{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:54:06Z","timestamp":1782856446769,"version":"3.54.5"},"reference-count":234,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>Experimental structures and accurate simulations can guide the design and synthesis of adamantanamines that can block AM2 wild-type and mutant AM2-mediated proton conductance.<\/jats:p>","DOI":"10.1039\/d5md01027f","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:01:23Z","timestamp":1771830083000},"page":"1811-1846","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adamantane-based inhibitors of the influenza A M2 proton channel: structure-based design, biological evaluation, and synthetic approaches"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-4792","authenticated-orcid":false,"given":"Marianna","family":"Stampolaki","sequence":"first","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece"},{"name":"Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Am Fassberg 11, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Eleni","family":"Kouridaki","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-1903","authenticated-orcid":false,"given":"Antonios","family":"Kolocouris","sequence":"additional","affiliation":[{"name":"Laboratory of Medicinal Chemistry, Section of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis-Zografou, Athens, 15771, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"11","key":"D5MD01027F\/cit1\/1","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1002\/pro.2158","volume":"21","author":"Hong","year":"2012","journal-title":"Protein Sci."},{"issue":"4","key":"D5MD01027F\/cit2\/1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/pro.2232","volume":"22","author":"Zhou","year":"2013","journal-title":"Protein Sci."},{"key":"D5MD01027F\/cit3\/1","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.bbamem.2010.04.015","author":"Pielak","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"1","key":"D5MD01027F\/cit4\/1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.sbi.2010.12.002","volume":"21","author":"Wang","year":"2011","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"1","key":"D5MD01027F\/cit5\/1","doi-asserted-by":"publisher","first-page":"184387","DOI":"10.1016\/j.bbamem.2024.184387","volume":"1867","author":"Georgiou","year":"2025","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D5MD01027F\/cit6\/1","doi-asserted-by":"publisher","first-page":"100122","DOI":"10.1016\/j.yjsbx.2025.100122","volume":"11","author":"Georgiou","year":"2025","journal-title":"J. Struct. Biol.: X"},{"key":"D5MD01027F\/cit7\/1","doi-asserted-by":"publisher","first-page":"796229","DOI":"10.3389\/fmolb.2021.796229","volume":"8","author":"Aledavood","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"2","key":"D5MD01027F\/cit8\/1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.virol.2010.12.003","volume":"411","author":"Rossman","year":"2011","journal-title":"Virology"},{"issue":"4","key":"D5MD01027F\/cit9\/1","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3390\/molecules26040880","volume":"26","author":"Mtambo","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"D5MD01027F\/cit10\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2217\/fvl.15.95","volume":"11","author":"Wang","year":"2016","journal-title":"Future Virol."},{"key":"D5MD01027F\/cit11\/1","doi-asserted-by":"publisher","first-page":"104780","DOI":"10.1016\/j.antiviral.2020.104780","volume":"178","author":"Jalily","year":"2020","journal-title":"Antiviral Res."},{"key":"D5MD01027F\/cit12\/1","volume-title":"Recent advances in pharmaceutical sciences","volume":"661","author":"Duque","year":"2011","unstructured":"M. D.Duque ,  E.Torres ,  E.Valverde ,  M.Barniol ,  S.Guardiola ,  M.Rey  and  S.V\u00e1zquez , Inhibitors of the M2 channel of influenza A virus,  Recent advances in pharmaceutical sciences , ed.  D. Mu\u00f1oz-Torrero ,  Transworld research network ,  2011 ,  vol. 661"},{"issue":"4","key":"D5MD01027F\/cit13\/1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/bip.22623","volume":"104","author":"Wang","year":"2015","journal-title":"Biopolymers"},{"key":"D5MD01027F\/cit14\/1","doi-asserted-by":"publisher","first-page":"116172","DOI":"10.1016\/j.ejmech.2024.116172","volume":"267","author":"Kumar","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01027F\/cit15\/1","doi-asserted-by":"publisher","first-page":"104780","DOI":"10.1016\/j.antiviral.2020.104780","volume":"178","author":"Jalily","year":"2020","journal-title":"Antiviral Res."},{"issue":"5","key":"D5MD01027F\/cit16\/1","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s11172-025-4616-4","volume":"74","author":"Shiryaev","year":"2025","journal-title":"Russ. Chem. Bull."},{"issue":"6","key":"D5MD01027F\/cit17\/1","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/s10593-020-02712-6","volume":"56","author":"Shiryaev","year":"2020","journal-title":"Chem. Heterocycl. Compd."},{"issue":"2","key":"D5MD01027F\/cit18\/1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.5562\/cca3540","volume":"92","author":"Pardali","year":"2019","journal-title":"Croat. Chem. Acta"},{"key":"D5MD01027F\/cit19\/1","doi-asserted-by":"publisher","first-page":"117592","DOI":"10.1016\/j.ejmech.2025.117592","volume":"291","author":"Dane","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01027F\/cit20\/1","doi-asserted-by":"publisher","first-page":"107863","DOI":"10.1016\/j.phrs.2025.107863","volume":"219","author":"Peng","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"7","key":"D5MD01027F\/cit21\/1","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1039\/D0CS01084G","volume":"50","author":"Ma","year":"2021","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"D5MD01027F\/cit22\/1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/17460441.2019.1560261","volume":"14","author":"Shin","year":"2019","journal-title":"Expert Opin. Drug Discovery"},{"issue":"1","key":"D5MD01027F\/cit23\/1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0092-8674(91)90576-K","volume":"67","author":"Martin","year":"1991","journal-title":"Cell"},{"issue":"3","key":"D5MD01027F\/cit24\/1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/0092-8674(92)90452-I","volume":"69","author":"Pinto","year":"1992","journal-title":"Cell"},{"key":"D5MD01027F\/cit25\/1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/0042-6822(92)90730-D","volume":"188","author":"Ciampor","year":"1992","journal-title":"Virology"},{"issue":"1","key":"D5MD01027F\/cit26\/1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0042-6822(92)91187-Y","volume":"190","author":"Grambas","year":"1992","journal-title":"Virology"},{"issue":"11","key":"D5MD01027F\/cit27\/1","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1002\/j.1460-2075.1990.tb07555.x","volume":"9","author":"Sugrue","year":"1990","journal-title":"EMBO J."