{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:35:15Z","timestamp":1789875315158,"version":"4.0.1"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"41","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":264,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100013355","name":"Institut Teknologi Sepuluh Nopember","doi-asserted-by":"publisher","award":["2045\/PKS\/ITS\/2024"],"award-info":[{"award-number":["2045\/PKS\/ITS\/2024"]}],"id":[{"id":"10.13039\/501100013355","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Intervertebral disc degeneration is a major contributor to lower back pain worldwide, underscoring the urgent need for effective, minimally invasive regenerative therapies.<\/jats:p>","DOI":"10.1039\/d5ra04291g","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T13:26:07Z","timestamp":1758547567000},"page":"34733-34745","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of alginate\/poly(vinyl alcohol)\/BaSO\n                    <sub>4<\/sub>\n                    hydrogels for nucleus pulposus regeneration"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-0566","authenticated-orcid":false,"given":"Amaliya","family":"Rasyida","sequence":"first","affiliation":[{"name":"Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dindra Fai'mundiarti","family":"Purnamabroto","sequence":"additional","affiliation":[{"name":"Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agung","family":"Purniawan","sequence":"additional","affiliation":[{"name":"Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra Carllistya","family":"Pramadio","sequence":"additional","affiliation":[{"name":"Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femiana","family":"Gapsari","sequence":"additional","affiliation":[{"name":"University of Brawijaya, Malang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina Salsabila","family":"Ednanda","sequence":"additional","affiliation":[{"name":"Department of Materials and Metallurgical Engineering, Faculty of Industrial Technology and Systems Engineering, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"D5RA04291G\/cit1\/1","doi-asserted-by":"publisher","first-page":"2818624","DOI":"10.1155\/2021\/2818624","volume":"2021","author":"Yan","year":"2021","journal-title":"BioMed Res. Int."},{"issue":"1","key":"D5RA04291G\/cit2\/1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s12967-017-1300-y","volume":"15","author":"Centeno","year":"2017","journal-title":"J. Transl. Med."},{"issue":"1","key":"D5RA04291G\/cit3\/1","doi-asserted-by":"publisher","first-page":"7890291","DOI":"10.1155\/2018\/7890291","volume":"2018","author":"Jin","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"D5RA04291G\/cit4\/1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.3934\/mbe.2011.8.1061","volume":"8","author":"Ngwa","year":"2011","journal-title":"Math. Biosci. Eng."},{"key":"D5RA04291G\/cit5\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/ort.1960.31.suppl-43.01","volume":"43","author":"Nachemson","year":"1960","journal-title":"Acta Orthop. Scand. Suppl."},{"issue":"Issue 12","key":"D5RA04291G\/cit6\/1","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/0142-9612(96)84936-2","volume":"17","author":"Bao","year":"1996","journal-title":"Biomaterials"},{"key":"D5RA04291G\/cit7\/1","doi-asserted-by":"publisher","first-page":"12019","DOI":"10.1088\/1755-1315\/649\/1\/012019","volume":"649","author":"Suryandaru","year":"2021","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"issue":"1","key":"D5RA04291G\/cit8\/1","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1038\/s41598-017-02497-3","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"D5RA04291G\/cit9\/1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4028\/www.scientific.net\/MSF.964.240","volume":"964","author":"Rasyida","year":"2019","journal-title":"Mater. Sci. Forum"},{"key":"D5RA04291G\/cit10\/1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.4028\/www.scientific.net\/MSF.964.161","volume":"964","author":"Rasyida","year":"2019","journal-title":"Mater. Sci. Forum"},{"issue":"1","key":"D5RA04291G\/cit11\/1","doi-asserted-by":"publisher","first-page":"7342","DOI":"10.1038\/s41598-020-64480-9","volume":"10","author":"Bahadoran","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"D5RA04291G\/cit12\/1","doi-asserted-by":"publisher","first-page":"779","DOI":"10.5137\/1019-5149.JTN.35925-21.3","volume":"32","author":"Permana","year":"2022","journal-title":"Turk. Neurosurg."