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Chem."],"abstract":"<jats:p>\n                    A direct synthetic approach to \u03b1,\u03b1-difluoro-\u03b2-amino amides\n                    <jats:italic>via<\/jats:italic>\n                    the zinc-promoted Reformatsky reaction of aldimines using bromodifluoroacetamides and the selective reduction of their amino amides to 2,2-difluoropropane-1,3-diamines.\n                  <\/jats:p>","DOI":"10.1039\/d5ob00388a","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T02:41:02Z","timestamp":1743993662000},"page":"4446-4450","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of \u03b1,\u03b1-difluoro-\u03b2-amino amides using aldimines and bromodifluoroacetamides\n                    <i>via<\/i>\n                    the Reformatsky reaction"],"prefix":"10.1039","volume":"23","author":[{"given":"Ryota","family":"Ozawa","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, Graduate School of Engineering, Tokyo Denki University, 5 Senju Asahi-cho Adachi-ku, Tokyo 120-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-8956","authenticated-orcid":false,"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Graduate School of Engineering, Tokyo Denki University, 5 Senju Asahi-cho Adachi-ku, Tokyo 120-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5OB00388A\/cit1\/1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/cbic.200301023","volume":"5","author":"B\u00f6hm","year":"2004","journal-title":"ChemBioChem"},{"key":"D5OB00388A\/cit2\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/jm030283g","volume":"47","author":"Clader","year":"2004","journal-title":"J. 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