{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:19:40Z","timestamp":1782879580941,"version":"3.54.5"},"reference-count":54,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>By densely attaching corneal tissue SELEX-derived aptamers to gold nanoparticles, spherical nucleic acids were created to stain the surface of the eyes.<\/jats:p>","DOI":"10.1039\/d5nr04649a","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:20:47Z","timestamp":1763634047000},"page":"496-505","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cornea-SELEX-derived DNA aptamers for preparing spherical nucleic acids and corneal staining"],"prefix":"10.1039","volume":"18","author":[{"given":"Xiaohan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka-Ying","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada"},{"name":"Centre for Eye and Vision Research (CEVR), 17 W Hong Kong Science Park, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-8618","authenticated-orcid":false,"given":"Man-Sau","family":"Wong","sequence":"additional","affiliation":[{"name":"Centre for Eye and Vision Research (CEVR), 17 W Hong Kong Science Park, Hong Kong, China"},{"name":"Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China"},{"name":"Research Center for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-9336","authenticated-orcid":false,"given":"Juewen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON N2L 3G1, Canada"},{"name":"Centre for Eye and Vision Research (CEVR), 17 W Hong Kong Science Park, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5NR04649A\/cit1\/1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1080\/20415990.2024.2346047","volume":"15","author":"Bisen","year":"2024","journal-title":"Ther. Delivery"},{"key":"D5NR04649A\/cit2\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/17425247.2022.2017878","volume":"19","author":"Loftsson","year":"2022","journal-title":"Expert Opin. Drug Delivery"},{"key":"D5NR04649A\/cit3\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/gels8020082","volume":"8","author":"Akhter","year":"2022","journal-title":"Gels"},{"key":"D5NR04649A\/cit4\/1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3390\/ph17040511","volume":"17","author":"Batur","year":"2024","journal-title":"Pharmaceuticals"},{"key":"D5NR04649A\/cit5\/1","doi-asserted-by":"crossref","first-page":"1246974","DOI":"10.3389\/fbioe.2023.1246974","volume":"11","author":"Cai","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D5NR04649A\/cit6\/1","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.1039\/D0PY00919A","volume":"11","author":"Nguyen","year":"2020","journal-title":"Polym. Chem."},{"key":"D5NR04649A\/cit7\/1","doi-asserted-by":"crossref","first-page":"12976","DOI":"10.3390\/ijms241612976","volume":"24","author":"Tsung","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5NR04649A\/cit8\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijbiomac.2018.01.120","volume":"110","author":"Krishnaswami","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"D5NR04649A\/cit9\/1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1517\/17425247.2012.690733","volume":"9","author":"Pahuja","year":"2012","journal-title":"Expert Opin. Drug Delivery"},{"key":"D5NR04649A\/cit10\/1","doi-asserted-by":"crossref","first-page":"2415353","DOI":"10.1002\/adma.202415353","volume":"37","author":"Shao","year":"2025","journal-title":"Adv. Mater."},{"key":"D5NR04649A\/cit11\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jconrel.2019.10.039","volume":"315","author":"Yu","year":"2019","journal-title":"J. Controlled Release"},{"key":"D5NR04649A\/cit12\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1208\/s12248-019-0326-x","volume":"21","author":"Chan","year":"2019","journal-title":"AAPS J."},{"key":"D5NR04649A\/cit13\/1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/pharmaceutics13020234","volume":"13","author":"L\u00f3pez-Cano","year":"2021","journal-title":"Pharmaceutics"},{"key":"D5NR04649A\/cit14\/1","doi-asserted-by":"crossref","first-page":"683153","DOI":"10.1155\/2014\/683153","volume":"2014","author":"Wagh","year":"2014","journal-title":"J. Nanotechnol."},{"key":"D5NR04649A\/cit15\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/nsr\/nwv001","volume":"2","author":"Meng","year":"2015","journal-title":"Natl. Sci. Rev."},{"key":"D5NR04649A\/cit16\/1","doi-asserted-by":"crossref","first-page":"26667","DOI":"10.1021\/jacs.4c03129","volume":"146","author":"Wu","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D5NR04649A\/cit17\/1","doi-asserted-by":"crossref","first-page":"115646","DOI":"10.1016\/j.addr.2025.115646","volume":"224","author":"Wong","year":"2025","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5NR04649A\/cit18\/1","doi-asserted-by":"crossref","first-page":"16800","DOI":"10.1002\/anie.202008663","volume":"60","author":"Yu","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR04649A\/cit19\/1","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1021\/acs.jproteome.4c00411","volume":"23","author":"Kraemer","year":"2024","journal-title":"J. Proteome Res."},{"key":"D5NR04649A\/cit20\/1","doi-asserted-by":"crossref","first-page":"118349","DOI":"10.1016\/j.trac.2025.118349","volume":"191","author":"Stangherlin","year":"2025","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D5NR04649A\/cit21\/1","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s40265-023-01948-8","volume":"83","author":"Kang","year":"2023","journal-title":"Drugs"},{"key":"D5NR04649A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ophtha.2011.02.045","volume":"118","author":"Sultan","year":"2011","journal-title":"Ophthalmology"},{"key":"D5NR04649A\/cit23\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/10409238.2011.614592","volume":"46","author":"Kanwar","year":"2011","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"D5NR04649A\/cit24\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejps.2015.12.014","volume":"83","author":"Xie","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"D5NR04649A\/cit25\/1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.biomaterials.2015.07.025","volume":"67","author":"Zhao","year":"2015","journal-title":"Biomaterials"},{"key":"D5NR04649A\/cit26\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5NR04649A\/cit27\/1","doi-asserted-by":"crossref","first-page":"114770","DOI":"10.1016\/j.addr.2023.114770","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Delivery Rev."