{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:32:24Z","timestamp":1792175544121,"version":"4.4.0"},"reference-count":161,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Overcoming the blood\u2013brain barrier for effective therapy in neurodegenerative diseases through multifunctional nanocarriers targeting oxidative stress, mitochondrial dysfunction, and neuroinflammation.<\/jats:p>","DOI":"10.1039\/d5ra03599f","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:56:40Z","timestamp":1760000200000},"page":"37540-37569","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cerium-based nanoparticles for neurodegeneration: emerging redox therapeutics beyond pharmaceuticals"],"prefix":"10.1039","volume":"15","author":[{"given":"Keerti","family":"Mishra","sequence":"first","affiliation":[{"name":"Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India"},{"name":"Jawaharlal Nehru University (JNU), New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shourya","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India"},{"name":"Jawaharlal Nehru University (JNU), New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrendra K.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafquat","family":"Rana","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India"},{"name":"Jawaharlal Nehru University (JNU), New Delhi, 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Yadav","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-9325","authenticated-orcid":false,"given":"Manish K.","family":"Chourasia","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"5","key":"D5RA03599F\/cit1\/1","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.3390\/jcm12051709","volume":"12","author":"Van Schependom","year":"2023","journal-title":"J. Clin. Med."},{"issue":"1","key":"D5RA03599F\/cit2\/1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/antiox12010094","volume":"12","author":"Angeloni","year":"2022","journal-title":"Antioxidants"},{"issue":"9","key":"D5RA03599F\/cit3\/1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1289\/ehp.7567","volume":"113","author":"Brown","year":"2005","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"D5RA03599F\/cit4\/1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nm1113","volume":"10","author":"Forman","year":"2004","journal-title":"Nat. Med."},{"issue":"1","key":"D5RA03599F\/cit5\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-024-84936-6","volume":"15","author":"Eleftheria","year":"2025","journal-title":"Sci. Rep."},{"issue":"24","key":"D5RA03599F\/cit6\/1","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.3390\/molecules25245789","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"issue":"2","key":"D5RA03599F\/cit7\/1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s40120-022-00338-8","volume":"11","author":"Tahami Monfared","year":"2022","journal-title":"Neurol. Ther."},{"issue":"7288","key":"D5RA03599F\/cit8\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08983","volume":"464","author":"Bishop","year":"2010","journal-title":"Nature"},{"key":"D5RA03599F\/cit9\/1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1749-6632.2009.05118.x","volume":"1184","author":"Halliday","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"9423","key":"D5RA03599F\/cit10\/1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(04)16305-8","volume":"363","author":"Samii","year":"2004","journal-title":"Lancet"},{"issue":"5","key":"D5RA03599F\/cit11\/1","doi-asserted-by":"publisher","first-page":"2283","DOI":"10.1093\/brain\/114.5.2283","volume":"114","author":"Fearnley","year":"1991","journal-title":"Brain"},{"issue":"49","key":"D5RA03599F\/cit12\/1","doi-asserted-by":"crossref","first-page":"47551","DOI":"10.1074\/jbc.M207356200","volume":"277","author":"Rakhit","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"5384","key":"D5RA03599F\/cit13\/1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1126\/science.281.5384.1851","volume":"281","author":"Bruijn","year":"2025","journal-title":"Science"},{"issue":"6","key":"D5RA03599F\/cit14\/1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ana.1312","volume":"50","author":"Margolis","year":"2001","journal-title":"Ann. Neurol."