{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:00:06Z","timestamp":1790373606706,"version":"4.1.0"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2026,12,5]],"date-time":"2026-12-05T00:00:00Z","timestamp":1796428800000},"content-version":"am","delay-in-days":338,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["DQCP20\/21PQ02"],"award-info":[{"award-number":["DQCP20\/21PQ02"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Illustration of novel iron-nickel bimetallic nanozyme with peroxidase-like activity for ultrasensitive uric acid detection and hyperuricaemia therapy evaluation.<\/jats:p>","DOI":"10.1039\/d5nr04096e","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:38:44Z","timestamp":1764941924000},"page":"211-221","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Novel iron\u2013nickel bimetallic nanozyme with peroxidase-like activity for ultrasensitive uric acid detection and hyperuricaemia therapy evaluation"],"prefix":"10.1039","volume":"18","author":[{"given":"Hanbing","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5691-6673","authenticated-orcid":false,"given":"Chang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5NR04096E\/cit1\/1","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3390\/biomedicines11051258","volume":"11","author":"Miake","year":"2023","journal-title":"Biomedicines"},{"key":"D5NR04096E\/cit2\/1","doi-asserted-by":"crossref","first-page":"154868","DOI":"10.1016\/j.phymed.2023.154868","volume":"116","author":"Guo","year":"2023","journal-title":"Phytomedicine"},{"key":"D5NR04096E\/cit3\/1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1080\/09540105.2021.1996540","volume":"32","author":"Wei-Yun","year":"2021","journal-title":"Food Agric. Immunol."},{"key":"D5NR04096E\/cit4\/1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00216-018-1524-6","volume":"411","author":"Wang","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"D5NR04096E\/cit5\/1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1161\/HYPERTENSIONAHA.117.10443","volume":"71","author":"Cheng","year":"2018","journal-title":"Hypertension"},{"key":"D5NR04096E\/cit6\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41584-018-0004-x","volume":"14","author":"Major","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"D5NR04096E\/cit7\/1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"D5NR04096E\/cit8\/1","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1038\/s41467-025-56100-9","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"D5NR04096E\/cit9\/1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1291\/hypres.24.691","volume":"24","author":"Iseki","year":"2001","journal-title":"Hypertens. Res."},{"key":"D5NR04096E\/cit10\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.talanta.2017.01.066","volume":"166","author":"Sheng","year":"2017","journal-title":"Talanta"},{"key":"D5NR04096E\/cit11\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.carres.2012.06.018","volume":"358","author":"Matsumoto","year":"2012","journal-title":"Carbohydr. Res."},{"key":"D5NR04096E\/cit12\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jelechem.2019.04.028","volume":"841","author":"Xu","year":"2019","journal-title":"J. Electroanal. Chem."},{"key":"D5NR04096E\/cit13\/1","first-page":"331","volume":"27","author":"Donadio","year":"2014","journal-title":"J. Nephrol."},{"key":"D5NR04096E\/cit14\/1","doi-asserted-by":"crossref","first-page":"111079","DOI":"10.1016\/j.microc.2024.111079","volume":"204","author":"Cao","year":"2024","journal-title":"Microchem. J."},{"key":"D5NR04096E\/cit15\/1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/1522-2683(200203)23:5<767::AID-ELPS767>3.0.CO;2-8","volume":"23","author":"Fanguy","year":"2002","journal-title":"Electrophoresis"},{"key":"D5NR04096E\/cit16\/1","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1021\/acs.analchem.0c05191","volume":"93","author":"Xie","year":"2021","journal-title":"Anal. Chem."},{"key":"D5NR04096E\/cit17\/1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/bmc.787","volume":"21","author":"Yao","year":"2007","journal-title":"Biomed. Chromatogr."},{"key":"D5NR04096E\/cit18\/1","doi-asserted-by":"crossref","first-page":"e24938","DOI":"10.1002\/ajpa.24938","volume":"184","author":"Buckberry","year":"2024","journal-title":"Am. J. Biol. Anthropol."},{"key":"D5NR04096E\/cit19\/1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/accountsmr.1c00074","volume":"2","author":"Zhang","year":"2021","journal-title":"Acc. Mater. Res."