{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:27:32Z","timestamp":1789986452462,"version":"4.0.1"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2027,1,14]],"date-time":"2027-01-14T00:00:00Z","timestamp":1799884800000},"content-version":"am","delay-in-days":378,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273862"],"award-info":[{"award-number":["82273862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404520"],"award-info":[{"award-number":["82404520"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473852"],"award-info":[{"award-number":["82473852"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["824B2106"],"award-info":[{"award-number":["824B2106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M752834"],"award-info":[{"award-number":["2024M752834"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Schematic comparison of FK@NE and Talymus for the treatment of dry eye disease. The graphic was created in https:\/\/BioRender.com and Adobe Illustrator.<\/jats:p>","DOI":"10.1039\/d5nr03630e","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T09:34:22Z","timestamp":1768383262000},"page":"3230-3244","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-safety tacrolimus nanoemulsion for dry eye disease treatment through anti-oxidant and anti-inflammatory effects"],"prefix":"10.1039","volume":"18","author":[{"given":"Meixing","family":"Shi","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemeng","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedong","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqi","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science & Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigen","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliang","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuena","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8062-8580","authenticated-orcid":false,"given":"Lihua","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"},{"name":"Jinhua Institute of Zhejiang University, Jinyi New District, Jinhua, Zhejiang 321015, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7114-6299","authenticated-orcid":false,"given":"Jian","family":"You","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, Zhejiang 310058, P. R. China"},{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, 79 Qingchun Road, Shangcheng District, Hangzhou, Zhejiang 310006, P. R. China"},{"name":"The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang 310000, P. R. China"},{"name":"Jinhua Institute of Zhejiang University, Jinyi New District, Jinhua, Zhejiang 321015, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5NR03630E\/cit1\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12886-022-02269-2","volume":"22","author":"Barabino","year":"2022","journal-title":"BMC Ophthalmol."},{"key":"D5NR03630E\/cit2\/1","doi-asserted-by":"crossref","first-page":"11084","DOI":"10.1021\/acsnano.3c11514","volume":"18","author":"Cui","year":"2024","journal-title":"ACS Nano"},{"key":"D5NR03630E\/cit3\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40265-024-02031-6","volume":"84","author":"Vald\u00e9s-Arias","year":"2024","journal-title":"Drugs"},{"key":"D5NR03630E\/cit4\/1","doi-asserted-by":"crossref","first-page":"156155","DOI":"10.1016\/j.cej.2024.156155","volume":"499","author":"Ding","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5NR03630E\/cit5\/1","doi-asserted-by":"crossref","first-page":"e077344","DOI":"10.1136\/bmj-2023-077344","volume":"384","author":"Safir","year":"2024","journal-title":"Br. Med. J."},{"key":"D5NR03630E\/cit6\/1","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.3390\/cells12232755","volume":"12","author":"Harrell","year":"2023","journal-title":"Cells"},{"key":"D5NR03630E\/cit7\/1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s40820-024-01322-7","volume":"16","author":"Chu","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"D5NR03630E\/cit8\/1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s40265-024-02016-5","volume":"84","author":"Zhuang-Yan","year":"2024","journal-title":"Drugs"},{"key":"D5NR03630E\/cit9\/1","first-page":"2400484","author":"Ghosh","year":"2024","journal-title":"Small Struct."},{"key":"D5NR03630E\/cit10\/1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12951-024-02383-x","volume":"22","author":"Hang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D5NR03630E\/cit11\/1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/med.21986","volume":"44","author":"Zhu","year":"2024","journal-title":"Med. Res. Rev."},{"key":"D5NR03630E\/cit12\/1","doi-asserted-by":"crossref","first-page":"122872","DOI":"10.1016\/j.biomaterials.2024.122872","volume":"314","author":"Lam","year":"2025","journal-title":"Biomaterials"},{"key":"D5NR03630E\/cit13\/1","doi-asserted-by":"crossref","first-page":"102967","DOI":"10.1016\/j.redox.2023.102967","volume":"68","author":"B\u00f6hm","year":"2023","journal-title":"Redox Biol."},{"key":"D5NR03630E\/cit14\/1","doi-asserted-by":"crossref","first-page":"109836","DOI":"10.1016\/j.exer.2024.109836","volume":"241","author":"Li","year":"2024","journal-title":"Exp. Eye Res."},{"key":"D5NR03630E\/cit15\/1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jconrel.2024.02.043","volume":"368","author":"Huang","year":"2024","journal-title":"J. Controlled Release"},{"key":"D5NR03630E\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2023.11.021","volume":"365","author":"Huang","year":"2024","journal-title":"J. Controlled Release"},{"key":"D5NR03630E\/cit17\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s12951-024-02499-0","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D5NR03630E\/cit18\/1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12951-024-02503-7","volume":"22","author":"Xia","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D5NR03630E\/cit19\/1","doi-asserted-by":"crossref","first-page":"2200435","DOI":"10.1002\/advs.202200435","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci."