{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:03:06Z","timestamp":1782975786915,"version":"3.54.5"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2027,2,11]],"date-time":"2027-02-11T00:00:00Z","timestamp":1802304000000},"content-version":"am","delay-in-days":406,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220611"],"award-info":[{"award-number":["BK20220611"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    Compound 2R, a verbenone\u2013selenophene hybrid, selectively inhibits A549 cells\n                    <jats:italic>via<\/jats:italic>\n                    ROS-mediated mitochondrial dysfunction, apoptosis and G0\/G1 arrest, with efficacy confirmed in a 3D tumor spheroid model.\n                  <\/jats:p>","DOI":"10.1039\/d5md01140j","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:23:08Z","timestamp":1770816188000},"page":"2130-2143","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Verbenone-based selenophene derivatives as potential anti-cancer agents: synthesis and biological evaluation in 2D and 3D A549 cell models"],"prefix":"10.1039","volume":"17","author":[{"given":"Jiale","family":"Han","sequence":"first","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"},{"name":"Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, Jiangsu, 226001, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-4739","authenticated-orcid":false,"given":"Biao","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"},{"name":"Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, Jiangsu, 226001, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2459-0573","authenticated-orcid":false,"given":"Xiaodong","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"},{"name":"Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, Jiangsu, 226001, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-9898","authenticated-orcid":false,"given":"Yunyun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong 226001, China"},{"name":"Nantong Key Laboratory of Small Molecular Drug Innovation, Nantong University, Nantong, Jiangsu, 226001, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"D5MD01140J\/cit1\/1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. Clin."},{"issue":"4","key":"D5MD01140J\/cit2\/1","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.annonc.2022.12.013","volume":"34","author":"Hendriks","year":"2023","journal-title":"Ann. Oncol."},{"issue":"11","key":"D5MD01140J\/cit3\/1","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/medicina60111845","volume":"60","author":"Stylianou","year":"2024","journal-title":"Medicina"},{"issue":"16","key":"D5MD01140J\/cit4\/1","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.3390\/cancers16162810","volume":"16","author":"Exertier","year":"2024","journal-title":"Cancers"},{"issue":"1","key":"D5MD01140J\/cit5\/1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/1389201022666210122125854","volume":"23","author":"Das","year":"2022","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"10","key":"D5MD01140J\/cit6\/1","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1021\/acs.jnatprod.4c01158","volume":"87","author":"Haldar","year":"2024","journal-title":"J. Nat. Prod."},{"issue":"12","key":"D5MD01140J\/cit7\/1","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/S1875-5364(24)60726-0","volume":"22","author":"Li","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"D5MD01140J\/cit8\/1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.jare.2023.11.007","volume":"63","author":"Xu","year":"2024","journal-title":"J. Adv. Res."},{"issue":"6","key":"D5MD01140J\/cit9\/1","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1021\/acs.jmedchem.7b00315","volume":"61","author":"Talele","year":"2018","journal-title":"J. Med. Chem."},{"key":"D5MD01140J\/cit10\/1","doi-asserted-by":"publisher","first-page":"115031","DOI":"10.1016\/j.ejmech.2022.115031","volume":"247","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"D5MD01140J\/cit11\/1","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1021\/acs.jnatprod.8b01022","volume":"82","author":"Ertl","year":"2019","journal-title":"J. Nat. Prod."},{"key":"D5MD01140J\/cit12\/1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.biochi.2024.09.002","volume":"228","author":"Vyhl\u00eddalov\u00e1","year":"2025","journal-title":"Biochimie"},{"key":"D5MD01140J\/cit13\/1","doi-asserted-by":"publisher","first-page":"107837","DOI":"10.1016\/j.biotechadv.2021.107837","volume":"53","author":"Zhu","year":"2021","journal-title":"Biotechnol. Adv."},{"key":"D5MD01140J\/cit14\/1","doi-asserted-by":"publisher","first-page":"131999","DOI":"10.1016\/j.molstruc.2021.131999","volume":"1251","author":"Petrovi\u0107","year":"2022","journal-title":"J. Mol. Struct."