{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:06:58Z","timestamp":1787004418542,"version":"build-2736575974"},"reference-count":140,"publisher":"Royal Society of Chemistry (RSC)","issue":"22","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"am","delay-in-days":489,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["CS-136\/2023"],"award-info":[{"award-number":["CS-136\/2023"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2021\/007123"],"award-info":[{"award-number":["CRG\/2021\/007123"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    Natural products synthesized from ynones are crucial due to their diverse biological activities, structural complexity, and versatility. This review compiles the total synthesis of natural products\n                    <jats:italic>via<\/jats:italic>\n                    ynones as intermediates in development of drugs.\n                  <\/jats:p>","DOI":"10.1039\/d5ob00524h","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T06:21:00Z","timestamp":1746426060000},"page":"5273-5292","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Total synthesis of natural products\n                    <i>via<\/i>\n                    conjugated ynone intermediates: a new millennium update"],"prefix":"10.1039","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-1085","authenticated-orcid":false,"given":"Sunita","family":"Bhagat","sequence":"first","affiliation":[{"name":"Department of Chemistry, ARSD College, Dhaula Kuan, New Delhi-110021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ARSD College, Dhaula Kuan, New Delhi-110021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ARSD College, Dhaula Kuan, New Delhi-110021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Gunjan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ARSD College, Dhaula Kuan, New Delhi-110021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Khullar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ARSD College, Dhaula Kuan, New Delhi-110021, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"D5OB00524H\/cit1\/1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"issue":"2","key":"D5OB00524H\/cit2\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"4","key":"D5OB00524H\/cit3\/1","first-page":"462","volume":"39","author":"Butler","year":"2022","journal-title":"Nat. Prod. Rep."},{"issue":"2","key":"D5OB00524H\/cit4\/1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0976-500X.155496","volume":"6","author":"Dubey","year":"2015","journal-title":"J. Pharmacol. Pharmacother."},{"key":"D5OB00524H\/cit5\/1","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1021\/acs.chemrev.9b00277","volume":"119","author":"Najera","year":"2019","journal-title":"Chem. Rev."},{"key":"D5OB00524H\/cit6\/1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1039\/D0OB02521F","volume":"19","author":"Wang","year":"2021","journal-title":"Org. Biomol. Chem."},{"issue":"02","key":"D5OB00524H\/cit7\/1","first-page":"161","author":"Whittaker","year":"2016","journal-title":"Synthesis"},{"key":"D5OB00524H\/cit8\/1","doi-asserted-by":"crossref","first-page":"100055","DOI":"10.1016\/j.tchem.2023.100055","volume":"9","author":"Taylor","year":"2024","journal-title":"Tetrahedron Chem"},{"key":"D5OB00524H\/cit9\/1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1002\/ejoc.201901921","volume":"17","author":"Wang","year":"2020","journal-title":"Eur. J. Org. Chem."},{"issue":"48","key":"D5OB00524H\/cit10\/1","doi-asserted-by":"crossref","first-page":"9145","DOI":"10.1016\/j.tet.2014.07.023","volume":"70","author":"Fraile","year":"2014","journal-title":"Tetrahedron"},{"issue":"5","key":"D5OB00524H\/cit11\/1","first-page":"687","author":"Abbiati","year":"2014","journal-title":"Synthesis"},{"issue":"3","key":"D5OB00524H\/cit12\/1","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1039\/C5RA23759A","volume":"6","author":"Rulev","year":"2016","journal-title":"RSC Adv."},{"issue":"2","key":"D5OB00524H\/cit13\/1","first-page":"161","author":"Whittaker","year":"2016","journal-title":"Synthesis"},{"issue":"7","key":"D5OB00524H\/cit14\/1","first-page":"1029","volume":"16","author":"Wang","year":"2018","journal-title":"Org. Biomol. Chem."