{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:42:26Z","timestamp":1788295346822,"version":"build-2803163510"},"reference-count":47,"publisher":"Royal Society of Chemistry (RSC)","issue":"20","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":133,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Conventional eye drops are associated with several limitations, including rapid drug clearance and low bioavailability, with only about 5% of the administered drug reaching the cornea to demonstrate therapeutic efficacy.<\/jats:p>","DOI":"10.1039\/d5ra01046b","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:51:32Z","timestamp":1747212692000},"page":"16110-16124","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Indomethacin-incorporated microemulsion-laden contact lenses for improved ocular drug delivery and therapeutic efficacy"],"prefix":"10.1039","volume":"15","author":[{"given":"Kashvi","family":"Panchal","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat 380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashkumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat 380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshilkumar","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat 380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mittal","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, L. M. College of Pharmacy, Ahmedabad, Gujarat 380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay R.","family":"Chidrawar","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS), Deemed-to-University, Green Industrial Park, TSIIC, Jadcherla, Hyderabad 509301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-4276","authenticated-orcid":false,"given":"Deepanjan","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-4444","authenticated-orcid":false,"given":"Popat","family":"Mohite","sequence":"additional","affiliation":[{"name":"AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra 401404, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Puri","sequence":"additional","affiliation":[{"name":"AETs St. John Institute of Pharmacy and Research, Palghar, Maharashtra 401404, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Ranch","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, L. M. College of Pharmacy, Ahmedabad, Gujarat 380009, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-3322","authenticated-orcid":false,"given":"Sudarshan","family":"Singh","sequence":"additional","affiliation":[{"name":"Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5RA01046B\/cit1\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2023.01.018","volume":"354","author":"Onugwu","year":"2023","journal-title":"J. Controlled Release"},{"key":"D5RA01046B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/polym13071102","volume":"13","author":"Franco","year":"2021","journal-title":"Polymers"},{"key":"D5RA01046B\/cit3\/1","first-page":"87","volume":"23","author":"Popescu","year":"2012","journal-title":"Ovidius Univ. Ann. Chem."},{"key":"D5RA01046B\/cit4\/1","doi-asserted-by":"crossref","first-page":"102112","DOI":"10.1016\/j.jddst.2020.102112","volume":"61","author":"Laddha","year":"2021","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5RA01046B\/cit5\/1","doi-asserted-by":"crossref","first-page":"101373","DOI":"10.1016\/j.jddst.2019.101373","volume":"55","author":"Dhaval","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5RA01046B\/cit6\/1","doi-asserted-by":"crossref","first-page":"102951","DOI":"10.1016\/j.jddst.2021.102951","volume":"67","author":"Londhe","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5RA01046B\/cit7\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejpb.2016.10.015","volume":"109","author":"Balguri","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D5RA01046B\/cit8\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1877912305666150418001132","volume":"5","author":"Gudhka","year":"2015","journal-title":"Recent Pat. Nanomed."},{"key":"D5RA01046B\/cit9\/1","doi-asserted-by":"crossref","first-page":"102342","DOI":"10.1016\/j.cis.2020.102342","volume":"288","author":"Grassiri","year":"2021","journal-title":"Adv. Colloid Interface Sci."},{"key":"D5RA01046B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3390\/nano14121004","volume":"14","author":"Leng","year":"2024","journal-title":"Nanomaterials"},{"key":"D5RA01046B\/cit11\/1","doi-asserted-by":"crossref","first-page":"101330","DOI":"10.1016\/j.jddst.2019.101330","volume":"54","author":"Xu","year":"2019","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5RA01046B\/cit12\/1","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1080\/09205063.2020.1764165","volume":"31","author":"Li","year":"2020","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"D5RA01046B\/cit13\/1","doi-asserted-by":"crossref","first-page":"103211","DOI":"10.1016\/j.jddst.2022.103211","volume":"70","author":"Datta","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5RA01046B\/cit14\/1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/01932691.2019.1710183","volume":"42","author":"Wei","year":"2021","journal-title":"J. Dispersion Sci. Technol."},{"key":"D5RA01046B\/cit15\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1208\/s12248-008-9024-9","volume":"10","author":"Ahuja","year":"2008","journal-title":"AAPS J."},{"key":"D5RA01046B\/cit16\/1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4103\/ijo.IJO_1612_21","volume":"70","author":"Singhal","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"D5RA01046B\/cit17\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1755-3768.1991.tb02703.x","volume":"69","author":"Sand","year":"1991","journal-title":"Acta Ophthalmol."},{"key":"D5RA01046B\/cit18\/1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00417-002-0581-9","volume":"240","author":"Baudouin","year":"2002","journal-title":"Graefe's Arch. Clin. Exp. Ophthalmol."},{"key":"D5RA01046B\/cit19\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/476525","volume":"2013","author":"Russo","year":"2013","journal-title":"Mediators Inflammation"},{"key":"D5RA01046B\/cit20\/1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0039-6257(84)90239-X","volume":"28","author":"Miyake","year":"1984","journal-title":"Surv. Ophthalmol."