{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:20:19Z","timestamp":1783016419002,"version":"3.54.6"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"15","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"am","delay-in-days":430,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"publisher","award":["2016\/68"],"award-info":[{"award-number":["2016\/68"]}],"id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"publisher","award":["2018\/1485"],"award-info":[{"award-number":["2018\/1485"]}],"id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>A nanoplatform was designed to vectorize a ferrocifen drug: two amphiphilic prodrugs were co-nanoprecipitated. These self-assemblies demonstrated to slow down significantly the lung tumor volume in mice, after a pulmonary administration.<\/jats:p>","DOI":"10.1039\/d5nr00643k","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T05:40:41Z","timestamp":1741326041000},"page":"9232-9244","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Self-assemblies of cell-penetrating peptides and ferrocifens: design and biological evaluation of an innovative platform for lung cancer treatment"],"prefix":"10.1039","volume":"17","author":[{"given":"L\u00e9na","family":"Guyon","sequence":"first","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Ladaycia","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Bosio","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-9345","authenticated-orcid":false,"given":"Laurent","family":"Lemaire","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"},{"name":"Univ Angers, Univ Rennes, INRAE, Inserm, CNRS, PRISM, Biogenouest, F-49000 Angers, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-0803","authenticated-orcid":false,"given":"Florence","family":"Franconi","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"},{"name":"Univ Angers, Univ Rennes, INRAE, Inserm, CNRS, PRISM, Biogenouest, F-49000 Angers, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Leli\u00e8vre","sequence":"additional","affiliation":[{"name":"Centre r\u00e9gional de pharmacovigilance, Laboratoire de pharmacologie-toxicologie, CHU Angers, 4 rue Larrey, F-49100 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolwenn","family":"Lautram","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pigeon","sequence":"additional","affiliation":[{"name":"CNRS, Institut Parisien de Chimie Mol\u00e9culaire (IPCM), Sorbonne Universit\u00e9, 4 Place Jussieu, 75005 Paris, France"},{"name":"PSL, Chimie ParisTech, 11 Rue Pierre et Marie Curie, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Jaouen","sequence":"additional","affiliation":[{"name":"CNRS, Institut Parisien de Chimie Mol\u00e9culaire (IPCM), Sorbonne Universit\u00e9, 4 Place Jussieu, 75005 Paris, France"},{"name":"PSL, Chimie ParisTech, 11 Rue Pierre et Marie Curie, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Passirani","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-6453","authenticated-orcid":false,"given":"Elise","family":"Lepeltier","sequence":"additional","affiliation":[{"name":"Univ Angers, Inserm, CNRS, MINT, SFR ICAT, F-49000 Angers, France"},{"name":"Institut Universitaire de France (IUF), France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"D5NR00643K\/cit1\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"D5NR00643K\/cit2\/1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.21037\/tlcr.2016.06.07","volume":"5","author":"Zappa","year":"2016","journal-title":"Transl. Lung Cancer Res."},{"issue":"4","key":"D5NR00643K\/cit3\/1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1056\/NEJMra035536","volume":"350","author":"Spira","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"D5NR00643K\/cit4\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.currproblcancer.2009.03.001","volume":"33","author":"Mahalingam","year":"2009","journal-title":"Curr. Probl. Cancer"},{"issue":"4","key":"D5NR00643K\/cit5\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1051\/bmdcn\/2017070423","volume":"7","author":"Huang","year":"2017","journal-title":"Biomedicine"},{"issue":"5","key":"D5NR00643K\/cit6\/1","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s12274-017-1892-9","volume":"11","author":"Guyon","year":"2018","journal-title":"Nano Res."},{"issue":"21","key":"D5NR00643K\/cit7\/1","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1021\/acs.jpclett.9b01493","volume":"10","author":"Guyon","year":"2019","journal-title":"J. Phys. Chem. Lett."},{"issue":"12","key":"D5NR00643K\/cit9\/1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.febslet.2013.04.031","volume":"587","author":"Bechara","year":"2013","journal-title":"FEBS Lett."