{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:28:28Z","timestamp":1791804508624,"version":"4.3.4"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2027,5,5]],"date-time":"2027-05-05T00:00:00Z","timestamp":1809475200000},"content-version":"am","delay-in-days":489,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171354"],"award-info":[{"award-number":["32171354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371003"],"award-info":[{"award-number":["82371003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Mater. Horiz."],"abstract":"<jats:p>This study introduces a Ca\/SrP microflower-doped triple-network hydrogel that modulates inflammation, promotes angiogenesis and osteogenesis, and restores mandibular bone defects.<\/jats:p>","DOI":"10.1039\/d5mh02395e","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:26:53Z","timestamp":1777980413000},"page":"6434-6449","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A bioactive microflower doped triple-network hydrogel for immunomodulation-mediated angio\/osteogenesis coordination in mandibular bone regeneration"],"prefix":"10.1039","volume":"13","author":[{"given":"Haochen","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-4030","authenticated-orcid":false,"given":"Jinfeng","family":"Liao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5MH02395E\/cit1\/1","doi-asserted-by":"crossref","first-page":"e2208781","DOI":"10.1002\/adma.202208781","volume":"35","author":"Su","year":"2023","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit2\/1","doi-asserted-by":"crossref","first-page":"121333","DOI":"10.1016\/j.biomaterials.2021.121333","volume":"281","author":"Moncal","year":"2022","journal-title":"Biomaterials"},{"key":"D5MH02395E\/cit3\/1","doi-asserted-by":"crossref","first-page":"9592","DOI":"10.1038\/s41467-024-53824-y","volume":"15","author":"Bai","year":"2024","journal-title":"Nat. Commun."},{"key":"D5MH02395E\/cit4\/1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41586-024-08208-z","volume":"636","author":"Robin","year":"2024","journal-title":"Nature"},{"key":"D5MH02395E\/cit5\/1","doi-asserted-by":"crossref","first-page":"e2206981","DOI":"10.1002\/advs.202206981","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"D5MH02395E\/cit6\/1","doi-asserted-by":"crossref","first-page":"108889","DOI":"10.1016\/j.cclet.2023.108889","volume":"35","author":"Zhang","year":"2024","journal-title":"Chinese Chem. Lett."},{"key":"D5MH02395E\/cit7\/1","doi-asserted-by":"crossref","first-page":"e2310876","DOI":"10.1002\/adma.202310876","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit8\/1","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.1038\/s41467-025-63270-z","volume":"16","author":"Fan","year":"2025","journal-title":"Nat. Commun."},{"key":"D5MH02395E\/cit9\/1","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1038\/s41467-023-41594-y","volume":"14","author":"Vinikoor","year":"2023","journal-title":"Nat. Commun."},{"key":"D5MH02395E\/cit10\/1","doi-asserted-by":"crossref","first-page":"18669","DOI":"10.1021\/acsnano.3c03857","volume":"17","author":"Ou","year":"2023","journal-title":"ACS Nano"},{"key":"D5MH02395E\/cit11\/1","doi-asserted-by":"crossref","first-page":"e2416715","DOI":"10.1002\/adma.202416715","volume":"37","author":"Wu","year":"2025","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit12\/1","doi-asserted-by":"crossref","first-page":"122948","DOI":"10.1016\/j.biomaterials.2024.122948","volume":"315","author":"Yun","year":"2025","journal-title":"Biomaterials"},{"key":"D5MH02395E\/cit13\/1","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1021\/acs.nanolett.3c04977","volume":"24","author":"Tan","year":"2024","journal-title":"Nano Lett."},{"key":"D5MH02395E\/cit14\/1","first-page":"267","volume":"21","author":"Cai","year":"2023","journal-title":"Bioact. Mater."