{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:13:26Z","timestamp":1791994406863,"version":"4.4.0"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"45","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100016044","name":"Universit\u00e9 Moulay Isma\u00efl","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Tobramycin (TOB) is an aminoglycoside antibiotic widely used to treat chronic lung infections and other bacterial diseases.<\/jats:p>","DOI":"10.1039\/d5ra03963k","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:52:59Z","timestamp":1760017979000},"page":"37579-37596","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Electrochemical sensor based on molecularly imprinted polymer and voltammetric electronic tongue technology: an efficient strategy for sensitive detection of tobramycin residues"],"prefix":"10.1039","volume":"15","author":[{"given":"Makhtar","family":"War","sequence":"first","affiliation":[{"name":"Biosensors and Nanotechnology Group, Department of Biology, Faculty of Sciences, Moulay Isma\u00efl University, B.P. 11201, Zitoune, 50003, Meknes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-9026","authenticated-orcid":false,"given":"Fatih","family":"\u015een","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kutahya Dumlupinar University, K\u00fctahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Halvaci","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kutahya Dumlupinar University, K\u00fctahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benachir","family":"Bouchikhi","sequence":"additional","affiliation":[{"name":"Biosensors and Nanotechnology Group, Department of Biology, Faculty of Sciences, Moulay Isma\u00efl University, B.P. 11201, Zitoune, 50003, Meknes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nezha","family":"El Bari","sequence":"additional","affiliation":[{"name":"Biosensors and Nanotechnology Group, Department of Biology, Faculty of Sciences, Moulay Isma\u00efl University, B.P. 11201, Zitoune, 50003, Meknes, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D5RA03963K\/cit1\/1","doi-asserted-by":"crossref","first-page":"113848","DOI":"10.1016\/j.jim.2025.113848","volume":"539","author":"Krithiga","year":"2025","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"D5RA03963K\/cit2\/1","doi-asserted-by":"crossref","first-page":"045501","DOI":"10.1149\/1945-7111\/ab6ff3","volume":"167","author":"Islam","year":"2020","journal-title":"J. Electrochem. Soc."},{"key":"D5RA03963K\/cit3\/1","doi-asserted-by":"crossref","first-page":"112046","DOI":"10.1016\/j.bios.2020.112046","volume":"153","author":"Joshi","year":"2020","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"D5RA03963K\/cit4\/1","first-page":"181","volume":"6","author":"He","year":"2020","journal-title":"Environ. Sci.:Water Res. Technol."},{"key":"D5RA03963K\/cit5\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.electacta.2013.08.132","volume":"112","author":"Gupta","year":"2013","journal-title":"Electrochim. Acta"},{"issue":"1\u20132","key":"D5RA03963K\/cit6\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0021-9673(04)01570-5","volume":"1058","author":"Oertel","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"D5RA03963K\/cit7\/1","doi-asserted-by":"crossref","first-page":"105658","DOI":"10.1016\/j.microc.2020.105658","volume":"160","author":"Da Silva Medeiros","year":"2021","journal-title":"Microchem. J."},{"key":"D5RA03963K\/cit8\/1","first-page":"201","volume":"43","author":"Deng","year":"2022","journal-title":"At. Spectrosc."},{"key":"D5RA03963K\/cit9\/1","volume-title":"Pharmacological Basis of Therapeutics","author":"Hardman","year":"2001","unstructured":"J. G.Hardman  and  L. E.Limbird Pharmacological Basis of Therapeutics .  Neurotransmission 2001"},{"issue":"9","key":"D5RA03963K\/cit10\/1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00604-024-06536-5","volume":"191","author":"Nasri","year":"2024","journal-title":"Microchim. Acta"},{"issue":"2","key":"D5RA03963K\/cit11\/1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1111\/1541-4337.12702","volume":"20","author":"Moga","year":"2021","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D5RA03963K\/cit12\/1","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s10973-018-7282-z","volume":"134","author":"Rosasco","year":"2018","journal-title":"J. Therm. Anal. Calorim."},{"key":"D5RA03963K\/cit13\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.talanta.2016.03.045","volume":"154","author":"Arsand","year":"2016","journal-title":"Talanta"},{"issue":"1\u20132","key":"D5RA03963K\/cit14\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0021-9673(00)00985-7","volume":"905","author":"Yang","year":"2001","journal-title":"J. Chromatogr. A"},{"key":"D5RA03963K\/cit15\/1","doi-asserted-by":"crossref","first-page":"120626","DOI":"10.1016\/j.saa.2021.120626","volume":"267","author":"Tavakoli","year":"2022","journal-title":"Spectrochim. Acta, Part A"},{"key":"D5RA03963K\/cit16\/1","doi-asserted-by":"crossref","first-page":"108797","DOI":"10.1016\/j.bioelechem.2024.108797","volume":"160","author":"Zhao","year":"2024","journal-title":"Bioelectrochemistry"},{"issue":"1","key":"D5RA03963K\/cit17\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.foodchem.2012.10.039","volume":"138","author":"Mono\u0161\u00edk","year":"2013","journal-title":"Food Chem."