{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:27Z","timestamp":1791489687428,"version":"4.3.4"},"reference-count":241,"publisher":"Royal Society of Chemistry (RSC)","issue":"31","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"am","delay-in-days":560,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100006687","name":"Universit\u00e9 Claude Bernard Lyon 1","doi-asserted-by":"publisher","award":["SENS 2022"],"award-info":[{"award-number":["SENS 2022"]}],"id":[{"id":"10.13039\/501100006687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Brain disorders affect over one billion people globally, presenting significant challenges for effective treatment due to the limited drug bioavailability in the brain. The graphical abstract was created with BioRender.<\/jats:p>","DOI":"10.1039\/d5nr00870k","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:01:06Z","timestamp":1752562866000},"page":"17947-17979","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Polymeric nanoparticles for efficient nose-to-brain delivery"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-3281","authenticated-orcid":false,"given":"Marie","family":"Bolon","sequence":"first","affiliation":[{"name":"UMR 5305: Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique, Institut de Biologie et Chimie des Prot\u00e9ines, CNRS\/Universit\u00e9 Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-2286","authenticated-orcid":false,"given":"Maxime","family":"Fieux","sequence":"additional","affiliation":[{"name":"UMR 5305: Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique, Institut de Biologie et Chimie des Prot\u00e9ines, CNRS\/Universit\u00e9 Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France"},{"name":"Service d'ORL, de chirurgie cervico-faciale et d'audiophonologie p\u00e9diatrique, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre B\u00e9nite, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6715-2226","authenticated-orcid":false,"given":"Claire","family":"Monge","sequence":"additional","affiliation":[{"name":"UMR 5305: Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique, Institut de Biologie et Chimie des Prot\u00e9ines, CNRS\/Universit\u00e9 Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-6769","authenticated-orcid":false,"given":"Sophie","family":"Richard","sequence":"additional","affiliation":[{"name":"UMR 5305: Laboratoire de Biologie Tissulaire et d'Ing\u00e9nierie Th\u00e9rapeutique, Institut de Biologie et Chimie des Prot\u00e9ines, CNRS\/Universit\u00e9 Claude Bernard Lyon 1, 7 Passage du Vercors, CEDEX 07, 69367 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5NR00870K\/cit1\/1","unstructured":"Le cerveau malade et ses maladies neurologiques, F\u00e9d\u00e9ration pour la Recherche sur le Cerveau (FRC). [cited 2023 Aug 28]. Available from:  https:\/\/www.frcneurodon.org\/comprendre-le-cerveau\/le-cerveau-malade-et-ses-maladies-neurologiques\/"},{"issue":"7","key":"D5NR00870K\/cit2\/1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s10529-020-02886-1","volume":"42","author":"Ahmadian-Moghadam","year":"2020","journal-title":"Biotechnol. Lett."},{"issue":"3","key":"D5NR00870K\/cit3\/1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3390\/pharmaceutics15030998","volume":"15","author":"Antunes","year":"2023","journal-title":"Pharmaceutics"},{"issue":"4","key":"D5NR00870K\/cit4\/1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.drudis.2022.01.016","volume":"27","author":"Tatulian","year":"2022","journal-title":"Drug Discovery Today"},{"issue":"1","key":"D5NR00870K\/cit5\/1","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D5NR00870K\/cit6\/1","doi-asserted-by":"crossref","first-page":"1039745","DOI":"10.3389\/fvets.2022.1039745","volume":"9","author":"Partridge","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"7","key":"D5NR00870K\/cit7\/1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"issue":"5","key":"D5NR00870K\/cit8\/1","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.apsb.2022.07.003","volume":"13","author":"Awad","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"D5NR00870K\/cit9\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3724\/zdxbyxb-2023-0069","volume":"52","author":"Hu","year":"2023","journal-title":"J. Zhejiang Univ., Med. Sci."},{"key":"D5NR00870K\/cit10\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2019.11.009","volume":"165\u2013166","author":"Pandit","year":"2020","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5NR00870K\/cit11\/1","unstructured":"Study Details | Safety and Effectiveness Study of Intranasal Insulin Glulisine on Cognitive and Memory in Mild-Mod AD Patients. | ClinicalTrials.gov. [cited 2024 Jun 13]. Available from:  https:\/\/clinicaltrials.gov\/study\/NCT01436045?term=Intranasal%20Administration&aggFilters=phase:3%202,status:com&cond=alzheimer&rank=2"},{"key":"D5NR00870K\/cit12\/1","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.2147\/IJN.S466042","volume":"19","author":"Wang","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"D5NR00870K\/cit13\/1","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/acs.jmedchem.4c02426","volume":"68","author":"Yang","year":"2025","journal-title":"J. Med. Chem."},{"key":"D5NR00870K\/cit14\/1","doi-asserted-by":"crossref","first-page":"105489","DOI":"10.1016\/j.jdent.2024.105489","volume":"152","author":"Zhou","year":"2025","journal-title":"J. Dent."},{"issue":"3","key":"D5NR00870K\/cit15\/1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/pharmaceutics15030746","volume":"15","author":"Maher","year":"2023","journal-title":"Pharmaceutics"},{"key":"D5NR00870K\/cit16\/1","doi-asserted-by":"crossref","first-page":"115196","DOI":"10.1016\/j.addr.2024.115196","volume":"207","author":"Chen","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"issue":"9","key":"D5NR00870K\/cit17\/1","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"issue":"1","key":"D5NR00870K\/cit18\/1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ijpharm.2017.06.052","volume":"528","author":"El-Say","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1","key":"D5NR00870K\/cit19\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejps.2012.04.013","volume":"47","author":"Fazil","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"D5NR00870K\/cit20\/1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/10717544.2014.907372","volume":"23","author":"Mittal","year":"2016","journal-title":"Drug Delivery"},{"issue":"3","key":"D5NR00870K\/cit21\/1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3390\/pharmaceutics14030629","volume":"14","author":"Crowe","year":"2022","journal-title":"Pharmaceutics"},{"issue":"11","key":"D5NR00870K\/cit22\/1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s00405-009-1073-x","volume":"266","author":"Escada","year":"2009","journal-title":"Arch. Oto-Rhino-Laryngol."