{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:43:43Z","timestamp":1782855823644,"version":"3.54.5"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"26","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"am","delay-in-days":518,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003398","name":"Shanxi Scholarship Council of China","doi-asserted-by":"publisher","award":["2024-144"],"award-info":[{"award-number":["2024-144"]}],"id":[{"id":"10.13039\/501100003398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>\n                    BSC is a new strategy for the treatment of sepsis, which can exert the activity of GPX enzyme to remove excess H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , inhibit the production of ROS, and suppress NF-\u03baB pathway, thereby inhibiting the production of inflammatory factors.\n                  <\/jats:p>","DOI":"10.1039\/d5nr01444a","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:00:36Z","timestamp":1748934036000},"page":"15866-15878","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Selenium nanoparticles combined with calycosin treated sepsis through synergistic anti-inflammatory and antioxidant effects"],"prefix":"10.1039","volume":"17","author":[{"given":"Bin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, Shanxi Province, China"},{"name":"Department of Medical Imaging, Shanxi Key Laboratory of Intelligent Imaging and Nanomedicine, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Shanxi Key Laboratory of Intelligent Imaging and Nanomedicine, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7534-3203","authenticated-orcid":false,"given":"Taigang","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Provincial Key Laboratory of Drug Synthesis and Novel Pharmaceutical Preparation Technology, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-5509","authenticated-orcid":false,"given":"Jiangfeng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Shanxi Key Laboratory of Intelligent Imaging and Nanomedicine, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China"},{"name":"Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan 030001, Shanxi Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5NR01444A\/cit1\/1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"Singer","year":"2016","journal-title":"J. Am. Med. Assoc."},{"key":"D5NR01444A\/cit2\/1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"D5NR01444A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1226162","DOI":"10.3389\/fnut.2023.1226162","volume":"10","author":"Hajmir","year":"2023","journal-title":"Front. Nutr."},{"key":"D5NR01444A\/cit4\/1","first-page":"3609","volume":"27","author":"Hajmir","year":"2022","journal-title":"Eating and Weight Disorders \u2013 Studies on Anorexia, Bulimia and Obesity"},{"key":"D5NR01444A\/cit5\/1","first-page":"56","volume":"9","author":"Liu","year":"2022","journal-title":"Mil. Med. Res."},{"key":"D5NR01444A\/cit6\/1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41565-022-01137-w","volume":"17","author":"Ye","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"D5NR01444A\/cit7\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3949\/ccjm.87a.18143","volume":"87","author":"Dugar","year":"2020","journal-title":"Cleve. Clin. J. Med."},{"key":"D5NR01444A\/cit8\/1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/s12951-023-02224-3","volume":"21","author":"Guo","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"D5NR01444A\/cit9\/1","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1021\/acsnano.3c10458","volume":"18","author":"Fu","year":"2024","journal-title":"ACS Nano"},{"key":"D5NR01444A\/cit10\/1","first-page":"46090","volume":"16","author":"Pan","year":"2024","journal-title":"Regener. Biomater."},{"key":"D5NR01444A\/cit11\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12951-022-01343-7","volume":"20","author":"Liu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"D5NR01444A\/cit12\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12951-023-02246-x","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D5NR01444A\/cit13\/1","doi-asserted-by":"crossref","first-page":"15189","DOI":"10.1021\/acsnano.5c00700","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"D5NR01444A\/cit14\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1142\/S0192415X16500014","volume":"44","author":"Auyeung","year":"2016","journal-title":"Am. J. Chin. Med."},{"key":"D5NR01444A\/cit15\/1","doi-asserted-by":"crossref","first-page":"828061","DOI":"10.3389\/fphar.2022.828061","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D5NR01444A\/cit16\/1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.biopha.2018.06.143","volume":"106","author":"Kong","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D5NR01444A\/cit17\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3390\/antiox11020222","volume":"11","author":"Chaouhan","year":"2022","journal-title":"Antioxidants"},{"key":"D5NR01444A\/cit18\/1","doi-asserted-by":"crossref","first-page":"115536","DOI":"10.1016\/j.jep.2022.115536","volume":"297","author":"Shi","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"D5NR01444A\/cit19\/1","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1007\/s13197-017-2902-3","volume":"54","author":"Hu","year":"2017","journal-title":"J Food Sci. Technol."