{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:47:09Z","timestamp":1790279229443,"version":"4.1.0"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"am","delay-in-days":497,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR081270"],"award-info":[{"award-number":["R01AR081270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Proteins form reversible complexes with two-dimensional nanosilicate particles, making the nanosilicates suitable for therapeutic delivery.<\/jats:p>","DOI":"10.1039\/d5nr00861a","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:21:14Z","timestamp":1747146074000},"page":"13477-13488","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Protein structure and bioactivity upon adsorption and desorption from nanosilicate sustained release delivery devices"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6355-4551","authenticated-orcid":false,"given":"Samuel","family":"Stealey","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Saint Louis University, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ether","family":"Dharmesh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Saint Louis University, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0284-0201","authenticated-orcid":false,"given":"Akhilesh K.","family":"Gaharwar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-4980","authenticated-orcid":false,"given":"Jai S.","family":"Rudra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-8351","authenticated-orcid":false,"given":"Silviya P.","family":"Zustiak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Saint Louis University, Saint Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5NR00861A\/cit1\/1","doi-asserted-by":"crossref","first-page":"106858","DOI":"10.1016\/j.ejps.2024.106858","volume":"201","author":"Gonzalez-Pujana","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"issue":"23","key":"D5NR00861A\/cit2\/1","doi-asserted-by":"crossref","first-page":"1900332","DOI":"10.1002\/adma.201900332","volume":"31","author":"Gaharwar","year":"2019","journal-title":"Adv. Mater."},{"key":"D5NR00861A\/cit3\/1","doi-asserted-by":"crossref","first-page":"100935","DOI":"10.1016\/j.mtbio.2023.100935","volume":"24","author":"Rodrigo","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"20","key":"D5NR00861A\/cit4\/1","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1039\/D2MA00528J","volume":"3","author":"Katti","year":"2022","journal-title":"Mater. Adv."},{"issue":"7","key":"D5NR00861A\/cit5\/1","first-page":"2407","volume":"14","author":"Tom\u00e1s","year":"2018","journal-title":"Biol. Med."},{"issue":"1","key":"D5NR00861A\/cit6\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jcis.2012.02.009","volume":"374","author":"Kolman","year":"2012","journal-title":"J. Colloid Interface Sci."},{"issue":"12","key":"D5NR00861A\/cit7\/1","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.3390\/molecules29122823","volume":"29","author":"Brunchi","year":"2024","journal-title":"Molecules"},{"issue":"1","key":"D5NR00861A\/cit8\/1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0021-9797(92)90254-J","volume":"151","author":"Thompson","year":"1992","journal-title":"J. Colloid Interface Sci."},{"key":"D5NR00861A\/cit9\/1","doi-asserted-by":"crossref","first-page":"101743","DOI":"10.1016\/j.coco.2023.101743","volume":"43","author":"Xu","year":"2023","journal-title":"Compos. Commun."},{"issue":"17","key":"D5NR00861A\/cit10\/1","doi-asserted-by":"crossref","first-page":"eabl9404","DOI":"10.1126\/sciadv.abl9404","volume":"8","author":"Brokesh","year":"2022","journal-title":"Sci. Adv."},{"key":"D5NR00861A\/cit11\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.actbio.2017.11.024","volume":"65","author":"Koshy","year":"2018","journal-title":"Acta Biomater."},{"issue":"1","key":"D5NR00861A\/cit12\/1","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/s41467-020-15152-9","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"D5NR00861A\/cit13\/1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1039\/C8BM00469B","volume":"6","author":"Sheikhi","year":"2018","journal-title":"Biomater. Sci."