{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:00:53Z","timestamp":1782878453528,"version":"3.54.5"},"reference-count":57,"publisher":"Royal Society of Chemistry (RSC)","issue":"43","license":[{"start":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:00:00Z","timestamp":1793145600000},"content-version":"am","delay-in-days":665,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Cystic fibrosis (CF) is one of the most common life-shortening genetic diseases, affecting between 70\u2009000 and 90\u2009000 people worldwide.<\/jats:p>","DOI":"10.1039\/d5nr03489b","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:45:38Z","timestamp":1761666338000},"page":"25336-25347","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electrochemical selection of a CFTR-specific aptamer and design of a COF-based aptasensor for the diagnosis of cystic fibrosis"],"prefix":"10.1039","volume":"17","author":[{"given":"Amina","family":"Rhouati","sequence":"first","affiliation":[{"name":"Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Al Mogren","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlem","family":"Teniou","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souna","family":"Elwary","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Khojastehnezhad","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnological Engineering, Universit\u00e9 de Sherbrooke, 2500 Boulevard de l'Universit\u00e9, Sherbrooke J1K 2R1, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Siaj","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnological Engineering, Universit\u00e9 de Sherbrooke, 2500 Boulevard de l'Universit\u00e9, Sherbrooke J1K 2R1, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-1430","authenticated-orcid":false,"given":"Mohammed","family":"Zourob","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Alfaisal University, Al Zahrawi Street, Al Maather, Al Takhassusi Road, Riyadh 11533, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"21","key":"D5NR03489B\/cit1\/1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1001\/jama.2023.8120","volume":"329","author":"Ong","year":"2023","journal-title":"J. Am. Med. Assoc."},{"issue":"3","key":"D5NR03489B\/cit2\/1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jcf.2022.01.009","volume":"21","author":"Guo","year":"2022","journal-title":"J. Cystic Fibrosis"},{"issue":"1","key":"D5NR03489B\/cit3\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s44162-024-00052-z","volume":"3","author":"Addissouky","year":"2024","journal-title":"J. Rare Dis."},{"issue":"5225","key":"D5NR03489B\/cit4\/1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.7543698","volume":"269","author":"Stutts","year":"1995","journal-title":"Science"},{"issue":"11","key":"D5NR03489B\/cit5\/1","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.3390\/cells10112844","volume":"10","author":"Hanssens","year":"2021","journal-title":"Cells"},{"key":"D5NR03489B\/cit6\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00018-016-2386-8","volume":"74","author":"Meng","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"D5NR03489B\/cit7\/1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jcf.2012.05.001","volume":"11","author":"Ooi","year":"2012","journal-title":"J. Cystic Fibrosis"},{"issue":"7","key":"D5NR03489B\/cit8\/1","first-page":"e16144","volume":"13","author":"Zaher","year":"2021","journal-title":"Cureus"},{"key":"D5NR03489B\/cit9\/1","doi-asserted-by":"crossref","first-page":"608821","DOI":"10.3389\/fped.2020.608821","volume":"8","author":"Coverstone","year":"2021","journal-title":"Front. Pediatr."},{"issue":"1","key":"D5NR03489B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.107.1.1","volume":"107","author":"Farrell","year":"2001","journal-title":"Pediatrics"},{"issue":"8","key":"D5NR03489B\/cit11\/1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S2213-2600(16)00053-9","volume":"4","author":"Castellani","year":"2016","journal-title":"Lancet Respir. Med."},{"issue":"3","key":"D5NR03489B\/cit12\/1","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.jpeds.2005.08.012","volume":"147","author":"Farrell","year":"2005","journal-title":"J. Pediatr."},{"issue":"3","key":"D5NR03489B\/cit13\/1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jcf.2018.03.002","volume":"17","author":"Schmidt","year":"2018","journal-title":"J. Cystic Fibrosis"},{"key":"D5NR03489B\/cit14\/1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jped.2018.04.005","volume":"95","author":"Gon\u00e7alves","year":"2019","journal-title":"J. Pediatr."