},{"key":"D5NR01444A\/cit20\/1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.gene.2018.06.057","volume":"675","author":"Dong","year":"2018","journal-title":"Gene"},{"key":"D5NR01444A\/cit21\/1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.intimp.2018.07.012","volume":"62","author":"Karkale","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"D5NR01444A\/cit22\/1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jchromb.2018.06.002","volume":"1092","author":"Baira","year":"2018","journal-title":"J. Chromatogr. B:Anal. Technol. Biomed. Life Sci."},{"key":"D5NR01444A\/cit23\/1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12951-022-01582-8","volume":"20","author":"Ko","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"D5NR01444A\/cit24\/1","first-page":"489","volume":"20","author":"Stepankova","year":"2023","journal-title":"Bioact. Mater."},{"key":"D5NR01444A\/cit25\/1","doi-asserted-by":"crossref","first-page":"112435","DOI":"10.1016\/j.foodres.2022.112435","volume":"164","author":"Chen","year":"2023","journal-title":"Food Res. Int."},{"key":"D5NR01444A\/cit26\/1","doi-asserted-by":"crossref","first-page":"115589","DOI":"10.1016\/j.envres.2023.115589","volume":"225","author":"Far","year":"2023","journal-title":"Environ. Res."},{"key":"D5NR01444A\/cit27\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejpb.2018.09.012","volume":"132","author":"Kadari","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D5NR01444A\/cit28\/1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ijbiomac.2018.03.108","volume":"114","author":"Chen","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR01444A\/cit29\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.actbio.2019.02.006","volume":"88","author":"Yang","year":"2019","journal-title":"Acta Biomaterialia"},{"key":"D5NR01444A\/cit30\/1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41467-025-55862-6","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"D5NR01444A\/cit31\/1","doi-asserted-by":"crossref","first-page":"2419242","DOI":"10.1002\/adfm.202419242","author":"Hu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"D5NR01444A\/cit32\/1","doi-asserted-by":"crossref","first-page":"131176","DOI":"10.1016\/j.ijbiomac.2024.131176","volume":"267","author":"Davidson","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR01444A\/cit33\/1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ejpb.2017.05.003","volume":"117","author":"Kumari","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D5NR01444A\/cit34\/1","first-page":"1051","volume":"10","author":"Xia","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"D5NR01444A\/cit35\/1","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1021\/nn202452c","volume":"6","author":"Liu","year":"2012","journal-title":"ACS Nano"},{"key":"D5NR01444A\/cit36\/1","doi-asserted-by":"crossref","first-page":"119220","DOI":"10.1016\/j.biomaterials.2019.05.031","volume":"216","author":"Zheng","year":"2019","journal-title":"Biomaterials"},{"key":"D5NR01444A\/cit37\/1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.actbio.2014.08.035","volume":"11","author":"Zheng","year":"2015","journal-title":"Acta Biomater."},{"key":"D5NR01444A\/cit38\/1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.actbio.2017.02.042","volume":"54","author":"Zhao","year":"2017","journal-title":"Acta Biomater."},{"key":"D5NR01444A\/cit39\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.actbio.2019.02.006","volume":"88","author":"Yang","year":"2019","journal-title":"Acta Biomater."},{"key":"D5NR01444A\/cit40\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00755-7","volume":"19","author":"Ding","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"D5NR01444A\/cit41\/1","doi-asserted-by":"crossref","first-page":"100929","DOI":"10.1016\/j.apmt.2020.100929","volume":"22","author":"Chen","year":"2021","journal-title":"Appl. Mater. Today"},{"key":"D5NR01444A\/cit42\/1","doi-asserted-by":"crossref","first-page":"12193","DOI":"10.1021\/jacs.3c02179","volume":"145","author":"Ouyang","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D5NR01444A\/cit43\/1","doi-asserted-by":"crossref","first-page":"30717","DOI":"10.1039\/C7RA02384G","volume":"7","author":"Deng","year":"2017","journal-title":"RSC Adv."},{"key":"D5NR01444A\/cit44\/1","doi-asserted-by":"crossref","first-page":"10224","DOI":"10.1002\/chem.201801725","volume":"24","author":"Huang","year":"2018","journal-title":"Chemistry"},{"key":"D5NR01444A\/cit45\/1","doi-asserted-by":"crossref","first-page":"101144","DOI":"10.1016\/j.nantod.2021.101144","volume":"38","author":"Pei","year":"2021","journal-title":"Nano Today"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D5NR01444A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:36:29Z","timestamp":1782851789000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/26\/15866-15878\/901137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":45,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2025,7,3]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr01444a","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5NR01444A\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01444A\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01444A\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01444A\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01444A\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5NR01444A\/v2\/response1","asserted-by":"object"}]},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}