},{"issue":"17","key":"D5NR00861A\/cit14\/1","doi-asserted-by":"crossref","first-page":"E3905","DOI":"10.1073\/pnas.1716164115","volume":"115","author":"Carrow","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"45","key":"D5NR00861A\/cit15\/1","doi-asserted-by":"crossref","first-page":"18457","DOI":"10.1039\/D3NR02447D","volume":"15","author":"Mousa","year":"2023","journal-title":"Nanoscale"},{"key":"D5NR00861A\/cit16\/1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/adma.200801393","volume":"21","author":"Zhang","year":"2009","journal-title":"Adv. Mater."},{"issue":"6","key":"D5NR00861A\/cit17\/1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3390\/ph16060821","volume":"16","author":"Stealey","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"1","key":"D5NR00861A\/cit18\/1","doi-asserted-by":"crossref","first-page":"e202300370","DOI":"10.1002\/cplu.202300370","volume":"89","author":"Massaro","year":"2024","journal-title":"ChemPlusChem"},{"issue":"26","key":"D5NR00861A\/cit19\/1","doi-asserted-by":"crossref","first-page":"21891","DOI":"10.1021\/acsami.8b06149","volume":"10","author":"Becher","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"7","key":"D5NR00861A\/cit20\/1","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1021\/acsami.8b17733","volume":"11","author":"Cross","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"D5NR00861A\/cit21\/1","doi-asserted-by":"crossref","first-page":"1701393","DOI":"10.1002\/adhm.201701393","volume":"7","author":"Li","year":"2018","journal-title":"Adv. Healthcare Mater."},{"issue":"24","key":"D5NR00861A\/cit22\/1","doi-asserted-by":"crossref","first-page":"27880","DOI":"10.1021\/acsami.1c05576","volume":"13","author":"Stealey","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"D5NR00861A\/cit23\/1","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.3390\/molecules29122823","volume":"29","author":"Brunchi","year":"2024","journal-title":"Molecules"},{"issue":"7","key":"D5NR00861A\/cit24\/1","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.0608582104","volume":"104","author":"Cedervall","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"D5NR00861A\/cit25\/1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/ja107583h","volume":"133","author":"Monopoli","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"D5NR00861A\/cit26\/1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/10408398809527473","volume":"26","author":"Proctor","year":"1988","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"5","key":"D5NR00861A\/cit27\/1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1189\/jlb.1107725","volume":"83","author":"Rosenberg","year":"2008","journal-title":"J. Leukocyte Biol."},{"issue":"5","key":"D5NR00861A\/cit28\/1","doi-asserted-by":"crossref","first-page":"539011","DOI":"10.1063\/1.2767206","volume":"91","author":"Fologea","year":"2007","journal-title":"Appl. Phys. Lett."},{"issue":"10","key":"D5NR00861A\/cit29\/1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1177\/27.10.41873","volume":"27","author":"Rennke","year":"1979","journal-title":"J. Histochem. Cytochem."},{"issue":"11","key":"D5NR00861A\/cit30\/1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1103\/PhysRevLett.29.705","volume":"29","author":"Magde","year":"1972","journal-title":"Phys. Rev. Lett."},{"issue":"5","key":"D5NR00861A\/cit31\/1","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1021\/bm061195r","volume":"8","author":"Michelman-Ribeiro","year":"2007","journal-title":"Biomacromolecules"},{"key":"D5NR00861A\/cit32\/1","doi-asserted-by":"crossref","first-page":"644450","DOI":"10.3389\/fphy.2021.644450","volume":"9","author":"Yu","year":"2021","journal-title":"Front. Phys."},{"issue":"12","key":"D5NR00861A\/cit33\/1","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1002\/bit.27949","volume":"118","author":"Ghassemi","year":"2021","journal-title":"Biotechnol. Bioeng."},{"issue":"1","key":"D5NR00861A\/cit34\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/ph15010056","volume":"15","author":"Stealey","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"12","key":"D5NR00861A\/cit35\/1","doi-asserted-by":"crossref","first-page":"6345","DOI":"10.1073\/pnas.120120397","volume":"97","author":"Sch\u00f6nbrunn","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"D5NR00861A\/cit36\/1","doi-asserted-by":"crossref","first-page":"e3253","DOI":"10.21769\/BioProtoc.3253","volume":"9","author":"Yammine","year":"2019","journal-title":"Bio-Protoc."