},{"issue":"6","key":"D5RA03599F\/cit15\/1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"MacDonald","year":"2025","journal-title":"Cell"},{"issue":"5940","key":"D5RA03599F\/cit16\/1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/306234a0","volume":"306","author":"Gusella","year":"1983","journal-title":"Nature"},{"issue":"8","key":"D5RA03599F\/cit17\/1","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1177\/1352458517694432","volume":"23","author":"Kobelt","year":"2017","journal-title":"Mult. Sclerosis"},{"issue":"Pt 7","key":"D5RA03599F\/cit18\/1","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/brain\/awr128","volume":"134","author":"Haider","year":"2011","journal-title":"Brain"},{"issue":"Pt 6","key":"D5RA03599F\/cit19\/1","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/brain\/awt110","volume":"136","author":"Fischer","year":"2013","journal-title":"Brain"},{"issue":"12","key":"D5RA03599F\/cit20\/1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","volume":"134","author":"Feske","year":"2021","journal-title":"Am. J. Med."},{"issue":"4","key":"D5RA03599F\/cit21\/1","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s11596-016-1612-9","volume":"36","author":"Zhou","year":"2016","journal-title":"J. Huazhong Univ. Sci. Technol., Med. Sci."},{"key":"D5RA03599F\/cit22\/1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c10982","author":"Liao","year":"2024","journal-title":"ACS Nano"},{"key":"D5RA03599F\/cit23\/1","doi-asserted-by":"crossref","first-page":"1259797","DOI":"10.3389\/fimmu.2023.1259797","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"D5RA03599F\/cit24\/1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1188\/16.CJON.S1.2-8","volume":"20","author":"Davis","year":"2016","journal-title":"Clin. J. Oncol. Nurs."},{"key":"D5RA03599F\/cit25\/1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/978-3-319-49864-5_18","volume-title":"Glioblastoma. Malignant Brain Tumors: State-of-the-Art Treatment","author":"Wirsching","year":"2017","unstructured":"H. G.Wirsching  and  M.Weller ,  Glioblastoma. Malignant Brain Tumors: State-of-the-Art Treatment ,  2017 , pp. ,  pp. 265\u2013288 ,  10.1007\/978-3-319-49864-5_18"},{"issue":"1","key":"D5RA03599F\/cit26\/1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12325-019-01148-5","volume":"37","author":"Rekatsina","year":"2020","journal-title":"Adv. Ther."},{"issue":"3","key":"D5RA03599F\/cit27\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D5RA03599F\/cit28\/1","doi-asserted-by":"crossref","first-page":"7632025","DOI":"10.1155\/2016\/7632025","volume":"2016","author":"Santos","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"7113","key":"D5RA03599F\/cit29\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"Lin","year":"2006","journal-title":"Nature"},{"issue":"3","key":"D5RA03599F\/cit30\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1871527317666180425122557","volume":"17","author":"Yaribeygi","year":"2018","journal-title":"CNS Neurol. Disord.:Drug Targets"},{"issue":"2","key":"D5RA03599F\/cit31\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"issue":"10","key":"D5RA03599F\/cit32\/1","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"D5RA03599F\/cit33\/1","first-page":"484613","volume":"2013","author":"Hsieh","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"D5RA03599F\/cit34\/1","doi-asserted-by":"crossref","first-page":"610813","DOI":"10.1155\/2015\/610813","volume":"2015","author":"Fischer","year":"2015","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"45","key":"D5RA03599F\/cit35\/1","doi-asserted-by":"crossref","first-page":"16064","DOI":"10.1523\/JNEUROSCI.4158-11.2011","volume":"31","author":"Tremblay","year":"2011","journal-title":"J. Neurosci."},{"key":"D5RA03599F\/cit36\/1","doi-asserted-by":"crossref","first-page":"610813","DOI":"10.1155\/2015\/610813","volume":"2015","author":"Fischer","year":"2015","journal-title":"Oxid. Med. Cell. Longevity"},{"issue":"3\u20134","key":"D5RA03599F\/cit37\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0891-5849(00)00317-8","volume":"29","author":"Cadenas","year":"2000","journal-title":"Free Radical Biol. Med."