},{"issue":"2","key":"D5MD01027F\/cit28\/1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.virusres.2009.05.010","volume":"143","author":"Nayak","year":"2009","journal-title":"Virus Res."},{"issue":"2","key":"D5MD01027F\/cit29\/1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.virol.2010.12.003","volume":"411","author":"Rossman","year":"2011","journal-title":"Virology"},{"issue":"2","key":"D5MD01027F\/cit30\/1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/0042-6822(91)90075-M","volume":"180","author":"Sugrue","year":"1991","journal-title":"Virology"},{"issue":"1","key":"D5MD01027F\/cit31\/1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1039\/b611613m","volume":"3","author":"Pinto","year":"2007","journal-title":"Mol. BioSyst."},{"issue":"Pt 2","key":"D5MD01027F\/cit32\/1","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1113\/jphysiol.1996.sp021495","volume":"494","author":"Chizhmakov","year":"1996","journal-title":"J. Physiol."},{"issue":"1","key":"D5MD01027F\/cit33\/1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1006\/viro.1994.1628","volume":"205","author":"Wang","year":"1994","journal-title":"Virology"},{"issue":"3","key":"D5MD01027F\/cit34\/1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/0092-8674(85)90211-9","volume":"40","author":"Lamb","year":"1985","journal-title":"Cell"},{"issue":"10","key":"D5MD01027F\/cit35\/1","doi-asserted-by":"publisher","first-page":"5078","DOI":"10.1128\/JVI.00119-10","volume":"84","author":"Rossman","year":"2010","journal-title":"J. Virol."},{"issue":"3","key":"D5MD01027F\/cit36\/1","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1128\/jvi.72.3.2449-2455.1998","volume":"72","author":"Park","year":"1998","journal-title":"J. Virol."},{"issue":"1","key":"D5MD01027F\/cit37\/1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1039\/b611613m","volume":"3","author":"Pinto","year":"2007","journal-title":"Mol. BioSyst."},{"issue":"20","key":"D5MD01027F\/cit38\/1","doi-asserted-by":"publisher","first-page":"10059","DOI":"10.1128\/jvi.01184-08","volume":"82","author":"Chen","year":"2008","journal-title":"J. Virol."},{"issue":"30","key":"D5MD01027F\/cit39\/1","doi-asserted-by":"publisher","first-page":"12283","DOI":"10.1073\/pnas.0905726106","volume":"106","author":"Ma","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"D5MD01027F\/cit40\/1","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1002\/j.1460-2075.1985.tb04038.x","volume":"4","author":"Hay","year":"1985","journal-title":"EMBO J."},{"issue":"7281","key":"D5MD01027F\/cit41\/1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nature08722","volume":"463","author":"Cady","year":"2010","journal-title":"Nature"},{"issue":"1","key":"D5MD01027F\/cit42\/1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1006\/viro.1994.1345","volume":"202","author":"Duff","year":"1994","journal-title":"Virology"},{"issue":"46","key":"D5MD01027F\/cit43\/1","doi-asserted-by":"publisher","first-page":"14160","DOI":"10.1021\/bi001799u","volume":"39","author":"Salom","year":"2000","journal-title":"Biochemistry"},{"issue":"7178","key":"D5MD01027F\/cit44\/1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nature06528","volume":"451","author":"Stouffer","year":"2008","journal-title":"Nature"},{"issue":"1","key":"D5MD01027F\/cit45\/1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0042-6822(92)91239-Q","volume":"190","author":"Duff","year":"1992","journal-title":"Virology"},{"issue":"9","key":"D5MD01027F\/cit46\/1","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.1128\/jvi.67.9.5585-5594.1993","volume":"67","author":"Wang","year":"1993","journal-title":"J. Virol."},{"issue":"45","key":"D5MD01027F\/cit47\/1","doi-asserted-by":"publisher","first-page":"E6955","DOI":"10.1073\/pnas.1615471113","volume":"113","author":"Liang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"D5MD01027F\/cit48\/1","doi-asserted-by":"publisher","first-page":"6865","DOI":"10.1073\/pnas.0601944103","volume":"103","author":"Hu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"D5MD01027F\/cit49\/1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0006-3495(95)80003-2","volume":"69","author":"Wang","year":"1995","journal-title":"Biophys. J."},{"issue":"18","key":"D5MD01027F\/cit50\/1","doi-asserted-by":"publisher","first-page":"6865","DOI":"10.1073\/pnas.0601944103","volume":"103","author":"Hu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"42","key":"D5MD01027F\/cit51\/1","doi-asserted-by":"publisher","first-page":"39880","DOI":"10.1074\/jbc.M206582200","volume":"277","author":"Tang","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"27","key":"D5MD01027F\/cit52\/1","doi-asserted-by":"publisher","first-page":"7977","DOI":"10.1021\/jp800171m","volume":"112","author":"Yi","year":"2008","journal-title":"J. Phys. Chem. B"},{"issue":"44","key":"D5MD01027F\/cit53\/1","doi-asserted-by":"publisher","first-page":"13170","DOI":"10.1021\/bi0262799","volume":"41","author":"Nishimura","year":"2002","journal-title":"Biochemistry"},{"issue":"46","key":"D5MD01027F\/cit54\/1","doi-asserted-by":"publisher","first-page":"14260","DOI":"10.1073\/pnas.1518493112","volume":"112","author":"Thomaston","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5MD01027F\/cit55\/1","doi-asserted-by":"publisher","first-page":"13357","DOI":"10.1073\/pnas.1705624114","volume":"114","author":"Thomaston","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"D5MD01027F\/cit56\/1","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1128\/jvi.68.3.1551-1563.1994","volume":"68","author":"Holsinger","year":"1994","journal-title":"J. Virol."