},{"key":"D5NR00643K\/cit10\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2019.07.020","volume":"309","author":"Xu","year":"2019","journal-title":"J. Controlled Release"},{"issue":"3","key":"D5NR00643K\/cit11\/1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-6147(00)01447-4","volume":"21","author":"Lindgren","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"D5NR00643K\/cit12\/1","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1073\/pnas.072699999","volume":"99","author":"Hartgerink","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"D5NR00643K\/cit13\/1","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1021\/nn203343z","volume":"5","author":"Soukasene","year":"2011","journal-title":"ACS Nano"},{"issue":"43","key":"D5NR00643K\/cit14\/1","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1039\/c3cc41896k","volume":"49","author":"Lin","year":"2013","journal-title":"Chem. Commun."},{"issue":"24","key":"D5NR00643K\/cit15\/1","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1039\/C5CS00486A","volume":"44","author":"Jaouen","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"D5NR00643K\/cit16\/1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/9781118742952.ch42","volume-title":"Advances in Organometallic Chemistry and Catalysis","author":"Jaouen","year":"2013","unstructured":"G.Jaouen  and  S.Top ,  The Ferrocifen Family as Potent and Selective Antitumor Compounds: Mechanisms of Action , in  Advances in Organometallic Chemistry and Catalysis ,  John Wiley & Sons, Ltd ,  2013 , pp.  563\u2013580 . Disponible sur:  https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/9781118742952.ch42"},{"issue":"21","key":"D5NR00643K\/cit17\/1","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1002\/chem.200305024","volume":"9","author":"Top","year":"2003","journal-title":"Chemistry"},{"issue":"7","key":"D5NR00643K\/cit18\/1","doi-asserted-by":"crossref","first-page":"e1701135","DOI":"10.1002\/adhm.201701135","volume":"7","author":"Yang","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"D5NR00643K\/cit19\/1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ncomms1952","volume":"3","author":"Kondo","year":"2012","journal-title":"Nat. Commun."},{"issue":"1","key":"D5NR00643K\/cit20\/1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijpharm.2014.11.029","volume":"478","author":"Gao","year":"2015","journal-title":"Int. J. Pharm."},{"issue":"8","key":"D5NR00643K\/cit21\/1","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1074\/jbc.M007540200","volume":"276","author":"Futaki","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"5","key":"D5NR00643K\/cit22\/1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1034\/j.1399-3011.2000.00723.x","volume":"56","author":"Mitchell","year":"2000","journal-title":"J. Pept. Res."},{"issue":"4","key":"D5NR00643K\/cit23\/1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.rmr.2018.02.001","volume":"35","author":"Rosi\u00e8re","year":"2018","journal-title":"Rev. Mal. Respir."},{"issue":"4","key":"D5NR00643K\/cit24\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.rmr.2018.02.002","volume":"35","author":"Rosi\u00e8re","year":"2018","journal-title":"Rev. Mal. Respir."},{"issue":"5","key":"D5NR00643K\/cit25\/1","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1073\/pnas.0608611104","volume":"104","author":"Lai","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"50","key":"D5NR00643K\/cit26\/1","doi-asserted-by":"crossref","first-page":"9726","DOI":"10.1002\/anie.200803526","volume":"47","author":"Wang","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"issue":"11","key":"D5NR00643K\/cit27\/1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/anie.201006849","volume":"50","author":"Yang","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR00643K\/cit28\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.addr.2017.08.010","volume":"124","author":"Huckaby","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5NR00643K\/cit29\/1","doi-asserted-by":"crossref","first-page":"A96","DOI":"10.1016\/j.rmr.2015.04.020","volume":"32","author":"Hureaux","year":"2015","journal-title":"Rev. Mal. Respir."},{"key":"D5NR00643K\/cit30\/1","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.2147\/IJN.S146740","volume":"12","author":"Hureaux","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"D5NR00643K\/cit31\/1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejpb.2005.04.009","volume":"61","author":"Bivas-Benita","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"D5NR00643K\/cit32\/1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/jam.2005.18.198","volume":"18","author":"Gagnadoux","year":"2005","journal-title":"J. Aerosol Med."},{"issue":"20","key":"D5NR00643K\/cit33\/1","doi-asserted-by":"crossref","first-page":"8358","DOI":"10.1021\/acs.jmedchem.7b00743","volume":"60","author":"Pigeon","year":"2017","journal-title":"J. Med. Chem."