{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:04:06Z","timestamp":1782893046876,"version":"3.54.5"},"reference-count":65,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2026,12,30]],"date-time":"2026-12-30T00:00:00Z","timestamp":1798588800000},"content-version":"am","delay-in-days":363,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["252300420229"],"award-info":[{"award-number":["252300420229"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    An atom-economical and metal-free synthesis of quinolines is achieved\n                    <jats:italic>via<\/jats:italic>\n                    TfOH-promoted cyclization of ene-ynamides, featuring broad functional group tolerance.\n                  <\/jats:p>","DOI":"10.1039\/d5ob01680k","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T08:00:47Z","timestamp":1767081647000},"page":"899-904","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metal-free quinoline synthesis\n                    <i>via<\/i>\n                    Br\u00f8nsted acid-promoted cyclization of ene-ynamides"],"prefix":"10.1039","volume":"24","author":[{"given":"Yijie","family":"Wang","sequence":"first","affiliation":[{"name":"Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbiao","family":"Chang","sequence":"additional","affiliation":[{"name":"Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-1688","authenticated-orcid":false,"given":"Xiao-Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Pingyuan Laboratory, State Key Laboratory of Antiviral Drugs, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5OB01680K\/cit1a\/1","doi-asserted-by":"crossref","first-page":"1622566","DOI":"10.3389\/fchem.2025.1622566","volume":"13","author":"Romero","year":"2025","journal-title":"Front. Chem."},{"key":"D5OB01680K\/cit1b\/1","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/med.22111","volume":"45","author":"Kontra","year":"2025","journal-title":"Med. Res. Rev."},{"key":"D5OB01680K\/cit1c\/1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.62347\/TTHX6526","volume":"17","author":"Srinivasa","year":"2025","journal-title":"Am. J. Transl. Res."},{"key":"D5OB01680K\/cit1d\/1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.2174\/0109298673258512231013060222","volume":"32","author":"Zhao","year":"2025","journal-title":"Curr. Med. Chem."},{"key":"D5OB01680K\/cit1e\/1","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s12010-024-05164-2","volume":"197","author":"Khan","year":"2025","journal-title":"Appl. Biochem. Biotechnol."},{"key":"D5OB01680K\/cit1f\/1","doi-asserted-by":"crossref","first-page":"e202500279","DOI":"10.1002\/cmdc.202500279","volume":"20","author":"Sultan","year":"2025","journal-title":"ChemMedChem"},{"key":"D5OB01680K\/cit1g\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2174\/0115734064318361240827072124","volume":"21","author":"Raghav","year":"2025","journal-title":"Med. Chem."},{"key":"D5OB01680K\/cit1h\/1","doi-asserted-by":"crossref","first-page":"117874","DOI":"10.1016\/j.ejmech.2025.117874","volume":"296","author":"Melo","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"D5OB01680K\/cit1i\/1","doi-asserted-by":"crossref","first-page":"115973","DOI":"10.1016\/j.bmc.2020.115973","volume":"32","author":"Matada","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"D5OB01680K\/cit1j\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/2215083805666190614115701","volume":"7","author":"Gupta","year":"2021","journal-title":"Curr. Tradit. Med."},{"key":"D5OB01680K\/cit1k\/1","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2174\/138955709791012247","volume":"9","author":"Kumar","year":"2009","journal-title":"Mini-Rev. Med. Chem."},{"key":"D5OB01680K\/cit1l\/1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1039\/b509528j","volume":"24","author":"Michael","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"D5OB01680K\/cit2a\/1","doi-asserted-by":"crossref","first-page":"125886","DOI":"10.1016\/j.saa.2025.125886","volume":"333","author":"Oleg\u00e1rio","year":"2025","journal-title":"Spectrochim. Acta, Part A"},{"key":"D5OB01680K\/cit2b\/1","doi-asserted-by":"crossref","first-page":"e00325","DOI":"10.1002\/slct.202500325","volume":"10","author":"Kumar","year":"2025","journal-title":"ChemistrySelect"},{"key":"D5OB01680K\/cit3a\/1","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1021\/acs.joc.5c00170","volume":"90","author":"Choudhary","year":"2025","journal-title":"J. Org. Chem."},{"key":"D5OB01680K\/cit3b\/1","doi-asserted-by":"crossref","first-page":"133982","DOI":"10.1016\/j.molstruc.2022.133982","volume":"1271","author":"Feng","year":"2023","journal-title":"J. Mol. Struct."