},{"issue":"16","key":"D5MD01027F\/cit57\/1","doi-asserted-by":"publisher","first-page":"8178","DOI":"10.1128\/JVI.00627-06","volume":"80","author":"McCown","year":"2006","journal-title":"J. Virol."},{"issue":"6","key":"D5MD01027F\/cit58\/1","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.cell.2010.08.029","volume":"142","author":"Rossman","year":"2010","journal-title":"Cell"},{"issue":"6003","key":"D5MD01027F\/cit59\/1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1126\/science.1191750","volume":"330","author":"Sharma","year":"2010","journal-title":"Science"},{"issue":"12","key":"D5MD01027F\/cit60\/1","doi-asserted-by":"publisher","first-page":"4335","DOI":"10.1529\/biophysj.106.090183","volume":"92","author":"Hu","year":"2007","journal-title":"Biophys. J."},{"issue":"7178","key":"D5MD01027F\/cit61\/1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/nature06528","volume":"451","author":"Stouffer","year":"2008","journal-title":"Nature"},{"issue":"44","key":"D5MD01027F\/cit62\/1","doi-asserted-by":"publisher","first-page":"13170","DOI":"10.1021\/bi0262799","volume":"41","author":"Nishimura","year":"2002","journal-title":"Biochemistry"},{"issue":"34","key":"D5MD01027F\/cit63\/1","doi-asserted-by":"publisher","first-page":"15075","DOI":"10.1073\/pnas.1007071107","volume":"107","author":"Acharya","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"34","key":"D5MD01027F\/cit64\/1","doi-asserted-by":"publisher","first-page":"15075","DOI":"10.1073\/pnas.1007071107","volume":"107","author":"Acharya","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"46","key":"D5MD01027F\/cit65\/1","doi-asserted-by":"publisher","first-page":"14260","DOI":"10.1073\/pnas.1518493112","volume":"112","author":"Thomaston","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7178","key":"D5MD01027F\/cit66\/1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nature06531","volume":"451","author":"Schnell","year":"2008","journal-title":"Nature"},{"issue":"7281","key":"D5MD01027F\/cit67\/1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/nature08722","volume":"463","author":"Cady","year":"2010","journal-title":"Nature"},{"issue":"30","key":"D5MD01027F\/cit68\/1","doi-asserted-by":"publisher","first-page":"11572","DOI":"10.1021\/ja202051n","volume":"133","author":"Cady","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"18","key":"D5MD01027F\/cit69\/1","doi-asserted-by":"publisher","first-page":"7379","DOI":"10.1073\/pnas.0902548106","volume":"106","author":"Pielak","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"32","key":"D5MD01027F\/cit70\/1","doi-asserted-by":"publisher","first-page":"10958","DOI":"10.1021\/ja101537p","volume":"132","author":"Andreas","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"D5MD01027F\/cit71\/1","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/j.str.2011.09.003","volume":"19","author":"Pielak","year":"2011","journal-title":"Structure"},{"issue":"45","key":"D5MD01027F\/cit72\/1","doi-asserted-by":"publisher","first-page":"15219","DOI":"10.1021\/jacs.8b06741","volume":"140","author":"Thomaston","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"32","key":"D5MD01027F\/cit73\/1","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1021\/acs.biochem.1c00437","volume":"60","author":"Thomaston","year":"2021","journal-title":"Biochemistry"},{"issue":"2","key":"D5MD01027F\/cit74\/1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.bbamem.2010.06.018","volume":"1808","author":"Astrahan","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"25","key":"D5MD01027F\/cit75\/1","doi-asserted-by":"publisher","first-page":"9903","DOI":"10.1021\/ja202288m","volume":"133","author":"Leonov","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"D5MD01027F\/cit76\/1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1073\/pnas.1216526110","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Supplement 1","key":"D5MD01027F\/cit77\/1","doi-asserted-by":"publisher","first-page":"S75","DOI":"10.1093\/cid\/ciq012","volume":"52","author":"Shrestha","year":"2011","journal-title":"Clin. Infect. Dis."},{"issue":"3","key":"D5MD01027F\/cit78\/1","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1021\/acs.jmedchem.7b01536","volume":"61","author":"Wang","year":"2018","journal-title":"J. Med. Chem."},{"issue":"26","key":"D5MD01027F\/cit79\/1","doi-asserted-by":"publisher","first-page":"9885","DOI":"10.1021\/ja4041412","volume":"135","author":"Williams","year":"2013","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"D5MD01027F\/cit80\/1","doi-asserted-by":"publisher","first-page":"4274","DOI":"10.1021\/ja102581n","volume":"133","author":"Cady","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"52","key":"D5MD01027F\/cit81\/1","doi-asserted-by":"publisher","first-page":"17987","DOI":"10.1021\/ja508461m","volume":"136","author":"Wu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"D5MD01027F\/cit82\/1","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1021\/acs.biochem.9b00971","volume":"59","author":"Thomaston","year":"2020","journal-title":"Biochemistry"},{"issue":"30","key":"D5MD01027F\/cit83\/1","doi-asserted-by":"publisher","first-page":"11572","DOI":"10.1021\/ja202051n","volume":"133","author":"Cady","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"3620","key":"D5MD01027F\/cit84\/1","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1126\/science.144.3620.862","volume":"144","author":"Davies","year":"1964","journal-title":"Science"},{"issue":"1","key":"D5MD01027F\/cit85\/1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/cpt19667138","volume":"7","author":"Wendel","year":"1966","journal-title":"Clin. Pharmacol. Ther."