},{"key":"D5RA03963K\/cit18\/1","doi-asserted-by":"crossref","first-page":"120953","DOI":"10.1016\/j.talanta.2020.120953","volume":"216","author":"Motia","year":"2020","journal-title":"Talanta"},{"key":"D5RA03963K\/cit19\/1","doi-asserted-by":"crossref","first-page":"104823","DOI":"10.1016\/j.microc.2020.104823","volume":"156","author":"Ou","year":"2020","journal-title":"Microchem. J."},{"key":"D5RA03963K\/cit20\/1","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1007\/s00604-016-1850-3","volume":"183","author":"Ait Lahcen","year":"2016","journal-title":"Microchim. Acta"},{"key":"D5RA03963K\/cit21\/1","doi-asserted-by":"crossref","first-page":"102468","DOI":"10.1016\/j.mtchem.2024.102468","volume":"43","author":"Wang","year":"2025","journal-title":"Mater. Today Chem."},{"key":"D5RA03963K\/cit22\/1","doi-asserted-by":"crossref","first-page":"120502","DOI":"10.1016\/j.talanta.2019.120502","volume":"209","author":"Ayankojo","year":"2020","journal-title":"Talanta"},{"key":"D5RA03963K\/cit23\/1","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1007\/s00216-011-5696-6","volume":"402","author":"Sharma","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"D5RA03963K\/cit24\/1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bios.2013.03.029","volume":"47","author":"Lai","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"D5RA03963K\/cit25\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.electacta.2018.01.060","volume":"264","author":"Mart\u00edn-Yerga","year":"2018","journal-title":"Electrochim. Acta"},{"issue":"12","key":"D5RA03963K\/cit26\/1","doi-asserted-by":"crossref","first-page":"121404","DOI":"10.1103\/PhysRevB.67.121404","volume":"67","author":"Skorodumova","year":"2003","journal-title":"Phys. Rev. B"},{"issue":"33","key":"D5RA03963K\/cit27\/1","doi-asserted-by":"crossref","first-page":"5665","DOI":"10.1039\/D4AY01148A","volume":"16","author":"Zhao","year":"2024","journal-title":"Anal. Methods"},{"key":"D5RA03963K\/cit28\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00604-020-04655-3","volume":"188","author":"Zhang","year":"2021","journal-title":"Microchim. Acta"},{"issue":"4","key":"D5RA03963K\/cit29\/1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3390\/electrochem4040035","volume":"4","author":"da Silva","year":"2023","journal-title":"Electrochem"},{"issue":"8","key":"D5RA03963K\/cit30\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3390\/chemosensors11080467","volume":"11","author":"Fu","year":"2023","journal-title":"Chemosensors"},{"key":"D5RA03963K\/cit31\/1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.aca.2018.09.064","volume":"1047","author":"Wang","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"D5RA03963K\/cit32\/1","doi-asserted-by":"crossref","first-page":"116148","DOI":"10.1016\/j.trac.2020.116148","volume":"135","author":"Garc\u00eda-Guzm\u00e1n","year":"2021","journal-title":"Trends Anal. Chem."},{"key":"D5RA03963K\/cit33\/1","doi-asserted-by":"crossref","first-page":"120999","DOI":"10.1016\/j.talanta.2020.120999","volume":"216","author":"Negahdary","year":"2020","journal-title":"Talanta"},{"key":"D5RA03963K\/cit34\/1","doi-asserted-by":"crossref","first-page":"128716","DOI":"10.1016\/j.foodchem.2020.128716","volume":"344","author":"Liu","year":"2021","journal-title":"Food Chem."},{"key":"D5RA03963K\/cit35\/1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.snb.2014.09.077","volume":"207","author":"Ha","year":"2015","journal-title":"Sens. Actuators, B"},{"key":"D5RA03963K\/cit36\/1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bios.2015.07.054","volume":"74","author":"Huynh","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"D5RA03963K\/cit37\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.snb.2017.04.165","volume":"250","author":"P\u00e9rez-R\u00e0fols","year":"2017","journal-title":"Sens. Actuators, B"},{"key":"D5RA03963K\/cit38\/1","doi-asserted-by":"crossref","first-page":"120114","DOI":"10.1016\/j.ijpharm.2020.120114","volume":"593","author":"Diouf","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"11","key":"D5RA03963K\/cit39\/1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1351\/pac200577111965","volume":"77","author":"Vlasov","year":"2005","journal-title":"Pure Appl. Chem."},{"key":"D5RA03963K\/cit40\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.talanta.2017.10.051","volume":"179","author":"Zhang","year":"2018","journal-title":"Talanta"},{"key":"D5RA03963K\/cit41\/1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cej.2012.11.099","volume":"217","author":"Ayad","year":"2013","journal-title":"Chem. Eng. J."},{"key":"D5RA03963K\/cit43\/1","doi-asserted-by":"crossref","first-page":"143194","DOI":"10.1016\/j.foodchem.2025.143194","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"D5RA03963K\/cit44\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.foodchem.2018.01.022","volume":"249","author":"Ma","year":"2018","journal-title":"Food Chem."