},{"key":"D5NR00861A\/cit37\/1","first-page":"100843","volume":"24","author":"Guliyeva","year":"2020","journal-title":"Biochem. Biophys. Rep."},{"issue":"23","key":"D5NR00861A\/cit38\/1","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.7150\/thno.37601","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"D5NR00861A\/cit39\/1","doi-asserted-by":"crossref","first-page":"15024","DOI":"10.1038\/s41598-019-51555-5","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"D5NR00861A\/cit40\/1","doi-asserted-by":"crossref","first-page":"e2102054","DOI":"10.1002\/adhm.202102054","volume":"11","author":"Kiaee","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"106","key":"D5NR00861A\/cit41\/1","doi-asserted-by":"crossref","first-page":"104117","DOI":"10.1039\/C6RA11669H","volume":"6","author":"Das","year":"2016","journal-title":"RSC Adv."},{"issue":"12","key":"D5NR00861A\/cit42\/1","doi-asserted-by":"crossref","first-page":"18940","DOI":"10.1021\/acsanm.2c04721","volume":"5","author":"Khachani","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"D5NR00861A\/cit43\/1","doi-asserted-by":"crossref","first-page":"775736","DOI":"10.3389\/fmolb.2021.775736","volume":"8","author":"Tokmakov","year":"2021","journal-title":"Front. Mol. Biosci."},{"issue":"14","key":"D5NR00861A\/cit44\/1","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.1039\/C5NR07806G","volume":"8","author":"Waters","year":"2016","journal-title":"Nanoscale"},{"issue":"3","key":"D5NR00861A\/cit45\/1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.18063\/ijb.702","volume":"9","author":"Cao","year":"2023","journal-title":"Int. J. Bioprint."},{"key":"D5NR00861A\/cit46\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.actbio.2017.11.024","volume":"65","author":"Koshy","year":"2018","journal-title":"Acta Biomater."},{"issue":"5","key":"D5NR00861A\/cit47\/1","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1016\/j.actbio.2013.01.006","volume":"9","author":"Wu","year":"2013","journal-title":"Acta Biomater."},{"issue":"29","key":"D5NR00861A\/cit48\/1","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1002\/adma.201100968","volume":"23","author":"Dawson","year":"2011","journal-title":"Adv. Mater."},{"issue":"1","key":"D5NR00861A\/cit49\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/14712598.2024.2436094","volume":"25","author":"Binder","year":"2025","journal-title":"Expert Opin. Biol. Ther."},{"issue":"6","key":"D5NR00861A\/cit50\/1","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1039\/D2LC00799A","volume":"23","author":"Bashiri","year":"2023","journal-title":"Lab Chip"},{"issue":"4","key":"D5NR00861A\/cit51\/1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.bbrc.2014.06.133","volume":"450","author":"Emadi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D5NR00861A\/cit52\/1","first-page":"Appendix 3A","volume":"Appendix 3","author":"Wingfield","year":"2001","journal-title":"Curr. Protoc. Protein Sci."},{"issue":"1\u20133","key":"D5NR00861A\/cit53\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-5793(01)03284-7","volume":"511","author":"Chang","year":"2002","journal-title":"FEBS Lett."},{"issue":"8","key":"D5NR00861A\/cit54\/1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1139\/cjc-2019-0008","volume":"97","author":"Rahdar","year":"2019","journal-title":"Can. J. Chem."},{"issue":"1","key":"D5NR00861A\/cit55\/1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jcis.2006.01.065","volume":"299","author":"Brandes","year":"2006","journal-title":"J. Colloid Interface Sci."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D5NR00861A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:14:36Z","timestamp":1783448076000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/21\/13477-13488\/900934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":55,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,5,29]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr00861a","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}