},{"issue":"2","key":"D5OB00524H\/cit15\/1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/1521-3773(20010119)40:2<339::AID-ANIE339>3.0.CO;2-J","volume":"40","author":"Arya","year":"2001","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00524H\/cit16\/1","doi-asserted-by":"crossref","first-page":"13600","DOI":"10.1039\/C9NJ01943J","volume":"34","author":"Li","year":"2019","journal-title":"New J. Chem."},{"issue":"5","key":"D5OB00524H\/cit17\/1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/adsc.202301270","volume":"366","author":"Behera","year":"2024","journal-title":"Adv. Synth. Catal."},{"issue":"14","key":"D5OB00524H\/cit18\/1","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1021\/jo025682i","volume":"67","author":"Jackson","year":"2002","journal-title":"J. Org. Chem."},{"issue":"12","key":"D5OB00524H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.phymed.2013.06.009","volume":"20","author":"Kuklev","year":"2013","journal-title":"Phytomedicine"},{"issue":"10","key":"D5OB00524H\/cit20\/1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1039\/D0OB02521F","volume":"19","author":"Wang","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"D5OB00524H\/cit21\/1","volume-title":"Science of Synthesis: Ketones","volume":"26","author":"Cossy","year":"2005","unstructured":"J.Cossy ,  Science of Synthesis: Ketones ,  Thieme ,  2005 , vol.  26"},{"key":"D5OB00524H\/cit22\/1","volume-title":"Organic Chemistry","author":"Bruice","year":"2013","unstructured":"P. Y.Bruice ,  Organic Chemistry ,  Pearson , 7th edn,  2013"},{"issue":"10","key":"D5OB00524H\/cit23\/1","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1021\/ja042435i","volume":"127","author":"Trost","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00524H\/cit24\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0065-2571(85)90048-2","volume":"23","author":"Jackson","year":"1985","journal-title":"Adv. Enzyme Regul."},{"issue":"22","key":"D5OB00524H\/cit25\/1","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.2174\/0929867023368809","volume":"9","author":"Lewy","year":"2002","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"D5OB00524H\/cit26\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tetlet.2007.11.001","volume":"49","author":"Lim","year":"2008","journal-title":"Tetrahedron Lett."},{"issue":"10","key":"D5OB00524H\/cit27\/1","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1248\/cpb.26.2515","volume":"26","author":"Fuji","year":"1978","journal-title":"Chem. Pharm. Bull."},{"issue":"8","key":"D5OB00524H\/cit28\/1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/ol100229f","volume":"12","author":"Tanaka","year":"2010","journal-title":"Org. Lett."},{"issue":"5","key":"D5OB00524H\/cit29\/1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1021\/acs.jnatprod.9b00826","volume":"83","author":"Tranter","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"12","key":"D5OB00524H\/cit30\/1","doi-asserted-by":"crossref","first-page":"e0146165","DOI":"10.1371\/journal.pone.0146165","volume":"11","author":"Lnakady","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"D5OB00524H\/cit31\/1","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1021\/ol200796r","volume":"13","author":"Jung","year":"2011","journal-title":"Org. Lett."},{"issue":"11","key":"D5OB00524H\/cit32\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2183\/pjab1945.27.436","volume":"27","author":"Nawa","year":"1951","journal-title":"Proc. Jpn. Acad."},{"issue":"5","key":"D5OB00524H\/cit33\/1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1248\/bpb.26.627","volume":"26","author":"Umebayashi","year":"2003","journal-title":"Biol. Pharm. Bull."},{"issue":"7","key":"D5OB00524H\/cit34\/1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1271\/bbb.67.1401","volume":"67","author":"Masuda","year":"2003","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"24","key":"D5OB00524H\/cit35\/1","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1039\/c2ob25685a","volume":"10","author":"Gouault","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"D5OB00524H\/cit36\/1","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.3762\/bjoc.9.242","volume":"9","author":"Trinh","year":"2013","journal-title":"Beilstein J. Org. Chem."