},{"issue":"3","key":"D5NR00870K\/cit23\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/pharmaceutics10030116","volume":"10","author":"G\u00e4nger","year":"2018","journal-title":"Pharmaceutics"},{"issue":"2","key":"D5NR00870K\/cit24\/1","first-page":"e1767","volume":"14","author":"Yokel","year":"2022","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"issue":"6","key":"D5NR00870K\/cit25\/1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1080\/17425247.2020.1762563","volume":"17","author":"Tan","year":"2020","journal-title":"Expert Opin. Drug Delivery"},{"issue":"7","key":"D5NR00870K\/cit26\/1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1517\/17425247.2013.790887","volume":"10","author":"Pardeshi","year":"2013","journal-title":"Expert Opin. Drug Delivery"},{"issue":"6","key":"D5NR00870K\/cit27\/1","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1166\/jnn.2016.11716","volume":"16","author":"Wang","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"3","key":"D5NR00870K\/cit28\/1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1021\/acs.molpharmaceut.7b00991","volume":"15","author":"Tanaka","year":"2018","journal-title":"Mol. Pharm."},{"issue":"5","key":"D5NR00870K\/cit29\/1","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.3390\/pharmaceutics15051399","volume":"15","author":"Tal\u00e9ns-Visconti","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"D5NR00870K\/cit30\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"D5NR00870K\/cit31\/1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev-cellbio-100617-062608","volume":"35","author":"Langen","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"1","key":"D5NR00870K\/cit32\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40005-022-00589-5","volume":"53","author":"Jeong","year":"2023","journal-title":"J. Pharm. Invest."},{"issue":"1","key":"D5NR00870K\/cit33\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1211\/0022357011775145","volume":"53","author":"Ugwoke","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"issue":"8","key":"D5NR00870K\/cit34\/1","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3390\/pharmaceutics15082032","volume":"15","author":"Cherait","year":"2023","journal-title":"Pharmaceutics"},{"issue":"2","key":"D5NR00870K\/cit35\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/02652048.2022.2041751","volume":"39","author":"Nigam","year":"2022","journal-title":"J. Microencapsulation"},{"key":"D5NR00870K\/cit36\/1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jconrel.2018.12.049","volume":"295","author":"Costa","year":"2019","journal-title":"J. Controlled Release"},{"issue":"8","key":"D5NR00870K\/cit37\/1","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.3390\/pharmaceutics15082119","volume":"15","author":"Madden","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"D5NR00870K\/cit38\/1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ijpharm.2017.09.018","volume":"532","author":"Leal","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"7","key":"D5NR00870K\/cit39\/1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/chemse\/bjz046","volume":"44","author":"Kennel","year":"2019","journal-title":"Chem. Senses"},{"issue":"1","key":"D5NR00870K\/cit40\/1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chest.2017.11.008","volume":"154","author":"Ma","year":"2018","journal-title":"Chest"},{"key":"D5NR00870K\/cit41\/1","first-page":"Doc07","volume":"9","author":"Beule","year":"2011","journal-title":"GMS Curr. Top. Otorhinolaryngol. Head Neck Surg."},{"issue":"3","key":"D5NR00870K\/cit42\/1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.4168\/aair.2019.11.3.306","volume":"11","author":"Jiao","year":"2018","journal-title":"Allergy, Asthma Immunol. Res."},{"issue":"7","key":"D5NR00870K\/cit43\/1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s40263-022-00930-4","volume":"36","author":"Lofts","year":"2022","journal-title":"CNS Drugs"},{"issue":"3","key":"D5NR00870K\/cit44\/1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.18433\/J3NC79","volume":"12","author":"Pires","year":"2009","journal-title":"J. Pharm. Pharm. Sci."},{"key":"D5NR00870K\/cit45\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jconrel.2018.05.011","volume":"281","author":"Agrawal","year":"2018","journal-title":"J. Controlled Release"},{"issue":"10","key":"D5NR00870K\/cit46\/1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1517\/17425247.5.10.1159","volume":"5","author":"Wu","year":"2008","journal-title":"Expert Opin. Drug Delivery"},{"issue":"5","key":"D5NR00870K\/cit47\/1","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3390\/pharmaceutics14051073","volume":"14","author":"Tai","year":"2022","journal-title":"Pharmaceutics"},{"key":"D5NR00870K\/cit48\/1","doi-asserted-by":"crossref","first-page":"e17227","DOI":"10.7717\/peerj.17227","volume":"12","author":"Fang","year":"2024","journal-title":"PeerJ"},{"issue":"8","key":"D5NR00870K\/cit49\/1","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.3390\/ijms26083861","volume":"26","author":"Zhang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"D5NR00870K\/cit50\/1","doi-asserted-by":"crossref","first-page":"732954","DOI":"10.3389\/fphar.2021.732954","volume":"12","author":"Spindler","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D5NR00870K\/cit51\/1","doi-asserted-by":"crossref","first-page":"121318","DOI":"10.1016\/j.carbpol.2023.121318","volume":"321","author":"Iqbal","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"D5NR00870K\/cit52\/1","doi-asserted-by":"crossref","first-page":"880377","DOI":"10.3389\/fphar.2022.880377","volume":"13","author":"Frigaard","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"3","key":"D5NR00870K\/cit53\/1","doi-asserted-by":"crossref","first-page":"e22189","DOI":"10.1002\/ddr.22189","volume":"85","author":"Rezaei","year":"2024","journal-title":"Drug Dev. Res."