},{"key":"D5OB01680K\/cit3c\/1","doi-asserted-by":"crossref","first-page":"104514","DOI":"10.1016\/j.bioorg.2020.104514","volume":"108","author":"Singh","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5OB01680K\/cit4a\/1","doi-asserted-by":"crossref","first-page":"113208","DOI":"10.1016\/j.ejmech.2021.113208","volume":"214","author":"Wang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5OB01680K\/cit4b\/1","doi-asserted-by":"crossref","first-page":"105117","DOI":"10.1016\/j.bioorg.2021.105117","volume":"114","author":"Seliem","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D5OB01680K\/cit4c\/1","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1021\/acs.jmedchem.9b00115","volume":"62","author":"Musharrafieh","year":"2019","journal-title":"J. Med. Chem."},{"key":"D5OB01680K\/cit5\/1","doi-asserted-by":"crossref","first-page":"143789","DOI":"10.1016\/j.molstruc.2025.143789","volume":"1349","author":"Mekheimer","year":"2026","journal-title":"J. Mol. Struct."},{"key":"D5OB01680K\/cit6\/1","doi-asserted-by":"crossref","first-page":"9486","DOI":"10.1021\/jacs.8b03738","volume":"140","author":"Jun","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB01680K\/cit7a\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1021\/cr60095a006","volume":"30","author":"Manske","year":"1942","journal-title":"Chem. Rev."},{"key":"D5OB01680K\/cit7b\/1","doi-asserted-by":"crossref","first-page":"24463","DOI":"10.1039\/C4RA01814A","volume":"4","author":"Prajapati","year":"2014","journal-title":"RSC Adv."},{"key":"D5OB01680K\/cit7c\/1","doi-asserted-by":"crossref","first-page":"20784","DOI":"10.1039\/D0RA03763J","volume":"10","author":"Weyesa","year":"2020","journal-title":"RSC Adv."},{"key":"D5OB01680K\/cit7d\/1","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1021\/ol8016726","volume":"10","author":"Horn","year":"2008","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit7e\/1","first-page":"2066","author":"Xing","year":"2011","journal-title":"Synthesis"},{"key":"D5OB01680K\/cit8a\/1","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1021\/acs.orglett.0c00539","volume":"22","author":"Gao","year":"2020","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit8b\/1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/adsc.201901300","volume":"362","author":"Liu","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"D5OB01680K\/cit8c\/1","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1002\/adsc.202100631","volume":"363","author":"Liu","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"D5OB01680K\/cit8d\/1","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1021\/acs.orglett.1c03231","volume":"23","author":"Hu","year":"2021","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit8e\/1","doi-asserted-by":"crossref","first-page":"5988","DOI":"10.1039\/D1QO00914A","volume":"8","author":"Huang","year":"2021","journal-title":"Org. Chem. Front."},{"key":"D5OB01680K\/cit8f\/1","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1021\/acs.orglett.1c01484","volume":"23","author":"Wang","year":"2021","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit8g\/1","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1039\/D1CC00181G","volume":"57","author":"Jana","year":"2021","journal-title":"Chem. Commun."},{"key":"D5OB01680K\/cit8h\/1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1021\/acs.orglett.2c04314","volume":"25","author":"Lu","year":"2023","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit8i\/1","doi-asserted-by":"crossref","first-page":"8099","DOI":"10.1021\/acs.joc.3c00095","volume":"88","author":"Lee","year":"2023","journal-title":"J. Org. Chem."},{"key":"D5OB01680K\/cit8j\/1","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.1021\/acs.joc.3c01451","volume":"88","author":"Zhang","year":"2023","journal-title":"J. Org. Chem."},{"key":"D5OB01680K\/cit9a\/1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1021\/acs.accounts.4c00712","volume":"58","author":"Pradhan","year":"2025","journal-title":"Acc. Chem. Res."},{"key":"D5OB01680K\/cit9b\/1","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1039\/D4QO00301B","volume":"11","author":"Zhao","year":"2024","journal-title":"Org. Chem. Front."},{"key":"D5OB01680K\/cit9c\/1","doi-asserted-by":"crossref","first-page":"e202300816","DOI":"10.1002\/anie.202300816","volume":"62","author":"Dutta","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB01680K\/cit9d\/1","doi-asserted-by":"crossref","first-page":"10715","DOI":"10.1039\/D3RA00139C","volume":"13","author":"Iftikhar","year":"2023","journal-title":"RSC Adv."},{"key":"D5OB01680K\/cit9e\/1","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.6023\/cjoc202200023","volume":"42","author":"Zhang","year":"2022","journal-title":"Chin. J. Org. Chem."