{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:28:08Z","timestamp":1782973688750,"version":"3.54.5"},"reference-count":23,"publisher":"Royal Society of Chemistry (RSC)","issue":"3","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009056","name":"Canadian Glycomics Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005247","name":"University of British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>The synthesis of 1,2-galacto-configured cyclophellitols aziridines yielded covalent inactivators of \u03b2-galactosidases but not of the alpha-glycosidases.<\/jats:p>","DOI":"10.1039\/d5ob01802a","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T18:41:39Z","timestamp":1765824099000},"page":"687-696","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and evaluation of carbagalactosyl 1,2-aziridines and -epoxides as glycosidase inhibitors"],"prefix":"10.1039","volume":"24","author":[{"given":"Yuqing","family":"Tian","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyann","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8380-7701","authenticated-orcid":false,"given":"Seyed A.","family":"Nasseri","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2397-0053","authenticated-orcid":false,"given":"Jolene P.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-5701","authenticated-orcid":false,"given":"Stephen G.","family":"Withers","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of British Columbia, Vancouver, V6T 1Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5OB01802A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41564-019-0469-7","volume":"4","author":"Rahfeld","year":"2019","journal-title":"Nat. Microbiol."},{"key":"D5OB01802A\/cit2\/1","doi-asserted-by":"crossref","first-page":"13497","DOI":"10.1021\/acscatal.4c03643","volume":"14","author":"Tian","year":"2024","journal-title":"ACS Catal."},{"key":"D5OB01802A\/cit3\/1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jmb.2011.07.057","volume":"412","author":"Fredslund","year":"2011","journal-title":"J. Mol. Biol."},{"key":"D5OB01802A\/cit4\/1","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1021\/bi061521n","volume":"46","author":"Comfort","year":"2007","journal-title":"Biochemistry"},{"key":"D5OB01802A\/cit5\/1","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.1021\/bi00156a016","volume":"31","author":"Street","year":"1992","journal-title":"Biochemistry"},{"key":"D5OB01802A\/cit6\/1","first-page":"64","volume-title":"Methods Enzymol","volume":"354","author":"Mosi","year":"2002","unstructured":"R. M.Mosi  and  S. G.Withers , in  Methods Enzymol , ed.  D. L. Purich ,  Academic Press ,  2002 , vol.  354 , pp.  64\u201384"},{"key":"D5OB01802A\/cit7\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1021\/ja952732a","volume":"118","author":"McCarter","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB01802A\/cit8\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/bi991958d","volume":"39","author":"Vocadlo","year":"2000","journal-title":"Biochemistry"},{"key":"D5OB01802A\/cit9\/1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/0006-291X(91)92016-D","volume":"177","author":"Withers","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D5OB01802A\/cit10\/1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.cbpa.2008.05.010","volume":"12","author":"Vocadlo","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D5OB01802A\/cit11\/1","doi-asserted-by":"crossref","first-page":"24729","DOI":"10.1021\/jacs.4c08840","volume":"146","author":"Artola","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB01802A\/cit12\/1","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/0957-4166(94)80177-0","volume":"5","author":"Tai","year":"1994","journal-title":"Tetrahedron: Asymmetry"},{"key":"D5OB01802A\/cit13\/1","doi-asserted-by":"crossref","first-page":"e202400723","DOI":"10.1002\/chem.202400723","volume":"30","author":"Ofman","year":"2024","journal-title":"Chem. \u2013 Eur. J."},{"key":"D5OB01802A\/cit14\/1","doi-asserted-by":"crossref","first-page":"7488","DOI":"10.1021\/acs.orglett.8b03260","volume":"20","author":"Lu","year":"2018","journal-title":"Org. Lett."},{"key":"D5OB01802A\/cit15\/1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1021\/acscentsci.0c00111","volume":"6","author":"Sobala","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"D5OB01802A\/cit16\/1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1055\/s-0037-1611806","volume":"30","author":"Ushida","year":"2019","journal-title":"Synlett"},{"key":"D5OB01802A\/cit17\/1","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1002\/ejoc.201600983","author":"Schr\u00f6der","year":"2016","journal-title":"Eur. J. Org. Chem."},{"key":"D5OB01802A\/cit18\/1","doi-asserted-by":"crossref","first-page":"7488","DOI":"10.1021\/acs.orglett.8b03260","volume":"20","author":"Lu","year":"2018","journal-title":"Org. Lett."},{"key":"D5OB01802A\/cit19\/1","doi-asserted-by":"crossref","first-page":"7829","DOI":"10.1021\/jo050521a","volume":"70","author":"Serrano","year":"2005","journal-title":"J. Org. Chem."},{"key":"D5OB01802A\/cit20\/1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0167-4838(94)00228-9","volume":"1247","author":"Zhu","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"D5OB01802A\/cit21\/1","doi-asserted-by":"crossref","first-page":"9961","DOI":"10.1021\/bi00156a015","volume":"31","author":"Kempton","year":"1992","journal-title":"Biochemistry"},{"key":"D5OB01802A\/cit22\/1","doi-asserted-by":"crossref","first-page":"14781","DOI":"10.1021\/bi011727i","volume":"40","author":"Juers","year":"2001","journal-title":"Biochemistry"},{"key":"D5OB01802A\/cit23\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pep.2005.01.016","volume":"41","author":"Studier","year":"2005","journal-title":"Protein Expression Purif."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/OB\/D5OB01802A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:05:18Z","timestamp":1782968718000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/24\/3\/687-696\/903406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,1,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ob01802a","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}