},{"key":"D5RA04291G\/cit13\/1","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/B978-008045154-1.50021-6","volume-title":"Scaffolds in Tissue Engineering Bone and Cartilage","author":"Hutmacher","year":"2000","unstructured":"D. W.Hutmacher ,  Scaffolds in Tissue Engineering Bone and Cartilage , ed.  D. F. B. T.-T. B. S. J. C. Williams ,  Elsevier Science ,  Oxford ,  2000 ,  pp. 175\u2013189 ,  10.1016\/B978-008045154-1.50021-6"},{"key":"D5RA04291G\/cit14\/1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.msec.2016.02.071","volume":"63","author":"Yan","year":"2016","journal-title":"Mater. Sci. Eng., C"},{"key":"D5RA04291G\/cit15\/1","doi-asserted-by":"publisher","first-page":"119294","DOI":"10.1016\/j.biomaterials.2019.119294","volume":"217","author":"Lueckgen","year":"2019","journal-title":"Biomaterials"},{"key":"D5RA04291G\/cit16\/1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.biomaterials.2018.06.038","volume":"179","author":"Campbell","year":"2018","journal-title":"Biomaterials"},{"issue":"3","key":"D5RA04291G\/cit17\/1","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1021\/acsmaterialsau.1c00070","volume":"2","author":"Kader","year":"2022","journal-title":"ACS Mater. Au"},{"key":"D5RA04291G\/cit18\/1","first-page":"149","volume-title":"Proceedings of national colloquium research and community services","volume":"5","author":"Ramadhani","year":"2021","unstructured":"F.Ramadhani ,  L.Miratsi ,  Z.Humaeroh  and  F.Afriani ,  Kemampuan Swelling Hidrogel Berbasis Pva\/Alginat ,  Proceedings of national colloquium research and community services ,  2021 ,  vol. 5 ,  pp. 149\u2013151 , [Online]. Available:  https:\/\/journal.ubb.ac.id\/index.php\/snppm\/article\/view\/2727%0Ahttps:\/\/journal.ubb.ac.id\/index.php\/snppm\/article\/download\/2727\/1598"},{"issue":"7\u20138","key":"D5RA04291G\/cit19\/1","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1163\/156856209X444312","volume":"20","author":"Cho","year":"2009","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"D5RA04291G\/cit20\/1","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.ijbiomac.2017.09.103","volume":"107","author":"Espona-Noguera","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"D5RA04291G\/cit21\/1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0820-5930(09)60005-0","volume":"34","author":"P\u00e9riard","year":"2003","journal-title":"Can. J. Med. Radiat. Technol."},{"issue":"4","key":"D5RA04291G\/cit22\/1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.engreg.2022.09.001","volume":"3","author":"Wang","year":"2022","journal-title":"Eng. Regen."},{"issue":"11","key":"D5RA04291G\/cit23\/1","doi-asserted-by":"publisher","first-page":"e21867","DOI":"10.1016\/j.heliyon.2023.e21867","volume":"9","author":"Han","year":"2023","journal-title":"Heliyon"},{"key":"D5RA04291G\/cit24\/1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.biomaterials.2015.04.029","volume":"59","author":"Zeng","year":"2015","journal-title":"Biomaterials"},{"issue":"3","key":"D5RA04291G\/cit25\/1","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.spinee.2012.12.005","volume":"13","author":"Huang","year":"2013","journal-title":"Spine J."},{"issue":"21","key":"D5RA04291G\/cit26\/1","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1089\/scd.2014.0203","volume":"23","author":"Yim","year":"2014","journal-title":"Stem Cell. Dev."},{"key":"D5RA04291G\/cit27\/1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/jbm.b.30814","volume":"83","author":"Boelen","year":"2007","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"D5RA04291G\/cit28\/1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jot.2022.03.006","volume":"33","author":"Jia","year":"2022","journal-title":"J. Orthop. Translat."},{"key":"D5RA04291G\/cit29\/1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.actbio.2023.08.023","volume":"170","author":"Jiang","year":"2023","journal-title":"Acta Biomater."},{"key":"D5RA04291G\/cit30\/1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.actbio.2023.08.029","volume":"170","author":"Brissenden","year":"2023","journal-title":"Acta Biomater."