},{"issue":"7","key":"D5MD01027F\/cit86\/1","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1001\/jama.1969.03160070046011","volume":"208","author":"Schwab","year":"1969","journal-title":"JAMA, J. Am. Med. Assoc."},{"issue":"13","key":"D5MD01027F\/cit87\/1","doi-asserted-by":"publisher","first-page":"3312","DOI":"10.1523\/JNEUROSCI.4262-04.2005","volume":"25","author":"Blanpied","year":"2005","journal-title":"J. Neurosci."},{"issue":"7","key":"D5MD01027F\/cit88\/1","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.str.2008.04.011","volume":"16","author":"Stouffer","year":"2008","journal-title":"Structure"},{"issue":"1","key":"D5MD01027F\/cit89\/1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1743-422X-6-67","volume":"6","author":"Furuse","year":"2009","journal-title":"Virol. J."},{"issue":"9492","key":"D5MD01027F\/cit90\/1","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/S0140-6736(05)67338-2","volume":"366","author":"Bright","year":"2005","journal-title":"Lancet"},{"issue":"6","key":"D5MD01027F\/cit91\/1","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3851\/IMP1656","volume":"15","author":"Lan","year":"2010","journal-title":"Antiviral Ther."},{"issue":"2","key":"D5MD01027F\/cit92\/1","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1128\/AAC.49.2.556-559.2005","volume":"49","author":"Abed","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"8","key":"D5MD01027F\/cit93\/1","doi-asserted-by":"publisher","first-page":"3442","DOI":"10.1128\/AAC.01385-09","volume":"54","author":"Brown","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"D5MD01027F\/cit94\/1","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1128\/JCM.00892-08","volume":"47","author":"Li","year":"2009","journal-title":"J. Clin. Microbiol."},{"issue":"3","key":"D5MD01027F\/cit95\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0119115","volume":"10","author":"Dong","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"D5MD01027F\/cit96\/1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1093\/molbev\/mst204","volume":"31","author":"Garcia","year":"2014","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"D5MD01027F\/cit97\/1","doi-asserted-by":"publisher","first-page":"11442","DOI":"10.1038\/s41467-025-66307-5","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"key":"D5MD01027F\/cit98\/1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.antiviral.2018.03.002","volume":"153","author":"Musharrafieh","year":"2018","journal-title":"Antiviral Res."},{"issue":"2","key":"D5MD01027F\/cit99\/1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1124\/mol.119.116640","volume":"96","author":"Musharrafieh","year":"2019","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"D5MD01027F\/cit100\/1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1021\/acsptsci.0c00018","volume":"3","author":"Musharrafieh","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"9","key":"D5MD01027F\/cit101\/1","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1021\/acs.jmedchem.6b01758","volume":"60","author":"Barniol-Xicota","year":"2017","journal-title":"J. Med. Chem."},{"issue":"17","key":"D5MD01027F\/cit102\/1","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1021\/jm950891z","volume":"39","author":"Kolocouris","year":"1996","journal-title":"J. Med. Chem."},{"issue":"8","key":"D5MD01027F\/cit103\/1","doi-asserted-by":"publisher","first-page":"e1008716","DOI":"10.1371\/JOURNAL.PPAT.1008716","volume":"16","author":"Scott","year":"2020","journal-title":"PLoS Pathog."},{"issue":"6","key":"D5MD01027F\/cit104\/1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1021\/jm00288a019","volume":"14","author":"Aldrich","year":"1971","journal-title":"J. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit105\/1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1021\/acsmedchemlett.7b00458","volume":"9","author":"Drakopoulos","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"issue":"9","key":"D5MD01027F\/cit106\/1","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1021\/acschembio.0c00553","volume":"15","author":"Tzitzoglaki","year":"2020","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"D5MD01027F\/cit107\/1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.bbamem.2010.08.021","volume":"1808","author":"Astrahan","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"issue":"41","key":"D5MD01027F\/cit108\/1","doi-asserted-by":"publisher","first-page":"5949","DOI":"10.1021\/acs.biochem.8b00721","volume":"57","author":"Santner","year":"2018","journal-title":"Biochemistry"},{"issue":"41","key":"D5MD01027F\/cit109\/1","doi-asserted-by":"publisher","first-page":"5957","DOI":"10.1021\/acs.biochem.8b00722","volume":"57","author":"Santner","year":"2018","journal-title":"Biochemistry"},{"issue":"46","key":"D5MD01027F\/cit110\/1","doi-asserted-by":"publisher","first-page":"14160","DOI":"10.1021\/bi001799u","volume":"39","author":"Salom","year":"2000","journal-title":"Biochemistry"},{"issue":"50","key":"D5MD01027F\/cit111\/1","doi-asserted-by":"publisher","first-page":"11872","DOI":"10.1021\/bi9014488","volume":"48","author":"Balannik","year":"2009","journal-title":"Biochemistry"},{"issue":"1","key":"D5MD01027F\/cit112\/1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.virusres.2003.10.004","volume":"99","author":"Czabotar","year":"2004","journal-title":"Virus Res."