},{"issue":"3","key":"D5OB00524H\/cit37\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10526-008-9180-y","volume":"54","author":"Berm\u00fadez-Torres","year":"2009","journal-title":"BioControl"},{"issue":"25","key":"D5OB00524H\/cit38\/1","doi-asserted-by":"crossref","first-page":"7717","DOI":"10.1002\/ange.201303224","volume":"125","author":"Kobayakawa","year":"2013","journal-title":"Angew. Chem."},{"issue":"6","key":"D5OB00524H\/cit39\/1","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.ejmech.2011.04.006","volume":"46","author":"Shi","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"D5OB00524H\/cit40\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/ja411270d","volume":"136","author":"Trost","year":"2014","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"D5OB00524H\/cit41\/1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1021\/np040028e","volume":"67","author":"Wright","year":"2004","journal-title":"J. Nat. Prod."},{"issue":"3","key":"D5OB00524H\/cit42\/1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1021\/ja017265d","volume":"124","author":"Lee","year":"2002","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"D5OB00524H\/cit43\/1","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1021\/acs.orglett.8b00225","volume":"20","author":"Ho","year":"2018","journal-title":"Org. Lett."},{"issue":"8","key":"D5OB00524H\/cit44\/1","first-page":"2058","volume":"25","author":"Lui","year":"2023","journal-title":"Org. Lett."},{"issue":"4","key":"D5OB00524H\/cit45\/1","first-page":"448","volume":"11","author":"Mohajer","year":"2020","journal-title":"Nat. Prod. J."},{"key":"D5OB00524H\/cit46\/1","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1021\/acs.orglett.9b03402","volume":"21","author":"Sirindel","year":"2019","journal-title":"Org. Lett."},{"key":"D5OB00524H\/cit47\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.abb.2009.05.014","volume":"487","author":"Edler","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"D5OB00524H\/cit48\/1","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1021\/acs.joc.9b02938","volume":"85","author":"Reddy","year":"2020","journal-title":"J. Org. Chem."},{"key":"D5OB00524H\/cit49\/1","first-page":"878","volume":"9","author":"Park","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"702","key":"D5OB00524H\/cit50\/1","doi-asserted-by":"crossref","first-page":"eabf6584","DOI":"10.1126\/scisignal.abf6584","volume":"14","author":"Montenegro-Burke","year":"2021","journal-title":"Sci. Signaling"},{"issue":"38","key":"D5OB00524H\/cit51\/1","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.1039\/D0OB01786H","volume":"18","author":"B\u00e4r","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"D5OB00524H\/cit52\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0305-1978(90)90034-D","volume":"18","author":"Rovirosa","year":"1990","journal-title":"Biochem. Syst. Ecol."},{"key":"D5OB00524H\/cit53\/1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1021\/np300744y","volume":"76","author":"Molinski","year":"2013","journal-title":"J. Nat. Prod."},{"key":"D5OB00524H\/cit54\/1","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1021\/acs.joc.0c00017","volume":"85","author":"Kim","year":"2020","journal-title":"J. Org. Chem."},{"key":"D5OB00524H\/cit55\/1","first-page":"1561","volume":"24","author":"Kawada","year":"2004","journal-title":"Anticancer Res."},{"key":"D5OB00524H\/cit56\/1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/jlac.199119910164","volume":"4","author":"Henkel","year":"1991","journal-title":"Liebigs Ann. Chem."},{"key":"D5OB00524H\/cit57\/1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/bbb\/zbab042","volume":"85","author":"Araki","year":"2021","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"D5OB00524H\/cit58\/1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0065-230X(08)60799-X","volume":"49","author":"Fujiki","year":"1987","journal-title":"Adv. Cancer Res."