},{"issue":"10","key":"D5MD01140J\/cit15\/1","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.3390\/molecules24101970","volume":"24","author":"Lara-Issasi","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"D5MD01140J\/cit16\/1","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.3390\/molecules27092612","volume":"27","author":"Gonz\u00e1lez-Velasco","year":"2022","journal-title":"Molecules"},{"key":"D5MD01140J\/cit17\/1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jep.2018.04.021","volume":"222","author":"Bahramsoltani","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"D5MD01140J\/cit18\/1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3390\/plants11060785","volume":"11","author":"Rashid","year":"2022","journal-title":"Plants"},{"issue":"17","key":"D5MD01140J\/cit19\/1","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.4155\/fmc-2023-0173","volume":"15","author":"Fawzi","year":"2023","journal-title":"Future Med. Chem."},{"issue":"6","key":"D5MD01140J\/cit20\/1","doi-asserted-by":"publisher","first-page":"4436","DOI":"10.1021\/acs.jmedchem.1c01859","volume":"65","author":"Hou","year":"2022","journal-title":"J. Med. Chem."},{"issue":"24","key":"D5MD01140J\/cit21\/1","doi-asserted-by":"publisher","first-page":"5907","DOI":"10.3390\/molecules25245907","volume":"25","author":"Hellwig","year":"2020","journal-title":"Molecules"},{"issue":"3","key":"D5MD01140J\/cit22\/1","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.3390\/ijms22031009","volume":"22","author":"Radomska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D5MD01140J\/cit23\/1","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1134\/S1068162022060279","volume":"48","author":"Yildirim","year":"2022","journal-title":"Russ. J. Bioorg. Chem."},{"issue":"275","key":"D5MD01140J\/cit24\/1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cbi.2017.07.015","volume":"25","author":"Domazetovic","year":"2017","journal-title":"Chem.-Biol. Interact."},{"issue":"4","key":"D5MD01140J\/cit25\/1","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/j.bmc.2011.01.005","volume":"19","author":"Schumacher","year":"2011","journal-title":"Bioorg. Med. Chem."},{"issue":"13","key":"D5MD01140J\/cit26\/1","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1002\/asia.201600472","volume":"11","author":"Paegle","year":"2016","journal-title":"Chem. \u2013 Asian J."},{"issue":"2","key":"D5MD01140J\/cit27\/1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/molecules23020507","volume":"23","author":"M\u00e1nikov\u00e1","year":"2018","journal-title":"Molecules"},{"issue":"5","key":"D5MD01140J\/cit28\/1","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1039\/c6ob02729f","volume":"15","author":"Mhetre","year":"2017","journal-title":"Org. Biomol. Chem."},{"issue":"1","key":"D5MD01140J\/cit29\/1","doi-asserted-by":"publisher","first-page":"2198163","DOI":"10.1080\/14756366.2023.2198163","volume":"38","author":"El-Kalyoubi","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"5","key":"D5MD01140J\/cit30\/1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.bcp.2006.10.019","volume":"73","author":"Shiah","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"D5MD01140J\/cit31\/1","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ejmech.2014.09.088","volume":"87","author":"Arsenyan","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"15","key":"D5MD01140J\/cit32\/1","doi-asserted-by":"publisher","first-page":"4174","DOI":"10.1039\/d2sc06860e","volume":"14","author":"Liu","year":"2023","journal-title":"Chem. Sci."},{"issue":"7\u20138","key":"D5MD01140J\/cit33\/1","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1159\/000504482","volume":"105","author":"Zhu","year":"2020","journal-title":"Pharmacology"},{"issue":"4","key":"D5MD01140J\/cit34\/1","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1021\/ci300083r","volume":"52","author":"Meslamani","year":"2012","journal-title":"J. Chem. Inf. Model."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MD\/D5MD01140J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:38:57Z","timestamp":1782970737000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/17\/4\/2130-2143\/1240274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d5md01140j","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5MD01140J\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD01140J\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD01140J\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD01140J\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD01140J\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5MD01140J\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}