},{"key":"D5MH02395E\/cit15\/1","doi-asserted-by":"crossref","first-page":"70005","DOI":"10.1002\/EXP.70005","volume":"5","author":"Du","year":"2025","journal-title":"Exploration"},{"key":"D5MH02395E\/cit16\/1","doi-asserted-by":"crossref","first-page":"2407483","DOI":"10.1002\/adfm.202407483","volume":"34","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5MH02395E\/cit17\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41577-019-0178-8","volume":"19","author":"Tsukasaki","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"D5MH02395E\/cit18\/1","first-page":"564","volume":"41","author":"Xu","year":"2024","journal-title":"Bioact. Mater."},{"key":"D5MH02395E\/cit19\/1","doi-asserted-by":"crossref","first-page":"121114","DOI":"10.1016\/j.biomaterials.2021.121114","volume":"277","author":"Newman","year":"2021","journal-title":"Biomaterials"},{"key":"D5MH02395E\/cit20\/1","doi-asserted-by":"publisher","first-page":"111641","DOI":"10.1016\/j.cclet.2025.111641","author":"Shen","year":"2025","journal-title":"Chinese Chem. Lett."},{"key":"D5MH02395E\/cit21\/1","doi-asserted-by":"crossref","first-page":"2401109","DOI":"10.1002\/adfm.202401109","volume":"34","author":"Yu","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5MH02395E\/cit22\/1","doi-asserted-by":"crossref","first-page":"e2304641","DOI":"10.1002\/advs.202304641","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"key":"D5MH02395E\/cit23\/1","doi-asserted-by":"crossref","first-page":"e2400229","DOI":"10.1002\/advs.202400229","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci."},{"key":"D5MH02395E\/cit24\/1","doi-asserted-by":"crossref","first-page":"2406237","DOI":"10.1002\/adfm.202406237","volume":"34","author":"Lee","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D5MH02395E\/cit25\/1","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1021\/acs.chemrev.1c00815","volume":"122","author":"Zhao","year":"2022","journal-title":"Chem. Rev."},{"key":"D5MH02395E\/cit26\/1","doi-asserted-by":"crossref","first-page":"e2304896","DOI":"10.1002\/adma.202304896","volume":"35","author":"Xiao","year":"2023","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit27\/1","first-page":"267","volume":"18","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"key":"D5MH02395E\/cit28\/1","first-page":"85","volume":"42","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"key":"D5MH02395E\/cit29\/1","doi-asserted-by":"crossref","first-page":"2302442","DOI":"10.1002\/adfm.202302442","volume":"33","author":"Zou","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D5MH02395E\/cit30\/1","doi-asserted-by":"crossref","first-page":"5708","DOI":"10.1021\/acsnano.5c17200","volume":"20","author":"An","year":"2026","journal-title":"ACS Nano"},{"key":"D5MH02395E\/cit31\/1","doi-asserted-by":"crossref","first-page":"102705","DOI":"10.1016\/j.cis.2022.102705","volume":"305","author":"Karimzadeh","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"key":"D5MH02395E\/cit32\/1","doi-asserted-by":"crossref","first-page":"e12267","DOI":"10.1002\/adma.202512267","volume":"38","author":"Chen","year":"2026","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit33\/1","doi-asserted-by":"crossref","first-page":"30437","DOI":"10.1021\/acsami.7b09176","volume":"9","author":"Tian","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5MH02395E\/cit34\/1","doi-asserted-by":"publisher","first-page":"111411","DOI":"10.1016\/j.cclet.2025.111411","author":"Zhu","year":"2025","journal-title":"Chinese Chem. Lett."},{"key":"D5MH02395E\/cit35\/1","doi-asserted-by":"crossref","first-page":"123798","DOI":"10.1016\/j.jhazmat.2020.123798","volume":"401","author":"Yue","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"D5MH02395E\/cit36\/1","doi-asserted-by":"crossref","first-page":"e2413901","DOI":"10.1002\/adma.202413901","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit37\/1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1151-2916.2001.tb00653.x","volume":"84","author":"Tas","year":"2001","journal-title":"J. Am. Ceram. Soc."