},{"issue":"17","key":"D5RA03599F\/cit38\/1","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1073\/pnas.85.17.6465","volume":"85","author":"Richter","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"D5RA03599F\/cit39\/1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3390\/ijms24021340","volume":"24","author":"Alkahtani","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D5RA03599F\/cit40\/1","doi-asserted-by":"crossref","first-page":"102357","DOI":"10.1016\/j.arr.2024.102357","volume":"99","author":"Gadhave","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"D5RA03599F\/cit41\/1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/ijms23031851","volume":"23","author":"Lamptey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"D5RA03599F\/cit42\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/ph11020044","volume":"11","author":"Dur\u00e3es","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"4","key":"D5RA03599F\/cit43\/1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1159\/000381546","volume":"1","author":"Chen","year":"2015","journal-title":"Integr. Med. Int."},{"issue":"1","key":"D5RA03599F\/cit44\/1","doi-asserted-by":"crossref","first-page":"a020412","DOI":"10.1101\/cshperspect.a020412","volume":"7","author":"Daneman","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D5RA03599F\/cit45\/1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jconrel.2017.12.015","volume":"270","author":"Zhou","year":"2018","journal-title":"J. Controlled Release"},{"issue":"1","key":"D5RA03599F\/cit46\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"2","key":"D5RA03599F\/cit47\/1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"issue":"3","key":"D5RA03599F\/cit48\/1","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3390\/ijms23031851","volume":"23","author":"Lamptey","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"D5RA03599F\/cit49\/1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pneurobio.2009.05.002","volume":"88","author":"Modi","year":"2009","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"D5RA03599F\/cit50\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1039\/B405713A","volume":"5","author":"Ma","year":"2005","journal-title":"Lab Chip"},{"issue":"1","key":"D5RA03599F\/cit51\/1","doi-asserted-by":"crossref","first-page":"e1153568","DOI":"10.1080\/21688370.2016.1153568","volume":"4","author":"Grabrucker","year":"2016","journal-title":"Tissue Barriers"},{"issue":"9","key":"D5RA03599F\/cit52\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1359-6446(04)03065-X","volume":"9","author":"Pardridge","year":"2004","journal-title":"Drug Discovery Today"},{"issue":"12","key":"D5RA03599F\/cit53\/1","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1002\/jnr.22738","volume":"89","author":"Devraj","year":"2011","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"D5RA03599F\/cit54\/1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1602\/neurorx.2.1.86","volume":"2","author":"L\u00f6scher","year":"2005","journal-title":"NeuroRx"},{"issue":"7","key":"D5RA03599F\/cit55\/1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.addr.2011.11.010","volume":"64","author":"Chen","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"issue":"4","key":"D5RA03599F\/cit56\/1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.pneurobio.2008.12.002","volume":"87","author":"Brasnjevic","year":"2009","journal-title":"Prog. Neurobiol."},{"key":"D5RA03599F\/cit57\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.neuropharm.2013.08.004","volume":"75","author":"Gu","year":"2013","journal-title":"Neuropharmacology"},{"issue":"1","key":"D5RA03599F\/cit58\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-022-01259-6","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct Target The"},{"issue":"2\u20133","key":"D5RA03599F\/cit59\/1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.mam.2012.11.006","volume":"34","author":"Saunders","year":"2013","journal-title":"Mol. Aspects Med."},{"issue":"2","key":"D5RA03599F\/cit60\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jphs.2019.12.008","volume":"15","author":"Hu","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"D5RA03599F\/cit61\/1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.apha.2014.06.001","volume":"71","author":"Preston","year":"2014","journal-title":"Adv. Pharmacol."