{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:40:29Z","timestamp":1782970829480,"version":"3.54.5"},"reference-count":62,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI150466"],"award-info":[{"award-number":["AI150466"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI158649"],"award-info":[{"award-number":["AI158649"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN272201700060C"],"award-info":[{"award-number":["HHSN272201700060C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI 148103"],"award-info":[{"award-number":["AI 148103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM132024"],"award-info":[{"award-number":["GM132024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA023168"],"award-info":[{"award-number":["P30 CA023168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>Diastereoselective Ugi-multicomponent reactions (Ugi-MCR) are investigated. These reactions provided bis-amides up to 91\u2009:\u20099 dr and moderate to good yields.<\/jats:p>","DOI":"10.1039\/d5ob01897h","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:37:32Z","timestamp":1773049052000},"page":"2542-2558","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ugi multicomponent reactions of optically active aldehydes and chiral aminoindanols: diastereoselective synthesis of bisamides relevant to SARS-CoV-2 Mpro inhibitors"],"prefix":"10.1039","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-1841","authenticated-orcid":false,"given":"Arun K.","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"},{"name":"Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amlan","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7655-8671","authenticated-orcid":false,"given":"Uttara","family":"Jayashankar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-8185","authenticated-orcid":false,"given":"Sydney N.","family":"Bogan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Mesecar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"},{"name":"Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA"},{"name":"Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D5OB01897H\/cit1\/1","first-page":"386","volume":"71","author":"Ugi","year":"1959","journal-title":"Angew. Chem."},{"key":"D5OB01897H\/cit2\/1","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1039\/c2cs15361k","volume":"41","author":"de Graaff","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"D5OB01897H\/cit3\/1","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1039\/D0OB01631D","volume":"18","author":"Nunes","year":"2020","journal-title":"Org. Biomol. Chem."},{"key":"D5OB01897H\/cit4\/1","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.1002\/anie.201006515","volume":"50","author":"Ruijter","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB01897H\/cit5\/1","doi-asserted-by":"crossref","first-page":"155893","DOI":"10.1016\/j.tetlet.2025.155893","volume":"174","author":"Bhattacharjee","year":"2026","journal-title":"Tetrahedron Lett."},{"key":"D5OB01897H\/cit6\/1","first-page":"255","volume":"6","author":"Zhang","year":"2025","journal-title":"Green Synth. Catal."},{"key":"D5OB01897H\/cit7\/1","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/chem.200802140","volume":"15","author":"Sunderhaus","year":"2009","journal-title":"Chemistry"},{"key":"D5OB01897H\/cit8\/1","doi-asserted-by":"crossref","first-page":"42644","DOI":"10.1039\/D0RA07501A","volume":"10","author":"Fouad","year":"2020","journal-title":"RSC Adv."},{"key":"D5OB01897H\/cit9\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1021\/acscombsci.0c00046","volume":"22","author":"Nazeri","year":"2020","journal-title":"ACS Comb. Sci."},{"key":"D5OB01897H\/cit10\/1","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.1021\/cr400615v","volume":"114","author":"Rotstein","year":"2014","journal-title":"Chem. Rev."},{"key":"D5OB01897H\/cit11\/1","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/cr100233r","volume":"112","author":"D\u00f6mling","year":"2012","journal-title":"Chem. Rev."},{"key":"D5OB01897H\/cit12\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1039\/D3OB01837G","volume":"22","author":"Larghi","year":"2024","journal-title":"Org. Biomol. Chem."},{"key":"D5OB01897H\/cit13\/1","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1021\/jo00302a007","volume":"55","author":"Rinehart","year":"1990","journal-title":"J. Org. Chem."