},{"key":"D5OB00524H\/cit59\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1039\/D1OB01972D","volume":"20","author":"Kataria","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D5OB00524H\/cit60\/1","first-page":"4981","volume":"29","author":"Tabata","year":"2009","journal-title":"Anticancer Res."},{"key":"D5OB00524H\/cit61\/1","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1016\/j.tetlet.2005.07.162","volume":"46","author":"Chandrasekhar","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"D5OB00524H\/cit62\/1","doi-asserted-by":"crossref","first-page":"e202200266","DOI":"10.1002\/slct.202200266","volume":"7","author":"Xing","year":"2022","journal-title":"ChemistrySelect"},{"key":"D5OB00524H\/cit63\/1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/ol702598q","volume":"10","author":"Kito","year":"2008","journal-title":"Org. Lett."},{"key":"D5OB00524H\/cit64\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3987\/REV-12-727","volume":"85","author":"Nagasawa","year":"2012","journal-title":"Heterocycles"},{"key":"D5OB00524H\/cit65\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1055\/a-1967-1284","volume":"34","author":"Ota","year":"2023","journal-title":"J. Synlett"},{"key":"D5OB00524H\/cit66\/1","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.2174\/092986706779010298","volume":"13","author":"de Fatima","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"D5OB00524H\/cit67\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ejmech.2014.05.081","volume":"82","author":"Benedekovi\u0107","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"D5OB00524H\/cit68\/1","volume-title":"Synthesis and Functionalization of Bioactive Nitrogen-Containing Heterocycles: Lycopodium and Isoquinoline Alkaloid","author":"Trinh","year":"2024","unstructured":"A.Trinh ,  Synthesis and Functionalization of Bioactive Nitrogen-Containing Heterocycles: Lycopodium and Isoquinoline Alkaloid ,  Doctor of Philosophy in Chemistry, University of Cambridge ,  2024"},{"issue":"23","key":"D5OB00524H\/cit69\/1","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1139\/v68-602","volume":"46","author":"Ayer","year":"1968","journal-title":"Can. J. Chem."},{"issue":"20","key":"D5OB00524H\/cit70\/1","doi-asserted-by":"crossref","first-page":"7095","DOI":"10.1021\/jacs.7b03280","volume":"139","author":"Zhao","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"D5OB00524H\/cit71\/1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1021\/ol100315g","volume":"12","author":"Yepremyan","year":"2010","journal-title":"Org. Lett."},{"issue":"3","key":"D5OB00524H\/cit72\/1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1042\/bj0990604","volume":"99","author":"Koeppen","year":"1966","journal-title":"Biochem. J."},{"issue":"19","key":"D5OB00524H\/cit73\/1","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/ol4021095","volume":"15","author":"Yuan","year":"2013","journal-title":"Org. Lett."},{"issue":"12","key":"D5OB00524H\/cit74\/1","first-page":"3987","volume":"78","author":"Miyata","year":"2009","journal-title":"Heterocycles"},{"issue":"9","key":"D5OB00524H\/cit75\/1","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1021\/cr050041j","volume":"108","author":"Patil","year":"2008","journal-title":"Chem. Rev."},{"issue":"12","key":"D5OB00524H\/cit76\/1","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1021\/cr0683966","volume":"106","author":"Zeni","year":"2006","journal-title":"Chem. Rev."},{"issue":"3","key":"D5OB00524H\/cit77\/1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1021\/cr020033s","volume":"103","author":"Horton","year":"2003","journal-title":"Chem. Rev."},{"issue":"5","key":"D5OB00524H\/cit78\/1","first-page":"627","volume":"9","author":"Cacchi","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"D5OB00524H\/cit79\/1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.phytol.2010.10.001","volume":"3","author":"Zhou","year":"2010","journal-title":"Phytochem. Lett."},{"issue":"2","key":"D5OB00524H\/cit80\/1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/jo502503w","volume":"80","author":"Boukouvalas","year":"2015","journal-title":"J. Org. Chem."