},{"issue":"4","key":"D5NR00870K\/cit54\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3390\/ph15040459","volume":"15","author":"Ma","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"2","key":"D5NR00870K\/cit55\/1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/1567201815666181011121750","volume":"16","author":"Qureshi","year":"2019","journal-title":"Curr. Drug Delivery"},{"issue":"1","key":"D5NR00870K\/cit56\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1567201815666181004094707","volume":"16","author":"Sunena","year":"2019","journal-title":"Curr. Drug Delivery"},{"key":"D5NR00870K\/cit57\/1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijpharm.2019.02.012","volume":"560","author":"Yu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit58\/1","doi-asserted-by":"crossref","first-page":"119148","DOI":"10.1016\/j.ijpharm.2020.119148","volume":"579","author":"Bhattamisra","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"4","key":"D5NR00870K\/cit59\/1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/10837450.2021.1888980","volume":"26","author":"Shukr","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"D5NR00870K\/cit60\/1","doi-asserted-by":"crossref","first-page":"108832","DOI":"10.1016\/j.neuropharm.2021.108832","volume":"201","author":"Uppuluri","year":"2021","journal-title":"Neuropharmacology"},{"key":"D5NR00870K\/cit61\/1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijbiomac.2022.08.210","volume":"221","author":"Ahmad","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"D5NR00870K\/cit62\/1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3390\/pharmaceutics13071042","volume":"13","author":"Cunha","year":"2021","journal-title":"Pharmaceutics"},{"issue":"17","key":"D5NR00870K\/cit63\/1","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.3390\/polym15173597","volume":"15","author":"Shakya","year":"2023","journal-title":"Polymers"},{"issue":"1","key":"D5NR00870K\/cit64\/1","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1080\/10717544.2018.1494226","volume":"25","author":"Chu","year":"2018","journal-title":"Drug Delivery"},{"issue":"5","key":"D5NR00870K\/cit65\/1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/biomedicines10050985","volume":"10","author":"Musumeci","year":"2022","journal-title":"Biomedicines"},{"key":"D5NR00870K\/cit66\/1","doi-asserted-by":"crossref","first-page":"122760","DOI":"10.1016\/j.ijpharm.2023.122760","volume":"636","author":"de Oliveira","year":"2023","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit67\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.addr.2016.05.020","volume":"107","author":"Lee","year":"2016","journal-title":"Adv. Drug Delivery Rev."},{"issue":"2","key":"D5NR00870K\/cit68\/1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/jps.23836","volume":"103","author":"Musumeci","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"D5NR00870K\/cit69\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2009.09.039","volume":"1303","author":"Veronesi","year":"2009","journal-title":"Brain Res."},{"key":"D5NR00870K\/cit70\/1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.msec.2016.03.015","volume":"63","author":"Jain","year":"2016","journal-title":"Mater. Sci. Eng., C"},{"issue":"8","key":"D5NR00870K\/cit71\/1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3390\/polym15081835","volume":"15","author":"El Yousfi","year":"2023","journal-title":"Polymers"},{"issue":"8","key":"D5NR00870K\/cit72\/1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2174\/138945011795906642","volume":"12","author":"Gou","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"D5NR00870K\/cit73\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.msec.2016.04.089","volume":"66","author":"Sawant","year":"2016","journal-title":"Mater. Sci. Eng., C"},{"issue":"7","key":"D5NR00870K\/cit74\/1","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3109\/10717544.2014.948643","volume":"23","author":"Alex","year":"2016","journal-title":"Drug Delivery"},{"issue":"8","key":"D5NR00870K\/cit75\/1","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1166\/jbn.2015.2078","volume":"11","author":"Fonseca","year":"2015","journal-title":"J. Biomed. Nanotechnol."},{"issue":"5","key":"D5NR00870K\/cit76\/1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/polym15051123","volume":"15","author":"Elmowafy","year":"2023","journal-title":"Polymers"},{"issue":"1","key":"D5NR00870K\/cit77\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.surfrep.2017.02.001","volume":"72","author":"Heinz","year":"2017","journal-title":"Surf. Sci. Rep."},{"key":"D5NR00870K\/cit78\/1","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.2147\/IJN.S298606","volume":"16","author":"Miyazawa","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"D5NR00870K\/cit79\/1","doi-asserted-by":"crossref","first-page":"100537","DOI":"10.1016\/j.coco.2020.100537","volume":"22","author":"Shaban","year":"2020","journal-title":"Compos. Commun."},{"issue":"1","key":"D5NR00870K\/cit80\/1","doi-asserted-by":"crossref","first-page":"2000092","DOI":"10.1002\/adtp.202000092","volume":"4","author":"Hartl","year":"2021","journal-title":"Adv. Ther."},{"issue":"2","key":"D5NR00870K\/cit81\/1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jcis.2006.07.031","volume":"302","author":"Santander-Ortega","year":"2006","journal-title":"J. Colloid Interface Sci."},{"issue":"11","key":"D5NR00870K\/cit82\/1","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/anie.201006849","volume":"50","author":"Yang","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR00870K\/cit83\/1","doi-asserted-by":"crossref","first-page":"121780","DOI":"10.1016\/j.ijpharm.2022.121780","volume":"621","author":"Moya","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"8","key":"D5NR00870K\/cit84\/1","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1021\/acs.molpharmaceut.1c00366","volume":"18","author":"Clementino","year":"2021","journal-title":"Mol. Pharm."