},{"key":"D5NR00643K\/cit34\/1","doi-asserted-by":"crossref","first-page":"114202","DOI":"10.1016\/j.ejmech.2022.114202","volume":"234","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"D5NR00643K\/cit35\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0003-9861(81)90160-0","volume":"210","author":"Glushko","year":"1981","journal-title":"Arch. Biochem. Biophys."},{"key":"D5NR00643K\/cit36\/1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/B978-0-323-91248-8.00008-8","volume-title":"Smart Polymeric Nano-Constructs in Drug Delivery","author":"Patha","year":"2023","unstructured":"A. S.Patha ,  T.Patil ,  P. K.Pandey ,  K.Kuche ,  R.Ghadi  and  S.Jain ,  Chapter 7 - Block copolymer micelles as long-circulating drug vehicles , in  Smart Polymeric Nano-Constructs in Drug Delivery , ed.  S. P. Vyas ,  U. Agrawal  and  R. Sharma ,  Academic Press ,  2023 , pp.  187\u2013220 . Disponible sur:  https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780323912488000088"},{"key":"D5NR00643K\/cit37\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jconrel.2021.07.025","volume":"337","author":"Franconi","year":"2021","journal-title":"J. Controlled Release"},{"key":"D5NR00643K\/cit38\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.addr.2018.07.017","volume":"136\u2013137","author":"Bernkop-Schn\u00fcrch","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"issue":"5","key":"D5NR00643K\/cit39\/1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/10717544.2011.567310","volume":"18","author":"Koren","year":"2011","journal-title":"Drug Delivery"},{"issue":"4","key":"D5NR00643K\/cit40\/1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/jamp.2009.0806","volume":"23","author":"Henning","year":"2010","journal-title":"J. Aerosol Med. Pulm. Drug Delivery"},{"issue":"1","key":"D5NR00643K\/cit41\/1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1039\/C6NR07353K","volume":"9","author":"Sanchez","year":"2017","journal-title":"Nanoscale"},{"issue":"9","key":"D5NR00643K\/cit42\/1","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1021\/acsnano.5b03876","volume":"9","author":"Xu","year":"2015","journal-title":"ACS Nano"},{"issue":"14","key":"D5NR00643K\/cit43\/1","doi-asserted-by":"crossref","first-page":"9823","DOI":"10.1021\/acs.jmedchem.3c00617","volume":"66","author":"Scalcon","year":"2023","journal-title":"J. Med. Chem."},{"key":"D5NR00643K\/cit44\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ddtec.2017.11.005","volume":"26","author":"Bode","year":"2017","journal-title":"Drug Discovery Today: Technol."},{"issue":"4","key":"D5NR00643K\/cit45\/1","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1021\/nn300524f","volume":"6","author":"Zhu","year":"2012","journal-title":"ACS Nano"},{"issue":"42","key":"D5NR00643K\/cit46\/1","doi-asserted-by":"crossref","first-page":"17047","DOI":"10.1073\/pnas.1304987110","volume":"110","author":"Zhu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"D5NR00643K\/cit47\/1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1021\/mp400703d","volume":"11","author":"Yang","year":"2014","journal-title":"Mol. Pharm."},{"issue":"7","key":"D5NR00643K\/cit48\/1","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1021\/acsnano.5b01326","volume":"9","author":"Pelaz","year":"2015","journal-title":"ACS Nano"},{"issue":"5","key":"D5NR00643K\/cit49\/1","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1039\/c3nr05559k","volume":"6","author":"Pozzi","year":"2014","journal-title":"Nanoscale"},{"issue":"5\u20136","key":"D5NR00643K\/cit50\/1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1039\/b904878b","volume":"1","author":"Aguilera","year":"2009","journal-title":"Integr. Biol."},{"issue":"10","key":"D5NR00643K\/cit51\/1","doi-asserted-by":"crossref","first-page":"7699","DOI":"10.1007\/s13277-015-3458-3","volume":"36","author":"Lemaire","year":"2015","journal-title":"Tumour Biol."},{"issue":"4","key":"D5NR00643K\/cit52\/1","doi-asserted-by":"crossref","first-page":"172040","DOI":"10.1098\/rsos.172040","volume":"5","author":"Fan","year":"2018","journal-title":"R. Soc. Open Sci."},{"issue":"1","key":"D5NR00643K\/cit53\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2010.03.017","volume":"392","author":"Pilcer","year":"2010","journal-title":"Int. J. Pharm."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D5NR00643K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:23:17Z","timestamp":1783012997000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/15\/9232-9244\/900862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":52,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,4,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr00643k","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5NR00643K\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00643K\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}