},{"issue":"10","key":"D5MD01027F\/cit113\/1","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/S0960-894X(03)00231-2","volume":"13","author":"Stylianakis","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"25","key":"D5MD01027F\/cit114\/1","doi-asserted-by":"publisher","first-page":"14772","DOI":"10.1073\/pnas.2536751100","volume":"100","author":"Cristian","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"31","key":"D5MD01027F\/cit115\/1","doi-asserted-by":"publisher","first-page":"13866","DOI":"10.1073\/pnas.1002051107","volume":"107","author":"Rosenberg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"D5MD01027F\/cit116\/1","doi-asserted-by":"publisher","first-page":"7379","DOI":"10.1073\/pnas.0902548106","volume":"106","author":"Pielak","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"D5MD01027F\/cit117\/1","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1128\/jvi.70.7.4246-4252.1996","volume":"70","author":"Tu","year":"1996","journal-title":"J. Virol."},{"issue":"21","key":"D5MD01027F\/cit118\/1","doi-asserted-by":"publisher","first-page":"11301","DOI":"10.1073\/pnas.94.21.11301","volume":"94","author":"Pinto","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"D5MD01027F\/cit119\/1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1006\/viro.1994.1628","volume":"205","author":"Wang","year":"1994","journal-title":"Virology"},{"issue":"3","key":"D5MD01027F\/cit120\/1","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/S0006-3495(96)79690-X","volume":"70","author":"Shimbo","year":"1996","journal-title":"Biophys. J."},{"issue":"8","key":"D5MD01027F\/cit121\/1","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1021\/jm101334y","volume":"54","author":"Duque","year":"2011","journal-title":"J. Med. Chem."},{"issue":"12","key":"D5MD01027F\/cit122\/1","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1021\/ml300279b","volume":"3","author":"Torres","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"issue":"7","key":"D5MD01027F\/cit123\/1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1021\/ml500108s","volume":"5","author":"Torres","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"D5MD01027F\/cit124\/1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ejmech.2015.04.030","volume":"96","author":"Rey-Carrizo","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01027F\/cit125\/1","doi-asserted-by":"publisher","first-page":"9265","DOI":"10.1021\/jm401340p","volume":"56","author":"Rey-carrizo","year":"2013","journal-title":"J. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit126\/1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.bpj.2015.11.2395","volume":"110","author":"McGuire","year":"2016","journal-title":"Biophys. J."},{"key":"D5MD01027F\/cit127\/1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.antiviral.2017.10.009","volume":"147","author":"Gordon","year":"2017","journal-title":"Antiviral Res."},{"issue":"2","key":"D5MD01027F\/cit128\/1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.antiviral.2012.09.001","volume":"96","author":"Zhao","year":"2012","journal-title":"Antiviral Res."},{"issue":"4","key":"D5MD01027F\/cit129\/1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1039\/c4md00515e","volume":"6","author":"Zhao","year":"2015","journal-title":"MedChemComm"},{"key":"D5MD01027F\/cit130\/1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ejmech.2015.12.013","volume":"108","author":"Dong","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"D5MD01027F\/cit131\/1","doi-asserted-by":"publisher","first-page":"5187","DOI":"10.1021\/acs.jmedchem.8b00042","volume":"61","author":"Zhao","year":"2018","journal-title":"J. Med. Chem."},{"key":"D5MD01027F\/cit132\/1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bioorg.2020.104106","volume":"102","author":"Dong","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"9","key":"D5MD01027F\/cit133\/1","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1021\/acschembio.0c00553","volume":"15","author":"Tzitzoglaki","year":"2020","journal-title":"ACS Chem. Biol."},{"issue":"3","key":"D5MD01027F\/cit134\/1","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1021\/acsmedchemlett.7b00458","volume":"9","author":"Drakopoulos","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"issue":"7","key":"D5MD01027F\/cit135\/1","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.1021\/jm301538e","volume":"56","author":"Wang","year":"2013","journal-title":"J. Med. Chem."},{"issue":"11","key":"D5MD01027F\/cit136\/1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1021\/acsmedchemlett.8b00336","volume":"9","author":"Hu","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"issue":"2","key":"D5MD01027F\/cit137\/1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1021\/acsmedchemlett.6b00311","volume":"8","author":"Drakopoulos","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"issue":"9","key":"D5MD01027F\/cit138\/1","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.1021\/jm901664a","volume":"53","author":"Hu","year":"2010","journal-title":"J. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit139\/1","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1021\/acs.jmedchem.7b01536","volume":"61","author":"Wang","year":"2018","journal-title":"J. Med. Chem."},{"issue":"7","key":"D5MD01027F\/cit140\/1","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.1021\/jm301538e","volume":"56","author":"Wang","year":"2013","journal-title":"J. Med. Chem."},{"issue":"11","key":"D5MD01027F\/cit141\/1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1021\/acsmedchemlett.8b00336","volume":"9","author":"Hu","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"issue":"16","key":"D5MD01027F\/cit142\/1","doi-asserted-by":"publisher","first-page":"e202300182","DOI":"10.1002\/cmdc.202300182","volume":"18","author":"Stampolaki","year":"2023","journal-title":"ChemMedChem"},{"issue":"23","key":"D5MD01027F\/cit143\/1","doi-asserted-by":"publisher","first-page":"8066","DOI":"10.1021\/ja900063s","volume":"131","author":"Wang","year":"2009","journal-title":"J. Am. Chem. Soc."},{"issue":"6","key":"D5MD01027F\/cit144\/1","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1021\/jacs.9b10984","volume":"142","author":"Movellan","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"11","key":"D5MD01027F\/cit145\/1","doi-asserted-by":"publisher","first-page":"4629","DOI":"10.1021\/jm500598u","volume":"57","author":"Kolocouris","year":"2014","journal-title":"J. Med. Chem."