},{"issue":"10","key":"D5OB00524H\/cit81\/1","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1007\/s00044-018-2246-1","volume":"27","author":"Mairink","year":"2018","journal-title":"Med. Chem. Res."},{"issue":"46","key":"D5OB00524H\/cit82\/1","doi-asserted-by":"crossref","first-page":"9084","DOI":"10.1016\/j.tet.2014.10.010","volume":"70","author":"Yuan","year":"2014","journal-title":"Tetrahedron"},{"issue":"1","key":"D5OB00524H\/cit83\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0166-3542(94)90093-0","volume":"25","author":"Yusa","year":"1994","journal-title":"Antiviral Res."},{"issue":"1","key":"D5OB00524H\/cit84\/1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2006.07.011","volume":"7","author":"Zheng","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"D5OB00524H\/cit85\/1","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1021\/acs.orglett.0c00172","volume":"22","author":"Singh","year":"2020","journal-title":"Org. Lett."},{"issue":"26","key":"D5OB00524H\/cit86\/1","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1021\/ol062581o","volume":"8","author":"Roethle","year":"2006","journal-title":"Org. Lett."},{"issue":"10","key":"D5OB00524H\/cit87\/1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1021\/ol049495d","volume":"6","author":"Marrero","year":"2004","journal-title":"Org. Lett."},{"issue":"9","key":"D5OB00524H\/cit88\/1","doi-asserted-by":"crossref","first-page":"151039","DOI":"10.1016\/j.tetlet.2019.151039","volume":"60","author":"Miyazawa","year":"2019","journal-title":"Tetrahedron Lett."},{"key":"D5OB00524H\/cit89\/1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1039\/p19900001655","author":"Fang","year":"1990","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"issue":"1","key":"D5OB00524H\/cit90\/1","first-page":"1","volume":"3","author":"Geran","year":"1972","journal-title":"Cancer Chemother. Rep."},{"key":"D5OB00524H\/cit91\/1","doi-asserted-by":"crossref","first-page":"9780","DOI":"10.1039\/D1CC04290D","volume":"57","author":"Tanaka","year":"2021","journal-title":"Chem. Commun."},{"key":"D5OB00524H\/cit92\/1","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1039\/C7NJ00059F","volume":"41","author":"Chen","year":"2017","journal-title":"New J. Chem."},{"key":"D5OB00524H\/cit93\/1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1021\/np0705054","volume":"71","author":"Stierle","year":"2008","journal-title":"J. Nat. Prod."},{"key":"D5OB00524H\/cit94\/1","doi-asserted-by":"crossref","first-page":"154827","DOI":"10.1016\/j.tetlet.2023.154827","volume":"132","author":"Kameyama","year":"2023","journal-title":"Tetrahedron Lett."},{"issue":"16","key":"D5OB00524H\/cit95\/1","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1021\/ol4013958","volume":"15","author":"Unsworth","year":"2013","journal-title":"Org. Lett."},{"issue":"21","key":"D5OB00524H\/cit96\/1","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1021\/ol302115z","volume":"14","author":"Park","year":"2012","journal-title":"Org. Lett."},{"key":"D5OB00524H\/cit97\/1","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1039\/D4OB00110A","volume":"22","author":"Kokaji","year":"2024","journal-title":"Org. Biomol. Chem."},{"key":"D5OB00524H\/cit98\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1039\/B610344H","volume":"1","author":"Winssinger","year":"2007","journal-title":"Chem. Commun."},{"issue":"44","key":"D5OB00524H\/cit99\/1","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1002\/anie.200501703","volume":"44","author":"Karpov","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"issue":"9","key":"D5OB00524H\/cit100\/1","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/np970493u","volume":"61","author":"Franco","year":"1998","journal-title":"J. Nat. Prod."},{"key":"D5OB00524H\/cit101\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2015.05.020","volume":"98","author":"Yadav","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"14","key":"D5OB00524H\/cit102\/1","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1039\/c1ob05522d","volume":"9","author":"Parsons","year":"2011","journal-title":"Org. Biomol. Chem."