},{"key":"D5NR00870K\/cit85\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s11671-021-03584-1","volume":"16","author":"Tao","year":"2021","journal-title":"Nanoscale Res. Lett."},{"issue":"1\u20132","key":"D5NR00870K\/cit86\/1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ijpharm.2017.07.018","volume":"529","author":"Choudhury","year":"2017","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit87\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jconrel.2023.06.001","volume":"359","author":"Lu","year":"2023","journal-title":"J. Controlled Release"},{"key":"D5NR00870K\/cit88\/1","doi-asserted-by":"crossref","first-page":"120146","DOI":"10.1016\/j.ijpharm.2020.120146","volume":"593","author":"W\u00fcnsch","year":"2021","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit89\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12943-023-01849-0","volume":"22","author":"Gajbhiye","year":"2023","journal-title":"Mol. Cancer"},{"issue":"Pt A","key":"D5NR00870K\/cit90\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","volume":"99","author":"Suk","year":"2016","journal-title":"Adv. Drug Delivery Rev."},{"issue":"Suppl 7","key":"D5NR00870K\/cit91\/1","first-page":"e2021519","volume":"92","author":"Bianchi","year":"2021","journal-title":"Acta Bio Med. Atenei Parmensis"},{"key":"D5NR00870K\/cit92\/1","doi-asserted-by":"crossref","first-page":"119776","DOI":"10.1016\/j.ijpharm.2020.119776","volume":"589","author":"Chatzitaki","year":"2020","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit93\/1","doi-asserted-by":"crossref","first-page":"213039","DOI":"10.1016\/j.bioadv.2022.213039","volume":"139","author":"Iqbal","year":"2022","journal-title":"Biomater. Adv."},{"issue":"1","key":"D5NR00870K\/cit94\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijpharm.2008.02.009","volume":"358","author":"Luppi","year":"2008","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit95\/1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jconrel.2017.06.032","volume":"261","author":"Sekerdag","year":"2017","journal-title":"J. Controlled Release"},{"issue":"1","key":"D5NR00870K\/cit96\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4103\/0975-7406.76478","volume":"3","author":"Shaikh","year":"2011","journal-title":"J. Pharm. BioAllied Sci."},{"issue":"Pt 4","key":"D5NR00870K\/cit97\/1","doi-asserted-by":"crossref","first-page":"136549","DOI":"10.1016\/j.ijbiomac.2024.136549","volume":"281","author":"Seyam","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR00870K\/cit98\/1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jcis.2019.01.043","volume":"540","author":"Arruda","year":"2019","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"D5NR00870K\/cit99\/1","first-page":"50","volume":"2","author":"Alawdi","year":"2021","journal-title":"J. Sci. Res. Med. Biol. Sci."},{"issue":"10","key":"D5NR00870K\/cit100\/1","doi-asserted-by":"crossref","first-page":"e1900194","DOI":"10.1002\/mabi.201900194","volume":"19","author":"Brannigan","year":"2019","journal-title":"Macromol. Biosci."},{"issue":"3","key":"D5NR00870K\/cit101\/1","first-page":"865","volume":"44","author":"Singh","year":"2016","journal-title":"Artif. Cells, Nanomed., Biotechnol."},{"issue":"18","key":"D5NR00870K\/cit102\/1","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1016\/j.biomaterials.2006.01.038","volume":"27","author":"Gao","year":"2006","journal-title":"Biomaterials"},{"issue":"3","key":"D5NR00870K\/cit103\/1","doi-asserted-by":"crossref","first-page":"1900342","DOI":"10.1002\/mabi.201900342","volume":"20","author":"Taipaleenm\u00e4ki","year":"2020","journal-title":"Macromol. Biosci."},{"key":"D5NR00870K\/cit104\/1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jconrel.2022.11.051","volume":"353","author":"Gao","year":"2023","journal-title":"J. Controlled Release"},{"issue":"9","key":"D5NR00870K\/cit105\/1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1080\/17425247.2016.1182485","volume":"13","author":"D\u2032souza","year":"2016","journal-title":"Expert Opin. Drug Delivery"},{"issue":"15","key":"D5NR00870K\/cit106\/1","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1016\/j.biomaterials.2013.02.003","volume":"34","author":"Liu","year":"2013","journal-title":"Biomaterials"},{"issue":"12","key":"D5NR00870K\/cit107\/1","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.2217\/nnm.13.178","volume":"8","author":"Laffleur","year":"2013","journal-title":"Nanomedicine"},{"key":"D5NR00870K\/cit108\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2017.12.025","volume":"195","author":"Crowe","year":"2018","journal-title":"Life Sci."},{"issue":"2","key":"D5NR00870K\/cit109\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3109\/1061186X.2011.622396","volume":"20","author":"Chen","year":"2012","journal-title":"J. Drug Targeting"},{"issue":"1","key":"D5NR00870K\/cit110\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijpharm.2007.03.039","volume":"340","author":"Gao","year":"2007","journal-title":"Int. J. Pharm."},{"issue":"5","key":"D5NR00870K\/cit111\/1","doi-asserted-by":"crossref","first-page":"e3300","DOI":"10.1002\/psc.3300","volume":"27","author":"Reissmann","year":"2021","journal-title":"J. Pept. Sci."},{"issue":"12","key":"D5NR00870K\/cit112\/1","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.3390\/cells12121643","volume":"12","author":"De Martini","year":"2023","journal-title":"Cells"},{"issue":"2","key":"D5NR00870K\/cit113\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00232-016-9940-z","volume":"250","author":"Zou","year":"2017","journal-title":"J. Membr. Biol."},{"issue":"9","key":"D5NR00870K\/cit114\/1","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1007\/s11095-011-0440-7","volume":"28","author":"Kanazawa","year":"2011","journal-title":"Pharm. Res."