{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:53:57Z","timestamp":1782885237446,"version":"3.54.5"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2027,4,24]],"date-time":"2027-04-24T00:00:00Z","timestamp":1808524800000},"content-version":"am","delay-in-days":478,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100004972","name":"Maryland Industrial Partnerships","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 GM158458"],"award-info":[{"award-number":["T32 GM158458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>4,6-Disubstituted quinolinones are potent BRD4 inhibitors.<\/jats:p>","DOI":"10.1039\/d5md01082a","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:34:51Z","timestamp":1777023291000},"page":"2630-2643","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lead optimization of\n                    <b>5jc21<\/b>\n                    (CG13250), a quinolin-2(1\n                    <i>H<\/i>\n                    )-one-based inhibitor of the BRD4 member of the bromodomain and extraterminal (BET) family of proteins"],"prefix":"10.1039","volume":"17","author":[{"given":"Jay","family":"Chauhan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pogash","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Convergene, 4800 Montgomery Lane, c\/o Dreyfuss 10th Floor, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun","family":"Raje","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Van Eker","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Strovel","sequence":"additional","affiliation":[{"name":"Convergene, 4800 Montgomery Lane, c\/o Dreyfuss 10th Floor, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-8334","authenticated-orcid":false,"given":"Steven","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St, Baltimore, MD 21201, USA"},{"name":"University of Maryland Marlene & Stewart Greenebaum Cancer Centre, 20 S. Greene St, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5MD01082A\/cit1\/1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"D5MD01082A\/cit2\/1","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1517\/14728222.7.5.623","volume":"7","author":"Pelengaris","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"D5MD01082A\/cit3\/1","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.bbagrm.2014.03.005","volume":"1849","author":"Fletcher","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"D5MD01082A\/cit4\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bmcl.2012.10.013","volume":"23","author":"Yap","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD01082A\/cit5\/1","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1021\/jm501440q","volume":"58","author":"Jung","year":"2015","journal-title":"J. Med. Chem."},{"key":"D5MD01082A\/cit6\/1","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1002\/cmdc.201402189","volume":"9","author":"Chauhan","year":"2014","journal-title":"ChemMedChem"},{"key":"D5MD01082A\/cit7\/1","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/s41417-022-00455-4","volume":"29","author":"Shukla","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"D5MD01082A\/cit8\/1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.18632\/oncotarget.1108","volume":"4","author":"Wang","year":"2013","journal-title":"Oncotarget"},{"key":"D5MD01082A\/cit9\/1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.70127","author":"Sriratanasak","year":"2026","journal-title":"Mol. Oncol."},{"key":"D5MD01082A\/cit10\/1","doi-asserted-by":"publisher","first-page":"e187204","DOI":"10.1172\/JCI187204","volume":"135","author":"Chareddy","year":"2025","journal-title":"J. Clin. Invest."},{"key":"D5MD01082A\/cit11\/1","doi-asserted-by":"publisher","first-page":"19184","DOI":"10.1021\/acs.jmedchem.5c01307","volume":"68","author":"Yang","year":"2025","journal-title":"J. Med. Chem."},{"key":"D5MD01082A\/cit12\/1","doi-asserted-by":"publisher","first-page":"118209","DOI":"10.1016\/j.ejmech.2025.118209","volume":"301","author":"Gao","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01082A\/cit13\/1","doi-asserted-by":"publisher","first-page":"e202508518","DOI":"10.1002\/anie.202508518","volume":"64","author":"Rosen","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5MD01082A\/cit14\/1","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12943-018-0915-9","volume":"17","author":"Donati","year":"2018","journal-title":"Mol. Cancer"},{"key":"D5MD01082A\/cit15\/1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1158\/1078-0432.CCR-13-2281","volume":"20","author":"Bandopadhayay","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"D5MD01082A\/cit16\/1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1038\/s41419-022-05505-1","volume":"13","author":"Hu","year":"2022","journal-title":"Cell Death Dis."},{"key":"D5MD01082A\/cit17\/1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","volume":"146","author":"Delmore","year":"2011","journal-title":"Cell"},{"key":"D5MD01082A\/cit18\/1","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/nature09504","volume":"468","author":"Filippakopoulos","year":"2010","journal-title":"Nature"},{"key":"D5MD01082A\/cit19\/1","doi-asserted-by":"publisher","first-page":"102323","DOI":"10.1016\/j.cbpa.2023.102323","volume":"75","author":"Gajjela","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D5MD01082A\/cit20\/1","doi-asserted-by":"publisher","first-page":"118230","DOI":"10.1016\/j.ejmech.2025.118230","volume":"301","author":"Zhang","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"D5MD01082A\/cit21\/1","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.3390\/molecules28073043","volume":"28","author":"To","year":"2023","journal-title":"Molecules"},{"key":"D5MD01082A\/cit22\/1","doi-asserted-by":"publisher","first-page":"102670","DOI":"10.1016\/j.rechem.2025.102670","volume":"18","author":"Deng","year":"2025","journal-title":"Results Chem."},{"key":"D5MD01082A\/cit23\/1","doi-asserted-by":"crossref","first-page":"8073","DOI":"10.1021\/jm4011302","volume":"56","author":"Vidler","year":"2013","journal-title":"J. Med. Chem."},{"key":"D5MD01082A\/cit24\/1","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1021\/jm401088k","volume":"56","author":"Mirguet","year":"2013","journal-title":"J. Med. Chem."},{"key":"D5MD01082A\/cit25\/1","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1021\/acs.molpharmaceut.8b00880","volume":"15","author":"Gu","year":"2018","journal-title":"Mol. Pharmaceutics"},{"key":"D5MD01082A\/cit26\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature10509","volume":"478","author":"Dawson","year":"2011","journal-title":"Nature"},{"key":"D5MD01082A\/cit27\/1","doi-asserted-by":"crossref","first-page":"129220","DOI":"10.1016\/j.bmcl.2023.129220","volume":"86","author":"Chauhan","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD01082A\/cit28\/1","doi-asserted-by":"publisher","first-page":"8369","DOI":"10.1021\/acs.jmedchem.7b00746","volume":"60","author":"McDaniel","year":"2017","journal-title":"J. Med. Chem."},{"key":"D5MD01082A\/cit29\/1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1126\/science.aaz8455","volume":"368","author":"Gilan","year":"2020","journal-title":"Science"},{"key":"D5MD01082A\/cit30\/1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.bbrc.2017.01.088","volume":"484","author":"Imayoshi","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D5MD01082A\/cit31\/1","doi-asserted-by":"publisher","first-page":"102057","DOI":"10.1016\/j.pupt.2021.102057","volume":"70","author":"Kaneshita","year":"2021","journal-title":"Pulm. Pharmacol. Ther."},{"key":"D5MD01082A\/cit32\/1","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1016\/j.bmcl.2018.08.039","volume":"28","author":"Yang","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5MD01082A\/cit33\/1","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1021\/acsmedchemlett.5b00084","volume":"6","author":"Chen","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"D5MD01082A\/cit34\/1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41573-021-00371-6","volume":"21","author":"B\u00e9k\u00e9s","year":"2022","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5MD01082A\/cit35\/1","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.chembiol.2024.07.005","volume":"31","author":"Raina","year":"2024","journal-title":"Cell Chem. Biol."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D5MD01082A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:38:30Z","timestamp":1782880710000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/17\/5\/2630-2643\/1228357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,27]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md01082a","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}