},{"key":"D5OB01680K\/cit9f\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.6023\/cjoc202107051","volume":"42","author":"Zhao","year":"2022","journal-title":"Chin. J. Org. Chem."},{"key":"D5OB01680K\/cit9g\/1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1055\/a-1344-5998","author":"Li","year":"2021","journal-title":"Synlett"},{"key":"D5OB01680K\/cit9h\/1","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1039\/D0CS00283F","volume":"50","author":"Hu","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D5OB01680K\/cit9i\/1","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1021\/acs.chemrev.0c00788","volume":"121","author":"Campeau","year":"2021","journal-title":"Chem. Rev."},{"key":"D5OB01680K\/cit9j\/1","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1002\/tcr.202100159","volume":"21","author":"Shandilya","year":"2021","journal-title":"Chem. Rec."},{"key":"D5OB01680K\/cit9k\/1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.6023\/cjoc202009025","volume":"41","author":"Zhou","year":"2021","journal-title":"Chin. J. Org. Chem."},{"key":"D5OB01680K\/cit9l\/1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1021\/acs.accounts.0c00417","volume":"53","author":"Hong","year":"2020","journal-title":"Acc. Chem. Res."},{"key":"D5OB01680K\/cit9m\/1","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1039\/D0CS00769B","volume":"49","author":"Lynch","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"D5OB01680K\/cit9n\/1","doi-asserted-by":"crossref","first-page":"8897","DOI":"10.1039\/D0CS00474J","volume":"49","author":"Chen","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"D5OB01680K\/cit9o\/1","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1021\/acscatal.0c04180","volume":"10","author":"Luo","year":"2020","journal-title":"ACS Catal."},{"key":"D5OB01680K\/cit9p\/1","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1021\/acscatal.9b01851","volume":"9","author":"Zhou","year":"2019","journal-title":"ACS Catal."},{"key":"D5OB01680K\/cit9q\/1","first-page":"59","volume":"48","author":"Evano","year":"2015","journal-title":"Aldrichimica Acta"},{"key":"D5OB01680K\/cit9r\/1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1021\/ar400193g","volume":"47","author":"Wang","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"D5OB01680K\/cit9s\/1","doi-asserted-by":"crossref","DOI":"10.1201\/9781032670997","volume-title":"The Chemistry of Ynamides: Development, Syntheses, and Applications in Organic Synthesis","author":"Evano","year":"2024","unstructured":"G.Evano  and  J.Zhao ,  The Chemistry of Ynamides: Development, Syntheses, and Applications in Organic Synthesis ,  Jenny Stanford Publishing , 1st edn,  2024"},{"key":"D5OB01680K\/cit10a\/1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1021\/jo502467m","volume":"80","author":"Yamaoka","year":"2015","journal-title":"J. Org. Chem."},{"key":"D5OB01680K\/cit10b\/1","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1021\/acs.orglett.4c01013","volume":"26","author":"Wang","year":"2024","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit11a\/1","doi-asserted-by":"crossref","first-page":"e202303665","DOI":"10.1002\/slct.202303665","volume":"8","author":"Kumar","year":"2023","journal-title":"ChemistrySelect"},{"key":"D5OB01680K\/cit11b\/1","doi-asserted-by":"crossref","first-page":"9775","DOI":"10.1039\/D0OB02000A","volume":"18","author":"Harry","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"D5OB01680K\/cit11c\/1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1039\/C7GC03175K","volume":"20","author":"Ahmed","year":"2018","journal-title":"Green Chem."},{"key":"D5OB01680K\/cit12a\/1","doi-asserted-by":"crossref","first-page":"15568","DOI":"10.1021\/acs.joc.1c02078","volume":"86","author":"Zhao","year":"2021","journal-title":"J. Org. Chem."},{"key":"D5OB01680K\/cit12b\/1","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1021\/acs.orglett.8b02197","volume":"20","author":"Kong","year":"2018","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit14\/1","doi-asserted-by":"crossref","first-page":"6562","DOI":"10.1021\/acs.orglett.0c02333","volume":"22","author":"Heo","year":"2020","journal-title":"Org. Lett."},{"key":"D5OB01680K\/cit15\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2494105: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2pqb0s","DOI":"10.5517\/ccdc.csd.cc2pqb0s"}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/OB\/D5OB01680K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:09:53Z","timestamp":1782886193000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/24\/4\/899-904\/1248833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,1,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ob01680k","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}