},{"key":"D5NR00870K\/cit115\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jconrel.2014.05.056","volume":"193","author":"He","year":"2014","journal-title":"J. Controlled Release"},{"issue":"36","key":"D5NR00870K\/cit116\/1","doi-asserted-by":"crossref","first-page":"9888","DOI":"10.1016\/j.biomaterials.2011.09.004","volume":"32","author":"Xia","year":"2011","journal-title":"Biomaterials"},{"issue":"11","key":"D5NR00870K\/cit117\/1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3390\/pharmaceutics13111745","volume":"13","author":"Kamei","year":"2021","journal-title":"Pharmaceutics"},{"key":"D5NR00870K\/cit118\/1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jconrel.2014.11.004","volume":"197","author":"Kamei","year":"2015","journal-title":"J. Controlled Release"},{"key":"D5NR00870K\/cit119\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bmt.2023.09.001","volume":"5","author":"Elumalai","year":"2024","journal-title":"Biomed. Technol."},{"issue":"4","key":"D5NR00870K\/cit120\/1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1124\/pr.54.4.561","volume":"54","author":"Qian","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"D5NR00870K\/cit121\/1","doi-asserted-by":"crossref","first-page":"126471","DOI":"10.1016\/j.ijbiomac.2023.126471","volume":"252","author":"Sharma","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR00870K\/cit122\/1","doi-asserted-by":"crossref","first-page":"6547","DOI":"10.2147\/IJN.S120939","volume":"11","author":"Bi","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"3","key":"D5NR00870K\/cit123\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0165-0173(98)00012-5","volume":"27","author":"Qian","year":"1998","journal-title":"Brain Res. Rev."},{"issue":"1","key":"D5NR00870K\/cit124\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s13346-017-0438-8","volume":"8","author":"Pan","year":"2018","journal-title":"Drug Delivery Transl. Res."},{"issue":"5","key":"D5NR00870K\/cit125\/1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/1061186X.2016.1223676","volume":"25","author":"Huey","year":"2017","journal-title":"J. Drug Targeting"},{"issue":"7","key":"D5NR00870K\/cit126\/1","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1021\/acs.molpharmaceut.7b00158","volume":"14","author":"Oswald","year":"2017","journal-title":"Mol. Pharm."},{"issue":"1","key":"D5NR00870K\/cit127\/1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1080\/10717544.2022.2064564","volume":"29","author":"Li","year":"2022","journal-title":"Drug Delivery"},{"issue":"2","key":"D5NR00870K\/cit128\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/pharmaceutics12020093","volume":"12","author":"Chung","year":"2020","journal-title":"Pharmaceutics"},{"key":"D5NR00870K\/cit129\/1","doi-asserted-by":"crossref","first-page":"606682","DOI":"10.3389\/fphar.2021.606682","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"D5NR00870K\/cit130\/1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1080\/10717544.2021.1943058","volume":"28","author":"Wang","year":"2021","journal-title":"Drug Delivery"},{"issue":"16","key":"D5NR00870K\/cit131\/1","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.2217\/nnm-2018-0417","volume":"14","author":"Wang","year":"2019","journal-title":"Nanomedicine"},{"issue":"8","key":"D5NR00870K\/cit132\/1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/cbin.10459","volume":"39","author":"Salatin","year":"2015","journal-title":"Cell Biol. Int."},{"issue":"4","key":"D5NR00870K\/cit133\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/pharmaceutics16040481","volume":"16","author":"Gandhi","year":"2024","journal-title":"Pharmaceutics"},{"issue":"1","key":"D5NR00870K\/cit134\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/pharmaceutics10010034","volume":"10","author":"Sonvico","year":"2018","journal-title":"Pharmaceutics"},{"key":"D5NR00870K\/cit135\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejpb.2020.05.001","volume":"152","author":"Kanazawa","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"3","key":"D5NR00870K\/cit136\/1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/pharmaceutics13030391","volume":"13","author":"Veronesi","year":"2021","journal-title":"Pharmaceutics"},{"issue":"12","key":"D5NR00870K\/cit137\/1","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1016\/j.actbio.2011.07.025","volume":"7","author":"Seju","year":"2011","journal-title":"Acta Biomater."},{"key":"D5NR00870K\/cit138\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2015.12.029","volume":"223","author":"Cruz","year":"2016","journal-title":"J. Controlled Release"},{"key":"D5NR00870K\/cit139\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijpharm.2019.05.050","volume":"566","author":"Guo","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"9","key":"D5NR00870K\/cit140\/1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1021\/acs.accounts.8b00292","volume":"51","author":"Mosquera","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"D5NR00870K\/cit141\/1","doi-asserted-by":"crossref","first-page":"100073","DOI":"10.1016\/j.crimmu.2023.100073","volume":"4","author":"Toscano","year":"2023","journal-title":"Curr. Res. Immunol."},{"issue":"1","key":"D5NR00870K\/cit142\/1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijpharm.2015.12.046","volume":"499","author":"Gartziandia","year":"2016","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit143\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.colsurfb.2017.03.035","volume":"154","author":"Bonaccorso","year":"2017","journal-title":"Colloids Surf., B"},{"key":"D5NR00870K\/cit144\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejps.2016.05.012","volume":"92","author":"Muntimadugu","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"issue":"4","key":"D5NR00870K\/cit145\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/1570163815666180418144019","volume":"16","author":"Rukmangathen","year":"2019","journal-title":"Curr. Drug Discovery Technol."