},{"issue":"16","key":"D5OB00524H\/cit103\/1","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1016\/j.bmc.2019.06.029","volume":"27","author":"Drie\u00dfen","year":"2019","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"D5OB00524H\/cit104\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/2212697X06666190509094514","volume":"6","author":"Chashoo","year":"2019","journal-title":"Clin. Cancer Drugs"},{"issue":"20","key":"D5OB00524H\/cit105\/1","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1002\/chem.200900119","volume":"15","author":"Merkul","year":"2009","journal-title":"Chem. \u2013 Eur. J."},{"issue":"28","key":"D5OB00524H\/cit106\/1","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.1021\/ja073590a","volume":"129","author":"Scheerer","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00524H\/cit107\/1","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1039\/p19820002505","volume":"10","author":"Ortega","year":"1982","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"issue":"17","key":"D5OB00524H\/cit108\/1","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1073\/pnas.182234399","volume":"99","author":"Roth","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"14","key":"D5OB00524H\/cit109\/1","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1021\/acs.orglett.9b01111","volume":"21","author":"Singh","year":"2019","journal-title":"Org. Lett."},{"key":"D5OB00524H\/cit110\/1","first-page":"181","volume-title":"The Alkaloids: Chemistry and Biology","volume":"65","author":"Kn\u00f6lker","year":"2008","unstructured":"H. J.Kn\u00f6lker  and  K. R.Reddy ,  The Alkaloids: Chemistry and Biology ,  Elsevier ,  2008 , vol.  65 , pp.  181\u2013193"},{"issue":"6","key":"D5OB00524H\/cit111\/1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.bmcl.2010.01.159","volume":"20","author":"Zhang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"41","key":"D5OB00524H\/cit112\/1","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1016\/j.tet.2011.07.053","volume":"67","author":"Intaraudom","year":"2011","journal-title":"Tetrahedron"},{"issue":"6","key":"D5OB00524H\/cit113\/1","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1021\/cr200447s","volume":"112","author":"Schmidt","year":"2012","journal-title":"Chem. Rev."},{"issue":"4","key":"D5OB00524H\/cit114\/1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.tet.2017.12.048","volume":"74","author":"Zhou","year":"2018","journal-title":"Tetrahedron"},{"issue":"25","key":"D5OB00524H\/cit115\/1","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1021\/ja010819s","volume":"123","author":"Thomas","year":"2001","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"D5OB00524H\/cit116\/1","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1021\/cr100380z","volume":"112","author":"Wang","year":"2012","journal-title":"Chem. Rev."},{"issue":"24","key":"D5OB00524H\/cit117\/1","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1002\/adma.201402726","volume":"26","author":"Aizawa","year":"2014","journal-title":"Adv. Mater."},{"issue":"6","key":"D5OB00524H\/cit118\/1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.7164\/antibiotics.33.683","volume":"33","author":"Sakano","year":"1980","journal-title":"J. Antibiot."},{"issue":"7","key":"D5OB00524H\/cit119\/1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.7164\/antibiotics.33.961","volume":"33","author":"Sakano","year":"1980","journal-title":"J. Antibiot."},{"issue":"11","key":"D5OB00524H\/cit120\/1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.7164\/antibiotics.39.1059","volume":"39","author":"Kase","year":"1986","journal-title":"J. Antibiot."},{"issue":"12","key":"D5OB00524H\/cit121\/1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.7164\/antibiotics.39.1066","volume":"39","author":"Akanishi","year":"1986","journal-title":"J. Antibiot."},{"issue":"13","key":"D5OB00524H\/cit122\/1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.7164\/antibiotics.39.1072","volume":"39","author":"Yasuzawa","year":"1986","journal-title":"J. Antibiot."},{"issue":"6","key":"D5OB00524H\/cit123\/1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.7164\/antibiotics.48.535","volume":"48","author":"Omura","year":"1995","journal-title":"J. Antibiot."