},{"issue":"7816","key":"D5RA03599F\/cit62\/1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41586-020-2453-z","volume":"583","author":"Yang","year":"2020","journal-title":"Nature"},{"key":"D5RA03599F\/cit63\/1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/B978-0-12-814001-7.00007-X","volume-title":"Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates","author":"Zhu","year":"2019","unstructured":"X.Zhu ,  K.Jin ,  Y.Huang  and  Z.Pang ,  Brain drug delivery by adsorption-mediated transcytosis ,  Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates ,  2019 ,  pp. 159\u2013183 .  https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/B978012814001700007X?via%3Dihub"},{"key":"D5RA03599F\/cit64\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","volume":"235","author":"Saraiva","year":"2016","journal-title":"J. Controlled Release"},{"issue":"2","key":"D5RA03599F\/cit65\/1","doi-asserted-by":"publisher","first-page":"e10153","DOI":"10.1002\/btm2.10153","volume":"5","author":"Nowak","year":"2020","journal-title":"Bioeng. Transl. Med."},{"issue":"6","key":"D5RA03599F\/cit66\/1","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1039\/C8MH01527A","volume":"6","author":"Zhu","year":"2019","journal-title":"Mater. Horiz."},{"key":"D5RA03599F\/cit67\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2016.07.051","volume":"238","author":"Banerjee","year":"2016","journal-title":"J. Controlled Release"},{"key":"D5RA03599F\/cit68\/1","doi-asserted-by":"crossref","first-page":"118278","DOI":"10.1016\/j.molliq.2021.118278","volume":"346","author":"Khaledian","year":"2022","journal-title":"J. Mol. Liq."},{"key":"D5RA03599F\/cit69\/1","doi-asserted-by":"crossref","first-page":"114485","DOI":"10.1016\/j.addr.2022.114485","volume":"189","author":"Correia","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"issue":"7","key":"D5RA03599F\/cit70\/1","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/s41596-024-01115-7","volume":"20","author":"Miao","year":"2025","journal-title":"Nat. Protoc."},{"issue":"7","key":"D5RA03599F\/cit71\/1","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1021\/bm101482r","volume":"12","author":"Yue","year":"2011","journal-title":"Biomacromolecules"},{"issue":"6","key":"D5RA03599F\/cit72\/1","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s13239-020-00496-6","volume":"11","author":"Zhang","year":"2020","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"5","key":"D5RA03599F\/cit73\/1","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.bpj.2010.06.016","volume":"99","author":"Stylianopoulos","year":"2010","journal-title":"Biophys. J."},{"key":"D5RA03599F\/cit74\/1","doi-asserted-by":"crossref","first-page":"114820","DOI":"10.1016\/j.addr.2023.114820","volume":"197","author":"Wu","year":"2023","journal-title":"Adv. Drug Delivery Rev."},{"issue":"7","key":"D5RA03599F\/cit75\/1","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.3390\/pharmaceutics15071868","volume":"15","author":"Huang","year":"2023","journal-title":"Pharmaceutics"},{"issue":"3","key":"D5RA03599F\/cit76\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jsps.2023.01.009","volume":"31","author":"Attia","year":"2023","journal-title":"Saudi Pharm. J."},{"issue":"7","key":"D5RA03599F\/cit77\/1","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/nano10071403","volume":"10","author":"Begines","year":"2020","journal-title":"Nanomaterials"},{"issue":"1","key":"D5RA03599F\/cit78\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-018-0412-8","volume":"16","author":"Sadowska-Bartosz","year":"2018","journal-title":"J. Nanobiotechnol."