},{"key":"D5NR00870K\/cit146\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.brainresbull.2018.10.009","volume":"143","author":"Erd\u0151","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"9","key":"D5NR00870K\/cit147\/1","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.addr.2006.07.012","volume":"58","author":"Sakagami","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"issue":"24","key":"D5NR00870K\/cit148\/1","doi-asserted-by":"crossref","first-page":"21360","DOI":"10.1021\/acsami.9b04766","volume":"11","author":"Schlachet","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5NR00870K\/cit149\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejpb.2023.01.013","volume":"184","author":"Silva","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"7","key":"D5NR00870K\/cit150\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/bios12070500","volume":"12","author":"Oprea","year":"2022","journal-title":"Biosensors"},{"key":"D5NR00870K\/cit151\/1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.redox.2017.04.003","volume":"12","author":"Zeng","year":"2017","journal-title":"Redox Biol."},{"key":"D5NR00870K\/cit152\/1","doi-asserted-by":"crossref","first-page":"123351","DOI":"10.1016\/j.ijpharm.2023.123351","volume":"644","author":"Zhao","year":"2023","journal-title":"Int. J. Pharm."},{"key":"D5NR00870K\/cit153\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1742-2094-9-115","volume":"9","author":"Stansley","year":"2012","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"D5NR00870K\/cit154\/1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.2042-7158.2012.01540.x","volume":"64","author":"Reichl","year":"2012","journal-title":"J. Pharm. Pharmacol."},{"issue":"3","key":"D5NR00870K\/cit155\/1","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/jps.21031","volume":"97","author":"Bai","year":"2008","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"D5NR00870K\/cit156\/1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s13346-022-01245-z","volume":"13","author":"Gabold","year":"2023","journal-title":"Drug Delivery Transl. Res."},{"issue":"6","key":"D5NR00870K\/cit157\/1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/17425247.2021.1873274","volume":"18","author":"Gholizadeh","year":"2021","journal-title":"Expert Opin. Drug Delivery"},{"key":"D5NR00870K\/cit158\/1","doi-asserted-by":"crossref","first-page":"131491","DOI":"10.1016\/j.ijbiomac.2024.131491","volume":"267","author":"Gadhave","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR00870K\/cit159\/1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ejpb.2019.04.002","volume":"139","author":"Mercier","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"9","key":"D5NR00870K\/cit160\/1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3390\/pharmaceutics13091508","volume":"13","author":"Craparo","year":"2021","journal-title":"Pharmaceutics"},{"issue":"6","key":"D5NR00870K\/cit161\/1","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s13346-020-00824-2","volume":"10","author":"Ferreira","year":"2020","journal-title":"Drug Delivery Transl. Res."},{"key":"D5NR00870K\/cit162\/1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.biomaterials.2018.10.030","volume":"198","author":"Shi","year":"2019","journal-title":"Biomaterials"},{"issue":"1\u20132","key":"D5NR00870K\/cit163\/1","first-page":"51","volume":"29","author":"Merkle","year":"1998","journal-title":"Adv. Drug Delivery Rev."},{"issue":"8","key":"D5NR00870K\/cit164\/1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1208\/s12249-021-02131-6","volume":"22","author":"Haroon","year":"2021","journal-title":"AAPS PharmSciTech"},{"issue":"19","key":"D5NR00870K\/cit165\/1","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.3390\/polym15193890","volume":"15","author":"Badran","year":"2023","journal-title":"Polymers"},{"key":"D5NR00870K\/cit166\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijbiomac.2017.12.056","volume":"109","author":"Raj","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR00870K\/cit167\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ijbiomac.2016.04.076","volume":"89","author":"Shah","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"11","key":"D5NR00870K\/cit168\/1","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.3390\/polym12112589","volume":"12","author":"Shrestha","year":"2020","journal-title":"Polymers"},{"issue":"7","key":"D5NR00870K\/cit169\/1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1080\/02652048.2017.1375038","volume":"34","author":"Javia","year":"2017","journal-title":"J. Microencapsulation"},{"issue":"2","key":"D5NR00870K\/cit170\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.xphs.2018.07.013","volume":"108","author":"Deepika","year":"2019","journal-title":"J. Pharm. Sci."},{"issue":"11","key":"D5NR00870K\/cit171\/1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4155\/tde-2019-0060","volume":"10","author":"Jani","year":"2019","journal-title":"Ther. Delivery"},{"issue":"12","key":"D5NR00870K\/cit172\/1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1248\/cpb.54.1722","volume":"54","author":"Du","year":"2006","journal-title":"Chem. Pharm. Bull."},{"issue":"15","key":"D5NR00870K\/cit173\/1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1080\/09205063.2013.798880","volume":"24","author":"Patil","year":"2013","journal-title":"J. Biomater. Sci., Polym. Ed."},{"issue":"5","key":"D5NR00870K\/cit174\/1","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1208\/s12249-015-0294-0","volume":"16","author":"Sharma","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"D5NR00870K\/cit175\/1","first-page":"156010","volume":"2014","author":"Sharma","year":"2014","journal-title":"BioMed Res. Int."},{"key":"D5NR00870K\/cit176\/1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijbiomac.2019.02.005","volume":"129","author":"Piazzini","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR00870K\/cit177\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijbiomac.2013.06.041","volume":"61","author":"Kumar","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"D5NR00870K\/cit178\/1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.3109\/03639045.2014.991400","volume":"41","author":"Jafarieh","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"1","key":"D5NR00870K\/cit179\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.carbpol.2012.02.051","volume":"89","author":"Haque","year":"2012","journal-title":"Carbohydr. Polym."},{"issue":"2","key":"D5NR00870K\/cit180\/1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1021\/acs.molpharmaceut.3c00773","volume":"21","author":"Okmen Altas","year":"2024","journal-title":"Mol. Pharm."