},{"key":"D5NR03630E\/cit20\/1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jconrel.2024.07.026","volume":"373","author":"Zhou","year":"2024","journal-title":"J. Controlled Release"},{"key":"D5NR03630E\/cit21\/1","doi-asserted-by":"crossref","first-page":"149898","DOI":"10.1016\/j.cej.2024.149898","volume":"486","author":"Wu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5NR03630E\/cit22\/1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actbio.2022.01.044","volume":"141","author":"Lin","year":"2022","journal-title":"Acta Biomater."},{"key":"D5NR03630E\/cit23\/1","first-page":"1","author":"Guo","year":"2024","journal-title":"Drug Delivery Transl. Res."},{"key":"D5NR03630E\/cit24\/1","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1111\/bcp.16203","volume":"90","author":"Khatri","year":"2024","journal-title":"Br. J. Clin. Pharmacol."},{"key":"D5NR03630E\/cit25\/1","doi-asserted-by":"crossref","first-page":"798998","DOI":"10.3389\/fphar.2022.798998","volume":"13","author":"Albarry","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D5NR03630E\/cit26\/1","doi-asserted-by":"crossref","first-page":"7518","DOI":"10.1021\/acs.biomac.4c01259","volume":"25","author":"Liu","year":"2024","journal-title":"Biomacromolecules"},{"key":"D5NR03630E\/cit27\/1","doi-asserted-by":"crossref","first-page":"105229","DOI":"10.1016\/j.ejps.2020.105229","volume":"144","author":"Zhang","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"D5NR03630E\/cit28\/1","doi-asserted-by":"crossref","first-page":"106207","DOI":"10.1016\/j.jddst.2024.106207","volume":"101","author":"Sigurdsson","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5NR03630E\/cit29\/1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/pharmaceutics14010118","volume":"14","author":"Barrieu","year":"2022","journal-title":"Pharmaceutics"},{"key":"D5NR03630E\/cit30\/1","doi-asserted-by":"crossref","first-page":"2203242","DOI":"10.1002\/adhm.202203242","volume":"12","author":"Wang","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D5NR03630E\/cit31\/1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jconrel.2020.10.025","volume":"328","author":"Singh","year":"2020","journal-title":"J. Controlled Release"},{"key":"D5NR03630E\/cit32\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2023.01.018","volume":"354","author":"Onugwu","year":"2023","journal-title":"J. Controlled Release"},{"key":"D5NR03630E\/cit33\/1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jconrel.2024.08.021","volume":"374","author":"Baumann","year":"2024","journal-title":"J. Controlled Release"},{"key":"D5NR03630E\/cit34\/1","doi-asserted-by":"crossref","first-page":"7356899","DOI":"10.1155\/2023\/7356899","volume":"2023","author":"Zaman","year":"2023","journal-title":"Int. J. Polym. Sci."},{"key":"D5NR03630E\/cit35\/1","doi-asserted-by":"crossref","first-page":"2411172","DOI":"10.1002\/advs.202411172","volume":"12","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"key":"D5NR03630E\/cit36\/1","doi-asserted-by":"crossref","first-page":"838168","DOI":"10.3389\/fphar.2022.838168","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D5NR03630E\/cit37\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1186\/s12951-024-02894-7","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D5NR03630E\/cit38\/1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.4103\/IJO.IJO_2791_22","volume":"71","author":"Thacker","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"D5NR03630E\/cit39\/1","doi-asserted-by":"crossref","first-page":"2403935","DOI":"10.1002\/adma.202403935","volume":"36","author":"Xie","year":"2024","journal-title":"Adv. Mater."},{"key":"D5NR03630E\/cit40\/1","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1016\/j.xphs.2023.05.001","volume":"112","author":"Wang","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"D5NR03630E\/cit41\/1","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1167\/iovs.15-18552","volume":"57","author":"Schlereth","year":"2016","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D5NR03630E\/cit42\/1","doi-asserted-by":"crossref","first-page":"eabj9617","DOI":"10.1126\/sciadv.abj9617","volume":"8","author":"Zhou","year":"2022","journal-title":"Sci. Adv."},{"key":"D5NR03630E\/cit43\/1","doi-asserted-by":"crossref","first-page":"110204","DOI":"10.1016\/j.exer.2024.110204","volume":"251","author":"Lu","year":"2025","journal-title":"Exp. Eye Res."},{"key":"D5NR03630E\/cit44\/1","doi-asserted-by":"crossref","first-page":"7541","DOI":"10.3390\/ma14247541","volume":"14","author":"Fernandes","year":"2021","journal-title":"Materials"},{"key":"D5NR03630E\/cit45\/1","doi-asserted-by":"crossref","first-page":"101157","DOI":"10.1016\/j.preteyeres.2022.101157","volume":"96","author":"Clahsen","year":"2023","journal-title":"Prog. Retinal Eye Res."},{"key":"D5NR03630E\/cit46\/1","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1016\/j.ymthe.2023.05.002","volume":"31","author":"Yu","year":"2023","journal-title":"Mol. Ther."},{"key":"D5NR03630E\/cit47\/1","doi-asserted-by":"crossref","first-page":"104936","DOI":"10.1016\/j.jddst.2023.104936","volume":"88","author":"Soe","year":"2023","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5NR03630E\/cit48\/1","first-page":"77","volume":"9","author":"Han","year":"2022","journal-title":"Bioact. Mater."},{"key":"D5NR03630E\/cit49\/1","doi-asserted-by":"crossref","first-page":"105406","DOI":"10.1016\/j.jddst.2024.105406","volume":"92","author":"Attia","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5NR03630E\/cit50\/1","doi-asserted-by":"crossref","first-page":"124755","DOI":"10.1016\/j.colsurfa.2020.124755","volume":"597","author":"Baz\u00e1n Henostroza","year":"2020","journal-title":"Colloids Surf., A"},{"key":"D5NR03630E\/cit51\/1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jconrel.2024.03.006","volume":"368","author":"Gu","year":"2024","journal-title":"J. Controlled Release"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/NR\/D5NR03630E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:37:18Z","timestamp":1782851838000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/18\/6\/3230-3244\/901898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr03630e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}