},{"key":"D5NR04096E\/cit20\/1","doi-asserted-by":"crossref","first-page":"112950","DOI":"10.1016\/j.colsurfb.2022.112950","volume":"221","author":"Bilal","year":"2023","journal-title":"Colloids Surf., B"},{"key":"D5NR04096E\/cit21\/1","doi-asserted-by":"crossref","first-page":"6165","DOI":"10.1002\/anie.200460649","volume":"43","author":"Manea","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR04096E\/cit22\/1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nnano.2007.260","volume":"2","author":"Gao","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"D5NR04096E\/cit23\/1","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1038\/s41467-021-23737-1","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"key":"D5NR04096E\/cit24\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jcis.2022.05.059","volume":"623","author":"Li","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"D5NR04096E\/cit25\/1","doi-asserted-by":"crossref","first-page":"144649","DOI":"10.1016\/j.cej.2023.144649","volume":"471","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"key":"D5NR04096E\/cit26\/1","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1021\/acs.chemrev.1c00417","volume":"122","author":"Marciniec","year":"2022","journal-title":"Chem. Rev."},{"key":"D5NR04096E\/cit27\/1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jcis.2024.02.160","volume":"663","author":"Feng","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"D5NR04096E\/cit28\/1","doi-asserted-by":"crossref","first-page":"e2211210","DOI":"10.1002\/adma.202211210","volume":"36","author":"Sheng","year":"2024","journal-title":"Adv. Mater."},{"key":"D5NR04096E\/cit29\/1","doi-asserted-by":"crossref","first-page":"150612","DOI":"10.1016\/j.cej.2024.150612","volume":"487","author":"Yang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5NR04096E\/cit30\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s42114-023-00719-z","volume":"6","author":"Zhu","year":"2023","journal-title":"Adv. Compos. Hybrid Mater."},{"key":"D5NR04096E\/cit31\/1","doi-asserted-by":"crossref","first-page":"148589","DOI":"10.1016\/j.cej.2024.148589","volume":"482","author":"Zhu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D5NR04096E\/cit32\/1","doi-asserted-by":"crossref","first-page":"24683","DOI":"10.1021\/acsanm.4c04563","volume":"7","author":"Gu","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"D5NR04096E\/cit33\/1","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1039\/D0EE03697H","volume":"14","author":"Li","year":"2021","journal-title":"Energy Environ. Sci."},{"key":"D5NR04096E\/cit34\/1","doi-asserted-by":"crossref","first-page":"134422","DOI":"10.1016\/j.snb.2023.134422","volume":"394","author":"Mu","year":"2023","journal-title":"Sens. Actuators, B"},{"key":"D5NR04096E\/cit35\/1","doi-asserted-by":"crossref","first-page":"113718","DOI":"10.1016\/j.bios.2021.113718","volume":"196","author":"Zhang","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"D5NR04096E\/cit36\/1","doi-asserted-by":"crossref","first-page":"122825","DOI":"10.1016\/j.cej.2019.122825","volume":"382","author":"He","year":"2020","journal-title":"Chem. Eng. J."},{"key":"D5NR04096E\/cit37\/1","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.1021\/acsnano.3c00423","volume":"17","author":"Zhu","year":"2023","journal-title":"ACS Nano"},{"key":"D5NR04096E\/cit38\/1","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1021\/acssuschemeng.1c07975","volume":"10","author":"Mu","year":"2022","journal-title":"ACS Sustainable Chem. Eng."},{"key":"D5NR04096E\/cit39\/1","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1007\/s12274-021-3406-z","volume":"14","author":"Li","year":"2021","journal-title":"Nano Res."},{"key":"D5NR04096E\/cit40\/1","doi-asserted-by":"crossref","first-page":"341788","DOI":"10.1016\/j.aca.2023.341788","volume":"1279","author":"Zhang","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"D5NR04096E\/cit41\/1","doi-asserted-by":"crossref","first-page":"1910085","DOI":"10.1002\/adfm.201910085","volume":"30","author":"Fang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D5NR04096E\/cit42\/1","doi-asserted-by":"crossref","first-page":"ehz872.097","DOI":"10.1093\/ehjci\/ehz872.097","volume":"41","author":"Barrientos","year":"2020","journal-title":"Eur. Heart J."},{"key":"D5NR04096E\/cit43\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pharmthera.2016.12.004","volume":"172","author":"Okafor","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"D5NR04096E\/cit44\/1","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1093\/eurheartj\/ehab619","volume":"42","author":"Kang","year":"2021","journal-title":"Eur. Heart J."},{"key":"D5NR04096E\/cit45\/1","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1002\/art.42266","volume":"74","author":"Yan","year":"2022","journal-title":"Arthritis Rheumatol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/NR\/D5NR04096E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:57:18Z","timestamp":1782878238000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/18\/1\/211-221\/902039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr04096e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}