},{"key":"D5NR00870K\/cit181\/1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijbiomac.2015.07.041","volume":"81","author":"Bari","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"D5NR00870K\/cit182\/1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.xphs.2022.08.034","volume":"112","author":"Salem","year":"2023","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"D5NR00870K\/cit183\/1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/bdd.2348","volume":"44","author":"Haasbroek-Pheiffer","year":"2023","journal-title":"Biopharm. Drug Dispos."},{"issue":"Suppl 1","key":"D5NR00870K\/cit184\/1","first-page":"23","volume":"25","author":"Salmon","year":"2015","journal-title":"Eur. J. Dermatol."},{"issue":"3","key":"D5NR00870K\/cit185\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00232-006-0861-0","volume":"211","author":"Fischer","year":"2006","journal-title":"J. Membr. Biol."},{"issue":"4","key":"D5NR00870K\/cit186\/1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/00005537-200004000-00021","volume":"110","author":"Keck","year":"2000","journal-title":"Laryngoscope"},{"key":"D5NR00870K\/cit187\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2045-8118-11-26","volume":"11","author":"Hladky","year":"2014","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"D5NR00870K\/cit188\/1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jcpa.2015.08.009","volume":"153","author":"Chamanza","year":"2015","journal-title":"J. Comp. Pathol."},{"issue":"1","key":"D5NR00870K\/cit189\/1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/pharmaceutics15010233","volume":"15","author":"Prentice","year":"2023","journal-title":"Pharmaceutics"},{"key":"D5NR00870K\/cit190\/1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.neubiorev.2021.11.041","volume":"132","author":"Regan","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"Pt 1","key":"D5NR00870K\/cit191\/1","first-page":"83","volume":"135","author":"Gross","year":"1982","journal-title":"J. Anat."},{"key":"D5NR00870K\/cit192\/1","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.2147\/IJN.S119033","volume":"11","author":"Clementino","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"D5NR00870K\/cit193\/1","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.jtha.2023.08.019","volume":"21","author":"Fieux","year":"2023","journal-title":"J. Thromb. Haemostasis"},{"key":"D5NR00870K\/cit194\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ejpb.2018.11.002","volume":"133","author":"Musumeci","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D5NR00870K\/cit195\/1","doi-asserted-by":"crossref","first-page":"110464","DOI":"10.1016\/j.apradiso.2022.110464","volume":"189","author":"El-Kawy","year":"2022","journal-title":"Appl. Radiat. Isot."},{"key":"D5NR00870K\/cit196\/1","unstructured":"Intranasal Instillation in Rodents, University of California, San Francisco, 2022 [cited 2024 Apr 20]. Available from:  https:\/\/iacuc.ucsf.edu\/sites\/g\/files\/tkssra751\/f\/wysiwyg\/STD%20PROCEDURE%20-%20Misc%20Rodent%20Procedures%20-%20Intranasal%20Instillation%20in%20Rodents.pdf"},{"issue":"4","key":"D5NR00870K\/cit197\/1","first-page":"L833","volume":"282","author":"Southam","year":"2002","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"issue":"6","key":"D5NR00870K\/cit198\/1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1517\/17425247.2014.894504","volume":"11","author":"Md","year":"2014","journal-title":"Expert Opin. Drug Delivery"},{"issue":"7","key":"D5NR00870K\/cit199\/1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/10611860903055470","volume":"17","author":"Mistry","year":"2009","journal-title":"J. Drug Targeting"},{"issue":"7","key":"D5NR00870K\/cit200\/1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s11095-023-03552-7","volume":"40","author":"Abou-Taleb","year":"2023","journal-title":"Pharm. Res."},{"key":"D5NR00870K\/cit201\/1","doi-asserted-by":"crossref","first-page":"123922","DOI":"10.1016\/j.ijpharm.2024.123922","author":"Wong","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"4","key":"D5NR00870K\/cit202\/1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/jps.21924","volume":"99","author":"Dhuria","year":"2010","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"D5NR00870K\/cit203\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience"},{"issue":"1","key":"D5NR00870K\/cit204\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0169-409X(97)00067-7","volume":"29","author":"Kublik","year":"1998","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5NR00870K\/cit205\/1","doi-asserted-by":"crossref","first-page":"127217","DOI":"10.1016\/j.ijbiomac.2023.127217","volume":"253","author":"Hard","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"21","key":"D5NR00870K\/cit206\/1","doi-asserted-by":"crossref","first-page":"13440","DOI":"10.3390\/ijms232113440","volume":"23","author":"Monge","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"D5NR00870K\/cit207\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s40290-023-00495-7","volume":"37","author":"Shrewsbury","year":"2023","journal-title":"Pharm. Med."},{"issue":"1","key":"D5NR00870K\/cit208\/1","first-page":"1","volume":"10","author":"Veronesi","year":"2020","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"issue":"9","key":"D5NR00870K\/cit209\/1","doi-asserted-by":"crossref","first-page":"094805","DOI":"10.1117\/1.JBO.28.9.094805","volume":"28","author":"Sun","year":"2023","journal-title":"J. Biomed. Opt."},{"key":"D5NR00870K\/cit210\/1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"D5NR00870K\/cit211\/1","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s13346-020-00816-2","volume":"10","author":"de Oliveira Junior","year":"2020","journal-title":"Drug Delivery Transl. Res."},{"issue":"5","key":"D5NR00870K\/cit212\/1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s13346-019-00622-5","volume":"9","author":"Nigam","year":"2019","journal-title":"Drug Delivery Transl. Res."