},{"issue":"43","key":"D5RA03599F\/cit79\/1","doi-asserted-by":"publisher","first-page":"1907308","DOI":"10.1002\/smll.201907308","volume":"16","author":"Eleftheriadou","year":"2020","journal-title":"Small"},{"issue":"12","key":"D5RA03599F\/cit80\/1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/bph.13551","volume":"174","author":"McBean","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"D5RA03599F\/cit81\/1","first-page":"63","volume":"12","author":"Kulkarni","year":"2023","journal-title":"ADMET DMPK"},{"issue":"3","key":"D5RA03599F\/cit82\/1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1039\/D3TB01786A","volume":"12","author":"Farasati Far","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"D5RA03599F\/cit83\/1","doi-asserted-by":"crossref","first-page":"109211","DOI":"10.1016\/j.jpcs.2019.109211","volume":"137","author":"Mishra","year":"2020","journal-title":"J. Phys. Chem. Solids"},{"issue":"30","key":"D5RA03599F\/cit84\/1","first-page":"19836","volume":"18","author":"Han","year":"2024","journal-title":"ACS Nano"},{"issue":"1\u20134","key":"D5RA03599F\/cit85\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11244-022-01630-5","volume":"66","author":"Ghotekar","year":"2023","journal-title":"Top. Catal."},{"issue":"6","key":"D5RA03599F\/cit86\/1","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.3390\/molecules28062639","volume":"28","author":"G\u0142owniak","year":"2023","journal-title":"Molecules"},{"issue":"8","key":"D5RA03599F\/cit87\/1","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1016\/j.ijhydene.2021.11.183","volume":"47","author":"Zonarsaghar","year":"2022","journal-title":"Int. J. Hydrogen Energy"},{"issue":"16","key":"D5RA03599F\/cit88\/1","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1021\/ac0300439","volume":"75","author":"Chen","year":"2003","journal-title":"Anal. Chem."},{"issue":"1","key":"D5RA03599F\/cit89\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11998-014-9595-6","volume":"12","author":"Figueira","year":"2015","journal-title":"J. Coat. Technol. Res."},{"issue":"12","key":"D5RA03599F\/cit90\/1","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.1007\/s10904-024-03263-5","volume":"34","author":"Selvaraj","year":"2024","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"D5RA03599F\/cit91\/1","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.2147\/IJN.S255784","volume":"15","author":"Nadeem","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"20","key":"D5RA03599F\/cit92\/1","doi-asserted-by":"publisher","first-page":"1907322","DOI":"10.1002\/smll.201907322","volume":"16","author":"Casals","year":"2020","journal-title":"Small"},{"key":"D5RA03599F\/cit93\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jallcom.2013.09.013","volume":"584","author":"Gangopadhyay","year":"2014","journal-title":"J. Alloys Compd."},{"issue":"4","key":"D5RA03599F\/cit94\/1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1444","volume":"9","author":"Rzigalinski","year":"2016","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"issue":"45","key":"D5RA03599F\/cit95\/1","doi-asserted-by":"crossref","first-page":"27194","DOI":"10.1039\/D0RA04736H","volume":"10","author":"Singh","year":"2020","journal-title":"RSC Adv."},{"key":"D5RA03599F\/cit96\/1","doi-asserted-by":"crossref","first-page":"100823","DOI":"10.1016\/j.mtbio.2023.100823","volume":"23","author":"Nosrati","year":"2023","journal-title":"Mater. Today Bio"},{"key":"D5RA03599F\/cit97\/1","doi-asserted-by":"crossref","first-page":"100304","DOI":"10.1016\/j.apsadv.2022.100304","volume":"11","author":"Kusuma","year":"2022","journal-title":"Appl. Surf. Sci. Adv."},{"issue":"5","key":"D5RA03599F\/cit98\/1","first-page":"496","volume":"62","author":"Farahmandjou","year":"2016","journal-title":"Rev. Mex. Fis."},{"key":"D5RA03599F\/cit99\/1","volume-title":"Handbook of Nanoparticles","author":"Li","year":"2016","unstructured":"J.Li  and  Q.Wu ,  Synthesis of nanoparticles via solvothermal and hydrothermal methods ,  Handbook of Nanoparticles ,  2016 ,  https:\/\/www.researchgate.net\/profile\/Abdelkader-Bouaziz\/post\/Without-sol-gel-route-how-to-control-porosity-of-zeolite\/attachment\/5f5b0a7bf2f988000194cfe2\/AS%3A934451383119874%401599801979526\/download\/Nanopart+Synthesis+3.pdf"},{"issue":"2","key":"D5RA03599F\/cit100\/1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/nano10020242","volume":"10","author":"Nyoka","year":"2020","journal-title":"Nanomaterials"},{"issue":"11","key":"D5RA03599F\/cit101\/1","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.1021\/cm010235p","volume":"13","author":"Zhang","year":"2001","journal-title":"Chem. Mater."},{"issue":"3","key":"D5RA03599F\/cit102\/1","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1111\/ijac.13365","volume":"17","author":"Ghahramani","year":"2020","journal-title":"Int. J. Appl. Ceram. Technol."