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Biomol. Chem."],"abstract":"<jats:p>\n                    We report a regioselective multicomponent synthesis of unprecedented \u03b1-boryl ureas\n                    <jats:italic>via<\/jats:italic>\n                    1,2-boronate migration. This enables late-stage functionalization and yielded a potent main protease inhibitor, underscoring \u03b1-boryl ureas as drug-like scaffolds.\n                  <\/jats:p>","DOI":"10.1039\/d5ob01846c","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T08:55:41Z","timestamp":1768380941000},"page":"1033-1041","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regioselective multicomponent synthesis of \u03b1-boryl ureas: discovery of a potent main protease inhibitor"],"prefix":"10.1039","volume":"24","author":[{"given":"Yusif I.","family":"Gyasi","sequence":"first","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyanarayana","family":"Nyalata","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophea","family":"Pa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Disni","family":"Gunasekera","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerabhadra R.","family":"Vulupala","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3420-2826","authenticated-orcid":false,"given":"Nagarjun R.","family":"Mallampudi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal R.","family":"Ramidi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-9290","authenticated-orcid":false,"given":"Shiqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA"},{"name":"Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M University, College Station, Texas 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5OB01846C\/cit1\/1","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1021\/cr00039a007","volume":"95","author":"Miyaura","year":"1995","journal-title":"Chem. 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