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Chem."],"abstract":"<jats:p>\n                    The first structure\u2013activity relationship study on \u03b3-alkylidenebutenolides [(4\n                    <jats:italic>Z<\/jats:italic>\n                    )- and (4\n                    <jats:italic>E<\/jats:italic>\n                    )-6,7-dihydroxyhepta-2,4-dien-4-olide 6-monobenzoate] (3 and 4) and 7-monobenzoate (1 and 2) was carried out using the related analogous (7\u201321).\n                  <\/jats:p>","DOI":"10.1039\/d5ob00449g","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T04:40:57Z","timestamp":1744087257000},"page":"4497-4507","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and biological evaluation of \u03b3-alkylidenebutenolides isolated from\n                    <i>Melodorum fruticosum<\/i>\n                    : the role of the propylidene-type side chain structure on anti-melanogenic activity"],"prefix":"10.1039","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5749-3959","authenticated-orcid":false,"given":"Katsuki","family":"Takashima","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Manse","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanami","family":"Masuda","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Marumoto","sequence":"additional","affiliation":[{"name":"Joint Research Centre, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-9396","authenticated-orcid":false,"given":"Fumihiro","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2794-5365","authenticated-orcid":false,"given":"Toshio","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7954-8874","authenticated-orcid":false,"given":"Genzoh","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"},{"name":"Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5OB00449G\/cit1\/1","doi-asserted-by":"crossref","first-page":"7298","DOI":"10.1039\/D1OB00875G","volume":"19","author":"Chatterjee","year":"2021","journal-title":"Org. 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