},{"key":"D5MH02395E\/cit38\/1","doi-asserted-by":"crossref","first-page":"121812","DOI":"10.1016\/j.carbpol.2024.121812","volume":"330","author":"Gao","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"D5MH02395E\/cit39\/1","doi-asserted-by":"crossref","first-page":"e2205325","DOI":"10.1002\/advs.202205325","volume":"9","author":"Sun","year":"2022","journal-title":"Adv. Sci."},{"key":"D5MH02395E\/cit40\/1","first-page":"615","volume":"25","author":"Zhou","year":"2023","journal-title":"Bioact. Mater."},{"key":"D5MH02395E\/cit41\/1","doi-asserted-by":"crossref","first-page":"e2108430","DOI":"10.1002\/adma.202108430","volume":"34","author":"Li","year":"2022","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit42\/1","doi-asserted-by":"crossref","first-page":"270008","DOI":"10.1002\/EXP.70008","volume":"5","author":"Xu","year":"2025","journal-title":"Exploration"},{"key":"D5MH02395E\/cit43\/1","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1038\/s41467-024-47696-5","volume":"15","author":"Han","year":"2024","journal-title":"Nat. Commun."},{"key":"D5MH02395E\/cit44\/1","doi-asserted-by":"crossref","first-page":"35214","DOI":"10.1021\/acsnano.4c08727","volume":"18","author":"Cai","year":"2024","journal-title":"ACS Nano"},{"key":"D5MH02395E\/cit45\/1","doi-asserted-by":"crossref","first-page":"112903","DOI":"10.1016\/j.matdes.2024.112903","volume":"241","author":"Chen","year":"2024","journal-title":"Mater. Des."},{"key":"D5MH02395E\/cit46\/1","doi-asserted-by":"crossref","first-page":"157088","DOI":"10.1016\/j.cej.2024.157088","volume":"500","author":"Wang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5MH02395E\/cit47\/1","doi-asserted-by":"crossref","first-page":"156915","DOI":"10.1016\/j.cej.2024.156915","volume":"500","author":"Xiang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5MH02395E\/cit48\/1","doi-asserted-by":"crossref","first-page":"eabf6654","DOI":"10.1126\/sciadv.abf6654","volume":"7","author":"Zhu","year":"2021","journal-title":"Sci. Adv."},{"key":"D5MH02395E\/cit49\/1","doi-asserted-by":"crossref","first-page":"119833","DOI":"10.1016\/j.biomaterials.2020.119833","volume":"239","author":"Mahon","year":"2020","journal-title":"Biomaterials"},{"key":"D5MH02395E\/cit50\/1","doi-asserted-by":"crossref","first-page":"151789","DOI":"10.1016\/j.cej.2024.151789","volume":"491","author":"Yao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5MH02395E\/cit51\/1","doi-asserted-by":"publisher","first-page":"e2502919","DOI":"10.1002\/adma.202502919,","author":"Yang","year":"2025","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit52\/1","doi-asserted-by":"crossref","first-page":"111319","DOI":"10.1016\/j.cclet.2025.111319","volume":"37","author":"Zhao","year":"2025","journal-title":"Chinese Chem. Lett."},{"key":"D5MH02395E\/cit53\/1","doi-asserted-by":"crossref","first-page":"e2414543","DOI":"10.1002\/adma.202414543","volume":"37","author":"Shuai","year":"2025","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit54\/1","doi-asserted-by":"crossref","first-page":"20230149","DOI":"10.1002\/EXP.20230149","volume":"4","author":"Sui","year":"2024","journal-title":"Exploration"},{"key":"D5MH02395E\/cit55\/1","doi-asserted-by":"crossref","first-page":"e2411571","DOI":"10.1002\/adma.202411571","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"key":"D5MH02395E\/cit56\/1","doi-asserted-by":"crossref","first-page":"e2409747","DOI":"10.1002\/smll.202409747","volume":"21","author":"Liu","year":"2025","journal-title":"Small"}],"container-title":["Materials Horizons"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/MH\/D5MH02395E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:09:17Z","timestamp":1783350557000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D5MH02395E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":56,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d5mh02395e","relation":{},"ISSN":["2051-6347","2051-6355"],"issn-type":[{"value":"2051-6347","type":"print"},{"value":"2051-6355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}