volume":"28","author":"Day","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"D5MD00913H\/cit3\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BST0390001","volume":"39","author":"Hardie","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"D5MD00913H\/cit4\/1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"D5MD00913H\/cit5\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2005.05.009","volume":"2","author":"Hawley","year":"2005","journal-title":"Cell Metab."},{"key":"D5MD00913H\/cit6\/1","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1242\/jcs.115.11.2433","volume":"115","author":"Barnes","year":"2002","journal-title":"J. Cell Sci."},{"key":"D5MD00913H\/cit7\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncb1080","volume":"6","author":"Almeida","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"D5MD00913H\/cit8\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D5MD00913H\/cit9\/1","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1073\/pnas.0705070104","volume":"104","author":"Jager","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5MD00913H\/cit10\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41573-019-0019-2","volume":"18","author":"Steinberg","year":"2019","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5MD00913H\/cit11\/1","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1021\/acs.jmedchem.4c02354","volume":"68","author":"Strang","year":"2025","journal-title":"J. Med. Chem."},{"key":"D5MD00913H\/cit12\/1","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1158\/1078-0432.CCR-14-3300","volume":"21","author":"Hardie","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"D5MD00913H\/cit13\/1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41556-018-0126-z","volume":"20","author":"Chhipa","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"6","key":"D5MD00913H\/cit14\/1","doi-asserted-by":"crossref","first-page":"dmm049203","DOI":"10.1242\/dmm.049203","volume":"15","author":"Andugulapati","year":"2022","journal-title":"Dis. Models Mech."},{"key":"D5MD00913H\/cit15\/1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/ame2.12016","volume":"1","author":"Guo","year":"2018","journal-title":"Anim. Models Exp. Med."},{"key":"D5MD00913H\/cit16\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.stem.2015.08.019","volume":"17","author":"Saito","year":"2015","journal-title":"Cell Stem Cell"},{"key":"D5MD00913H\/cit17\/1","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1038\/s41467-023-41663-2","volume":"14","author":"Yin","year":"2023","journal-title":"Nat. Commun."},{"key":"D5MD00913H\/cit18\/1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2174\/1389450116666150316223655","volume":"17","author":"Wang","year":"2016","journal-title":"Curr. Drug Targets"},{"key":"D5MD00913H\/cit19\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ccell.2019.08.005","volume":"36","author":"Guieze","year":"2019","journal-title":"Cancer Cell"},{"key":"D5MD00913H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1114582","DOI":"10.3389\/fimmu.2023.1114582","volume":"14","author":"Keerthana","year":"2023","journal-title":"Front. Immunol."},{"key":"D5MD00913H\/cit21\/1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Invest."},{"key":"D5MD00913H\/cit22\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20070797","volume":"408","author":"Bain","year":"2007","journal-title":"Biochem. J."},{"key":"D5MD00913H\/cit23\/1","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1016\/j.febslet.2007.11.038","volume":"581","author":"Emerling","year":"2007","journal-title":"FEBS Lett."},{"key":"D5MD00913H\/cit24\/1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1021\/cb9002865","volume":"5","author":"Hao","year":"2010","journal-title":"ACS Chem. Biol."},{"key":"D5MD00913H\/cit25\/1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1158\/1535-7163.MCT-13-0579","volume":"13","author":"Liu","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"D5MD00913H\/cit26\/1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.bcp.2009.03.005","volume":"77","author":"Vucicevic","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"D5MD00913H\/cit27\/1","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.1074\/jbc.RA118.003547","volume":"293","author":"Dite","year":"2018","journal-title":"J. Biol. Chem."},{"key":"D5MD00913H\/cit28\/1","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1042\/BCJ20210284","volume":"478","author":"Ahwazi","year":"2021","journal-title":"Biochem. J."},{"key":"D5MD00913H\/cit29\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s13402-020-00584-8","volume":"44","author":"Lemos","year":"2021","journal-title":"Cell. Oncol."