},{"key":"D5NR04649A\/cit28\/1","doi-asserted-by":"crossref","first-page":"2401309","DOI":"10.1002\/adhm.202401309","volume":"14","author":"Wong","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"D5NR04649A\/cit29\/1","doi-asserted-by":"crossref","first-page":"2404053","DOI":"10.1002\/adma.202404053","volume":"36","author":"Wong","year":"2024","journal-title":"Adv. Mater."},{"key":"D5NR04649A\/cit30\/1","doi-asserted-by":"crossref","first-page":"14865","DOI":"10.1039\/D5SC03552J","volume":"16","author":"Zandieh","year":"2025","journal-title":"Chem. Sci."},{"key":"D5NR04649A\/cit31\/1","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1039\/D3TB00598D","volume":"11","author":"Wong","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"D5NR04649A\/cit32\/1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1167\/iovs.01-1156","volume":"44","author":"Carrasquillo","year":"2003","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D5NR04649A\/cit33\/1","doi-asserted-by":"crossref","first-page":"20230008","DOI":"10.1002\/EXP.20230008","volume":"4","author":"Wong","year":"2023","journal-title":"Exploration"},{"key":"D5NR04649A\/cit34\/1","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/cr2001178","volume":"112","author":"Saha","year":"2012","journal-title":"Chem. Rev."},{"key":"D5NR04649A\/cit35\/1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1021\/ja209351u","volume":"134","author":"Cutler","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D5NR04649A\/cit36\/1","doi-asserted-by":"crossref","first-page":"100117","DOI":"10.1016\/j.asems.2024.100117","volume":"3","author":"Xia","year":"2024","journal-title":"Adv. Sens. Energy Mater."},{"key":"D5NR04649A\/cit37\/1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nprot.2006.38","volume":"1","author":"Liu","year":"2006","journal-title":"Nat. Protoc."},{"key":"D5NR04649A\/cit38\/1","doi-asserted-by":"crossref","first-page":"e202410353","DOI":"10.1002\/anie.202410353","volume":"63","author":"Wang","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5NR04649A\/cit39\/1","doi-asserted-by":"crossref","first-page":"e20230007","DOI":"10.1002\/smo.20230007","volume":"1","author":"Gu","year":"2023","journal-title":"Smart Mol."},{"key":"D5NR04649A\/cit40\/1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.abn9859","volume":"380","author":"Yang","year":"2023","journal-title":"Science"},{"key":"D5NR04649A\/cit41\/1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.277.5329.1078","volume":"277","author":"Elghanian","year":"1997","journal-title":"Science"},{"key":"D5NR04649A\/cit42\/1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s41563-019-0549-3","volume":"19","author":"Yao","year":"2020","journal-title":"Nat. Mater."},{"key":"D5NR04649A\/cit43\/1","doi-asserted-by":"crossref","first-page":"216835","DOI":"10.1016\/j.ccr.2025.216835","volume":"541","author":"Song","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"D5NR04649A\/cit44\/1","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1093\/nar\/gkm237","volume":"35","author":"Dougan","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"D5NR04649A\/cit45\/1","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1021\/nl072471q","volume":"7","author":"Giljohann","year":"2007","journal-title":"Nano Lett."},{"key":"D5NR04649A\/cit46\/1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1126\/science.1125559","volume":"312","author":"Rosi","year":"2006","journal-title":"Science"},{"key":"D5NR04649A\/cit47\/1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.matt.2019.08.008","volume":"1","author":"Liu","year":"2019","journal-title":"Matter"},{"key":"D5NR04649A\/cit48\/1","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1021\/ja304118z","volume":"134","author":"Pei","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D5NR04649A\/cit49\/1","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.1021\/ja3014055","volume":"134","author":"Zhang","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"D5NR04649A\/cit50\/1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1002\/cjoc.202400113","volume":"42","author":"Ding","year":"2024","journal-title":"Chin. J. Chem."},{"key":"D5NR04649A\/cit51\/1","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1021\/jacs.0c00217","volume":"142","author":"Hu","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D5NR04649A\/cit52\/1","doi-asserted-by":"crossref","first-page":"100132","DOI":"10.1016\/j.asems.2024.100132","volume":"4","author":"Wang","year":"2025","journal-title":"Adv. Sens. Energy Mater."},{"key":"D5NR04649A\/cit53\/1","doi-asserted-by":"crossref","first-page":"117863","DOI":"10.1016\/j.bios.2025.117863","volume":"289","author":"Wang","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"D5NR04649A\/cit54\/1","doi-asserted-by":"crossref","first-page":"14743","DOI":"10.1021\/acs.analchem.9b04142","volume":"91","author":"Zhang","year":"2019","journal-title":"Anal. Chem."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/NR\/D5NR04649A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:37:51Z","timestamp":1782877071000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/18\/1\/496-505\/902173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5nr04649a","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}