},{"issue":"5","key":"D5MD01027F\/cit146\/1","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1021\/acs.jmedchem.6b01115","volume":"60","author":"Tzitzoglaki","year":"2017","journal-title":"J. Med. Chem."},{"issue":"2","key":"D5MD01027F\/cit147\/1","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1021\/acsmedchemlett.6b00311","volume":"8","author":"Drakopoulos","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"issue":"5","key":"D5MD01027F\/cit148\/1","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1021\/jacs.5b13129","volume":"138","author":"Wright","year":"2016","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"D5MD01027F\/cit149\/1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1021\/acsptsci.0c00018","volume":"3","author":"Musharrafieh","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D5MD01027F\/cit150\/1","doi-asserted-by":"publisher","first-page":"100090","DOI":"10.1016\/j.yjsbx.2023.100090","volume":"8","author":"Tekwani Movellan","year":"2023","journal-title":"J. Struct. Biol.: X"},{"issue":"30","key":"D5MD01027F\/cit151\/1","doi-asserted-by":"publisher","first-page":"12283","DOI":"10.1073\/pnas.0905726106","volume":"106","author":"Ma","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5MD01027F\/cit152\/1","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fcell.2019.00093","volume":"7","author":"Kellokumpu","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"issue":"13","key":"D5MD01027F\/cit153\/1","doi-asserted-by":"publisher","first-page":"5738","DOI":"10.1021\/jm5005804","volume":"57","author":"Rey-Carrizo","year":"2014","journal-title":"J. Med. Chem."},{"issue":"1","key":"D5MD01027F\/cit154\/1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nmeth.4067","volume":"14","author":"Huang","year":"2016","journal-title":"Nat. Methods"},{"issue":"45","key":"D5MD01027F\/cit155\/1","doi-asserted-by":"publisher","first-page":"15219","DOI":"10.1021\/jacs.8b06741","author":"Thomaston","year":"2018","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"D5MD01027F\/cit156\/1","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1128\/AAC.39.10.2204","volume":"39","author":"Kurtz","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"issue":"10","key":"D5MD01027F\/cit157\/1","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1016\/j.bmc.2005.12.056","volume":"14","author":"Zoidis","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"13","key":"D5MD01027F\/cit158\/1","doi-asserted-by":"publisher","first-page":"5738","DOI":"10.1021\/jm5005804","volume":"57","author":"Rey-Carrizo","year":"2014","journal-title":"J. Med. Chem."},{"issue":"32","key":"D5MD01027F\/cit159\/1","doi-asserted-by":"publisher","first-page":"12834","DOI":"10.1021\/ja204969m","volume":"133","author":"Wang","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"23","key":"D5MD01027F\/cit160\/1","doi-asserted-by":"publisher","first-page":"9925","DOI":"10.1016\/j.bmc.2008.10.028","volume":"16","author":"Camps","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"8","key":"D5MD01027F\/cit161\/1","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1016\/j.bmc.2009.02.007","volume":"17","author":"Duque","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"D5MD01027F\/cit162\/1","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1021\/acs.jmedchem.6b01758","volume":"60","author":"Barniol-Xicota","year":"2017","journal-title":"J. Med. Chem."},{"issue":"12","key":"D5MD01027F\/cit163\/1","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1021\/ml300279b","volume":"3","author":"Torres","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"issue":"9","key":"D5MD01027F\/cit164\/1","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1016\/j.bmc.2014.03.025","volume":"22","author":"Valverde","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"9","key":"D5MD01027F\/cit165\/1","doi-asserted-by":"publisher","first-page":"3831","DOI":"10.1021\/jm901664a","volume":"53","author":"Hu","year":"2010","journal-title":"J. Med. Chem."},{"key":"D5MD01027F\/cit166\/1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ejmech.2015.04.030","volume":"96","author":"Rey-Carrizo","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"D5MD01027F\/cit167\/1","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1021\/acs.jmedchem.6b01115","volume":"60","author":"Tzitzoglaki","year":"2017","journal-title":"J. Med. Chem."},{"issue":"16","key":"D5MD01027F\/cit168\/1","doi-asserted-by":"publisher","first-page":"6781","DOI":"10.1021\/acs.jmedchem.7b00057","volume":"60","author":"Spyrakis","year":"2017","journal-title":"J. Med. Chem."},{"issue":"12","key":"D5MD01027F\/cit169\/1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1021\/ar000033j","volume":"33","author":"Kollman","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"D5MD01027F\/cit170\/1","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.1021\/acs.chemrev.9b00055","author":"Wang","year":"2019","journal-title":"Chem. Rev."},{"issue":"2","key":"D5MD01027F\/cit171\/1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0021-9991(76)90078-4","volume":"22","author":"Bennett","year":"1976","journal-title":"J. Comput. Phys."},{"issue":"12","key":"D5MD01027F\/cit172\/1","doi-asserted-by":"publisher","first-page":"124105","DOI":"10.1063\/1.2978177","volume":"129","author":"Shirts","year":"2008","journal-title":"J. Chem. Phys."},{"issue":"1","key":"D5MD01027F\/cit173\/1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1021\/acs.jcim.5b00467","volume":"56","author":"Homeyer","year":"2016","journal-title":"J. Chem. Inf. Model."},{"issue":"2","key":"D5MD01027F\/cit174\/1","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1021\/ct300899n","volume":"9","author":"Gkeka","year":"2013","journal-title":"J. Chem. Theory Comput."},{"issue":"5","key":"D5MD01027F\/cit175\/1","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1021\/acs.jcim.6b00079","volume":"56","author":"Ioannidis","year":"2016","journal-title":"J. Chem. Inf. Model."