},{"key":"D5RA01046B\/cit21\/1","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1111\/j.1755-3768.2012.02520.x","volume":"91","author":"Weber","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"D5RA01046B\/cit22\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5152\/eurasianjmed.2018.0010","volume":"50","author":"Gunaydin","year":"2018","journal-title":"Eurasian J. Med."},{"key":"D5RA01046B\/cit23\/1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/B978-0-12-820007-0.00028-3","volume-title":"Remington: the Science and Practice of Pharmacy","author":"Maulvi","year":"2020","unstructured":"F. A.Maulvi ,  K. M.Ranch ,  A. R.Desai ,  D. T.Desai  and  M. R.Shukla , in  Remington: the Science and Practice of Pharmacy ,  Elsevier ,  2020 ,  pp. 565\u2013575 ,  10.1016\/B978-0-12-820007-0.00028-3"},{"key":"D5RA01046B\/cit24\/1","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1080\/17425247.2016.1201059","volume":"13","author":"Battaglia","year":"2016","journal-title":"Expert Opin. Drug Delivery"},{"key":"D5RA01046B\/cit25\/1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/10837450.2021.1944206","volume":"26","author":"Siafaka","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"D5RA01046B\/cit26\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3390\/pharmaceutics13040444","volume":"13","author":"Mahran","year":"2021","journal-title":"Pharmaceutics"},{"key":"D5RA01046B\/cit27\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/10717544.2021.2021323","volume":"29","author":"Ma","year":"2022","journal-title":"Drug Delivery"},{"key":"D5RA01046B\/cit28\/1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1208\/s12249-007-9022-8","volume":"9","author":"Darole","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"D5RA01046B\/cit29\/1","doi-asserted-by":"crossref","first-page":"101792","DOI":"10.1016\/j.jddst.2020.101792","volume":"57","author":"Xu","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D5RA01046B\/cit30\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-022-02459-7","volume":"24","author":"Abd El Wahab","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"D5RA01046B\/cit31\/1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/jps.10412","volume":"92","author":"Moreno","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"D5RA01046B\/cit32\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2016.02.012","volume":"226","author":"Maulvi","year":"2016","journal-title":"J. Controlled Release"},{"key":"D5RA01046B\/cit33\/1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.actbio.2019.01.004","volume":"86","author":"Maulvi","year":"2019","journal-title":"Acta Biomater."},{"key":"D5RA01046B\/cit34\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.clae.2006.03.002","volume":"29","author":"Moore","year":"2006","journal-title":"Contact Lens and Anterior Eye"},{"issue":"18","key":"D5RA01046B\/cit35\/1","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1080\/09205063.2024.2391233","volume":"35","author":"Chawnani","year":"2024","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"D5RA01046B\/cit36\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijpharm.2018.06.059","volume":"548","author":"Maulvi","year":"2018","journal-title":"Int. J. Pharm."},{"key":"D5RA01046B\/cit37\/1","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1021\/jm068049o","volume":"50","author":"Guillory","year":"2007","journal-title":"J. Med. Chem."},{"key":"D5RA01046B\/cit38\/1","volume-title":"Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying I) Chemicals Inducing Serious Eye Damage and Ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage","year":"2023","unstructured":"Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying I) Chemicals Inducing Serious Eye Damage and Ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage ,  OECD ,  2023"},{"key":"D5RA01046B\/cit39\/1","doi-asserted-by":"crossref","first-page":"432376","DOI":"10.1155\/2015\/432376","volume":"2015","author":"Dave","year":"2015","journal-title":"Sci. World J."},{"key":"D5RA01046B\/cit40\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1201\/b14258","volume-title":"Principles and Methods of Toxicology","author":"Walles Hayes","year":"2007","unstructured":"A.Walles Hayes ,  Principles and Methods of Toxicology ,  CRC Press ,  2007 ,  p. 44"},{"key":"D5RA01046B\/cit41\/1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/bioengineering9080384","volume":"9","author":"Algahtani","year":"2022","journal-title":"Bioengineering"},{"issue":"6","key":"D5RA01046B\/cit42\/1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3390\/pharmaceutics11060262","volume":"11","author":"Torres-Luna","year":"2019","journal-title":"Pharmaceutics"},{"key":"D5RA01046B\/cit43\/1","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.3390\/nano13162311","volume":"13","author":"Racovita","year":"2023","journal-title":"Nanomaterials"},{"key":"D5RA01046B\/cit44\/1","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s13202-022-01475-4","volume":"12","author":"Dongqi","year":"2022","journal-title":"J. Pet. Explor. Prod. Technol."},{"key":"D5RA01046B\/cit45\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2004.11.033","volume":"292","author":"Gulsen","year":"2005","journal-title":"Int. J. Pharm."},{"key":"D5RA01046B\/cit46\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12886-022-02255-8","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Ophthalmol."},{"key":"D5RA01046B\/cit47\/1","doi-asserted-by":"crossref","first-page":"e19111","DOI":"10.1371\/journal.pone.0019111","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA01046B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:21:18Z","timestamp":1782930078000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/20\/16110-16124\/906250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":47,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,5,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra01046b","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5RA01046B\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA01046B\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA01046B\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA01046B\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA01046B\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA01046B\/v1\/decision1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}