},{"issue":"2\u20133","key":"D5RA03599F\/cit103\/1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1466-6049(00)00024-6","volume":"2","author":"Konstantinov","year":"2000","journal-title":"Int. J. Inorg. Mater."},{"issue":"3","key":"D5RA03599F\/cit104\/1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1039\/D3TB01786A","volume":"12","author":"Farasati Far","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"2","key":"D5RA03599F\/cit105\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/antiox5020015","volume":"5","author":"Nelson","year":"2016","journal-title":"Antioxidants"},{"issue":"30","key":"D5RA03599F\/cit106\/1","first-page":"19836","volume":"18","author":"Han","year":"2024","journal-title":"ACS Nano"},{"issue":"2","key":"D5RA03599F\/cit107\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/antiox5020015","volume":"5","author":"Nelson","year":"2016","journal-title":"Antioxidants"},{"issue":"1","key":"D5RA03599F\/cit108\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-024-84936-6","volume":"15","author":"Kumar","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"D5RA03599F\/cit109\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-019-0516-9","volume":"17","author":"Thakur","year":"2019","journal-title":"J. Nanobiotechnol."},{"issue":"14","key":"D5RA03599F\/cit110\/1","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1039\/D4MH00055B","volume":"11","author":"Othman","year":"2024","journal-title":"Mater. Horiz."},{"issue":"36","key":"D5RA03599F\/cit111\/1","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1039\/D1TB01091C","volume":"9","author":"Wu","year":"2021","journal-title":"J. Mater. Chem. B"},{"issue":"51","key":"D5RA03599F\/cit112\/1","doi-asserted-by":"crossref","first-page":"e2102342","DOI":"10.1002\/smll.202102342","volume":"17","author":"Lord","year":"2021","journal-title":"Small"},{"issue":"19","key":"D5RA03599F\/cit113\/1","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1039\/C6TB00396F","volume":"4","author":"Gupta","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"1","key":"D5RA03599F\/cit114\/1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbagen.2013.10.009","volume":"1840","author":"Ciofani","year":"2014","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"8","key":"D5RA03599F\/cit115\/1","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/s11095-013-1071-y","volume":"30","author":"Ciofani","year":"2013","journal-title":"Pharm. Res."},{"key":"D5RA03599F\/cit116\/1","doi-asserted-by":"crossref","first-page":"1131168","DOI":"10.3389\/fncel.2023.1131168","volume":"17","author":"Hanzha","year":"2023","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"D5RA03599F\/cit117\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2174\/157341309788185523","volume":"5","author":"D'Angelo","year":"2009","journal-title":"Curr. Nanosci."},{"issue":"2","key":"D5RA03599F\/cit118\/1","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1021\/acsnano.5b08045","volume":"10","author":"Kwon","year":"2016","journal-title":"ACS Nano"},{"issue":"6","key":"D5RA03599F\/cit119\/1","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1039\/c3sc50697e","volume":"4","author":"Li","year":"2013","journal-title":"Chem. Sci."},{"issue":"41","key":"D5RA03599F\/cit120\/1","doi-asserted-by":"publisher","first-page":"14523","DOI":"10.1002\/chem.201603233","volume":"22","author":"Guan","year":"2016","journal-title":"Chem.\u2013Eur. J."},{"issue":"6","key":"D5RA03599F\/cit121\/1","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1002\/anie.202011711","volume":"60","author":"Singh","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"issue":"19","key":"D5RA03599F\/cit122\/1","doi-asserted-by":"publisher","first-page":"1807965","DOI":"10.1002\/adma.201807965","volume":"31","author":"Kim","year":"2019","journal-title":"Adv. Mater."},{"issue":"10","key":"D5RA03599F\/cit123\/1","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/cdd.2014.72","volume":"21","author":"Dowding","year":"2014","journal-title":"Cell Death Differ."},{"issue":"8","key":"D5RA03599F\/cit124\/1","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1021\/acschemneuro.1c00847","volume":"13","author":"MacHhi","year":"2022","journal-title":"ACS Chem. Neurosci."