},{"key":"D5RA03963K\/cit45\/1","doi-asserted-by":"crossref","first-page":"134287","DOI":"10.1016\/j.foodchem.2022.134287","volume":"403","author":"Qiao","year":"2023","journal-title":"Food Chem."},{"issue":"1","key":"D5RA03963K\/cit46\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3390\/s22010269","volume":"22","author":"Abera","year":"2021","journal-title":"Sensors"},{"issue":"8","key":"D5RA03963K\/cit47\/1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1080\/00032719.2018.1537282","volume":"52","author":"Jiang","year":"2019","journal-title":"Anal. Lett."},{"issue":"2065","key":"D5RA03963K\/cit49\/1","doi-asserted-by":"crossref","first-page":"20150202","DOI":"10.1098\/rsta.2015.0202","volume":"374","author":"Jolliffe","year":"2016","journal-title":"Philos. Trans. R. Soc., A"},{"key":"D5RA03963K\/cit50\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-4615-5703-6_3","volume-title":"Nonlinear Modeling: Advanced Black-Box Techniques","author":"Vapnik","year":"1998","unstructured":"V.Vapnik ,  The support vector method of function estimation , in  Nonlinear Modeling: Advanced Black-Box Techniques ,  Springer US ,  Boston, MA ,  1998 ,  pp. 55\u201385"},{"issue":"1","key":"D5RA03963K\/cit51\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/s8010142","volume":"8","author":"El Barbri","year":"2008","journal-title":"Sensors"},{"key":"D5RA03963K\/cit52\/1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejpb.2016.10.006","volume":"109","author":"Chetoni","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"86","key":"D5RA03963K\/cit53\/1","doi-asserted-by":"crossref","first-page":"70387","DOI":"10.1039\/C5RA13383A","volume":"5","author":"Sun","year":"2015","journal-title":"RSC Adv."},{"key":"D5RA03963K\/cit54\/1","doi-asserted-by":"crossref","first-page":"120577","DOI":"10.1016\/j.talanta.2019.120577","volume":"209","author":"Diouf","year":"2020","journal-title":"Talanta"},{"key":"D5RA03963K\/cit55\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.scitotenv.2019.01.331","volume":"664","author":"Motia","year":"2019","journal-title":"Sci. Total Environ."},{"key":"D5RA03963K\/cit56\/1","doi-asserted-by":"crossref","first-page":"107404","DOI":"10.1016\/j.bioelechem.2019.107404","volume":"132","author":"Aghoutane","year":"2020","journal-title":"Bioelectrochemistry"},{"key":"D5RA03963K\/cit57\/1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jelechem.2018.03.069","volume":"823","author":"Motia","year":"2018","journal-title":"J. Electroanal. Chem."},{"key":"D5RA03963K\/cit58\/1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.msec.2018.04.069","volume":"90","author":"Zhou","year":"2018","journal-title":"Mater. Sci. Eng., C"},{"key":"D5RA03963K\/cit59\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.microc.2008.04.003","volume":"90","author":"Valentini","year":"2008","journal-title":"Microchem. J."},{"key":"D5RA03963K\/cit60\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0304-4165(97)00079-2","volume":"1379","author":"Sachetelli","year":"1998","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"D5RA03963K\/cit61\/1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.talanta.2013.10.064","volume":"120","author":"Yola","year":"2014","journal-title":"Talanta"},{"key":"D5RA03963K\/cit62\/1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.snb.2016.07.110","volume":"238","author":"Deiminiat","year":"2017","journal-title":"Sens. Actuators, B"},{"issue":"8","key":"D5RA03963K\/cit63\/1","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1007\/s10853-019-04258-1","volume":"55","author":"Nair","year":"2020","journal-title":"J. Mater. Sci."},{"issue":"11","key":"D5RA03963K\/cit64\/1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/acssensors.6b00564","volume":"1","author":"Peveler","year":"2016","journal-title":"ACS Sens."},{"issue":"3","key":"D5RA03963K\/cit65\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1515\/mms-2015-0039","volume":"22","author":"Smulko","year":"2015","journal-title":"Metrol. Meas. Syst."},{"issue":"2","key":"D5RA03963K\/cit66\/1","first-page":"1124","volume":"35","author":"Zhou","year":"2024","journal-title":"IEEE Trans. Neural Netw. Learn. Syst."},{"issue":"Part A","key":"D5RA03963K\/cit67\/1","first-page":"121801","volume":"238","author":"Park","year":"2024","journal-title":"Expert Syst. Appl."},{"key":"D5RA03963K\/cit68\/1","first-page":"110352","volume":"151","author":"Chen","year":"2025","journal-title":"Pattern Recognit."},{"issue":"1","key":"D5RA03963K\/cit69\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11063-012-9219-z","volume":"57","author":"Liu","year":"2025","journal-title":"Neural Process. Lett."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA03963K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:22:04Z","timestamp":1782940924000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/45\/37579-37596\/907401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":67,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,10,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra03963k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}