{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:34:06Z","timestamp":1782884046328,"version":"3.54.5"},"reference-count":57,"publisher":"Royal Society of Chemistry (RSC)","issue":"25","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"am","delay-in-days":517,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19H02685"],"award-info":[{"award-number":["19H02685"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19023"],"award-info":[{"award-number":["22K19023"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    The intermediary-produced CF\n                    <jats:sub>2<\/jats:sub>\n                    H radical, produced by one-electron oxidation of difluoromethylborates [pinB(Aryl)CF\n                    <jats:sub>2<\/jats:sub>\n                    H][K(18-cr-6)] using photo-redox catalysts, is advantageous for synthesizing the difluoromethylated benzene-fused \u03b3-sultams.\n                  <\/jats:p>","DOI":"10.1039\/d5ob00598a","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T04:40:38Z","timestamp":1748839238000},"page":"6225-6230","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The boron effect on radical difluoromethylation of\n                    <i>N<\/i>\n                    -sulfonyl cyclic ketimines"],"prefix":"10.1039","volume":"23","author":[{"given":"Yu-En","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo (Science Tokyo), 2-12-1-H-113 Ookayama, Meguro-ku, Tokyo 152-8552, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kakeru","family":"Konagaya","sequence":"additional","affiliation":[{"name":"Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo (Science Tokyo), 2-12-1-H-113 Ookayama, Meguro-ku, Tokyo 152-8552, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-8499","authenticated-orcid":false,"given":"Shigekazu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Institute of Science Tokyo (Science Tokyo), 2-12-1-H-113 Ookayama, Meguro-ku, Tokyo 152-8552, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5OB00598A\/cit1a\/1","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1021\/cr1003776","volume":"111","author":"Majumdar","year":"2011","journal-title":"Chem. Rev."},{"key":"D5OB00598A\/cit1b\/1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ejoc.201701491","author":"Debnath","year":"2018","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB00598A\/cit1c\/1","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1002\/ejoc.202000603","author":"Grygorenko","year":"2020","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB00598A\/cit1d\/1","first-page":"e202400535","volume":"13","author":"Chen","year":"2024","journal-title":"Asian J. Org. Chem."},{"key":"D5OB00598A\/cit1e\/1","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1039\/D3MD00653K","volume":"15","author":"Chong","year":"2024","journal-title":"RSC Med. Chem."},{"key":"D5OB00598A\/cit2a\/1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1021\/ol000130c","volume":"2","author":"Dauban","year":"2000","journal-title":"Org. Lett."},{"key":"D5OB00598A\/cit2b\/1","doi-asserted-by":"crossref","first-page":"7483","DOI":"10.1016\/j.bmcl.2010.10.006","volume":"20","author":"Kiefer","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5OB00598A\/cit2c\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1248\/cpb.59.46","volume":"59","author":"Kim","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"D5OB00598A\/cit2d\/1","doi-asserted-by":"crossref","first-page":"12073","DOI":"10.1038\/s41598-018-30610-7","volume":"8","author":"Mukherjee","year":"2018","journal-title":"Sci. Rep."},{"key":"D5OB00598A\/cit2e\/1","doi-asserted-by":"crossref","first-page":"6530","DOI":"10.1002\/ejoc.202000351","author":"Stepannikova","year":"2021","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB00598A\/cit2f\/1","doi-asserted-by":"crossref","first-page":"127667","DOI":"10.1016\/j.bmcl.2020.127667","volume":"31","author":"Shin","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5OB00598A\/cit3\/1","doi-asserted-by":"crossref","first-page":"638902","DOI":"10.1155\/2014\/638902","volume":"2014","author":"Mork\u016bnait\u0117","year":"2014","journal-title":"BioMed. Res. Int."