},{"key":"D5NR03489B\/cit15\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jcf.2004.05.017","volume":"3","author":"Farinha","year":"2004","journal-title":"J. Cystic Fibrosis"},{"issue":"4","key":"D5NR03489B\/cit16\/1","doi-asserted-by":"crossref","first-page":"E226","DOI":"10.25011\/cim.v37i4.21728","volume":"37","author":"Liu","year":"2014","journal-title":"Clinical and Investigative Medicine"},{"issue":"1","key":"D5NR03489B\/cit17\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s41231-022-00117-5","volume":"7","author":"Wang","year":"2022","journal-title":"Transl. Med. Commun."},{"issue":"6","key":"D5NR03489B\/cit18\/1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.mcp.2009.07.001","volume":"23","author":"Davidson","year":"2009","journal-title":"Mol. Cell. Probes"},{"key":"D5NR03489B\/cit19\/1","first-page":"335","volume-title":"CFTR Folding Consortium: methods available for studies of CFTR folding and correction : Cystic Fibrosis: Diagnosis and Protocols, Volume II: Methods and Resources to Understand Cystic Fibrosis","author":"Peters","year":"2011","unstructured":"K. W.Peters ,  et al. ,  CFTR Folding Consortium: methods available for studies of CFTR folding and correction , in  Cystic Fibrosis: Diagnosis and Protocols, Volume II: Methods and Resources to Understand Cystic Fibrosis ,  2011 , pp.  335\u2013353"},{"issue":"4","key":"D5NR03489B\/cit20\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.12665\/J114.KedzierskiCaltagirone","volume":"11","author":"Kedzierski","year":"2012","journal-title":"Bioprocess J."},{"issue":"10","key":"D5NR03489B\/cit21\/1","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.3390\/ijms18102142","volume":"18","author":"Zhuo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"4968","key":"D5NR03489B\/cit22\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.2200121","volume":"249","author":"Tuerk","year":"1990","journal-title":"Science"},{"issue":"6287","key":"D5NR03489B\/cit23\/1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/346818a0","volume":"346","author":"Ellington","year":"1990","journal-title":"Nature"},{"issue":"8","key":"D5NR03489B\/cit24\/1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1080\/10643389.2019.1634457","volume":"50","author":"Kud\u0142ak","year":"2020","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"D5NR03489B\/cit25\/1","doi-asserted-by":"crossref","first-page":"122776","DOI":"10.1016\/j.talanta.2021.122776","volume":"235","author":"Bajaj","year":"2021","journal-title":"Talanta"},{"issue":"5","key":"D5NR03489B\/cit26\/1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/toxins15050326","volume":"15","author":"Jaric","year":"2023","journal-title":"Toxins"},{"issue":"1","key":"D5NR03489B\/cit27\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/EBC20150008","volume":"60","author":"Hammond","year":"2016","journal-title":"Essays Biochem."},{"issue":"1","key":"D5NR03489B\/cit28\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/s22010161","volume":"22","author":"Grabowska","year":"2021","journal-title":"Sensors"},{"key":"D5NR03489B\/cit29\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bios.2017.06.011","volume":"97","author":"Wang","year":"2017","journal-title":"Biosens. Bioelectron."},{"issue":"16","key":"D5NR03489B\/cit30\/1","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1021\/acs.chemrev.9b00550","volume":"120","author":"Geng","year":"2020","journal-title":"Chem. Rev."},{"issue":"7","key":"D5NR03489B\/cit31\/1","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.1021\/acsanm.0c01327","volume":"3","author":"Hu","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"issue":"24","key":"D5NR03489B\/cit32\/1","doi-asserted-by":"crossref","first-page":"12216","DOI":"10.1021\/acsaem.3c01913","volume":"6","author":"Khojastehnezhad","year":"2023","journal-title":"ACS Appl. Energy Mater."},{"issue":"23","key":"D5NR03489B\/cit33\/1","doi-asserted-by":"crossref","first-page":"28476","DOI":"10.1021\/acsami.3c02914","volume":"15","author":"Khojastehnezhad","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"47","key":"D5NR03489B\/cit34\/1","doi-asserted-by":"crossref","first-page":"16984","DOI":"10.1039\/D0TC04202A","volume":"8","author":"Zhu","year":"2020","journal-title":"J. Mater. Chem. C"},{"issue":"19","key":"D5NR03489B\/cit35\/1","doi-asserted-by":"crossref","first-page":"22570","DOI":"10.1021\/acsanm.4c03284","volume":"7","author":"Gamraoui","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"issue":"8","key":"D5NR03489B\/cit36\/1","doi-asserted-by":"crossref","first-page":"11415","DOI":"10.1021\/acsami.4c14030","volume":"17","author":"Khojastehnezhad","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5NR03489B\/cit37\/1","doi-asserted-by":"crossref","first-page":"112638","DOI":"10.1016\/j.bios.2020.112638","volume":"169","author":"Wang","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"D5NR03489B\/cit38\/1","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1021\/acsnano.2c11346","volume":"17","author":"Shi","year":"2023","journal-title":"ACS Nano"},{"issue":"30","key":"D5NR03489B\/cit39\/1","doi-asserted-by":"crossref","first-page":"18308","DOI":"10.1039\/D1RA02342J","volume":"11","author":"Fu","year":"2021","journal-title":"RSC Adv."