{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T14:56:34Z","timestamp":1793631394916,"version":"4.5.1"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"35","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":224,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515220139"],"award-info":[{"award-number":["2022A1515220139"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>We have developed a novel type of mineralized collagen scaffold loaded with isoniazid, which exhibits excellent drug release properties, degradability, anti-tuberculosis performance, biocompatibility and osteogenicity.<\/jats:p>","DOI":"10.1039\/d5ra03800f","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:04:58Z","timestamp":1755075898000},"page":"28730-28738","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of an innovative isoniazid-loaded biomimetic mineralized bone collagen scaffold in bone defect treatment"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-983X","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, The First Dongguan Affiliated Hospital, Guangdong Medical University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Department, Dongguan Southeast Central Hospital, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-feng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery, The First Dongguan Affiliated Hospital, Guangdong Medical University, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"2","key":"D5RA03800F\/cit1\/1","first-page":"61","volume":"2","author":"Kulchavenya","year":"2014","journal-title":"Ther. Adv. Infect. Dis."},{"issue":"4 Suppl","key":"D5RA03800F\/cit2\/1","first-page":"96s","volume":"8","author":"Rajasekaran","year":"2018","journal-title":"GSJ"},{"issue":"8","key":"D5RA03800F\/cit3\/1","doi-asserted-by":"crossref","first-page":"e0221427","DOI":"10.1371\/journal.pone.0221427","volume":"14","author":"Shen","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"D5RA03800F\/cit4\/1","first-page":"119","volume":"100-b","author":"Broderick","year":"2018","journal-title":"BJJ"},{"issue":"7","key":"D5RA03800F\/cit5\/1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/nep.13399","volume":"24","author":"Sharma","year":"2019","journal-title":"Nephrology"},{"issue":"6","key":"D5RA03800F\/cit6\/1","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.21037\/apm-21-1224","volume":"10","author":"Liu","year":"2021","journal-title":"Ann. Palliat. Med."},{"issue":"11","key":"D5RA03800F\/cit7\/1","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.3390\/ma16114117","volume":"16","author":"Ferraz","year":"2023","journal-title":"Materials"},{"issue":"7","key":"D5RA03800F\/cit8\/1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/ph15070879","volume":"15","author":"Xue","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"6","key":"D5RA03800F\/cit9\/1","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.3390\/ma15062274","volume":"15","author":"Alc\u00e2ntara","year":"2022","journal-title":"Materials"},{"issue":"7","key":"D5RA03800F\/cit10\/1","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1088\/0031-9155\/54\/7\/020","volume":"54","author":"Umoh","year":"2009","journal-title":"Phys. Med. Biol."},{"issue":"18","key":"D5RA03800F\/cit11\/1","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.3390\/ijms231810288","volume":"23","author":"D\u00edez-Pascual","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"D5RA03800F\/cit12\/1","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.3390\/ma16114017","volume":"16","author":"Lukina","year":"2023","journal-title":"Materials"},{"issue":"1","key":"D5RA03800F\/cit13\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/ijms24010529","volume":"24","author":"Dec","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"D5RA03800F\/cit14\/1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/09205063.2022.2127143","volume":"34","author":"Kumawat","year":"2023","journal-title":"J. Biomater. Sci., Polym. Ed."},{"issue":"3","key":"D5RA03800F\/cit15\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/08853282241257613","volume":"39","author":"Zhang","year":"2024","journal-title":"J. Biomater. Appl."},{"issue":"null","key":"D5RA03800F\/cit16\/1","first-page":"1","volume":"46","author":"Gao","year":"2025","journal-title":"Bioact. Mater."},{"issue":"Pt 1","key":"D5RA03800F\/cit17\/1","doi-asserted-by":"crossref","first-page":"137314","DOI":"10.1016\/j.ijbiomac.2024.137314","volume":"283","author":"Nabizadeh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"D5RA03800F\/cit18\/1","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.3390\/pharmaceutics14122660","volume":"14","author":"Zhang","year":"2022","journal-title":"Pharmaceutics"},{"issue":"4","key":"D5RA03800F\/cit19\/1","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1016\/j.dental.2020.12.006","volume":"37","author":"Ou","year":"2021","journal-title":"Dent. Mater."},{"issue":"4","key":"D5RA03800F\/cit20\/1","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1021\/acssuschemeng.0c08009","volume":"9","author":"Shuai","year":"2021","journal-title":"ACS Sustain. Chem. Eng."},{"issue":"3","key":"D5RA03800F\/cit21\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.biomaterials.2009.09.063","volume":"31","author":"Murphy","year":"2010","journal-title":"Biomaterials"},{"issue":"4","key":"D5RA03800F\/cit22\/1","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1021\/acsabm.9b01175","volume":"3","author":"Zhao","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"issue":"null","key":"D5RA03800F\/cit23\/1","doi-asserted-by":"crossref","first-page":"107453","DOI":"10.1016\/j.bpc.2025.107453","volume":"323","author":"Chen","year":"2025","journal-title":"Biophys. Chem."},{"issue":"null","key":"D5RA03800F\/cit24\/1","doi-asserted-by":"crossref","first-page":"124183","DOI":"10.1016\/j.ijpharm.2024.124183","volume":"657","author":"Oliva","year":"2024","journal-title":"Int. J. Pharm."},{"key":"D5RA03800F\/cit25\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijbiomac.2016.05.067","volume":"91","author":"Elango","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"D5RA03800F\/cit26\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10561-017-9653-2","volume":"19","author":"Han","year":"2018","journal-title":"Cell Tissue Banking"},{"issue":"8","key":"D5RA03800F\/cit27\/1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jcpe.12270","volume":"41","author":"Pelaez","year":"2014","journal-title":"J. Clin. Periodontol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA03800F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:30:31Z","timestamp":1782887431000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/35\/28730-28738\/907337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":27,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2025,8,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra03800f","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}