},{"issue":"1","key":"D5MD01027F\/cit176\/1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1021\/acs.jctc.9b00591","volume":"16","author":"Tian","year":"2020","journal-title":"J. Chem. Theory Comput."},{"issue":"12","key":"D5MD01027F\/cit177\/1","doi-asserted-by":"publisher","first-page":"124105","DOI":"10.1063\/1.2978177","volume":"129","author":"Shirts","year":"2008","journal-title":"J. Chem. Phys."},{"issue":"5","key":"D5MD01027F\/cit178\/1","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1021\/cr100264t","volume":"113","author":"Wanka","year":"2013","journal-title":"Chem. Rev."},{"issue":"26","key":"D5MD01027F\/cit179\/1","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.2174\/092986710792065027","volume":"17","author":"Lamoureux","year":"2010","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"D5MD01027F\/cit180\/1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3390\/molecules22020297","volume":"22","author":"\u0160timac","year":"2017","journal-title":"Molecules"},{"issue":"6","key":"D5MD01027F\/cit181\/1","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1016\/j.ejmech.2011.01.047","volume":"46","author":"Liu","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"3620","key":"D5MD01027F\/cit182\/1","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1126\/science.144.3620.862","volume":"144","author":"Davies","year":"1964","journal-title":"Science"},{"issue":"2","key":"D5MD01027F\/cit183\/1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1021\/jm00296a021","volume":"13","author":"Whitney","year":"1970","journal-title":"J. Med. Chem."},{"issue":"6","key":"D5MD01027F\/cit184\/1","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1021\/jm00288a019","volume":"14","author":"Aldrich","year":"1971","journal-title":"J. Med. Chem."},{"issue":"2","key":"D5MD01027F\/cit185\/1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1021\/jm00272a003","volume":"15","author":"Lundahl","year":"1972","journal-title":"J. Med. Chem."},{"issue":"2","key":"D5MD01027F\/cit186\/1","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1021\/jm00272a004","volume":"15","author":"Van Hes","year":"1972","journal-title":"J. Med. Chem."},{"issue":"5","key":"D5MD01027F\/cit187\/1","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0960-894X(01)00838-1","volume":"12","author":"Kolocouris","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"17","key":"D5MD01027F\/cit188\/1","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1021\/jm950891z","volume":"39","author":"Kolocouris","year":"1996","journal-title":"J. Med. Chem."},{"issue":"10","key":"D5MD01027F\/cit189\/1","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1016\/j.bmc.2005.12.056","volume":"14","author":"Zoidis","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit190\/1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.bmcl.2006.10.092","volume":"17","author":"Tataridis","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"D5MD01027F\/cit191\/1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.bioorg.2006.05.004","volume":"34","author":"Setaki","year":"2006","journal-title":"Bioorg. Chem."},{"issue":"24","key":"D5MD01027F\/cit192\/1","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.1016\/j.bmc.2003.09.024","volume":"11","author":"Stamatiou","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit193\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/095632020301400305","volume":"14","author":"Zoidis","year":"2003","journal-title":"Antiviral Chem. Chemother."},{"issue":"18","key":"D5MD01027F\/cit194\/1","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1021\/jm00044a010","volume":"37","author":"Kolocouris","year":"1994","journal-title":"J. Med. Chem."},{"issue":"15","key":"D5MD01027F\/cit195\/1","doi-asserted-by":"publisher","first-page":"4358","DOI":"10.1016\/j.bmcl.2007.04.108","volume":"17","author":"Kolocouris","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"24","key":"D5MD01027F\/cit196\/1","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/S0960-894X(99)00631-9","volume":"9","author":"Kolocouris","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"16","key":"D5MD01027F\/cit197\/1","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/S0960-894X(01)00388-2","volume":"11","author":"Stamatiou","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"6","key":"D5MD01027F\/cit198\/1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bioorg.2010.09.001","volume":"38","author":"Fytas","year":"2010","journal-title":"Bioorg. Chem."},{"key":"D5MD01027F\/cit199\/1","doi-asserted-by":"publisher","first-page":"106104","DOI":"10.1016\/j.antiviral.2025.106104","volume":"236","author":"Tietjen","year":"2025","journal-title":"Antiviral Res."},{"issue":"23","key":"D5MD01027F\/cit200\/1","doi-asserted-by":"publisher","first-page":"8066","DOI":"10.1021\/ja900063s","volume":"131","author":"Wang","year":"2009","journal-title":"J. Am. Chem. Soc."},{"issue":"8","key":"D5MD01027F\/cit201\/1","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1021\/jm101334y","volume":"54","author":"Duque","year":"2011","journal-title":"J. Med. Chem."},{"issue":"7","key":"D5MD01027F\/cit202\/1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1021\/ml500108s","volume":"5","author":"Torres","year":"2014","journal-title":"ACS Med. Chem. Lett."},{"key":"D5MD01027F\/cit203\/1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.ejmech.2015.04.030","volume":"96","author":"Rey-Carrizo","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01027F\/cit204\/1","doi-asserted-by":"publisher","first-page":"9265","DOI":"10.1021\/jm401340p","volume":"56","author":"Rey-carrizo","year":"2013","journal-title":"J. Med. Chem."},{"issue":"2","key":"D5MD01027F\/cit205\/1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.antiviral.2012.09.001","volume":"96","author":"Zhao","year":"2012","journal-title":"Antiviral Res."