},{"key":"D5OB01897H\/cit14\/1","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1021\/ja026216d","volume":"124","author":"Endo","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB01897H\/cit15\/1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.cell.2017.05.042","volume":"169","author":"Maffioli","year":"2017","journal-title":"Cell"},{"key":"D5OB01897H\/cit16\/1","doi-asserted-by":"crossref","first-page":"7956","DOI":"10.1039\/D2CC02442J","volume":"58","author":"Okawa","year":"2022","journal-title":"Chem. Commun."},{"key":"D5OB01897H\/cit17\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7164\/antibiotics.49.37","volume":"49","author":"Sakamoto","year":"1996","journal-title":"J. Antibiot."},{"key":"D5OB01897H\/cit18\/1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3987\/COM-12-S(N)38","volume":"86","author":"Ieda","year":"2012","journal-title":"Heterocycles"},{"key":"D5OB01897H\/cit19\/1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/13543776.2021.1858797","volume":"31","author":"Younus","year":"2021","journal-title":"Expert Opin. Ther. Pat."},{"key":"D5OB01897H\/cit20\/1","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1039\/D0QO01480J","volume":"8","author":"John","year":"2021","journal-title":"Org. Chem. Front."},{"key":"D5OB01897H\/cit21\/1","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1021\/cr100233r","volume":"112","author":"D\u00f6mling","year":"2012","journal-title":"Chem. Rev."},{"key":"D5OB01897H\/cit22\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3390\/molecules25030505","volume":"25","author":"Insuasty","year":"2020","journal-title":"Molecules"},{"key":"D5OB01897H\/cit23\/1","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.3390\/ijms24076581","volume":"24","author":"Graziano","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5OB01897H\/cit24\/1","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"D5OB01897H\/cit25\/1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s40265-022-01692-5","volume":"82","author":"Lamb","year":"2022","journal-title":"Drugs"},{"key":"D5OB01897H\/cit26\/1","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1021\/acs.joc.3c01274","volume":"88","author":"Preschel","year":"2023","journal-title":"J. Org. Chem."},{"key":"D5OB01897H\/cit27\/1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm301580n","volume":"56","author":"Jacobs","year":"2013","journal-title":"J. Med. Chem."},{"key":"D5OB01897H\/cit28\/1","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/acs.jmedchem.1c00509","volume":"65","author":"Kitamura","year":"2022","journal-title":"J. Med. Chem."},{"key":"D5OB01897H\/cit29\/1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1021\/acsinfecdis.3c00565","volume":"10","author":"Ashraf-Uz-Zaman","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"D5OB01897H\/cit30\/1","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/anie.200460548","volume":"44","author":"Ram\u00f3n","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"D5OB01897H\/cit31\/1","doi-asserted-by":"crossref","first-page":"eaas8707","DOI":"10.1126\/science.aas8707","volume":"361","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"D5OB01897H\/cit32\/1","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1021\/acs.orglett.6b00827","volume":"18","author":"Katsuyama","year":"2016","journal-title":"Org. Lett."},{"key":"D5OB01897H\/cit33\/1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1021\/acs.accounts.8b00105","volume":"51","author":"Wang","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"D5OB01897H\/cit34\/1","first-page":"937","author":"Ghosh","year":"2000","journal-title":"Synthesis"},{"key":"D5OB01897H\/cit35\/1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1055\/s-1998-2092","author":"Ghosh","year":"1998","journal-title":"Synthesis"},{"key":"D5OB01897H\/cit36\/1","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1016\/j.tetlet.2005.06.070","volume":"46","author":"Ghosh","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"D5OB01897H\/cit37\/1","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1021\/jo00012a049","volume":"56","author":"Schmid","year":"1991","journal-title":"J. Org. Chem."},{"key":"D5OB01897H\/cit38\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/00304948.2015.1088753","volume":"47","author":"Dibello","year":"2015","journal-title":"Org. Prep. Proced. Int."},{"key":"D5OB01897H\/cit39\/1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0040-4020(01)87445-7","volume":"42","author":"Jurczak","year":"1986","journal-title":"Tetrahedron"},{"key":"D5OB01897H\/cit40\/1","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/S0040-4039(00)88039-9","volume":"24","author":"Mulzer","year":"1983","journal-title":"Tetrahedron Lett."