},{"issue":"1","key":"D5MD00913H\/cit30\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3390\/ijms25010453","volume":"25","author":"Hawley","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5MD00913H\/cit31\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/cbt.10.1.12162","volume":"10","author":"Laderoute","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"D5MD00913H\/cit32\/1","doi-asserted-by":"crossref","first-page":"112316","DOI":"10.1016\/j.ejmech.2020.112316","volume":"197","author":"Matheson","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00913H\/cit33\/1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/jnc.12203","volume":"125","author":"Georgievska","year":"2013","journal-title":"J. Neurochem."},{"key":"D5MD00913H\/cit34\/1","doi-asserted-by":"crossref","first-page":"111842","DOI":"10.1016\/j.biopha.2021.111842","volume":"141","author":"Khetmalis","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"D5MD00913H\/cit35\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/cmdc.201500475","volume":"11","author":"Ngai","year":"2016","journal-title":"ChemMedChem"},{"key":"D5MD00913H\/cit36\/1","first-page":"826","volume":"2","author":"Jiao","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D5MD00913H\/cit37\/1","doi-asserted-by":"crossref","first-page":"7839","DOI":"10.1039\/D0RA10672K","volume":"11","author":"Mansour","year":"2021","journal-title":"RSC Adv."},{"key":"D5MD00913H\/cit38\/1","doi-asserted-by":"crossref","first-page":"28630","DOI":"10.1039\/D0RA05288D","volume":"10","author":"Raji Reddy","year":"2020","journal-title":"RSC Adv."},{"key":"D5MD00913H\/cit39\/1","doi-asserted-by":"crossref","first-page":"e4407","DOI":"10.1002\/bmc.4407","volume":"33","author":"Matsunaga","year":"2019","journal-title":"Biomed. Chromatogr."},{"key":"D5MD00913H\/cit40\/1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nbt.2017","volume":"29","author":"Anastassiadis","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"D5MD00913H\/cit41\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/cr.2014.150","volume":"25","author":"Li","year":"2015","journal-title":"Cell Res."},{"key":"D5MD00913H\/cit42\/1","doi-asserted-by":"crossref","first-page":"9107","DOI":"10.1021\/jm201724m","volume":"55","author":"Berg","year":"2012","journal-title":"J. Med. Chem."},{"key":"D5MD00913H\/cit43\/1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ejmech.2018.12.073","volume":"164","author":"Xu","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD00913H\/cit44\/1","doi-asserted-by":"crossref","first-page":"108095","DOI":"10.1016\/j.compbiolchem.2024.108095","volume":"111","author":"Mohammadi","year":"2024","journal-title":"Comput. Biol. Chem."},{"key":"D5MD00913H\/cit45\/1","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1007\/s11030-024-11026-0","volume":"29","author":"Niharika","year":"2025","journal-title":"Mol. Diversity"},{"key":"D5MD00913H\/cit46\/1","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1038\/s41598-025-85868-5","volume":"15","author":"Ganai","year":"2025","journal-title":"Sci. Rep."},{"key":"D5MD00913H\/cit47\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10571-025-01568-8","volume":"45","author":"Haque","year":"2025","journal-title":"Cell. Mol. Neurobiol."},{"key":"D5MD00913H\/cit48\/1","doi-asserted-by":"crossref","first-page":"21632","DOI":"10.1038\/s41598-025-04129-7","volume":"15","author":"Alhassan","year":"2025","journal-title":"Sci. Rep."},{"key":"D5MD00913H\/cit49\/1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10822-014-9727-1","volume":"28","author":"Beckstein","year":"2014","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"D5MD00913H\/cit50\/1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1021\/ci800324m","volume":"49","author":"Halgren","year":"2009","journal-title":"J. Chem. Inf. Model."},{"key":"D5MD00913H\/cit51\/1","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1002\/prot.23106","volume":"79","author":"Li","year":"2011","journal-title":"Proteins"},{"key":"D5MD00913H\/cit52\/1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jpba.2018.08.013","volume":"160","author":"Posocco","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D5MD00913H\/cit53\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.molcel.2013.03.022","volume":"50","author":"Suzuki","year":"2013","journal-title":"Mol. Cell"},{"key":"D5MD00913H\/cit54\/1","doi-asserted-by":"crossref","first-page":"33902","DOI":"10.1074\/jbc.M802537200","volume":"283","author":"Horike","year":"2008","journal-title":"J. Biol. Chem."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D5MD00913H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:53:03Z","timestamp":1782885183000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/17\/1\/370-384\/1247723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md00913h","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}