{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:59:36Z","timestamp":1789469976602,"version":"build-2803163510"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"am","delay-in-days":471,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22076132"],"award-info":[{"award-number":["22076132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21976128"],"award-info":[{"award-number":["21976128"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22376154"],"award-info":[{"award-number":["22376154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>ZIF-8-based dual-modality biomimetic smart nanoparticles loaded with ICG and rapamycin are used for the combination therapy of radiation sensitization and photothermal therapy of advanced tumors.<\/jats:p>","DOI":"10.1039\/d5nr01093d","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:00:36Z","timestamp":1744866036000},"page":"12134-12148","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A ZIF-8-based dual-modal smart responsive nanoplatform for overcoming radiotherapy resistance in advanced tumors"],"prefix":"10.1039","volume":"17","author":[{"given":"Yi","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqi","family":"Song","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"China Institute for Radiation Protection, National Atomic Energy Agency Nuclear Technology (Nonclinical Evaluation of Radiopharmaceuticals) Research and Development Center, CNNC Key Laboratory on Radio-Toxicology and Radiopharmaceutical Preclinical Evaluation, Taiyuan 030006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8839-4029","authenticated-orcid":false,"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanglin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-1024","authenticated-orcid":false,"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-4702","authenticated-orcid":false,"given":"Ran","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5NR01093D\/cit1\/1","doi-asserted-by":"publisher","first-page":"9759","DOI":"10.1039\/d1cs01145f","volume":"51","author":"Pan","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D5NR01093D\/cit2\/1","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nrclinonc.2015.120","volume":"12","author":"Schaue","year":"2015","journal-title":"Nat. Rev. Clin Oncol."},{"key":"D5NR01093D\/cit3\/1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41392-024-01889-y","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduction Targeted Ther."},{"key":"D5NR01093D\/cit4\/1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/s0140-6736(21)00233-6","volume":"398","author":"Chandra","year":"2021","journal-title":"Lancet"},{"key":"D5NR01093D\/cit5\/1","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12943-023-01801-2","volume":"22","author":"Wu","year":"2023","journal-title":"Mol. Cancer"},{"key":"D5NR01093D\/cit6\/1","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.3390\/cells9071651","volume":"9","author":"Olivares-Urbano","year":"2020","journal-title":"Cells"},{"key":"D5NR01093D\/cit7\/1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s13402-023-00906-6","volume":"47","author":"Porrazzo","year":"2024","journal-title":"Cell Oncol."},{"key":"D5NR01093D\/cit8\/1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.radmp.2020.01.006","volume":"1","author":"Huang","year":"2020","journal-title":"Radiat. Med. Prot."},{"key":"D5NR01093D\/cit9\/1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jbo.2016.03.001","volume":"5","author":"Feng","year":"2016","journal-title":"J. Bone Oncol."},{"key":"D5NR01093D\/cit10\/1","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.3390\/antiox11081509","volume":"11","author":"Sung","year":"2022","journal-title":"Antioxidants"},{"key":"D5NR01093D\/cit11\/1","doi-asserted-by":"publisher","first-page":"910292","DOI":"10.3389\/fphar.2022.910292","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D5NR01093D\/cit12\/1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-024-02448-0","author":"Jiang","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"D5NR01093D\/cit13\/1","doi-asserted-by":"publisher","first-page":"e2402929","DOI":"10.1002\/adma.202402929","volume":"36","author":"Ma","year":"2024","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit14\/1","doi-asserted-by":"publisher","first-page":"e2314197","DOI":"10.1002\/adma.202314197","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit15\/1","doi-asserted-by":"publisher","first-page":"e2304328","DOI":"10.1002\/adma.202304328","volume":"36","author":"Yi","year":"2024","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit16\/1","doi-asserted-by":"publisher","first-page":"101919","DOI":"10.1016\/j.nantod.2023.101919","volume":"51","author":"Luo","year":"2023","journal-title":"Nano Today"},{"key":"D5NR01093D\/cit17\/1","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1021\/acsnano.8b06795","volume":"13","author":"Huang","year":"2019","journal-title":"ACS Nano"},{"key":"D5NR01093D\/cit18\/1","doi-asserted-by":"publisher","first-page":"101832","DOI":"10.1016\/j.nantod.2023.101823","volume":"50","author":"Liu","year":"2023","journal-title":"Nano Today"},{"key":"D5NR01093D\/cit19\/1","doi-asserted-by":"publisher","first-page":"e1707567","DOI":"10.1002\/adma.201707567","volume":"30","author":"Shan","year":"2018","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit20\/1","doi-asserted-by":"publisher","first-page":"e202304419","DOI":"10.1002\/anie.202304419","volume":"62","author":"Chi","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR01093D\/cit21\/1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.mattod.2023.07.003","volume":"68","author":"Liu","year":"2023","journal-title":"Mater. Today"},{"key":"D5NR01093D\/cit22\/1","doi-asserted-by":"publisher","first-page":"1801507","DOI":"10.1002\/advs.201801507","volume":"6","author":"Zhang","year":"2019","journal-title":"Adv. Sci."