{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:39:04Z","timestamp":1790019544898,"version":"4.0.1"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"32","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":201,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22173084"],"award-info":[{"award-number":["22173084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    Biocompatible matrinium-based ionic liquids with fatty acid anions were prepared\n                    <jats:italic>via<\/jats:italic>\n                    an atom-economic approach, showing improved antimicrobial activity and cytotoxicity profiles for MatILs with longer anionic alkyl chains compared to matrine.\n                  <\/jats:p>","DOI":"10.1039\/d5ra03216d","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T15:58:30Z","timestamp":1753113510000},"page":"25758-25770","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Matrinium-based active pharmaceutical ingredient ionic liquids: chain length effect on micellization, bioactivity and thermodynamic behaviors"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-4881","authenticated-orcid":false,"given":"Zhenning","family":"Yan","sequence":"first","affiliation":[{"name":"College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5RA03216D\/cit1\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jconrel.2021.08.032","volume":"338","author":"Wu","year":"2021","journal-title":"J. Control. Release"},{"key":"D5RA03216D\/cit2\/1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/cg8009496","volume":"9","author":"Dean","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"D5RA03216D\/cit3\/1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.molliq.2019.01.063","volume":"278","author":"Moshikur","year":"2019","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit4\/1","doi-asserted-by":"crossref","first-page":"28126","DOI":"10.1039\/C3RA47615D","volume":"4","author":"Ara\u00fajo","year":"2014","journal-title":"RSC Adv."},{"key":"D5RA03216D\/cit5\/1","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1039\/C9CS00016J","volume":"48","author":"Gomes","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"D5RA03216D\/cit6\/1","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1080\/03639045.2017.1349788","volume":"43","author":"de Almeida","year":"2017","journal-title":"Drug Dev. Ind. Pharm."},{"key":"D5RA03216D\/cit7\/1","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1021\/acssuschemeng.6b00171","volume":"4","author":"Patinha","year":"2016","journal-title":"ACS Sustainable Chem. Eng."},{"key":"D5RA03216D\/cit8\/1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jep.2019.02.045","volume":"236","author":"Ren","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"D5RA03216D\/cit9\/1","doi-asserted-by":"crossref","first-page":"5780","DOI":"10.3390\/molecules28155780","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"key":"D5RA03216D\/cit10\/1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.wear.2004.01.005","volume":"257","author":"Adhvaryu","year":"2004","journal-title":"Wear"},{"key":"D5RA03216D\/cit11\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0045-6535(00)00328-3","volume":"43","author":"Willing","year":"2001","journal-title":"Chemosphere"},{"key":"D5RA03216D\/cit12\/1","doi-asserted-by":"crossref","first-page":"8200","DOI":"10.1039\/C5CS00444F","volume":"44","author":"Jordan","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"D5RA03216D\/cit13\/1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.molliq.2018.06.101","volume":"266","author":"Shah","year":"2018","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit14\/1","doi-asserted-by":"crossref","first-page":"113586","DOI":"10.1016\/j.molliq.2020.113586","volume":"313","author":"Bessa","year":"2020","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit15\/1","doi-asserted-by":"crossref","first-page":"11379","DOI":"10.1021\/acs.chemrev.5b00158","volume":"115","author":"Greaves","year":"2015","journal-title":"Chem. Rev."},{"key":"D5RA03216D\/cit16\/1","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1021\/je600565m","volume":"52","author":"Pires","year":"2007","journal-title":"J. Chem. Eng. Data"},{"key":"D5RA03216D\/cit17\/1","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1021\/acsabm.3c01040","volume":"7","author":"Hassanpour","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"D5RA03216D\/cit18\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jcis.2019.04.095","volume":"551","author":"Ali","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"D5RA03216D\/cit19\/1","volume-title":"Vogel's Textbook of Practical Organic Chemistry","author":"Furniss","year":"1989","unstructured":"B. S.Furniss ,  Vogel's Textbook of Practical Organic Chemistry ,  Pearson Education ,  India ,  1989"},{"key":"D5RA03216D\/cit20\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12896-022-00746-6","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Biotechnol."},{"key":"D5RA03216D\/cit21\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.chemosphere.2019.05.026","volume":"229","author":"Mustahil","year":"2019","journal-title":"Chemosphere"},{"key":"D5RA03216D\/cit22\/1","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1021\/acssuschemeng.8b04343","volume":"7","author":"Lobo Ferreira","year":"2019","journal-title":"ACS Sustain. Chem. Eng."