},{"key":"D5RA04291G\/cit31\/1","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.3390\/polym15122592","volume":"15","author":"Savic Gajic","year":"2023","journal-title":"Polymers"},{"issue":"6","key":"D5RA04291G\/cit32\/1","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1039\/C1CS15203C","volume":"41","author":"Li","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"D5RA04291G\/cit33\/1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.actbio.2014.10.027","volume":"12","author":"Wang","year":"2015","journal-title":"Acta Biomater."},{"issue":"2","key":"D5RA04291G\/cit34\/1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/jbm.b.31344","volume":"90","author":"Spiller","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"D5RA04291G\/cit35\/1","doi-asserted-by":"publisher","first-page":"100779","DOI":"10.1016\/j.mex.2019.100779","volume":"7","author":"Zhang","year":"2020","journal-title":"MethodsX"},{"issue":"3","key":"D5RA04291G\/cit36\/1","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1007\/s00248-015-0683-7","volume":"71","author":"de Lima Brossi","year":"2016","journal-title":"Microb. Ecol."},{"issue":"7","key":"D5RA04291G\/cit37\/1","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1002\/jbm.a.34106","volume":"100","author":"Gorgieva","year":"2012","journal-title":"J. Biomed. Mater. Res., Part A"},{"issue":"6","key":"D5RA04291G\/cit38\/1","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/S0142-9612(00)00201-5","volume":"22","author":"Kuo","year":"2001","journal-title":"Biomaterials"},{"issue":"6","key":"D5RA04291G\/cit39\/1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s10856-009-3692-6","volume":"20","author":"Tan","year":"2009","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"19","key":"D5RA04291G\/cit40\/1","doi-asserted-by":"publisher","first-page":"11632","DOI":"10.1039\/D1RA07368K","volume":"12","author":"Yumin","year":"2022","journal-title":"RSC Adv."},{"issue":"1","key":"D5RA04291G\/cit41\/1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s10856-020-06480-9","volume":"32","author":"Zhang","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"1","key":"D5RA04291G\/cit42\/1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.colsurfa.2011.06.015","volume":"385","author":"Gao","year":"2011","journal-title":"Colloids Surf., A"},{"issue":"2","key":"D5RA04291G\/cit43\/1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.13189\/ujms.2013.010207","volume":"1","author":"Hadi","year":"2013","journal-title":"Univers. J. Mater. Sci."},{"key":"D5RA04291G\/cit44\/1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.colsurfb.2015.08.026","volume":"136","author":"Nair","year":"2015","journal-title":"Colloids Surf., B"},{"key":"D5RA04291G\/cit45\/1","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jmbbm.2017.01.037","volume":"69","author":"Newell","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"4","key":"D5RA04291G\/cit46\/1","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1021\/acs.biomac.5b00027","volume":"16","author":"Wang","year":"2015","journal-title":"Biomacromolecules"},{"key":"D5RA04291G\/cit47\/1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1743-8977-8-9","volume":"8","author":"Kroll","year":"2011","journal-title":"Part. Fibre Toxicol."},{"issue":"4","key":"D5RA04291G\/cit48\/1","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1080\/109374001753146216","volume":"4","author":"Dallas","year":"2001","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"issue":"4","key":"D5RA04291G\/cit49\/1","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"key":"D5RA04291G\/cit50\/1","doi-asserted-by":"publisher","first-page":"040008","DOI":"10.1063\/1.4938323","volume":"1699","author":"Barleany","year":"2015","journal-title":"AIP Conf. Proc."},{"issue":"3","key":"D5RA04291G\/cit51\/1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.22146\/ijc.21235","volume":"14","author":"Erizal","year":"2014","journal-title":"Indones. J. Chem."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/RA\/D5RA04291G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:00:52Z","timestamp":1783015252000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/15\/41\/34733-34745\/907525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":51,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2025,9,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d5ra04291g","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}