},{"key":"D5NR01093D\/cit23\/1","doi-asserted-by":"publisher","first-page":"1700996","DOI":"10.1002\/adma.201700996","volume":"29","author":"Song","year":"2017","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit24\/1","doi-asserted-by":"publisher","first-page":"6258","DOI":"10.7150\/thno.74808","volume":"12","author":"He","year":"2022","journal-title":"Theranostics"},{"key":"D5NR01093D\/cit25\/1","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1021\/acsami.1c21860","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5NR01093D\/cit26\/1","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s40843-023-2774-8","volume":"67","author":"Song","year":"2024","journal-title":"Sci. China Mater."},{"key":"D5NR01093D\/cit27\/1","doi-asserted-by":"publisher","first-page":"142961","DOI":"10.1016\/j.cej.2023.142961","volume":"465","author":"Rao","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D5NR01093D\/cit28\/1","doi-asserted-by":"publisher","first-page":"e1802745","DOI":"10.1002\/smll.201802745","volume":"14","author":"Yan","year":"2018","journal-title":"Small"},{"key":"D5NR01093D\/cit29\/1","doi-asserted-by":"publisher","first-page":"e202215307","DOI":"10.1002\/anie.202215307","author":"Ding","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR01093D\/cit30\/1","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1039\/c9cs00472f","volume":"48","author":"Troyano","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"D5NR01093D\/cit31\/1","doi-asserted-by":"publisher","first-page":"e2209690","DOI":"10.1002\/adma.202209690","author":"Jin","year":"2022","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit32\/1","doi-asserted-by":"publisher","first-page":"e2108525","DOI":"10.1002\/adma.202108525","volume":"34","author":"Liu","year":"2022","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit33\/1","doi-asserted-by":"publisher","first-page":"e2302700","DOI":"10.1002\/advs.202302700","author":"Chen","year":"2023","journal-title":"Adv. Sci."},{"key":"D5NR01093D\/cit34\/1","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1021\/acs.chemrev.2c00879","volume":"123","author":"Wang","year":"2023","journal-title":"Chem. Rev."},{"key":"D5NR01093D\/cit35\/1","doi-asserted-by":"publisher","first-page":"7721","DOI":"10.1021\/acsnano.3c00288","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"key":"D5NR01093D\/cit36\/1","doi-asserted-by":"publisher","first-page":"e1706759","DOI":"10.1002\/adma.201706759","volume":"30","author":"Fang","year":"2018","journal-title":"Adv. Mater."},{"key":"D5NR01093D\/cit37\/1","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.3390\/cancers11121836","volume":"11","author":"Harris","year":"2019","journal-title":"Cancers"},{"key":"D5NR01093D\/cit38\/1","doi-asserted-by":"publisher","first-page":"e1285","DOI":"10.1002\/ctm2.1285","volume":"13","author":"Krishnan","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"D5NR01093D\/cit39\/1","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1021\/acsnano.8b06556","volume":"13","author":"Jia","year":"2019","journal-title":"ACS Nano"},{"key":"D5NR01093D\/cit40\/1","doi-asserted-by":"publisher","first-page":"1909369","DOI":"10.1002\/adfm.201909369","volume":"30","author":"Wang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D5NR01093D\/cit41\/1","doi-asserted-by":"publisher","first-page":"122026","DOI":"10.1016\/j.biomaterials.2023.122026","volume":"295","author":"Ma","year":"2023","journal-title":"Biomaterials"},{"key":"D5NR01093D\/cit42\/1","doi-asserted-by":"publisher","first-page":"e20220012","DOI":"10.1002\/inmd.20220012","volume":"1","author":"Chen","year":"2023","journal-title":"J. Interdiscip. Nanomed."},{"key":"D5NR01093D\/cit43\/1","doi-asserted-by":"publisher","first-page":"625","DOI":"10.2217\/nnm-2019-0388","volume":"15","author":"Zou","year":"2020","journal-title":"Nanomedicine"},{"key":"D5NR01093D\/cit44\/1","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1021\/nl500618u","volume":"14","author":"Fang","year":"2014","journal-title":"Nano Lett."},{"key":"D5NR01093D\/cit45\/1","doi-asserted-by":"publisher","first-page":"9850","DOI":"10.1021\/acsami.9b00294","volume":"11","author":"Wu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5NR01093D\/cit46\/1","doi-asserted-by":"publisher","first-page":"120308","DOI":"10.1016\/j.biomaterials.2020.120308","volume":"258","author":"Xu","year":"2020","journal-title":"Biomaterials"},{"key":"D5NR01093D\/cit47\/1","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/j.cclet.2018.02.014","volume":"29","author":"Yang","year":"2018","journal-title":"Chin. Chem. Lett."},{"key":"D5NR01093D\/cit48\/1","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.colsurfa.2019.02.025","volume":"568","author":"Wang","year":"2019","journal-title":"Colloids Surf., A"},{"key":"D5NR01093D\/cit49\/1","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D5NR01093D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:37:45Z","timestamp":1783449465000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/19\/12134-12148\/901021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":49,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2025,5,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr01093d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5NR01093D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01093D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01093D\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01093D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01093D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01093D\/v1\/review1","asserted-by":"object"}]},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}