{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:03:32Z","timestamp":1788545012651,"version":"build-2803163510"},"reference-count":40,"publisher":"Royal Society of Chemistry (RSC)","issue":"29","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":190,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100015763","name":"Szegedi Tudom\u00e1nyegyetem","doi-asserted-by":"publisher","award":["7621"],"award-info":[{"award-number":["7621"]}],"id":[{"id":"10.13039\/501100015763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Magyarorsz\u00e1g Korm\u00e1nya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Regioisomeric estradiol\u2013benzoxazolone hybrids featuring a shared aromatic ring were efficiently synthesized, and their anticancer activities were comparatively evaluated. Derivatives bearing the 2,3-ring fusion exhibited enhanced biological activity.<\/jats:p>","DOI":"10.1039\/d5ra01977j","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T07:36:11Z","timestamp":1752132971000},"page":"23954-23965","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aromatic scaffold-integrated hybrids of estradiol and benzoxazol-2-ones: synthesis and\n                    <i>in vitro<\/i>\n                    anticancer activity of\n                    <i>N<\/i>\n                    -substituted regioisomeric pairs"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8838-8745","authenticated-orcid":false,"given":"Ferenc","family":"Kov\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Molecular and Analytical Chemistry, University of Szeged, D\u00f3m t\u00e9r 7-8, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildik\u00f3","family":"Huli\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Doctoral School of Biology, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9di","family":"\u00c1rva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Doctoral School of Biology, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Kocsis","sequence":"additional","affiliation":[{"name":"Department of Molecular and Analytical Chemistry, University of Szeged, D\u00f3m t\u00e9r 7-8, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Kiricsi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Doctoral School of Biology, University of Szeged, K\u00f6z\u00e9p fasor 52, H-6726 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-0551","authenticated-orcid":false,"given":"\u00c9va","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Molecular and Analytical Chemistry, University of Szeged, D\u00f3m t\u00e9r 7-8, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5RA01977J\/cit1\/1","doi-asserted-by":"publisher","first-page":"7821","DOI":"10.1039\/D3OB01330H","volume":"21","author":"Kumar","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"D5RA01977J\/cit2\/1","doi-asserted-by":"publisher","first-page":"2300245","DOI":"10.1002\/ardp.202300245","volume":"356","author":"Prasher","year":"2023","journal-title":"Arch. Pharm."},{"key":"D5RA01977J\/cit3\/1","doi-asserted-by":"publisher","first-page":"877","DOI":"10.2174\/0929867053507388","volume":"12","author":"Poupaert","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"D5RA01977J\/cit4\/1","doi-asserted-by":"publisher","first-page":"9258","DOI":"10.1021\/acs.jmedchem.5b01188","volume":"58","author":"Bach","year":"2015","journal-title":"J. Med. Chem."},{"key":"D5RA01977J\/cit5\/1","doi-asserted-by":"publisher","first-page":"716","DOI":"10.2174\/1871520620666200807221731","volume":"21","author":"Bilginer","year":"2021","journal-title":"Anticancer Agents Med. Chem."},{"key":"D5RA01977J\/cit6\/1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.2174\/1871520620666200721125820","volume":"21","author":"Erdag","year":"2021","journal-title":"Anticancer Agents Med. Chem."},{"key":"D5RA01977J\/cit7\/1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/14756360701841772","volume":"24","author":"G\u00f6khan-Kelek\u00e7i","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5RA01977J\/cit8\/1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/cbdd.13784","volume":"97","author":"Tang","year":"2021","journal-title":"Chem. Biol. Drug Des"},{"key":"D5RA01977J\/cit9\/1","doi-asserted-by":"publisher","first-page":"127086","DOI":"10.1016\/j.bmcl.2020.127086","volume":"30","author":"Zhi","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D5RA01977J\/cit10\/1","doi-asserted-by":"publisher","first-page":"113124","DOI":"10.1016\/j.ejmech.2020.113124","volume":"212","author":"Erdogan","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA01977J\/cit11\/1","doi-asserted-by":"publisher","first-page":"113269","DOI":"10.1016\/j.ejmech.2021.113269","volume":"215","author":"Zhang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA01977J\/cit12\/1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2174\/0929867053363540","volume":"12","author":"Lima","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"D5RA01977J\/cit13\/1","doi-asserted-by":"publisher","first-page":"7456","DOI":"10.3390\/molecules27217456","volume":"27","author":"Kov\u00e1cs","year":"2022","journal-title":"Molecules"},{"key":"D5RA01977J\/cit14\/1","doi-asserted-by":"publisher","first-page":"e202300352","DOI":"10.1002\/cmdc.202300352","volume":"18","author":"Kov\u00e1cs","year":"2023","journal-title":"ChemMedChem"},{"key":"D5RA01977J\/cit15\/1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jsbmb.2013.02.018","volume":"137","author":"Frank","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"D5RA01977J\/cit16\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/1574885512666170109143715","volume":"12","author":"Borah","year":"2017","journal-title":"Curr. Drug Ther."