},{"key":"D5RA03216D\/cit23\/1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.molliq.2017.10.042","volume":"248","author":"Serra","year":"2017","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit24\/1","first-page":"655","volume":"69","author":"Rudraraju","year":"2014","journal-title":"Pharmazie"},{"key":"D5RA03216D\/cit25\/1","doi-asserted-by":"crossref","first-page":"112352","DOI":"10.1016\/j.fluid.2019.112352","volume":"505","author":"Zafarani-Moattar","year":"2020","journal-title":"Fluid Phase Equilib."},{"key":"D5RA03216D\/cit26\/1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.molliq.2019.03.046","volume":"283","author":"Wu","year":"2019","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit27\/1","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1021\/la025770y","volume":"18","author":"Carpena","year":"2002","journal-title":"Langmuir"},{"key":"D5RA03216D\/cit28\/1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11743-012-1409-1","volume":"16","author":"Liu","year":"2013","journal-title":"J. Surfactants Deterg."},{"key":"D5RA03216D\/cit29\/1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.colsurfa.2007.09.020","volume":"316","author":"Jungnickel","year":"2008","journal-title":"Colloid Surface A"},{"key":"D5RA03216D\/cit30\/1","first-page":"135","volume":"51","author":"Kopecky","year":"1996","journal-title":"Pharmazie"},{"key":"D5RA03216D\/cit31\/1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1021\/la950508t","volume":"12","author":"Song","year":"1996","journal-title":"Langmuir"},{"key":"D5RA03216D\/cit32\/1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jcis.2007.05.052","volume":"314","author":"Inoue","year":"2007","journal-title":"J. Colloid Interface Sci."},{"key":"D5RA03216D\/cit33\/1","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.20964\/2017.05.53","volume":"12","author":"Khan","year":"2017","journal-title":"Int. J. Electrochem. Sci."},{"key":"D5RA03216D\/cit34\/1","doi-asserted-by":"crossref","first-page":"138399","DOI":"10.1016\/j.cplett.2021.138399","volume":"769","author":"Kumar","year":"2021","journal-title":"Chem. Phys. Lett."},{"key":"D5RA03216D\/cit35\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s003960000402","volume":"279","author":"Burke","year":"2001","journal-title":"Colloid Polym. Sci."},{"key":"D5RA03216D\/cit36\/1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.colsurfa.2007.12.001","volume":"317","author":"Dong","year":"2008","journal-title":"Colloid Surface A"},{"key":"D5RA03216D\/cit37\/1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jct.2007.10.007","volume":"40","author":"Gardas","year":"2008","journal-title":"J. Chem. Thermodyn."},{"key":"D5RA03216D\/cit38\/1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/j100600a014","volume":"78","author":"Kaulgud","year":"1974","journal-title":"J. Phys. Chem."},{"key":"D5RA03216D\/cit39\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10953-006-8936-1","volume":"35","author":"Blanco","year":"2006","journal-title":"J. Solution Chem."},{"key":"D5RA03216D\/cit40\/1","doi-asserted-by":"crossref","first-page":"117664","DOI":"10.1016\/j.molliq.2021.117664","volume":"343","author":"Ramkumar","year":"2021","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit41\/1","doi-asserted-by":"crossref","first-page":"110884","DOI":"10.1016\/j.molliq.2019.110884","volume":"287","author":"Patil","year":"2019","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit42\/1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1021\/j100496a007","volume":"82","author":"Millero","year":"1978","journal-title":"J. Phys. Chem."},{"key":"D5RA03216D\/cit43\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.molliq.2017.08.113","volume":"244","author":"Singh","year":"2017","journal-title":"J. Mol. Liq."},{"key":"D5RA03216D\/cit44\/1","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s11095-022-03336-5","volume":"39","author":"Fang","year":"2022","journal-title":"Pharm. Res."},{"key":"D5RA03216D\/cit45\/1","first-page":"135","volume":"51","author":"Kopecky","year":"1996","journal-title":"Pharmazie"},{"key":"D5RA03216D\/cit46\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijpharm.2018.05.021","volume":"546","author":"Moshikur","year":"2018","journal-title":"Int. J. Pharm."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA03216D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:56:39Z","timestamp":1782942999000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/32\/25758-25770\/907096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":46,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2025,7,21]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra03216d","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D5RA03216D\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA03216D\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA03216D\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA03216D\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA03216D\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D5RA03216D\/v2\/decision1","asserted-by":"object"}]},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}