},{"issue":"4","key":"D5NR00870K\/cit213\/1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2174\/1567201812666150507120124","volume":"13","author":"Sharma","year":"2016","journal-title":"Curr. Drug Delivery"},{"issue":"9","key":"D5NR00870K\/cit214\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11095-019-2662-z","volume":"36","author":"de Oliveira Junior","year":"2019","journal-title":"Pharm. Res."},{"issue":"4","key":"D5NR00870K\/cit215\/1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1166\/jbn.2019.2724","volume":"15","author":"Li","year":"2019","journal-title":"J. Biomed. Nanotechnol."},{"issue":"12","key":"D5NR00870K\/cit216\/1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1080\/17425247.2019.1690452","volume":"16","author":"Cayero-Otero","year":"2019","journal-title":"Expert Opin. Drug Delivery"},{"key":"D5NR00870K\/cit217\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejpb.2019.09.008","volume":"144","author":"Dalpiaz","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"D5NR00870K\/cit218\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2174\/2211738510666220303160414","volume":"10","author":"Jha","year":"2022","journal-title":"Pharm. Nanotechnol."},{"issue":"3","key":"D5NR00870K\/cit219\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejps.2012.12.007","volume":"48","author":"Md","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"D5NR00870K\/cit220\/1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1080\/10717544.2020.1760960","volume":"27","author":"Hao","year":"2020","journal-title":"Drug Delivery"},{"key":"D5NR00870K\/cit221\/1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ijbiomac.2016.06.001","volume":"91","author":"Ahmad","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR00870K\/cit222\/1","doi-asserted-by":"crossref","first-page":"102119","DOI":"10.1016\/j.nano.2019.102119","volume":"24","author":"Sava","year":"2020","journal-title":"Nanomedicine"},{"key":"D5NR00870K\/cit223\/1","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2147\/IJN.S439181","volume":"19","author":"Koo","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"D5NR00870K\/cit224\/1","first-page":"3146","author":"Ieven","year":"2023","journal-title":"J. Allergy Clin. Immunol.: Pract."},{"key":"D5NR00870K\/cit225\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.nantod.2017.06.008","volume":"15","author":"Hassan","year":"2017","journal-title":"Nano Today"},{"key":"D5NR00870K\/cit226\/1","unstructured":"Search for: Other terms: Nanoparticle, Recruiting studies | Card Results | ClinicalTrials.gov. [cited 2025 Jun 16]. Available from:  https:\/\/clinicaltrials.gov\/search?term=Nanoparticle&aggFilters=status:rec"},{"issue":"6","key":"D5NR00870K\/cit227\/1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3390\/pharmaceutics16060746","volume":"16","author":"Omidian","year":"2024","journal-title":"Pharmaceutics"},{"issue":"5","key":"D5NR00870K\/cit228\/1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/joa.13813","volume":"242","author":"Mar\u00e9chal","year":"2022","journal-title":"J. Anat."},{"key":"D5NR00870K\/cit229\/1","doi-asserted-by":"crossref","first-page":"106630","DOI":"10.1016\/j.ejps.2023.106630","volume":"192","author":"Luo","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"D5NR00870K\/cit230\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00018-024-05557-w","volume":"82","author":"Liu","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"D5NR00870K\/cit231\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41386-024-01980-6","volume":"50","author":"Calabro","year":"2025","journal-title":"Neuropsychopharmacology"},{"issue":"48","key":"D5NR00870K\/cit232\/1","doi-asserted-by":"crossref","first-page":"28941","DOI":"10.1039\/D0RA04212A","volume":"10","author":"Sorrentino","year":"2020","journal-title":"RSC Adv."},{"key":"D5NR00870K\/cit233\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ejpb.2015.05.019","volume":"94","author":"Di Gioia","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"7","key":"D5NR00870K\/cit234\/1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3109\/03639045.2013.789051","volume":"40","author":"Sharma","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"1","key":"D5NR00870K\/cit235\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3390\/pharmaceutics14010147","volume":"14","author":"Trapani","year":"2022","journal-title":"Pharmaceutics"},{"issue":"3","key":"D5NR00870K\/cit236\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/2211738506666180813122437","volume":"6","author":"Brar","year":"2018","journal-title":"Pharm. Nanotechnol."},{"issue":"12","key":"D5NR00870K\/cit237\/1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1080\/17425247.2023.2228685","volume":"20","author":"Hanna","year":"2023","journal-title":"Expert Opin. Drug Delivery"},{"issue":"24","key":"D5NR00870K\/cit238\/1","doi-asserted-by":"crossref","first-page":"13258","DOI":"10.3390\/ijms222413258","volume":"22","author":"Akel","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D5NR00870K\/cit239\/1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"5","key":"D5NR00870K\/cit240\/1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3390\/biomedicines10050985","volume":"10","author":"Musumeci","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"D5NR00870K\/cit241\/1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijpharm.2013.04.084","volume":"452","author":"Abdelbary","year":"2013","journal-title":"Int. J. Pharm."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D5NR00870K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T18:29:43Z","timestamp":1783276183000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/31\/17947-17979\/900940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":241,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2025,8,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr00870k","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5NR00870K\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00870K\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00870K\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00870K\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00870K\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR00870K\/v2\/response1","asserted-by":"object"}]},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}