},{"issue":"12","key":"D5RA03599F\/cit125\/1","doi-asserted-by":"publisher","first-page":"10582","DOI":"10.1021\/nn403743b","volume":"7","author":"Heckman","year":"2013","journal-title":"ACS Nano"},{"issue":"1","key":"D5RA03599F\/cit126\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-025-03263-8","volume":"23","author":"Ma","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"D5RA03599F\/cit127\/1","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1021\/acsnano.7b07625","volume":"12","author":"Chen","year":"2018","journal-title":"ACS Nano"},{"key":"D5RA03599F\/cit128\/1","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.2147\/IJN.S434873","volume":"18","author":"Hu","year":"2023","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"D5RA03599F\/cit129\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3233\/JPD-130230","volume":"3","author":"Dias","year":"2013","journal-title":"J. Parkinsons Dis."},{"key":"D5RA03599F\/cit130\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuint.2017.05.011","volume":"108","author":"Hegazy","year":"2017","journal-title":"Neurochem. Int."},{"key":"D5RA03599F\/cit131\/1","doi-asserted-by":"crossref","first-page":"1188470","DOI":"10.3389\/fphar.2023.1188470","volume":"14","author":"Mohammad","year":"2023","journal-title":"Front. Pharmacol"},{"issue":"2","key":"D5RA03599F\/cit132\/1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3390\/nano10020235","volume":"10","author":"Ruotolo","year":"2020","journal-title":"Nanomaterials"},{"issue":"4","key":"D5RA03599F\/cit133\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ajme.2016.12.006","volume":"53","author":"Abd","year":"2017","journal-title":"Alexandria J. Med."},{"issue":"2","key":"D5RA03599F\/cit134\/1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.5152\/ABCR.2023.23150","volume":"5","author":"Cicek","year":"2023","journal-title":"Arch. Basic Clin. Res."},{"issue":"30","key":"D5RA03599F\/cit135\/1","doi-asserted-by":"publisher","first-page":"9408","DOI":"10.1002\/anie.201805052","volume":"57","author":"Kwon","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"issue":"4","key":"D5RA03599F\/cit136\/1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41593-025-01896-4","volume":"28","author":"Cheng","year":"2025","journal-title":"Nat. Neurosci."},{"issue":"8","key":"D5RA03599F\/cit137\/1","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.nano.2016.06.009","volume":"12","author":"DeCoteau","year":"2016","journal-title":"Nanomedicine"},{"key":"D5RA03599F\/cit138\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/B978-0-323-85544-0.00012-5","volume-title":"Nanomedical Drug Delivery for Neurodegenerative Diseases","author":"Haque","year":"2022","unstructured":"S.Haque  and  C. R.Patra ,  Metal nanoparticles for neurodegenerative diseases ,  Nanomedical Drug Delivery for Neurodegenerative Diseases ,  2022 ,  pp. 183\u2013206"},{"issue":"24","key":"D5RA03599F\/cit139\/1","doi-asserted-by":"crossref","first-page":"13281","DOI":"10.3390\/ijms252413281","volume":"25","author":"Dong","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"D5RA03599F\/cit140\/1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/978-981-13-8731-9_6","volume-title":"Nanomedicine in Brain Diseases: Principles and Application","author":"Zhang","year":"2019","unstructured":"R.Zhang ,  X.Yan  and  K.Fan ,  The Advances of Nanozyme in Brain Disease ,  Nanomedicine in Brain Diseases: Principles and Application ,  2019 ,  pp. 139\u2013179 ,  10.1007\/978-981-13-8731-9_6"},{"issue":"12","key":"D5RA03599F\/cit141\/1","doi-asserted-by":"publisher","first-page":"10582","DOI":"10.1021\/nn403743b","volume":"7","author":"Heckman","year":"2013","journal-title":"ACS Nano"},{"key":"D5RA03599F\/cit142\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.expneurol.2015.08.008","volume":"273","author":"Eitan","year":"2015","journal-title":"Exp. Neurol."