{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:14:41Z","timestamp":1772136881963,"version":"3.50.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001688","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","award":["Core funds"],"award-info":[{"award-number":["Core funds"]}],"id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001688","name":"International Centre for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","award":["Core funds"],"award-info":[{"award-number":["Core funds"]}],"id":[{"id":"10.13039\/501100001688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Oral cancer (OC) is a malignant tumour with high morbidity and mortality. Significant contributory factors include alcohol and tobacco abuse that dysregulate the proteome and metabolome. We assessed saliva as a noninvasive bio-sample to understand the changes in proteome and metabolome in OC, tobacco abusers (TA), and controls. OC, TA, and control samples (n = 22, 21, and 21, respectively) were subjected to LFQ-proteomics and NMR-based metabolomics analyses individually and integrated using systems biology; 292 out of 758 proteins with two or more unique peptides were significantly differently regulated. Functional annotation revealed that differentially expressed proteins are involved in important cellular metabolic processes. PLS-DA in metabolomics separated OC from the control and TA, and K-means clustering of proteomics and metabolomics profiles revealed distinguishing proteins and metabolites in OC, TA, and the control. Integrated analysis revealed convergence on molecules like transketolase (TKTT), transaldolase (TALDO), kallikrein 1 (KLK1), enolase A (ENOA), glucose-6-phosphate isomerase (G6PI), and aldolase A and C (ALDOA and ALDOC). Finally, the characteristic discriminatory features of several clusters between OC, TA, and the control remain valid only among high tobacco abusers. The results reveal metabolites that could serve as early indicators for OC, especially among chewing tobacco abusers, and therefore establish the basis for larger cohort studies to develop them as predictive OC biomarkers.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d5mo00058k","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:10:11Z","timestamp":1756883411000},"page":"594-606","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differentially regulated saliva proteome and metabolome: a way forward for risk-assessment of oral cancer among tobacco abusers"],"prefix":"10.1093","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5564-6165","authenticated-orcid":false,"given":"Bolaji Fatai","family":"Oyeyemi","sequence":"first","affiliation":[{"name":"Cell Biology and Genetics Unit, Department of Zoology, University of Ilorin b , P.M.B. 1515 Ilorin Nigeria"},{"name":"Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg a , New Delhi 110067, India neelsb@icgeb.res.in"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5236-4525","authenticated-orcid":false,"given":"Shruti","family":"Dabral","sequence":"additional","affiliation":[{"name":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg c , New Delhi 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Paramaraj","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vardhman Mahavir Medical College (VMMC)-Safdarjung Hospital d , New Delhi 110058, India drchintamani7@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"VProteomics, Valerian Chem Private Limited e , Noida, Uttar Pradesh, 201301, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7491-8994","authenticated-orcid":false,"given":"Gagan Deep","family":"Jhingan","sequence":"additional","affiliation":[{"name":"VProteomics, Valerian Chem Private Limited e , Noida, Uttar Pradesh, 201301, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-2930","authenticated-orcid":false,"given":"Dhiraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg c , New Delhi 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-594X","authenticated-orcid":false,"family":"Chintamani","sequence":"additional","affiliation":[{"name":"Department of Surgery, Vardhman Mahavir Medical College (VMMC)-Safdarjung Hospital d , New Delhi 110058, India drchintamani7@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-6977","authenticated-orcid":false,"given":"Abhinav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Trauma Surgery and Critical Care, Department of Surgical Disciplines, Jai Prakash Narayan Apex Trauma Centre (JPNATC), All India Institute of Medical Sciences (AIIMS) f , New Delhi 110029, India dr.abhinav@aiims.gov.in"},{"name":"Department of Surgery, Vardhman Mahavir Medical College (VMMC)-Safdarjung Hospital d , New Delhi 110058, India drchintamani7@gmail.