},{"issue":"39","key":"D5NR03489B\/cit40\/1","doi-asserted-by":"crossref","first-page":"51837","DOI":"10.1021\/acsami.4c07040","volume":"16","author":"Nejabat","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D5NR03489B\/cit41\/1","doi-asserted-by":"crossref","first-page":"341075","DOI":"10.1016\/j.aca.2023.341075","volume":"1252","author":"Yang","year":"2023","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"D5NR03489B\/cit42\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00604-021-04867-1","volume":"188","author":"Eissa","year":"2021","journal-title":"Microchim. Acta"},{"issue":"1","key":"D5NR03489B\/cit43\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2017.02.024","volume":"169","author":"Liu","year":"2017","journal-title":"Cell"},{"key":"D5NR03489B\/cit44\/1","doi-asserted-by":"crossref","first-page":"107872","DOI":"10.1016\/j.jmgm.2021.107872","volume":"105","author":"Ahmad","year":"2021","journal-title":"J. Mol. Graphics Modell."},{"issue":"2","key":"D5NR03489B\/cit45\/1","doi-asserted-by":"crossref","first-page":"e31196","DOI":"10.1371\/journal.pone.0031196","volume":"7","author":"Kaur","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"D5NR03489B\/cit46\/1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1021\/bc500286r","volume":"25","author":"Armstrong","year":"2014","journal-title":"Bioconjugate Chem."},{"issue":"1","key":"D5NR03489B\/cit47\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1039\/D4SD00296B","volume":"4","author":"Alhindawi","year":"2025","journal-title":"Sens. Diagn."},{"key":"D5NR03489B\/cit48\/1","doi-asserted-by":"crossref","first-page":"343605","DOI":"10.1016\/j.aca.2024.343605","author":"Li","year":"2025","journal-title":"Anal. Chim. Acta"},{"issue":"2","key":"D5NR03489B\/cit49\/1","doi-asserted-by":"crossref","first-page":"210221","DOI":"10.20964\/2021.02.36","volume":"16","author":"Wahyuni","year":"2021","journal-title":"Int. J. Electrochem. Sci."},{"issue":"2","key":"D5NR03489B\/cit50\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/membranes14020053","volume":"14","author":"Grabarczyk","year":"2024","journal-title":"Membranes"},{"issue":"27","key":"D5NR03489B\/cit51\/1","doi-asserted-by":"crossref","first-page":"22504","DOI":"10.1021\/acsomega.9b03176","volume":"4","author":"Huo","year":"2019","journal-title":"ACS Omega"},{"issue":"1","key":"D5NR03489B\/cit52\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chphma.2023.08.003","volume":"3","author":"Akinnawo","year":"2024","journal-title":"ChemPhysMater"},{"issue":"4","key":"D5NR03489B\/cit53\/1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3390\/foods12040842","volume":"12","author":"Yang","year":"2023","journal-title":"Foods"},{"key":"D5NR03489B\/cit54\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bios.2018.09.089","volume":"123","author":"Liu","year":"2019","journal-title":"Biosens. Bioelectron."},{"issue":"8","key":"D5NR03489B\/cit55\/1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/elan.201700155","volume":"29","author":"Alshehri","year":"2017","journal-title":"Electroanalysis"},{"key":"D5NR03489B\/cit56\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bios.2018.05.048","volume":"117","author":"Eissa","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"7","key":"D5NR03489B\/cit57\/1","doi-asserted-by":"crossref","first-page":"e22212","DOI":"10.1371\/journal.pone.0022212","volume":"6","author":"Sorio","year":"2011","journal-title":"PLoS One"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/NR\/D5NR03489B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:18:14Z","timestamp":1782875894000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/17\/43\/25336-25347\/901856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":57,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2025,11,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr03489b","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}