},{"issue":"4","key":"D5MD01027F\/cit206\/1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1039\/c4md00515e","volume":"6","author":"Zhao","year":"2015","journal-title":"MedChemComm"},{"issue":"4","key":"D5MD01027F\/cit207\/1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1021\/ml100297w","volume":"2","author":"Wang","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"issue":"15","key":"D5MD01027F\/cit208\/1","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.1016\/j.bmc.2015.06.030","volume":"23","author":"Torres-G\u00f3mez","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"D5MD01027F\/cit209\/1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1039\/D1OB01916C","volume":"20","author":"Weigel","year":"2022","journal-title":"Org. Biomol. Chem."},{"issue":"03","key":"D5MD01027F\/cit210\/1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1055\/s-0037-1610321","volume":"51","author":"Hrdina","year":"2019","journal-title":"Synthesis"},{"issue":"23","key":"D5MD01027F\/cit211\/1","doi-asserted-by":"publisher","first-page":"9925","DOI":"10.1016\/j.bmc.2008.10.028","volume":"16","author":"Camps","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit212\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/095632020301400305","volume":"14","author":"Zoidis","year":"2003","journal-title":"Antiviral Chem. Chemother."},{"issue":"5","key":"D5MD01027F\/cit213\/1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/0223-5234(91)90154-F","volume":"26","author":"Fytas","year":"1991","journal-title":"Eur. J. Med. Chem."},{"issue":"34","key":"D5MD01027F\/cit214\/1","doi-asserted-by":"publisher","first-page":"130408","DOI":"10.1016\/j.tet.2019.06.016","volume":"75","author":"Tzitzoglaki","year":"2019","journal-title":"Tetrahedron"},{"issue":"24","key":"D5MD01027F\/cit215\/1","doi-asserted-by":"publisher","first-page":"5485","DOI":"10.1016\/j.bmc.2003.09.024","volume":"11","author":"Stamatiou","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"24","key":"D5MD01027F\/cit216\/1","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1016\/S0960-894X(99)00631-9","volume":"9","author":"Kolocouris","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"18","key":"D5MD01027F\/cit217\/1","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1021\/jm00044a010","volume":"37","author":"Kolocouris","year":"1994","journal-title":"J. Med. Chem."},{"issue":"22","key":"D5MD01027F\/cit219\/1","doi-asserted-by":"publisher","first-page":"7636","DOI":"10.3390\/molecules28227636","volume":"28","author":"Todd","year":"2023","journal-title":"Molecules"},{"issue":"2","key":"D5MD01027F\/cit220\/1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.5562\/cca3540","volume":"92","author":"Pardali","year":"2019","journal-title":"Croat. Chem. Acta"},{"issue":"5","key":"D5MD01027F\/cit221\/1","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1021\/acs.jmedchem.6b01115","volume":"60","author":"Tzitzoglaki","year":"2017","journal-title":"J. Med. Chem."},{"issue":"3","key":"D5MD01027F\/cit222\/1","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1021\/acs.jmedchem.5b01910","volume":"59","author":"Li","year":"2016","journal-title":"J. Med. Chem."},{"issue":"10","key":"D5MD01027F\/cit223\/1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1021\/acsinfecdis.6b00130","volume":"2","author":"Li","year":"2016","journal-title":"ACS Infect. Dis."},{"issue":"4","key":"D5MD01027F\/cit224\/1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1073\/pnas.1216526110","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D5MD01027F\/cit225\/1","doi-asserted-by":"publisher","first-page":"100083","DOI":"10.1016\/j.ejmcr.2022.100083","volume":"6","author":"Tzitzoglaki","year":"2022","journal-title":"Eur. J. Med. Chem. Rep."},{"issue":"52","key":"D5MD01027F\/cit226\/1","doi-asserted-by":"publisher","first-page":"17987","DOI":"10.1021\/ja508461m","volume":"136","author":"Wu","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D5MD01027F\/cit227\/1","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1111\/bph.13504","volume":"173","author":"Vauquelin","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"D5MD01027F\/cit228\/1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ejmech.2010.10.010","volume":"46","author":"Zhao","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01027F\/cit229\/1","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1021\/acs.jmedchem.6b01852","volume":"60","author":"Li","year":"2017","journal-title":"J. Med. Chem."},{"key":"D5MD01027F\/cit230\/1","doi-asserted-by":"publisher","first-page":"100083","DOI":"10.1016\/j.ejmcr.2022.100083","volume":"6","author":"Tzitzoglaki","year":"2022","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"D5MD01027F\/cit231\/1","doi-asserted-by":"publisher","first-page":"105124","DOI":"10.1016\/j.ejps.2019.105124","volume":"141","author":"Musharrafieh","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"D5MD01027F\/cit232\/1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1124\/mol.119.116640","volume":"96","author":"Musharrafieh","year":"2019","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"D5MD01027F\/cit233\/1","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1021\/acs.jmedchem.5b01910","volume":"59","author":"Li","year":"2016","journal-title":"J. Med. Chem."},{"issue":"10","key":"D5MD01027F\/cit234\/1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1021\/acsinfecdis.6b00130","volume":"2","author":"Li","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"D5MD01027F\/cit235\/1","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1021\/acs.jmedchem.6b01852","volume":"60","author":"Li","year":"2017","journal-title":"J. Med. Chem."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D5MD01027F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:43:56Z","timestamp":1782852236000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/17\/4\/1811-1846\/1236628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":234,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md01027f","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}