},{"issue":"24","key":"D5OB00524H\/cit124\/1","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1182\/blood-2017-05-782292","volume":"129","author":"Levis","year":"2017","journal-title":"Blood"},{"key":"D5OB00524H\/cit125\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1182\/bloodadvances.2017011080","volume":"2","author":"Stone","year":"2018","journal-title":"Blood Adv."},{"key":"D5OB00524H\/cit126\/1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1021\/acs.orglett.0c00053","volume":"22","author":"Rossi-Ashton","year":"2020","journal-title":"Org. Lett."},{"key":"D5OB00524H\/cit127\/1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/anie.201406866","volume":"54","author":"Mith","year":"2015","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00524H\/cit128\/1","doi-asserted-by":"crossref","first-page":"15532","DOI":"10.1021\/acs.joc.1c02009","volume":"86","author":"Jiang","year":"2021","journal-title":"J. Org. Chem."},{"key":"D5OB00524H\/cit129\/1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1039\/b401662a","volume":"21","author":"Marshall","year":"2004","journal-title":"Nat. Prod. Rep."},{"key":"D5OB00524H\/cit130\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cbdv.201400434","volume":"13","author":"Ibrahim","year":"2016","journal-title":"Chem. Biodiversity"},{"key":"D5OB00524H\/cit131\/1","doi-asserted-by":"crossref","DOI":"10.1007\/1-4020-3484-9","volume-title":"Bioactive Marine Natural Products","author":"Bhakuni","year":"2005","unstructured":"D. S.Bhakuni  and  D. S.Rawat , in  Bioactive Marine Natural Products ,  Springer Science & Business Media: Anamaya Publishers ,  2005 , ch. 9"},{"issue":"35","key":"D5OB00524H\/cit132\/1","doi-asserted-by":"crossref","first-page":"11594","DOI":"10.1021\/jacs.5b07438","volume":"137","author":"Trost","year":"2015","journal-title":"J. Am. Chem. Soc."},{"issue":"10","key":"D5OB00524H\/cit133\/1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1348-0421.1994.tb01850.x","volume":"38","author":"Kohama","year":"1994","journal-title":"Microbiol. Immunol."},{"issue":"2","key":"D5OB00524H\/cit134\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.7164\/antibiotics.49.91","volume":"49","author":"Kohama","year":"1996","journal-title":"J. Antibiot."},{"issue":"8","key":"D5OB00524H\/cit135\/1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1089\/jir.1998.18.863","volume":"18","author":"Koishi","year":"1998","journal-title":"J. Interferon Cytokine Res."},{"issue":"4","key":"D5OB00524H\/cit136\/1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/107999002753675776","volume":"22","author":"Koishi","year":"2002","journal-title":"J. Interferon Cytokine Res."},{"issue":"14","key":"D5OB00524H\/cit137\/1","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1021\/jo8005599","volume":"73","author":"Miyashita","year":"2008","journal-title":"J. Org. Chem."},{"issue":"6","key":"D5OB00524H\/cit138\/1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/oxfordjournals.jbchem.a022375","volume":"125","author":"Usui","year":"1999","journal-title":"J. Biochem."},{"key":"D5OB00524H\/cit139\/1","author":"Nichols","year":"2024","unstructured":"T. W.Nichols , Expanding the Scope of the Bohlmann-Rahtz Reaction: New Routes to 3-Nitropyridines, \u03b4\u03b4-Carbolines, and \u03b2-Carbolines, M.Phil. Thesis,  University of Cambridge ,  2024"},{"key":"D5OB00524H\/cit140\/1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ejphar.2010.10.048","volume":"650","author":"Yonezawa","year":"2011","journal-title":"Eur. J. Pharmacol."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/OB\/D5OB00524H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:05:55Z","timestamp":1782885955000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/23\/22\/5273-5292\/902796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":140,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2025,6,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ob00524h","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5OB00524H\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00524H\/v3\/decision1","asserted-by":"object"}]},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}