{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:04:22Z","timestamp":1782972262275,"version":"3.54.5"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","issue":"24","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":138,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001475","name":"Nanyang Technological University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001475","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["M21K2c0114"],"award-info":[{"award-number":["M21K2c0114"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    A metal-free, superacid-catalyzed method for the \u03b1-deuteration of carbonyl compounds using D\n                    <jats:sub>2<\/jats:sub>\n                    O was reported, offering broad substrate scope, high efficiency, and practical applicability for deuterium labeling in medicinal and synthetic chemistry.\n                  <\/jats:p>","DOI":"10.1039\/d5ob00683j","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:01:02Z","timestamp":1747638062000},"page":"5758-5762","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Superacid-catalysed \u03b1-deuteration of ketones with D\n                    <sub>2<\/sub>\n                    O"],"prefix":"10.1039","volume":"23","author":[{"given":"Haiying","family":"Yuan","sequence":"first","affiliation":[{"name":"Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaibo","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-337X","authenticated-orcid":false,"given":"Teck-Peng","family":"Loh","sequence":"additional","affiliation":[{"name":"Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China"},{"name":"Division of Chemistry and Biological Chemistry, School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China"},{"name":"Division of Chemistry and Biological Chemistry, School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Jia","sequence":"additional","affiliation":[{"name":"Henan Linker Technology Key Laboratory, College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5OB00683J\/cit1a\/1","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1002\/anie.201107334","volume":"51","author":"Simmons","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00683J\/cit1b\/1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/jlcr.1818","volume":"53","author":"Atzrodt","year":"2010","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"D5OB00683J\/cit2a\/1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41573-023-00703-8","volume":"22","author":"Di Martino","year":"2023","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5OB00683J\/cit2b\/1","first-page":"8","volume":"2","author":"Harbeson","year":"2014","journal-title":"Med. Chem."},{"key":"D5OB00683J\/cit2c\/1","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/jm4007998","volume":"57","author":"Gant","year":"2014","journal-title":"J. Med. Chem."},{"key":"D5OB00683J\/cit2d\/1","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1021\/acs.jmedchem.8b01808","volume":"62","author":"Pirali","year":"2019","journal-title":"J. Med. Chem."},{"key":"D5OB00683J\/cit2e\/1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd.2016.63","volume":"15","author":"Mullard","year":"2016","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5OB00683J\/cit3a\/1","first-page":"305","volume":"16","author":"Mullard","year":"2017","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5OB00683J\/cit3b\/1","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1200\/JCO.21.00163","volume":"39","author":"Qin","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"D5OB00683J\/cit3c\/1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/d41573-022-00139-6","volume":"21","author":"Mullard","year":"2022","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5OB00683J\/cit3d\/1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1021\/acs.biochem.7b00765","volume":"57","author":"DeWitt","year":"2018","journal-title":"Biochemistry"},{"key":"D5OB00683J\/cit4a\/1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1158\/2159-8290.CD-21-0832","volume":"12","author":"Li","year":"2022","journal-title":"Cancer Discovery"},{"key":"D5OB00683J\/cit4b\/1","first-page":"269","volume":"458","author":"Sanderson","year":"2009","journal-title":"Nature"},{"key":"D5OB00683J\/cit5a\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/cpdd.3","volume":"2","author":"Braman","year":"2013","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"D5OB00683J\/cit5b\/1","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3390\/jcm4061325","volume":"4","author":"Perez-Gomez","year":"2015","journal-title":"J. Clin. Med."},{"key":"D5OB00683J\/cit6a\/1","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1016\/S0040-4020(01)96361-6","volume":"24","author":"Rape","year":"1968","journal-title":"Tetrahedron"},{"key":"D5OB00683J\/cit6b\/1","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1021\/jo070307h","volume":"72","author":"Sabot","year":"2007","journal-title":"J. Org. Chem."},{"key":"D5OB00683J\/cit6c\/1","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1002\/anie.201000825","volume":"49","author":"Rempt","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00683J\/cit6d\/1","doi-asserted-by":"crossref","first-page":"10785","DOI":"10.1021\/ja026880u","volume":"124","author":"Peng","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00683J\/cit6e\/1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/adsc.202001507","volume":"363","author":"Galkin","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"D5OB00683J\/cit6f\/1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/jlcr.879","volume":"47","author":"Berthelette","year":"2004","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"D5OB00683J\/cit6g\/1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jlcr.3210","volume":"57","author":"Zhan","year":"2014","journal-title":"J. Labelled Compd. Radiopharm."},{"key":"D5OB00683J\/cit6h\/1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s44160-022-00139-9","volume":"1","author":"Tanaka","year":"2022","journal-title":"Nat. Synth."},{"key":"D5OB00683J\/cit7a\/1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/adsc.201901419","volume":"362","author":"Chang","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"D5OB00683J\/cit7b\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1021\/jacs.6b11908","volume":"139","author":"Shang","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB00683J\/cit8a\/1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/ejoc.200400669","author":"Kr\u00fcger","year":"2005","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB00683J\/cit8b\/1","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1021\/jo071119u","volume":"72","author":"Wheatley","year":"2007","journal-title":"J. Org. Chem."},{"key":"D5OB00683J\/cit9a\/1","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1021\/acscatal.1c05546","volume":"12","author":"Zhang","year":"2022","journal-title":"ACS Catal."},{"key":"D5OB00683J\/cit9b\/1","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1039\/D2QO01081J","volume":"9","author":"Zhang","year":"2022","journal-title":"Org. Chem. Front."},{"key":"D5OB00683J\/cit10\/1","doi-asserted-by":"crossref","first-page":"e202408509","DOI":"10.1002\/anie.202408509","volume":"63","author":"Zhang","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00683J\/cit11a\/1","doi-asserted-by":"crossref","first-page":"101246","DOI":"10.1016\/j.xcrp.2023.101246","volume":"4","author":"Zhang","year":"2023","journal-title":"Cell Rep. Phys. Sci."},{"key":"D5OB00683J\/cit11b\/1","doi-asserted-by":"crossref","first-page":"14123","DOI":"10.1021\/acscatal.2c04010","volume":"12","author":"Zhang","year":"2022","journal-title":"ACS Catal."},{"key":"D5OB00683J\/cit11c\/1","doi-asserted-by":"crossref","first-page":"e202406588","DOI":"10.1002\/anie.202406588","volume":"63","author":"Zhang","year":"2024","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB00683J\/cit12a\/1","doi-asserted-by":"crossref","first-page":"eadg4924","DOI":"10.1126\/sciadv.adg4924","volume":"9","author":"Teng","year":"2023","journal-title":"Sci. Adv."},{"key":"D5OB00683J\/cit12b\/1","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1021\/jacs.3c12050","volume":"146","author":"Zhang","year":"2024","journal-title":"J. Am. Chem. Soc."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/OB\/D5OB00683J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:44:23Z","timestamp":1782967463000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/23\/24\/5758-5762\/902882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":35,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,6,18]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ob00683j","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5OB00683J\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00683J\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00683J\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00683J\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00683J\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5OB00683J\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}