},{"key":"D5OB01897H\/cit41\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15227\/orgsyn.072.0006","volume":"72","author":"Schmid","year":"1995","journal-title":"Org. Synth."},{"key":"D5OB01897H\/cit42\/1","unstructured":"Single-Crystal X-Ray analysis was performed in our X-Ray Crystallography laboratory at Purdue University, Dr. Matthias Zeller, Department of Chemistry, Purdue University"},{"key":"D5OB01897H\/cit43\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2501300: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2pyt3l","DOI":"10.5517\/ccdc.csd.cc2pyt3l"},{"key":"D5OB01897H\/cit44\/1","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1021\/acs.joc.9b03401","volume":"85","author":"Jakas","year":"2020","journal-title":"J. Org. Chem."},{"key":"D5OB01897H\/cit45\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2474023: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2p1f6d","DOI":"10.5517\/ccdc.csd.cc2p1f6d"},{"key":"D5OB01897H\/cit46\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2474024: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2p1f7f","DOI":"10.5517\/ccdc.csd.cc2p1f7f"},{"key":"D5OB01897H\/cit47\/1","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.3390\/molecules24244588","volume":"24","author":"Caruso","year":"2019","journal-title":"Molecules"},{"key":"D5OB01897H\/cit48\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tetasy.2015.11.006","volume":"27","author":"Mucha","year":"2016","journal-title":"Tetrahedron: Asymmetry"},{"key":"D5OB01897H\/cit49\/1","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/chem.200401215","volume":"11","author":"Lilly","year":"2005","journal-title":"Chem. \u2013 Eur. J."},{"key":"D5OB01897H\/cit50\/1","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1039\/C9SC01761E","volume":"10","author":"Richardson","year":"2019","journal-title":"Chem. Sci."},{"key":"D5OB01897H\/cit52\/1","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1021\/jo062059f","volume":"72","author":"Zhu","year":"2007","journal-title":"J. Org. Chem."},{"key":"D5OB01897H\/cit53\/1","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1021\/acs.joc.4c00178","volume":"89","author":"Mandal","year":"2024","journal-title":"J. Org. Chem."},{"key":"D5OB01897H\/cit54\/1","doi-asserted-by":"publisher","year":"2026","unstructured":"CCDC 2474025: Experimental Crystal Structure Determination ,  2026 ,  10.5517\/ccdc.csd.cc2p1f8g","DOI":"10.5517\/ccdc.csd.cc2p1f8g"},{"key":"D5OB01897H\/cit55\/1","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1016\/S0040-4039(00)89719-1","volume":"9","author":"Ch\u00e9rest","year":"1968","journal-title":"Tetrahedron Lett."},{"key":"D5OB01897H\/cit56\/1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/ja00344a063","volume":"105","author":"DeShong","year":"1983","journal-title":"J. Am. Chem. Soc."},{"key":"D5OB01897H\/cit57\/1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/cber.19150480154","volume":"48","author":"Mumm","year":"1915","journal-title":"Ber. Dtsch. Chem. Ges."},{"key":"D5OB01897H\/cit58\/1","doi-asserted-by":"crossref","first-page":"e4106","DOI":"10.1002\/poc.4106","volume":"33","author":"Rouhani","year":"2020","journal-title":"J. Phys. Org. Chem."},{"key":"D5OB01897H\/cit59\/1","doi-asserted-by":"crossref","first-page":"10079","DOI":"10.1021\/jm401497a","volume":"56","author":"Moreau","year":"2013","journal-title":"J. Med. Chem."},{"key":"D5OB01897H\/cit60\/1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0008-6215(91)84120-4","volume":"217","author":"J\u00e4ger","year":"1991","journal-title":"Carbohydr. Res."},{"key":"D5OB01897H\/cit61\/1","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/acs.orglett.8b00479","volume":"20","author":"Liu","year":"2018","journal-title":"Org. Lett."},{"key":"D5OB01897H\/cit64\/1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bmc.2006.10.060","volume":"15","author":"Foss","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"D5OB01897H\/cit67\/1","doi-asserted-by":"crossref","first-page":"9897","DOI":"10.1021\/jm401075x","volume":"56","author":"Hennessy","year":"2013","journal-title":"J. Med. Chem."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/OB\/D5OB01897H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:27:13Z","timestamp":1782966433000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/24\/12\/2542-2558\/1236410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,3,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ob01897h","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}