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-4978","authenticated-orcid":false,"given":"N\u00e9el Sarovar","family":"Bhavesh","sequence":"additional","affiliation":[{"name":"Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg a , New Delhi 110067, India neelsb@icgeb.res.in"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"issue":"4","key":"2026013001290583500_cit1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.oooo.2011.11.001","article-title":"Clinical and histopathologic parameters in survival of oral squamous cell carcinoma","volume":"113","author":"Dissanayaka","year":"2012","journal-title":"Oral Surg. 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Biotechnol. J."},{"issue":"28","key":"2026013001290583500_cit30","doi-asserted-by":"crossref","first-page":"16167","DOI":"10.1073\/pnas.2001395117","article-title":"Oral squamous cell carcinoma diagnosed from saliva metabolic profiling","volume":"117","author":"Song","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"2026013001290583500_cit31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrc.2017.96","article-title":"Sphingolipid metabolism in cancer signalling and therapy","volume":"18","author":"Ogretmen","year":"2018","journal-title":"Nat. Rev. Cancer"},{"issue":"4","key":"2026013001290583500_cit32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrc1043","article-title":"Early detection: proteomic applications for the early detection of cancer","volume":"3","author":"Wulfkuhle","year":"2003","journal-title":"Nat. Rev. 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Dis. Sci."},{"issue":"2","key":"2026013001290583500_cit38","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.canlet.2011.11.002","article-title":"Lipocalin 2 in cancer: When good immunity goes bad","volume":"316","author":"Rodvold","year":"2012","journal-title":"Cancer Lett."},{"issue":"3","key":"2026013001290583500_cit39","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.it.2019.01.006","article-title":"Neutrophil Degranulation, Plasticity, and Cancer Metastasis","volume":"40","author":"Mollinedo","year":"2019","journal-title":"Trends Immunol."},{"key":"2026013001290583500_cit40","first-page":"156795","article-title":"\u03b1-Enolase, a multifunctional protein: its role on pathophysiological situations","volume":"2012","author":"D\u00edaz-Ramos","year":"2012","journal-title":"BioMed Res. Int."},{"issue":"9","key":"2026013001290583500_cit41","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.ejca.2010.03.018","article-title":"ENO1, a potential prognostic head and neck cancer marker, promotes transformation partly via chemokine CCL20 induction","volume":"46","author":"Tsai","year":"2010","journal-title":"Eur. J. Cancer"},{"issue":"4","key":"2026013001290583500_cit42","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1349-7006.2007.00411.x","article-title":"Differential expression of the human alpha-enolase gene in oral epithelium and squamous cell carcinoma","volume":"98","author":"Ito","year":"2007","journal-title":"Cancer Sci."},{"issue":"1","key":"2026013001290583500_cit43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-5793(00)01494-0","article-title":"ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1)","volume":"473","author":"Feo","year":"2000","journal-title":"FEBS Lett."},{"issue":"50","key":"2026013001290583500_cit44","doi-asserted-by":"crossref","first-page":"87623","DOI":"10.18632\/oncotarget.21007","article-title":"Disrupting glucose-6-phosphate isomerase fully suppresses the Warburg effect and activates OXPHOS with minimal impact on tumor growth except in hypoxia","volume":"8","author":"de Padua","year":"2017","journal-title":"Oncotarget"},{"key":"2026013001290583500_cit45","doi-asserted-by":"crossref","first-page":"946572","DOI":"10.1155\/2015\/946572","article-title":"Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes","volume":"2015","author":"Stefanini","year":"2015","journal-title":"Dis. Markers"},{"issue":"48","key":"2026013001290583500_cit46","doi-asserted-by":"crossref","first-page":"32989","DOI":"10.1074\/jbc.R109.027946","article-title":"Functional roles of human kallikrein-related peptidases","volume":"284","author":"Sotiropoulou","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2026013001290583500_cit47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fonc.2017.00087","article-title":"Emerging Role of the Pentose Phosphate Pathway in Hepatocellular Carcinoma","volume":"7","author":"Kowalik","year":"2017","journal-title":"Front. Oncol."},{"issue":"3","key":"2026013001290583500_cit48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cdp.2008.08.008","article-title":"Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck","volume":"32","author":"Basta","year":"2008","journal-title":"Cancer Detect. 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