},{"key":"D5OB00598A\/cit4a\/1","doi-asserted-by":"crossref","first-page":"112923","DOI":"10.1016\/j.ejmech.2020.112923","volume":"209","author":"Kumar","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5OB00598A\/cit4b\/1","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1080\/14756366.2022.2052868","volume":"37","author":"Kciuk","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5OB00598A\/cit4c\/1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3109\/14756366.2011.638921","volume":"27","author":"Liu","year":"2012","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5OB00598A\/cit5\/1","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1021\/jm500255y","volume":"57","author":"Moeker","year":"2014","journal-title":"J. Med. Chem."},{"key":"D5OB00598A\/cit6\/1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.tet.2009.10.070","volume":"66","author":"Zakharova","year":"2010","journal-title":"Tetrahedron"},{"key":"D5OB00598A\/cit7\/1","doi-asserted-by":"crossref","first-page":"8868","DOI":"10.1021\/acs.jmedchem.6b00685","volume":"59","author":"Azevedo","year":"2016","journal-title":"J. Med. Chem."},{"key":"D5OB00598A\/cit8\/1","doi-asserted-by":"crossref","first-page":"112575","DOI":"10.1016\/j.ejmech.2020.112575","volume":"204","author":"Ma","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D5OB00598A\/cit9a\/1","volume-title":"Fluorine in Medicinal Chemistry and Chemical Biology","year":"2009","unstructured":"Fluorine in Medicinal Chemistry and Chemical Biology , ed.  I. Ojima ,  Wiley ,  Chichester ,  2009"},{"key":"D5OB00598A\/cit9b\/1","volume-title":"Modern Fluoroorganic Chemistry","year":"2013","unstructured":"Modern Fluoroorganic Chemistry , ed.  P. Kirsch ,  Wiley ,  Weinheim ,  2013"},{"key":"D5OB00598A\/cit9c\/1","volume-title":"Organofluorine Compounds in Biology and Medicine","author":"Reddy","year":"2015","unstructured":"V. P.Reddy ,  Organofluorine Compounds in Biology and Medicine ,  Elsevier ,  Amsterdam ,  2015"},{"key":"D5OB00598A\/cit9d\/1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1126\/science.1131943","volume":"317","author":"M\u00fcller","year":"2007","journal-title":"Science"},{"key":"D5OB00598A\/cit9e\/1","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1021\/jm800219f","volume":"51","author":"Hagmann","year":"2008","journal-title":"J. Med. Chem."},{"key":"D5OB00598A\/cit9f\/1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1021\/cr4002879","volume":"114","author":"Wang","year":"2014","journal-title":"Chem. Rev."},{"key":"D5OB00598A\/cit9g\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/cmdc.201402555","volume":"10","author":"Xing","year":"2015","journal-title":"ChemMedChem"},{"key":"D5OB00598A\/cit9h\/1","doi-asserted-by":"crossref","first-page":"107578","DOI":"10.1016\/j.cclet.2022.06.001","volume":"34","author":"He","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"D5OB00598A\/cit10\/1","doi-asserted-by":"crossref","first-page":"15498","DOI":"10.1002\/chem.201904175","volume":"25","author":"Zimmermann","year":"2019","journal-title":"Chem. \u2013 Eur. J."},{"key":"D5OB00598A\/cit11\/1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ja3110818","volume":"135","author":"Wang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00598A\/cit12\/1","doi-asserted-by":"crossref","first-page":"15850","DOI":"10.1021\/jacs.8b09251","volume":"140","author":"Li","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00598A\/cit13\/1","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1002\/asia.202000854","volume":"20","author":"Yokawa","year":"2020","journal-title":"Chem. \u2013 Asian J."},{"key":"D5OB00598A\/cit14\/1","doi-asserted-by":"crossref","first-page":"8042","DOI":"10.1021\/acs.joc.3c00056","volume":"88","author":"Konagaya","year":"2023","journal-title":"J. Org. Chem."},{"key":"D5OB00598A\/cit15a\/1","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1021\/jo00111a021","volume":"60","author":"Erickson","year":"1995","journal-title":"J. Org. Chem."},{"key":"D5OB00598A\/cit15b\/1","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/jm1013693","volume":"54","author":"Meanwell","year":"2011","journal-title":"J. Med. Chem."},{"key":"D5OB00598A\/cit15c\/1","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1021\/jacs.7b04457","volume":"139","author":"Sessler","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00598A\/cit15d\/1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.jmedchem.6b01691","volume":"60","author":"Zafrani","year":"2017","journal-title":"J. Med. Chem."