},{"key":"D5RA01977J\/cit17\/1","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1080\/17460441.2024.2322990","volume":"19","author":"de Sena Murteira Pinheiro","year":"2024","journal-title":"Expert Opin. Drug Discovery"},{"key":"D5RA01977J\/cit18\/1","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1002\/ijc.21590","volume":"118","author":"V Fernandez","year":"2006","journal-title":"Int. J. Cancer"},{"key":"D5RA01977J\/cit19\/1","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/s0039-128x(96)00242-5","volume":"62","author":"Anstead","year":"1997","journal-title":"Steroids"},{"key":"D5RA01977J\/cit20\/1","doi-asserted-by":"publisher","first-page":"652","DOI":"10.2174\/1871520617666171114111721","volume":"18","author":"Minorics","year":"2018","journal-title":"Anticancer Agents Med. Chem."},{"key":"D5RA01977J\/cit21\/1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3892\/ol.2020.11925","volume":"20","author":"Tang","year":"2020","journal-title":"Oncol. Lett."},{"key":"D5RA01977J\/cit22\/1","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.ejmech.2014.06.010","volume":"82","author":"Bandyopadhyay","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA01977J\/cit23\/1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1080\/14756366.2020.1838500","volume":"36","author":"J\u00f3j\u00e1rt","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D5RA01977J\/cit24\/1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ejmech.2017.06.039","volume":"138","author":"Zou","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D5RA01977J\/cit25\/1","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1021\/acs.jmedchem.7b01312","volume":"61","author":"Le Hiress","year":"2018","journal-title":"J. Med. Chem."},{"key":"D5RA01977J\/cit26\/1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/slct.201600147","volume":"1","author":"Kumar","year":"2016","journal-title":"ChemistrySelect"},{"key":"D5RA01977J\/cit27\/1","doi-asserted-by":"publisher","first-page":"7203","DOI":"10.1039\/c7sc02859h","volume":"8","author":"Sherborne","year":"2017","journal-title":"Chem. Sci."},{"key":"D5RA01977J\/cit28\/1","doi-asserted-by":"publisher","first-page":"7421","DOI":"10.1021\/ja0260465","volume":"124","author":"Klapars","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA01977J\/cit29\/1","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1039\/c3cs60289c","volume":"43","author":"Sambiagio","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"D5RA01977J\/cit30\/1","doi-asserted-by":"publisher","first-page":"13885","DOI":"10.1039\/d1ra01889b","volume":"11","author":"Kov\u00e1cs","year":"2021","journal-title":"RSC Adv."},{"key":"D5RA01977J\/cit31\/1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"D5RA01977J\/cit32\/1","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Sports"},{"key":"D5RA01977J\/cit33\/1","doi-asserted-by":"publisher","first-page":"132858","DOI":"10.1016\/j.molstruc.2022.132858","volume":"1261","author":"Petrasheuskaya","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D5RA01977J\/cit34\/1","doi-asserted-by":"publisher","first-page":"7308","DOI":"10.1021\/acscatal.8b01881","volume":"8","author":"Hardouin Duparc","year":"2018","journal-title":"ACS Catal."},{"key":"D5RA01977J\/cit35\/1","doi-asserted-by":"publisher","first-page":"7948","DOI":"10.1021\/om300586p","volume":"31","author":"King","year":"2012","journal-title":"Organometallics"},{"key":"D5RA01977J\/cit36\/1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/B978-0-12-821263-9.00005-9","volume-title":"Copper in N-Heterocyclic Chemistry","author":"Fatykhov","year":"2021","unstructured":"R. F.Fatykhov ,  O. N.Chupakhin ,  V. L.Rusinov , and  I. A.Khalymbadzha , in  Copper in N-Heterocyclic Chemistry , ed.  A. Srivastava ,  Elsevier ,  2021 ,  p. 161 ,  10.1016\/B978-0-12-821263-9.00005-9"},{"key":"D5RA01977J\/cit37\/1","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1039\/D4CY00034J","volume":"14","author":"Devi","year":"2024","journal-title":"Catal. Sci. Technol."},{"key":"D5RA01977J\/cit38\/1","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.1021\/jacs.8b00400","volume":"140","author":"Thomas","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D5RA01977J\/cit39\/1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/cdd.2017.169","volume":"25","author":"Aubrey","year":"2018","journal-title":"Cell Death Differ."},{"key":"D5RA01977J\/cit40\/1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41392-023-01347-1","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduction Targeted Ther."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA01977J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:11:56Z","timestamp":1782886316000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/29\/23954-23965\/906595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":40,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2025,7,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra01977j","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}