},{"issue":"1","key":"D5RA03599F\/cit143\/1","first-page":"21","volume":"23","author":"Hekmatimoghadam","year":"2018","journal-title":"Beyhagh"},{"key":"D5RA03599F\/cit144\/1","doi-asserted-by":"crossref","first-page":"114271","DOI":"10.1016\/j.colsurfb.2024.114271","volume":"245","author":"Abdelalim","year":"2025","journal-title":"Colloids Surf., B"},{"key":"D5RA03599F\/cit145\/1","doi-asserted-by":"crossref","first-page":"121904","DOI":"10.1016\/j.biomaterials.2022.121904","volume":"291","author":"Li","year":"2022","journal-title":"Biomaterials"},{"issue":"6","key":"D5RA03599F\/cit146\/1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.freeradbiomed.2011.06.006","volume":"51","author":"Estevez","year":"2011","journal-title":"Free Radical Biol. Med."},{"issue":"7","key":"D5RA03599F\/cit147\/1","doi-asserted-by":"publisher","first-page":"6794","DOI":"10.1021\/acsnano.8b01994","volume":"12","author":"Bao","year":"2018","journal-title":"ACS Nano"},{"issue":"44","key":"D5RA03599F\/cit148\/1","doi-asserted-by":"crossref","first-page":"11039","DOI":"10.1002\/anie.201203780","volume":"51","author":"Kim","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"issue":"1","key":"D5RA03599F\/cit149\/1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s11596-018-1858-5","volume":"38","author":"Zhang","year":"2018","journal-title":"Curr. Med. Sci."},{"key":"D5RA03599F\/cit150\/1","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jconrel.2023.12.016","volume":"365","author":"Jiang","year":"2024","journal-title":"J. Controlled Release"},{"issue":"25","key":"D5RA03599F\/cit151\/1","doi-asserted-by":"publisher","first-page":"11622","DOI":"10.1007\/s10853-020-04872-4","volume":"55","author":"Sridharan","year":"2020","journal-title":"J. Mater. Sci."},{"issue":"20","key":"D5RA03599F\/cit152\/1","doi-asserted-by":"crossref","first-page":"30441","DOI":"10.1016\/j.ceramint.2022.06.322","volume":"48","author":"Foroutan","year":"2022","journal-title":"Ceram. Int."},{"issue":"15","key":"D5RA03599F\/cit153\/1","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1080\/17435889.2024.2350357","volume":"19","author":"Koula","year":"2024","journal-title":"Nanomedicine"},{"key":"D5RA03599F\/cit154\/1","volume-title":"Investigating Ceria Nanocrystals Uptake by Glioblastoma Multiforme Cells and its Related Effects: An Electron Microscopy Study","author":"Aloufi","year":"2017","unstructured":"B.Aloufi ,  Investigating Ceria Nanocrystals Uptake by Glioblastoma Multiforme Cells and its Related Effects: An Electron Microscopy Study ,  2017 ,  http:\/\/hdl.handle.net\/10754\/622702"},{"issue":"4","key":"D5RA03599F\/cit155\/1","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1021\/cr4001594","volume":"114","author":"Gai","year":"2014","journal-title":"Chem. Rev."},{"issue":"4","key":"D5RA03599F\/cit156\/1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1002\/anie.201000235","volume":"50","author":"Patzke","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"issue":"9","key":"D5RA03599F\/cit157\/1","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.3390\/molecules27092678","volume":"27","author":"Barker","year":"2022","journal-title":"Molecules"},{"key":"D5RA03599F\/cit158\/1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jiec.2023.05.037","volume":"125","author":"Noh","year":"2023","journal-title":"J. Ind. Eng. Chem."},{"issue":"4","key":"D5RA03599F\/cit159\/1","first-page":"209","volume":"4","author":"Karkan","year":"2019","journal-title":"Nanomed. Res. J."},{"key":"D5RA03599F\/cit160\/1","volume-title":"Rare Earth Nanotechnology","author":"Das","year":"2012","unstructured":"G. K.Das  and  T. T. T.Yang ,  Structural control and surface modifications of rare earth nanomaterials , in  Rare Earth Nanotechnology , ed.  T. Tan Thatt Yang ,  Jenny Stanford Publishing ,  2012 , 1st edn"},{"key":"D5RA03599F\/cit161\/1","doi-asserted-by":"crossref","first-page":"161237","DOI":"10.1016\/j.jallcom.2021.161237","volume":"887","author":"Xu","year":"2021","journal-title":"J. Alloys Compd."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA03599F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:24:32Z","timestamp":1782930272000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/45\/37540-37569\/907253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":161,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,10,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra03599f","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}