},{"key":"D5OB00598A\/cit15e\/1","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1021\/acs.jmedchem.9b00604","volume":"62","author":"Zafrani","year":"2019","journal-title":"J. Med. Chem."},{"key":"D5OB00598A\/cit16\/1","volume-title":"Bioisosteres in Medicinal Chemistry","year":"2012","unstructured":"Bioisosteres in Medicinal Chemistry , ed.  N. Brown ,  Wiley-VCH ,  Weinheim ,  2012"},{"key":"D5OB00598A\/cit17a\/1","first-page":"4549","author":"Levi","year":"2019","journal-title":"Synthesis"},{"key":"D5OB00598A\/cit17b\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.chempr.2017.11.004","volume":"4","author":"Koike","year":"2018","journal-title":"Chem"},{"key":"D5OB00598A\/cit17c\/1","doi-asserted-by":"crossref","first-page":"8214","DOI":"10.1039\/D1CS00360G","volume":"50","author":"Sap","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D5OB00598A\/cit17d\/1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature10108","volume":"473","author":"Furuya","year":"2011","journal-title":"Nature"},{"key":"D5OB00598A\/cit17e\/1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.3762\/bjoc.16.183","volume":"16","author":"Yakubov","year":"2020","journal-title":"Beilstein J. Org. Chem."},{"key":"D5OB00598A\/cit17f\/1","doi-asserted-by":"crossref","first-page":"e202400423","DOI":"10.1002\/ejoc.202400423","author":"Li","year":"2024","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB00598A\/cit18\/1","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1021\/cr300503r","volume":"113","author":"Prier","year":"2013","journal-title":"Chem. Rev."},{"key":"D5OB00598A\/cit19\/1","doi-asserted-by":"crossref","first-page":"11747","DOI":"10.1021\/acs.joc.4c00679","volume":"89","author":"Kou","year":"2024","journal-title":"J. Org. Chem."},{"key":"D5OB00598A\/cit20a\/1","doi-asserted-by":"crossref","first-page":"7280","DOI":"10.1021\/ja026572w","volume":"124","author":"Andrews","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00598A\/cit20b\/1","doi-asserted-by":"crossref","first-page":"4756","DOI":"10.1063\/1.474838","volume":"22","author":"Van Zee","year":"1997","journal-title":"J. Chem. Phys."},{"key":"D5OB00598A\/cit20c\/1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1039\/C39830000326","author":"Symons","year":"1983","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"D5OB00598A\/cit20d\/1","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1002\/chem.202004692","volume":"27","author":"Suzuki","year":"2021","journal-title":"Chem. \u2013 Eur. J."},{"key":"D5OB00598A\/cit21a\/1","doi-asserted-by":"crossref","first-page":"e202400815","DOI":"10.1002\/anie.202400815","volume":"63","author":"Grotjahn","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00598A\/cit21b\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1021\/acs.orglett.4c04260","volume":"27","author":"Wendlandt","year":"2025","journal-title":"Org. Lett."},{"key":"D5OB00598A\/cit22\/1","doi-asserted-by":"crossref","first-page":"100945","DOI":"10.1016\/j.checat.2024.100945","volume":"4","author":"Zhu","year":"2024","journal-title":"Chem Catal."},{"key":"D5OB00598A\/cit23\/1","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1038\/s41467-024-48949-z","volume":"15","author":"Duan","year":"2024","journal-title":"Nat. Commun."},{"key":"D5OB00598A\/cit24\/1","first-page":"28034","volume":"146","author":"Garwood","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00598A\/cit25\/1","doi-asserted-by":"crossref","first-page":"6263","DOI":"10.1002\/ejoc.201300829","author":"Zhang","year":"2013","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB00598A\/cit26\/1","doi-asserted-by":"crossref","first-page":"8503","DOI":"10.1039\/C9SC03765A","volume":"10","author":"Friese","year":"2019","journal-title":"Chem. Sci."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/OB\/D5OB00598A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:22:56Z","timestamp":1782879776000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/23\/25\/6225-6230\/902836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":57,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ob00598a","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}